19 results about "Hydroxyquinolines" patented technology

The application discloses a high-activity 8-hydroxyquinoline rhodium complex in vivo and in vitro and a synthesis method and application thereof. The 5,7-dichloro-8-hydroxy-2-methylquinoline, dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, methanol, dimethyl sulfoxide and triethylamine are taken, and under a closed condition, the reaction is carried out at 80 DEG C for 3 days; after being cooled to 37 DEG C, filtration and drying are carried out, and the 5-chloro-8-hydroxyquinoline rhodium complex is obtained. The 5-chloro-8-hydroxyquinoline rhodium complex has obvious inhibiting effect on SK-OV-3 and SK-OV-3 / DDP cancer cells, shows superior antitumor activity, and has small toxicity to normal HL-7702 cells; the 5-chloro-8-hydroxyquinoline rhodium complex has potential medicinal value and is expected to be used for preparation of various antitumor drugs.

This invention belongs to the field of MOF mixed matrix membrane technology, and discloses a MOF mixed matrix membrane for ion sieving and its preparation method. The preparation method includes dissolving an organic ligand and a metal source in an organic compound, ultrasonically treating it to obtain a precursor solution, subjecting the precursor solution to a hydrothermal reaction to obtain a first intermediate product, washing and vacuum drying the first intermediate product to obtain MOF-808 powder; dissolving 8-hydroxyquinoline in anhydrous ethanol, adding the MOF-808 powder, and sealing and stirring to obtain 8-Hq@MOF-808 powder; filtering the 8-Hq@MOF-808 powder onto a substrate, spin-coating an epoxy resin solution onto the substrate containing the 8-Hq@MOF-808 powder, and drying at room temperature to obtain the MOF mixed matrix membrane. The phenolic hydroxyl oxygen atom and pyridine ring nitrogen atom of 8-hydroxyquinoline act as bidentate ligands, forming a stable five-membered chelate ring with metal ions, exhibiting high coordination efficiency.

The application provides a 5-amino-8-hydroxyquinoline-alginic acid polyolefin material ash removal agent and a preparation method and application thereof, and the ash removal agent has a structure of formula I. In the application, 5-amino-8-hydroxyquinoline and alginic acid are connected by a chemical bond to form an ash removal agent of a polyolefin solution. Compared with the prior art, the ash removal agent has more active sites, can be fully complexed with metal ash, and can effectively remove metal ash in a polypropylene material; the preparation method of the ash removal agent is simple, the ash removal rate is fast, the removal rate of metal ions is high, the adsorption capacity is large and the like; and the ash removal agent is not limited to the basic ash content of the polyolefin material, has a wide raw material source, has good stability, can meet the requirements of a fixed bed reaction device, is not limited by a basic production process, and does not affect the stability and continuity of normal production.

The application discloses a kind of steel rust-proof paint and preparation method thereof, belong to chemical industry coating technical field.The steel rust-proof paint is composed of A component and B component;Wherein, A component includes: polyol resin copolymer emulsion, carboxyl modified polyethylene glycol modified 8-hydroxyquinoline loaded NiCo-LDH composite material corrosion inhibitor, physical antirust pigment, graphene, wetting dispersant, defoaming agent and stabilizer;B component includes: isocyanate curing agent.The provided steel rust-proof paint has no toxic and harmful ingredients, meets the requirements of green environmental protection;At the same time, good salt water resistance (480h no abnormality), good salt fog resistance (480h no bubble, no shedding, no rust), strong adhesion, good impact resistance, and good storage stability (30 days no precipitation).

The invention belongs to the technical field of resource recovery and purification, and discloses a method for treating an acidic reaction solution in the production process of 8-hydroxyquinoline, which comprises the following steps of: producing 8-hydroxyquinoline by using hydrochloric acid instead of traditional sulfuric acid, obtaining the acidic reaction solution after the reaction is finished, and deacidifying; adding an organic solvent into the deacidified acidic reaction liquid, then adding a neutralizer to adjust the pH value, carrying out extraction, transferring 8-hydroxyquinoline into an organic phase, leaving an intermediate layer and sodium chloride brine, and carrying out filter pressing treatment on the intermediate layer; performing oil-water separation on the sodium chloride saline water, the intermediate layer pressure filtrate and the organic phase containing the 8-hydroxyquinoline through a phase separation tower; performing purification treatment on sodium chloride brine obtained by oil-water separation, performing atmospheric distillation on an organic phase obtained by oil-water separation to obtain an organic solvent, and performing reduced pressure distillation to obtain 8-hydroxyquinoline. The method has remarkable economic benefits and environmental benefits, and an efficient and feasible technical path is provided for green and sustainable development of 8-hydroxyquinoline production.

