38results about How to "Improve the quality evaluation system" patented technology

The invention discloses a fingerprint spectrum of isodon lanceolata and an establishment method and application thereof, the method comprises preparation of a test sample and high performance liquid chromatography detection conditions, and the high performance liquid chromatography detection conditions are as follows: a chromatographic column is a Kromasil 100-5C18 chromatographic column (250mm*4.6mm, 5[mu]m); a mobile phase is a methanol -0.1% glacial acetic acid aqueous solution; a gradient elution mode is adopted: 0 min, 10 min, 26 min and 60 min, and methanol is 20%, 35%, 37% and 70%; the sample size is 3-10 [mu]L; and the detection wavelength is 239 nm, the flow velocity is 1 mL / min, and the column temperature is 20-35 DEG C. According to the isodon lanceolatus medicinal material fingerprint spectrum established by the invention, 12 common peaks are determined, through the abundant chromatographic peak information and the evaluation of the similarity of the common peaks, the overall evaluation of the quality of the medicinal material is facilitated, the uniformity and stability of the internal quality of the medicinal material are ensured, the quality of the isodon lanceolatus medicinal material can be effectively monitored, and the authenticity of the isodon lanceolatus medicinal material can be effectively identified.

The invention discloses a method for constructing an HPLC fingerprint of Shengfa tablets, belonging to the technical field of traditional Chinese medicine analysis. The traditional Chinese medicine tablets of Shengfa Tablets made from black dates and black beans were the detection targets, and high performance liquid chromatography was used to obtain the fingerprints of Shengfa Tablets by high performance liquid chromatography. The fingerprint spectrum constructed by the present invention has 10 common characteristic peaks, and 10 chemical components are confirmed and identified by using DAD detector and UFLC-TRIPLETOF-DAD-MS / MS technical means. The quality control method of the invention can comprehensively and systematically detect the medicinal materials in the prescription, and has practical application value for the quality control of the whole process of the preparation production process and the quality evaluation of the final product.

The invention discloses a method for establishing a Chinese angelica decoction piece fingerprint as well as the fingerprint, and relates to the technical field of a fingerprint of traditional Chinesemedicine materials. The method comprises preparation of a test sample solution and a high-performance liquid chromatography detection condition, atlas is processed by using fingerprint software, and the fingerprint of the Chinese angelica decoction piece is acquired; chromatographic data is imported into SPSS19.0 version software to perform clustering analysis, and the clustering result of a standard self-made decoction piece and a commercially available detection piece is obtained. The method has the following positive effects: the mutual mode of the Chinese angelica decoction piece HPLC fingerprint is established, 29 common peaks are calibrated, the quality can be effectively represented, the simplicity of the original quality control method is overcome, and the application value is relatively high.

The invention belongs to the field of fingerprints of traditional Chinese medicinal materials, and in particular relates to a method for establishing the HPLC fingerprints of Zhuang medicine Baihuajiuliming. The method for establishing the HPLC fingerprint of Zhuang medicine Baihuajiuliming uses caffeic acid, the main component of Baihuajiuliming, as a reference, and obtains the common pattern fingerprint of Zhuang medicine Baihuajiuliming accordingly. There are 10 chromatographic peaks in the fingerprint spectrum, which can fully reflect the chemical components in the medicinal material Baihua Jiuliming. The amount of information is relatively rich, and the method has good reproducibility. It provides a more powerful theoretical basis for controlling the quality of medicinal materials and identifying the advantages and disadvantages of medicinal materials. The quality control and authenticity identification level of the medicine Baihua Jiuliming has realized the rapid and accurate identification of the authenticity of Baihua Jiuliming.

The invention discloses an HPLC fingerprint of Zhideke granules and a quality analysis method thereof. The quality analysis method uses cluster analysis to analyze the fingerprints of Zhideke granule samples, and the shared results of multiple batches of samples are analyzed. The peak area of ​​the peak was normalized as a variable, imported into IBM SPSS Statistics 20.0 software, and the sum of squared deviation method was selected, and the Euclidean distance was used as the measurement standard of the sample to obtain a dendrogram. Classify Zhideke Granules and evaluate the quality of Zhideke Granules. It can more accurately evaluate the comprehensive quality score of Zhideke Granules, and provide a basis for establishing a sound quality standard for Zhideke Granules, with a view to establishing a quality control and evaluation system for Zhideke Granules.

