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Method for preparing sulfydryl modified ferroferric oxide/silicon dioxide magnetic nanoparticles

A technology of magnetic nanoparticles and ferroferric oxide, which is applied in the field of medical materials, can solve problems such as cumbersome process steps, solvent methanol is volatile, and human poisoning, and achieves the effects of simple operation process, good dispersion performance, and mild reaction conditions

Active Publication Date: 2015-12-09
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction temperature of the two in the modification process is above 60 °C. The former needs to continuously feed nitrogen gas during the reaction process, and the solvent methanol is very volatile after heating and has a toxic effect on the human body; Need to modify the surface of nanoparticles with amino groups, the process steps are too cumbersome

Method used

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  • Method for preparing sulfydryl modified ferroferric oxide/silicon dioxide magnetic nanoparticles
  • Method for preparing sulfydryl modified ferroferric oxide/silicon dioxide magnetic nanoparticles
  • Method for preparing sulfydryl modified ferroferric oxide/silicon dioxide magnetic nanoparticles

Examples

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Effect test

Embodiment 1

[0041] A method for preparing the mercapto-modified ferric oxide / silicon dioxide magnetic nanoparticles of the present invention comprises the following steps:

[0042] (1) Take 1mmol of FeCl 3 ·6H 2 O in a beaker, then add 30ml of ethylene glycol and 2g of polyethylene glycol 2000, stir magnetically until uniformly dispersed, then continue to add 3g of anhydrous sodium acetate, and stir to obtain a uniformly dispersed mixed solution. Then add the mixed solution into the autoclave, raise the temperature to 200°C and react for 6 hours, after the reaction is completed, water cool to room temperature, magnetically separate, wash the solid matter obtained after separation with alcohol several times, and then put it in a 60°C drying oven under vacuum Dry to obtain magnetic ferric oxide particles.

[0043] (2) Disperse 50 mg of the magnetic ferric iron tetroxide particles prepared in step (1) in 75 mL of ethanol solution, sonicate for 40 min, continue to add 23.5 mL of deionized w...

Embodiment 2

[0047] A method for preparing the mercapto-modified ferric oxide / silicon dioxide magnetic nanoparticles of the present invention comprises the following steps:

[0048] (1) Take 1mmol of FeCl 3 ·6H 2 O in a beaker, then add 30ml of ethylene glycol and 2g of polyethylene glycol 2000, stir magnetically until uniformly dispersed, then continue to add 3g of anhydrous sodium acetate, and stir to obtain a uniformly dispersed mixed solution. Then add the mixed solution into the autoclave, raise the temperature to 200°C and react for 6 hours, after the reaction is completed, water cool to room temperature, magnetically separate, wash the solid matter obtained after separation with alcohol several times, and then put it in a 60°C drying oven under vacuum Dry to obtain magnetic ferric oxide particles.

[0049] (2) Disperse 50 mg of the magnetic ferric iron tetroxide particles prepared in step (1) in 150 mL of ethanol solution, sonicate for 40 min, then add 47 mL of deionized water and...

Embodiment 3

[0053] A method for preparing the mercapto-modified ferric oxide / silicon dioxide magnetic nanoparticles of the present invention comprises the following steps:

[0054] (1) Take 1mmol of FeCl 3 ·6H 2 O in a beaker, then add 30ml of ethylene glycol and 2g of polyethylene glycol 2000, stir magnetically until uniformly dispersed, then continue to add 3g of anhydrous sodium acetate, and stir to obtain a uniformly dispersed mixed solution. Then add the mixed solution into the autoclave, raise the temperature to 200°C and react for 6 hours, after the reaction is completed, water cool to room temperature, magnetically separate, wash the solid matter obtained after separation with alcohol several times, and then put it in a 60°C drying oven under vacuum Dry to obtain magnetic ferric oxide particles. The particle size distribution is shown in Figure 5 As shown, the average particle size is 157nm.

[0055] (2) Disperse 50 mg of the magnetic ferric iron tetroxide particles prepared ...

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Abstract

The invention discloses a method for preparing sulfydryl modified ferroferric oxide / silicon dioxide magnetic nanoparticles. The method comprises the following steps that 1, magnetic ferroferric oxide particles are prepared with trivalent ferric salt serving as raw materials through a solvothermal method; 2, tetraethoxysilane is adopted as a silicon source, generated silicon dioxide wraps the surfaces of the magnetic ferroferric oxide particles through a sol-gel method, and ferroferric oxide / silicon dioxide magnetic nanoparticles are formed; 3, the ferroferric oxide / silicon dioxide magnetic nanoparticles are placed in a methylbenzene solution and dispersed evenly to obtain a solution A, dimercaptosuccinate is added to a dimethyl sulfoxide solution and dispersed evenly to obtain a solution B, the solution A and the solution B are mixed and stirred and react for a period of time, then solid-liquid separation, cleaning and drying are carried out, and then the sulfydryl modified ferroferric oxide / silicon dioxide magnetic nanoparticles are obtained. The magnetic nanoparticles are good in dispersing performance, achieve good stability and biocompatibility, and has potential application value in the bio-medical field.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a preparation method of mercapto-modified ferric oxide / silicon dioxide magnetic nanoparticles. Background technique [0002] Due to their special magnetic properties, magnetic nanoparticles have broad application prospects in the field of biomedicine, which can be summarized into two types: in vitro application and in vivo application. In in vitro applications, it can be used to label and separate cells, proteins, DNA, bacteria and viruses, etc.; in in vivo applications, it can be used as a contrast agent for magnetic resonance imaging, a drug carrier, and overheating to treat tumors. Magnetic nanoparticles represented by iron oxides will make great contributions to human health in the near future. In order to enable magnetic nanoparticles to better serve human health as soon as possible, basic research on the preparation, modification, and functionalization of nanoparticles is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02H01F1/11
Inventor 郭学益毛芳芳田庆华王惟嘉
Owner CENT SOUTH UNIV
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