10results about How to "High potential application value" patented technology

The invention belongs to the field of biomedical engineering, and particularly relates to gradient collagen hydroxyapatite conductive hydrogel and a preparation method thereof. The preparation method comprises the following steps: uniformly distributing hydroxyapatite in a collagen solution, adding sodium alginate and polyvinyl alcohol, and mixing to obtain a mixed solution; hydroxyapatite particles are distributed in a gradient mode along a hydrogel support through centrifugal treatment, then freezing treatment is conducted, a salt solution composed of metal ions and hydrophilic anions is introduced, on one hand, the introduced metal ions can form a cross-linked structure on sodium alginate, and on the other hand, the hydrophilic anions can form a hydrophilic structure on the other hand; meanwhile, part of freely moving metal ions can be intercepted in the hydrogel to provide conductivity for the gel; on the other hand, the mechanical property of the hydrogel scaffold is rapidly improved by hydrophilic anions through an ion specificity effect. Therefore, the hydrogel has excellent mechanical properties and conductivity, and meanwhile, due to gradient distribution of hydroxyapatite, the hydrogel is more similar to a full-thickness osteochondral tissue structure, and the hydrogel has a better application prospect in bone tissue engineering.

The invention discloses a preparation method of a magnesium alloy plate with a gradient twin structure, and belongs to the technical field of heterostructure material preparation. According to the method, firstly, a magnesium alloy plate serves as a base plate, magnesium alloy wires of the same mark are adopted for double-heat-source auxiliary heating stirring friction solid-phase additive manufacturing, and a deposition plate with crystal grains preferentially oriented in the thickness direction is obtained by regulating and controlling the heating temperature and deposition head process parameters; keeping the heating state of the substrate, performing heat source-assisted ultrasonic rolling on the deposited plate, and enabling crystal grains in the thickness direction of the plate to generate twinning deformation of different degrees by regulating and controlling rolling parameters; and finally, separating the substrate from the deposition plate to obtain the magnesium alloy plate with the gradient twin structure. Heterogeneous particles are not introduced, the material is pure, the technological process is short, the production efficiency is high, the cost is low, the prepared plate is small in grain, the gradient twin crystal structure penetrates through the thickness, the comprehensive performance is excellent, and the method is suitable for industrial production and can be applied to the fields of automobiles, aerospace, medical instruments and the like.

The invention discloses a novel modified oxadiazole polymer and a preparation method and application thereof, a hydrazine compound and an ester compound are subjected to three-step synthesis condensation polymerization, and the preparation method comprises the following three steps: firstly, the hydrazine compound and the ester compound are subjected to an esterification reaction to obtain a product hydrazide ester compound; secondly, carrying out high-temperature cyclization synthesis reaction on the product hydrazide ester compound to obtain an oxadiazole ester compound; and finally, carrying out synthesis polycondensation reaction on the oxadiazole ester compound and an alcohol compound to obtain the novel oxadiazole polymer. Compared with a traditional common PET foam material, the novel oxadiazole polymer material prepared by the method has better flexibility, higher rigidity, higher tensile strength and higher wear resistance, is suitable for being applied to preparation of high-strength, high-toughness and friction-resistant materials such as foamed plastics, fibers, films, coatings and adhesives, and has very high potential application value. The technology is expected to generate important application in various fields and promote the development of the scientific and engineering fields.

The invention discloses an organic photo-thermal eutectic material based on crown ether derivatives and a preparation method and application thereof, and relates to the technical field of organic photo-thermal materials. Wherein the organic eutectic material is a host-guest eutectic formed by assembling an electron-rich donor molecule crown ether derivative and an electron-deficient acceptor molecule through a charge transfer effect. Compared with a single subject or object, the eutectic material has a remarkable near-infrared light absorption characteristic and can be applied to interface water evaporation. Tedious and complex molecular design and synthesis processes are avoided, the preparation process is simple and easy to implement, and meanwhile, the polyurethane foam loaded with the organic photo-thermal eutectic material shows an excellent water evaporation advantage and shows a great potential application value in the fields of seawater desalination and the like.

This invention discloses a method for preparing an amphiphilic photocatalyst using carbon nitride-supported metal oxides and its application in the aqueous-phase benzene hydroxylation reaction. This catalyst not only retains the unique amphiphilicity of carbon nitride, improving the interfacial contact and mass transfer process between the water / benzene phases and promoting the rapid and efficient transfer of •OH generated in the aqueous phase to benzene to participate in the reaction, but also forms a good interfacial contact between the metal oxide and carbon nitride phases during molten salt heat treatment. Under illumination, photogenerated electrons can efficiently migrate from carbon nitride to the surface of the metal oxide, driving the rapid photo-Fenton reaction. Therefore, this catalyst exhibits excellent catalytic performance in the photocatalytic aqueous-phase benzene hydroxylation reaction to prepare phenol. This invention does not require the addition of additional organic solvents and can achieve a highly efficient benzene hydroxylation reaction in a pure aqueous phase, conforming to the concept of green chemistry and showing good prospects for industrial application.