The invention discloses a detection method of a fingerprint spectrum of an astragalus membranaceus and poria cocos kidney invigoration tablet and the fingerprint spectrum of the astragalus membranaceus and poria cocos kidney invigoration tablet. According to the method, a standard fingerprint spectrum of the astragalus membranaceus and poria cocos kidney invigoration tablet is established; high performance liquid chromatography and gradient elution are adopted; the number of theoretical plates is calculated according to a sinomenine peak and is not less than 100000. The similarity between thefingerprint spectrum of the astragalus membranaceus and poria cocos kidney invigoration tablet obtained by the method and a control fingerprint spectrum is greater than 0.9; the fingerprint spectrum can comprehensively and effectively characterize quality of the astragalus membranaceus and poria cocos kidney invigoration tablet; a quality evaluation system of the astragalus membranaceus and poriacocos kidney invigoration tablet is perfected; the obtained fingerprint spectrum of the astragalus membranaceus and poria cocos kidney invigoration tablet has many characteristic peaks and is high insimilarity; the quality of the astragalus membranaceus and poria cocos kidney invigoration tablet can be monitored accurately and reliably; the detected fingerprint spectrum is recognized by a traditional Chinese medicine chromatographic fingerprint spectrum similarity evaluation system provided by Chinese Pharmacopoeia Commission; the fingerprint spectrum of the astragalus membranaceus and poriacocos kidney invigoration tablet is evaluated according to an obtained similarity result; a conclusion is relatively objective and accurate; and the method has the advantages that the method is simpleand convenient, excellent in stability, high in precision, good in repeatability and the like.

The invention discloses a method for establishing a fingerprint of a green tangerine peel medicinal material and a fingerprint thereof, and relates to the technical field of fingerprints of Chinese medicinal materials. The method comprises the steps of (a), preparation of a reference solution; (b), preparation of a test solution; (c), HPLC detection conditions; (d), formulation of a standard fingerprint with hesperidin as a reference peak; (e), quality control of the fingerprint. According to the method, a pretreatment method for each test product is simple, characteristic components are completely reserved, the repeatability and stability are good, the degree of precision is high, and there is a certain specificity; the separation effect of each characteristic peak in the obtained fingerprint is good; the method can be used for identifying the authenticity and quality of the green tangerine peel medicinal material.

The invention relates to the technical field of Chinese herbal fingerprints, particularly to a Pholidota cantonensis Rolfe Chinese herbal fingerprint establishing method and a fingerprint thereof. Themethod comprises the following steps of (1) preparation of reference solution, (2) preparation of sample solution, (3) high performance liquid chromatography and (4) measurement. The Pholidota cantonensis Rolfe Chinese herbal fingerprint establishing method and the fingerprint thereof have the advantages of good reproducibility, high precision and good stability; the established Pholidota cantonensis Rolfe Chinese herbal fingerprint can achieve relatively comprehensive control and assessment of the inherent quality of Pholidota cantonensis Rolfe, monitor the quality and identify Pholidota cantonensis Rolfe, ensure authenticity, safety, effectiveness, stability and consistency of herbs, provide a reference basis for further development and design of Chinese herb standards and regularize and ensure clinical medication.

The invention discloses a Chinese pothos herb fingerprint establishing method and a Chinese pothos herb fingerprint, and relates to the technical field of the fingerprints of traditional Chinese medicinal materials. The method comprises the following steps: 1, sample preparation: adding Chinese pothos herb powder into a test tube, adding a proper amount of a methanol solution, immersing for 24h, carrying out ultrasonic concussion for 40min, cooling, shaking up, carrying out coarse filtration, and filtering by using a microporous filtering membrane to obtain a sample solution; and 2, high performance liquid chromatography detection conditions: carrying out high performance liquid chromatography detection on the sample solution according to the following conditions: the chromatographic column uses octadecyl silane chemically bonded silica as a filler, the mobile phase is acetonitrile-0.085% phosphoric acid, the sample introduction amount is 10-25muL, a gradient elution mode is adopted, the detection wavelength is 310nm, the flow velocity is 0.8mL / min, and the column temperature is 20-35DEG C in order to obtain the Chinese pothos herb fingerprint. The Chinese pothos herb fingerprint established in the invention can be used for effectively monitoring the quality of Chinese pothos herb and identifying the truth of Chinese pothos herb.