This invention provides a high-precision two-component copper etching solution and its preparation method. The etching solution comprises a component A and a component B: component A contains hydrogen peroxide, phosphoric acid, and 8-hydroxyquinoline; component B contains silver-sealed mesoporous silica nanoparticles, citric acid, and ethoxylated acetylenol. The silver-sealed mesoporous silica nanoparticles use thiolized mesoporous silica as a carrier, internally loading the ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide salt, and the surface forms a sealing layer by thiol-binding the silver nanoparticles. During use, the two components are mixed, and hydrogen peroxide and phosphoric acid oxidize and dissolve the silver nanoparticle sealing layer, releasing the ionic liquid. This invention improves storage stability through a two-component design and enables on-demand release of the ionic liquid, suppressing lateral etching in the later stages of etching, improving the precision of copper etching and the flatness of the copper surface, making it suitable for fine circuit processing.

This invention discloses a substrate solution formulation and preparation method for the Antu A2000 fully automated chemiluminescence immunoassay analyzer, belonging to the field of in vitro diagnostic reagent technology. The substrate solution includes solution A and solution B, wherein solution A consists of hydrogen peroxide, a buffer, and a hydrogen peroxide stabilizer; solution B consists of purified luminol, a luminescence enhancer, and a buffer. The hydrogen peroxide stabilizer is selected from HEDP, 8-hydroxyquinoline, urea, or sodium polyacrylate; the luminescence enhancer is selected from 4-morpholinopyridine, p-iodophenol, or imidazole; luminol is purified by ethanol-water gradient recrystallization and ether extraction. The preparation method includes: weighing and dissolving the components, adjusting the pH, stirring and filtering, and dispensing into opaque containers. This invention uses a stabilizer to improve the stability of hydrogen peroxide, an enhancer to increase the luminescence intensity, and reduces impurity interference, resulting in high sensitivity and low cost. It can completely replace the original reagents, exhibiting significant economic and social benefits.

This invention discloses a graded purification method for wet-process phosphoric acid, relating to the field of phosphoric acid chemical industry. The method includes the following steps: S100, adding an inorganic precipitant to wet-process phosphoric acid to carry out a main precipitation reaction; S200, adding active seed crystals to the material obtained in step S100 to carry out a seed-induced interface activation reaction; S300, adding an organic complexing agent to the material obtained in step S200 to carry out a complexation reaction; S400, adding a flocculant to the material obtained in step S300, and obtaining purified phosphoric acid through solid-liquid separation; wherein the inorganic precipitant is a diatomaceous earth-based composite precipitant modified with phytic acid and ionic liquid; and the organic complexing agent is a mixture of dithiophosphate compounds and hydroxyquinoline compounds. This invention achieves a removal rate of over 85% for major impurities such as iron, aluminum, and magnesium, and a removal rate of over 95% for trace heavy metals such as arsenic, cadmium, and lead, with a phosphorus yield of over 96.5%, by constructing a four-stage synergistic system of main precipitation-seed activation-deep complexation-flocculation enhancement.

The application provides a method for preparing 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid and belongs to the technical field of drug synthesis. The method uses 2-hydroxyquinoline-4-carboxylic acid as a raw material to prepare 6-((((9H-fluoren-yl)methoxy)carbonyl)amino)quinoline-4-carboxylic acid. The method has the advantages of easy-to-obtain raw material, simple steps and low cost, is suitable for industrial production, and has a wide application prospect.

The application relates to the technical field of fibers, and discloses an antibacterial far-infrared fiber and a preparation method thereof. The preparation method comprises the following steps: introducing an antibacterial unit hydroxyethyl hexahydro-sym-triazine into polyurethane acrylate, polymerizing the polyurethane acrylate with acrylate monomers, performing surface modification on far-infrared material nano-zirconium dioxide, further grafting 8-hydroxy quinolinyl group chelated silver particles, forming an antibacterial agent with far-infrared heating and antibacterial properties, introducing the antibacterial agent into chemical fiber slices, and endowing the fiber with far-infrared heating and antibacterial properties, and effectively enhancing the flexibility and mechanical properties of the fiber.

This invention belongs to the field of agricultural technology and relates to a nano-encapsulated 8-hydroxyquinoline composition, its preparation method, and its applications. The 8-hydroxyquinoline composition comprises core-shell structured nanoparticles; the core-shell structured nanoparticles consist of a core layer, an intermediate layer, and a shell layer from the inside out; the core layer is formed by the self-assembly of 8-hydroxyquinoline copper and a natural polymer material. The 8-hydroxyquinoline composition of this invention possesses a core-shell structure, exhibiting not only high activity but also significant sustained-release and targeted response characteristics, greatly improving the antibacterial efficiency against plant pathogens and showing broad application prospects.

This invention discloses an anti-drug-resistant lung cancer compound, its preparation method, and its applications. The invention involves reacting 5-chloro-8-hydroxyquinoline, dichloro(pentamethylcyclopentadienyl)rhodium(III) dimer, methanol, dimethyl sulfoxide, and triethylamine under sealed conditions at 80 °C for 3 days. After cooling to 37 °C, the mixture is filtered and dried to obtain the final product. The 5-chloro-8-hydroxyquinoline rhodium complex exhibits superior antitumor activity by targeting and inhibiting the growth of lung cancer cells A549 and cisplatin-resistant lung cancer cells A549 / DDP, while showing low toxicity to normal HL-7702 cells. It possesses potential pharmaceutical value and is expected to be used in the preparation of various antitumor drugs.

The application belongs to the field of fresh-cut flower preservation technology, and particularly relates to a fresh-cut Chinese rose flower preservative and application thereof. The preservative solution comprises the following components: 10-30 g / L of sucrose, 100-150 mg / L of potassium nitrate, 100-150 mg / L of citric acid, 50-100 mg / L of calcium chloride, 10-50 mg of chlorogenic acid, 10-50 mg of salicylic acid, 100-150 mg / L of 8-hydroxyquinoline and 10-50 mg / L of melatonin. The effective components in the fresh-cut Chinese rose flower preservative interact with each other, can not only delay the aging and bent stem process of the fresh-cut Chinese rose flower, but also improve the brightness of the fresh-cut Chinese rose flower, and greatly improve the ornamental value of the fresh-cut Chinese rose flower.

This invention discloses a method for preparing and applying 8-hydroxyquinoline-functionalized polypeptide molecules and their metal complexes. HQ-FFGGRGD (HQD) is prepared via solid-phase polypeptide synthesis. Using 2-chlorotriphenylmethylchloro resin as a carrier, amino acids and 8-hydroxyquinoline-7-carboxylic acid are sequentially coupled, followed by cleavage and purification to obtain the HQD molecule. This molecule can self-assemble into a stable nanostructure through coordination and multiple non-covalent interactions under the drive of transition metal ions, yielding the HQD metal complex. The HQD metal complex can efficiently load chemotherapeutic drugs to form drug-loaded nanosystems, exhibiting pH-responsive and laser-responsive drug release characteristics, significantly enhancing intracellular drug uptake. This invention integrates chemokinetic therapy, photothermal therapy, DNA damage, and chemotherapy into a single nanoplatform, achieving multimodal synergistic anti-tumor therapy with advantages such as good biocompatibility, strong targeting, simple preparation, and high therapeutic efficiency.

The present application relates to the technical field of scale inhibitor production, in particular to a reverse osmosis membrane scale inhibitor for high-iron and high-aluminum sewage treatment and a preparation method thereof; the scale inhibitor is used to solve the problems of poor scale inhibition performance of the existing scale inhibitor and scale deposition on the surface of the reverse osmosis membrane; firstly, amino butyric acid hydroxamic acid and amino phenyl vinyl-8-hydroxyquinoline are synthesized, and then iminodiacetic acid groups of chelating resin are respectively reacted with amino groups in the amino butyric acid hydroxamic acid and the amino phenyl vinyl-8-hydroxyquinoline to obtain chelating resin modified by hydroxamic acid groups and 8-hydroxyquinolyl groups; the hydroxamic acid groups form stable chelates with iron ions and aluminum ions through six-toothed octahedral complex structures; the 8-hydroxyquinolyl groups form five-membered ring chelates through hydroxyl oxygen and quinoline ring nitrogen atoms, have chelating capacity for aluminum ions and iron ions, inhibit the generation of membrane surface scale and organic deposits, and keep the membrane surface clean.

This invention discloses a method for preparing 7-(5-nitro-4-methyl-2-pyridineazo)-8-hydroxyquinoline and its application in the detection of trace platinum. The preparation method includes the following steps: (1) preparing 5-nitro-4-methyl-2-aminopyridine diazonium salt; (2) preparing 7-(5-nitro-4-methyl-2-pyridineazo)-8-hydroxyquinoline. 7-(5-nitro-4-methyl-2-pyridineazo)-8-hydroxyquinoline, as a chelating agent, reacts with platinum in water to form a hydrophobic chelate. Then, ionic liquid extraction is used. The extract phase does not need to be diluted and can be directly used for the determination of platinum in water by graphite furnace atomic absorption spectrometry. This solves the defects of ionic liquids, which are viscous and difficult to transfer directly or easily adsorbed on instrument components. The operation steps are simplified by eliminating the need for dilution. At the same time, the detection method provided by this invention is convenient to operate and has high precision.