The invention discloses an anti-PD-L1 antibody and application thereof, and belongs to the technical field of monoclonal antibodies. The number of the anti-PD-L1 antibodies is five, the five anti-PD-L1 antibodies are respectively an anti-PD-L1 antibody 203-64, an anti-PD-L1 antibody 203-69, an anti-PD-L1 antibody 203-10, an anti-PD-L1 antibody 203-59 and an anti-PD-L1 antibody 203-9, and amino acid sequences of VH and VL of the anti-PD-L1 antibodies and nucleotide sequences of coding genes of the anti-PD-L1 antibodies are shown as SEQ ID NO.1-20. The invention also discloses an application of the anti-PD-L1 antibody in preparation of anti-tumor drugs. The anti-PD-L1 antibody disclosed by the invention has good affinity with a human PDL1 protein and a monkey PDL1 protein, and can be used for treating tumors. According to the present invention, the completely humanized single-chain antibody specifically bound with PD-L1 is enriched, the potential new antibody drug is provided for the clinical treatment of tumors, and the high potential application value and the high potential significance are provided.

The invention discloses application of N-stearoyl glycine in improving rice blast resistance, and relates to the technical field of plant immune resistance inducers and green agricultural invests.It is found for the first time that after plants are treated with low-concentration N-stearoyl glycine, systematic resistance of rice to rice blast can be induced by activating an OsNPR1-OsPR2-OsMAPK6 module, and therefore the application of N-stearoyl glycine in improving rice blast resistance is achieved. The N-stearoyl glycine can be used as an effective component with plant immunity resistance. The plant immune resistance inducer prepared by taking N-stearoylglycine as an effective component can be used for preventing and treating by a spraying method, is high in operability, simple and quick, and can be used for effectively preventing and treating expansion and spreading of diseases. In addition, the N-stearoyl glycine is an animal endogenous metabolite, is easy to degrade and has no residual risk; and the N-stearoyl glycine is low in cost and conforms to the current agricultural sustainable development direction.

The invention relates to a novel room-temperature phosphorescent illuminant with mechanochromism characteristics and a preparation method of the room-temperature phosphorescent illuminant. The reaction structural formula is as shown in Figure 1. Carbazole and 1, 4-dibromobutane are used as raw materials, acetone is used as a solvent, potassium hydroxide is added, and stirring reaction is performed; performing extraction, drying, rotary evaporation, separation and purification to obtain an intermediate; mixing and reacting the obtained intermediate, cyano diphenol or cyano naphthol, acetone, potassium iodide and potassium carbonate; 4 '-(4-(9H-carbazole-9-yl) butoxy)-[1, 1'-biphenyl]-4-carbonitrile or 6-(4-(9H-carbazole-9-yl) butoxy)-2-naphthyl nitrile with mechanochromic characteristic and room temperature phosphorescence emission is obtained through extraction, drying, rotary evaporation, separation and purification. The molecular structure of the material does not contain metal elements, does not contain heavy atoms such as bromine and iodine, has no distorted D-A conformation, and has high potential application value in the fields of anti-counterfeiting, information encryption, organic light-emitting diodes, biosensing imaging and the like.

The application relates to a kind of nanoparticles based on polyphenol compound modification and its preparation and application.The nanoparticles are mainly Cu 2‑x Se (0<=x<=1) nanoparticles, the surface is modified using polyphenol compounds, and nanoparticles with antioxidant protection are obtained by reasonable use of different surface modifiers.The preparation method can obtain nanoparticles with adjustable size, good water dispersibility, good biocompatibility and strong antioxidant effect.The application also discloses the application of nanoparticles after different modifications as new antioxidants, effective removal of reactive oxygen species (ROS), protection of neuronal cell damage and improvement of ischemia-reperfusion injury.

The invention discloses application of N-lauroyl isoleucine to improvement of resistance to rice sheath blight disease, and relates to the technical field of plant immune resistance inducers and green agricultural invests.It is found for the first time that after plants are treated with low-concentration N-lauroyl isoleucine, systematic resistance of rice to the sheath blight disease can be induced by activating an OsNPR1-OsPR2-OsMAPK6 pathway, and therefore the N-lauroyl isoleucine can be used for improving the resistance of the rice sheath blight disease. The N-lauroyl isoleucine can be used as an effective component of a plant immune resistance inducer. The plant immune resistance inducer prepared by taking the N-lauroyl isoleucine as an effective component can be used for preventing and treating through a spraying method, is high in operability, simple and quick, and can be used for effectively preventing and treating the expansion and spreading of diseases. In addition, the N-lauroyl isoleucine is a biological endogenous metabolite, is easy to degrade and has no residual risk; and the N-lauroyl isoleucine is low in cost and conforms to the current agricultural sustainable development direction.