Compound for generating nucleic acid cross-linking action by induction and its preparing method and use

A technology of cross-linking and compounds, which is applied in the direction of active ingredients of hydroxyl compounds, organic chemistry, drug combination, etc., can solve problems such as side effects and no specific recognition of tumor cells, and achieve the effect of simple preparation
CN101012191AInactive Publication Date: 2007-08-08WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV
Publication Date
2007-08-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a compound to induce structure to generate crosslinking action of nucleic acid, which comprises the following steps: transmitting phenolic hydroxyl group in the 2, 6-dimethyl phenol, diphenol or hydroquinone into benzyl bromine under alkaline condition; substituting benzyl bromine group into selenium benzene group acted by sodium borohydride and diphenyl sulphone diselenide; stripping protection to obtain compound 1, compound 2 or compound 3.
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Description

technical field

[0001] The invention relates to a compound capable of inducing nucleic acid cross-linking, a preparation method and application thereof, and belongs to the fields of medicinal chemistry, organic chemistry and biochemistry. Background technique

[0002] Cancer is a general term for a group of more than 100 diseases that can affect any part of the body. Its high morbidity and mortality are a long-standing problem for humans and provide great challenges for researchers. Regarding the research on the mechanism of cancer, it is generally believed that the DNA in the cells changes first, leading to its mutation or the activation of oncogenes. Therefore, in the clinical treatment and research of cancer, most of them are anti-tumor drugs that target DNA. This type of drug research can be divided into two categories according to the different forms of action: drugs with covalent bonds and drugs with non-covalent bonds. The former are DNA alkylating agents and cross-li...

Claims

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