Pharmaceutical composition for treating respiratory system diseases and preparation method thereof

A technique for respiratory diseases and compositions, which is applied in the field of pharmaceutical compositions for treating respiratory diseases and its preparation, and can solve the problems of poor stability of terbutaline sulfate, poor stability of ipratropium bromide, and poor stability of terbutaline sulfate. Stability and other issues, to achieve the effect of improving the safety of medication, facilitating transportation and storage, and meeting the needs of clinical medication

Inactive Publication Date: 2021-06-25
HAINAN STAR PHARM CO LTD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Terbutaline sulfate has poor stability and needs to be protected from light and kept in airtight storage
Terbutaline sulfate contains resorcinol groups, and the resorcinol groups turn pink when exposed to light, air or contact with iron ions, so terbutaline sulfate is unstable and easily affected by metal ions, Effects of oxygen and light
Ipratropium bromide has poor stability and needs to be stored in the dark below 30°C

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for treating respiratory system diseases and preparation method thereof
  • Pharmaceutical composition for treating respiratory system diseases and preparation method thereof
  • Pharmaceutical composition for treating respiratory system diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1a

[0037]

[0038]

[0039] According to the prescription in Example 1a, add dispersion medium (water for injection), stabilizer (ascorbic acid), osmotic pressure regulator (sodium chloride), albuterol, acetylcysteine, acidic pH regulator in the liquid preparation tank successively, After stirring evenly, use an alkaline pH regulator to adjust the pH, the temperature of the water for injection is 20°C, and the product is aseptically treated by the sterilization and filtration production process, and the whole process is filled with nitrogen and repacked.

Embodiment 2a

[0048]

[0049] According to the prescription in Example 2a, add dispersion medium (water for injection), stabilizer (ascorbic acid), osmotic pressure regulator (sodium chloride), albuterol, acetylcysteine, acidic pH regulator in the liquid preparation tank successively, After mixing evenly, use an alkaline pH regulator to adjust the pH, the temperature of the water for injection is 30°C, and the product is aseptically treated by the sterile filtration production process, and the whole process is filled with nitrogen for sub-packaging.

Embodiment 3a

[0051]

[0052]

[0053]According to the prescription in Example 3a, add dispersion medium (water for injection), stabilizer (ascorbic acid), osmotic pressure regulator (sodium chloride), albuterol, acetylcysteine, acidic pH regulator in the liquid preparation tank successively, After mixing evenly, use an alkaline pH regulator to adjust the pH, the temperature of the water for injection is 40°C, and the product is aseptically treated by the sterile filtration production process, and the whole process is filled with nitrogen for sub-packaging.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a pharmaceutical composition for treating respiratory system diseases and a preparation method thereof. The composition comprises the following components: a bronchiectasis agent, acetylcysteine, a stabilizer, an osmotic pressure regulator, a pH regulator, a dispersion medium and inert gas, wherein the bronchiectasis agent is a beta2 adrenergic receptor agonist or an anti-choline drug. The stability of the pharmaceutical composition is improved by adding the stabilizer and filling the inert gas in the composition of the pharmaceutical composition so that the pharmaceutical composition is convenient to store, transport and use.

Description

technical field [0001] The invention relates to the field of drugs for respiratory diseases, in particular to a pharmaceutical composition for treating respiratory diseases and a preparation method thereof. Background technique [0002] Bronchodilators are a group of drugs commonly used in respiratory diseases, which can resist bronchoconstriction, expand bronchial smooth muscle, reverse airway obstruction, and relieve airway narrowing, mainly to relieve bronchospasm. When the airway is narrowed or narrowed, people will experience hypoxia, and the clinical symptoms are generally manifested as oppression, wheezing, liver disease, and irritability. Bronchodilators can be taken orally, inhaled, intravenously, etc. to dilate the spasm bronchi and improve breathing. [0003] Acetylcysteine ​​(Acetylcysteine) has been widely used clinically as an expectorant since the 1960s, and it is an expectorant with the most comprehensive mechanism of action in clinical practice. Since acet...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/198A61K47/18A61K47/22A61K47/04A61K9/08A61K31/137A61K31/46A61P11/00
CPCA61K45/06A61K31/198A61K47/183A61K47/22A61K47/02A61K9/08A61K31/137A61K31/46A61P11/00A61K2300/00
Inventor 徐志斌张颖卓张志强
Owner HAINAN STAR PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap