62results about How to "Characterizing quality" patented technology

The invention relates to a method for controlling the quality of radix scutellariae medicinal materials, comprising the following steps: taking standard radix scutellariae medical materials, obtaining a nuclear magnetic resonance spectroscopy thereof, and using characteristic ingredients of the radix scutellariae to identify the characteristic peak of medicinal effective ingredients as the characteristic peak of the radix scutellariae; taking a radix scutellariae sample to be tested, adopting the same method as a preparation method, a test condition and a test method of the standard radix scutellariae medical materials to test, obtaining a fingerprint electropherogram, and comparing the nuclear magnetic resonance spectroscopy of the radix scutellariae medicinal materials to be tested with the fingerprint electropherogram of the standard radix scutellariae medical materials. According to the differences of characteristic resonance peaks of the fingerprint electropherogram between the radix scutellariae medicinal materials to be tested and the standard radix scutellariae medical materials and number of common characteristic resonance peaks, the radix scutellariae medicinal materials can be classified as the following grades: high-class products: N is greater than 20, first-class products: N is greater than and equal to 18 and is less than or equal to 20, second-class products: N is greater than or equal to 16 and is less than 18, qualified products: N is greater than or equal to 14 and is less than 16, and unqualified products: N is less than 14.

The present invention discloses a Shenqi hypoglycemic preparation HPLC standard finger print and a construction method thereof. The construction method comprises the following steps: preparing test sample solutions and a reference solution, measuring the test sample solutions and the reference solution by using the HPLC method and the linear gradient elution process, so as to obtain the Shenqi hypoglycemic preparation finger prints, wherein the chromatographic condition is that a mobile phase A is acetonitrile, a mobile phase B is 0.1% (v/v) phosphoric acid solution, the detection wavelength is 203nm, the column temperature is 25-35 DEG C and the flow rate is 0.8-1.2mL/min. The common characteristic peaks of at least ten finger prints are used as the characteristic peaks of the standard finger print; the standard finger print comprises 38 characteristic peaks, and the numbers of the characteristic peaks of saponin of ginseng stem and leaf, astragalus, Chinese magnoliaving, rehmannia root and raspberry are 13, 4, 7, 3 and 4 respectively. The Shenqi hypoglycemic preparation HPLC standard finger print and the construction method thereof can comprehensively and accurately evaluate the whole quality of the Shenqi hypoglycemic preparation, and facilitate to ensure the quality and the clinical curative effect of the Shenqi hypoglycemic preparation.

The present invention relates to a determining method for the fingerprint map of a pogostemi herba healthy energy soft capsule, which belongs to the field of Chinese medicine modernization. The determining method for the fingerprint map of the pogostemi herba healthy energy soft capsule comprises: the preparation of a sample; the preparation of reference object solution; chromatostrip condition: the chromatographic column is a plastic quartz capillary column; polysiloxane is stationary phase; procedure temperature: initial temperature is between 40 DEG C to 100 DEG C and raised to 230 DEG C to 280 DEG C at the speed of 2 DEG C to 6 DEG C per minute; the temperature in a vaporizer is between 230 DEG C to 280 DEG C; an interface temperature is between 230 DEG C to 280 DEG C; the range of mass charge ratio is 10 to 1000. The determining method: chromatogram maps in 1 hour are recorded by using GC-MS; taking the acreage of the patchouli alcohol as 1 to calculate the relative ratio of the peak area. The advantages of the present invention are that the fingerprint technique and the GC-MS equipment are combined to carry out nature and quantified determinations; the present invention can be taken as the standard fingerprint of the pogostemi herba healthy energy soft capsule content determination to discriminate active principles; the method is of stable, high accuracy and good reproducibility.

The invention provides a method for detecting quality of medicinal water extracts of Qipi oral liquid based on an HPLC (High Performance Liquid Chromatography) fingerprint spectrum. The method comprises the following steps of: preparing a comparison product solution and a tested sample solution; performing HPLC measurement; establishing a standard fingerprint spectrum; and detecting the sample. According to the method, a freezing technology and quality of the medicinal water extracts of the Qipi oral liquid can be effectively represented, energy source is saved and labor hour is reduced; the method is beneficial to monitoring the quality of products; and the method has the advantages of simple method, excellent stability, high precision, excellent repeatability, and the like.

The invention provides an HPLC fingerprint spectrum determination method for cannabis sativa. The method is characterized by comprising the steps of (1) preparing a test solution: taking the cannabissativa medicinal material, crushing, sieving and baking the cannabis sativa medicinal material, precisely weighing baked cannabis sativa medicinal material powder, adding an extracting agent, carryingout ultrasonic extraction, carrying out standing until the room temperature is reached, passing through a microporous filter membrane, and taking subsequent filtrate; (2) preparing a reference solution: taking cannabidiolic acid, cannabidivarin, cannabigerol, cannabidiol, delta 9-tetrahydrocannabinol, cannabichromene, tetrahydrocannabinol and geranylflavone A reference substances, and adding methanol to dissolve the reference substances so as to prepare the reference substance solution; and (3) performing determination: precisely sucking the reference solution and the test solution into an HPLC, performing determination, and recording a chromatogram.

The invention discloses a high performance liquid chromatography (HPLC) standard fingerprint spectrum of a lucid ganoderma capsule preparation and a construction method and application of the standard fingerprint spectrum. The construction method comprises the following steps: preparing a test solution and a reference substance solution, and carrying out linear gradient elution, wherein a mobile phase A is acetonitrile, a mobile phase B is 0.05-0.15 percent (v/v) phosphoric acid aqueous solution, the detection wavelength is 252nm, the column temperature is 25-35 DEG C, the flow velocity is 1.0mL/min; measuring through HPLC, obtaining a lucid ganoderma capsule fingerprint spectrum, and taking a common characteristic peak of at least 14 batches of fingerprint spectrums as the characteristic peak of the standard fingerprint spectrum, wherein the standard fingerprint spectrum totally has 40 characteristic peaks, and the numbers of characteristic peaks belonging to lucid ganoderma, bighead atractylodes rhizome, rhizoma polygonati, the seed of Chinese dodder, schisandra chinensis, liquorice and the fruit of Chinese wolfberry are respectively 20, 3, 3, 5, 1, 5 and 2. According to the method and the standard fingerprint spectrum, the overall quality of the lucid ganoderma preparation can be comprehensively and accurately evaluated, and the quality and drug effect of the lucid ganoderma preparation are guaranteed.

The invention discloses a FeO content prediction method based on a sintering machine tail section video, and relates to the field of steel production. The method mainly comprises the following steps:determining a falling moment, removing an abnormal audio sequence, dividing an image sequence and preprocessing, carrying out audio preprocessing, extracting image features, extracting audio features,constructing a video quality database, and constructing, training and testing a quality prediction model. Compared with the prior art, the method has the advantages that the severe conditions of thesintering machine tail are considered, the characteristics of the video information are represented more comprehensively from the aspects of images and audios, and quantitative prediction of the FeO content can be achieved.

The invention relates to a method for building a fingerprint of loquat leaf medicinal materials and a fingerprint thereof. The method comprises the following steps of: firstly collecting the loquat leaf medicinal materials for over 10 batches, preparing test sample solution and a reference product solution, implementing measurement by referring to and applying a high-efficiency liquid chromatography method and a high-efficiency capillary electrophoresis method, and finally implementing analysis by applying a computation software of the similarity between the fingerprint of traditional Chinese medicines (which is recommended by the State Pharmacopoeia Committee). The method of the invention has the advantages of simplicity, stability, high precision, good reproducibility and easy grasp, can grasp the variety and the quality condition of the loquat leaves from the integral characteristic face and the high profile of chromatogram, and can be used as one of the methods for evaluating the quality of the loquat leaves and distinguishing the loquat leaves between true and false.

The invention belongs to the technical field of test equipment, and relates to shield tail brush dynamic sealing pressure resistance test equipment. The equipment comprises a base, a support frame spanning the middle part of the base, a simulated shield tail steel cylinder pivoted above the support frame, a transmission track horizontally penetrating through the axial hollow part of the simulatedshield tail steel cylinder, and a simulated segment and a self-sealing steel cylinder which can move along the transmission track, wherein the simulated segment and the self-sealing steel cylinder arerespectively disposed at two sides of the simulation shield tail steel cylinder. The outer diameters of the simulated segment and the self-sealing steel cylinder are smaller than the inner diameter of the simulation shield tail steel cylinder, and the axes of the simulated segment and the self-sealing steel cylinder are collinear with the horizontal axis of the simulation shield tail steel cylinder; the inner wall of the simulation shield tail steel cylinder is provided with a plurality of oil receiving ring grooves used for installing shield tail brushes in a mirror symmetry mode, the innersides of the oil receiving ring grooves are communicated with a plurality of pressure sensors, and the bottom of the simulation shield tail steel cylinder is provided with a segment gap adjusting device used for adjusting the angle. The structure can simulate the dynamic process of the shield tunneling machine, and can test the wear resistance and dynamic sealing performance of the shield tail brush at the same time.

The invention provides a preparation method of morchella esculenta wine. The method comprises the following steps: firstly, treating fresh and clean morchella esculenta at a high pressure of 80-120MPa for 8-15min, then freezing the morchella esculenta at a temperature of -30 to -25 DEG C for 1-2 days, removing frost flakes from the surface of the morchella esculenta, and then soaking the morchella esculenta in basic liquor, thereby obtaining the morchella esculenta wine with a unique flavor and an extremely good mouthfeel. Then, a fingerprint chromatogram of the morchella esculenta wine is established by adopting high-performance liquid chromatography. The preparation method of the morchella esculenta wine is simple, the product is savory and mellow and keeps the scent for a long time, and the method can significantly prolong the discoloring time of the product and effectively keep the clarity and stability of a wine body. Meanwhile, the method for establishing the fingerprint chromatogram of the morchella esculenta wine is easy to implement, and the stability, reproducibility and specificity of the method are good, and can provide a reference for quality control of the morchella esculenta wine.

A fingerprint assay method for detecting the aquatic extract of tangerine peel to evaluate the quality of tangerine peel includes such steps as adding the tangerine peel in water, reflux extracting, filtering, adsorbing by macro-reticular resin column, water washing, washing with ethanol or methanol, eluting with ethanol or methanol, collecting eluting liquid, evaporating off ethanol or methanol, loading in measuring glass, adding water, and efficient liquid-phase chromatography to obtain fingerprint.

The invention relates to a determination method for radix curcumae fingerprint and a standard fingerprint thereof. The determination method comprises the following steps of preparing of a test samplesolution, preparing of a reference sample solution, determining by gas chromatography, and determining by liquid chromatography, so as to obtain a chromatogram map; contrasting the obtained standard radix curcumae gas fingerprint and the liquid fingerprint, wherein the qualified product is obtained when the obtained standard radix curcumae gas fingerprint is consistent with the liquid fingerprint.The determination method has the advantages that the determination method is simple, rapid, accurate, stable and reliable, and is used for controlling the quality of the radix curcumae; the quality of the radix curcumae can be more comprehensively, objectively and scientifically evaluated; the validity of the preparation is guaranteed.

The invention relates to a method for determining an effective component of total glycoside in smilax glabra ethanol water solution extract and belongs to the field of pharmaceutical analysis methods. The method adopts a high-efficiency liquid chromatography to establish a fingerprint chromatogram characterized by taking the astilbin chromatographic peak as an internal reference peak, comprising the following steps of (a) putting 1g of smilax glabra total glycoside dry powder into a 25mL volumetric flask, adding methanol for dissolution and diluting the solution to a scale to obtain sample solution; (b) putting astilbin into methanol solution to prepare reference solution with the concentration of 0.1mg of astilbin per ml; (c) including chromatographic conditions: the chromatographic column is octadecylsilyl as filling; the mobile phase: A phase is methanol, and B phase is gradient elution formed by 0.3 percent of acetic acid solution; the flow velocity is 0.8ml/min; the detection wavelength is 323-327nm; the column temperature is 25-35 DEG C; and the theoretical plate number is over 3000 based on astilbin peak; and (d) determination. The method is simple, convenient and stable, has high precision, good reproducibility and easy control and can characterize the mass of the smilax glabra total glycoside.

The invention discloses a fingerprint spectrum detection method of Xiaoyao pills. The method comprises the following steps: step 1, preparing a Xiaoyao pill test solution; 2, preparing a mixed reference substance solution; 3, respectively and precisely sucking the test sample and the reference substance solution, injecting the test sample and the reference substance solution into a liquid chromatogram instrument, and recording chromatograms; and 4, exporting the Xiaoyao pill fingerprint spectrum instrument, importing into a traditional Chinese medicine chromatographic fingerprint spectrum similarity evaluation system, selecting chromatographic peaks existing in the chromatograms of different batches of Xiaoyao pills as common peaks, generating a contrast fingerprint spectrum of the Xiaoyao pills by using an average value calculation method, and calculating the relative retention time and the relative peak area of each common peak. The Xiaoyao pill fingerprint spectrum researched by the invention can comprehensively and objectively evaluate the quality of Xiaoyao pills. The detection method provided by the invention has the advantages of good stability, high accuracy, good repeatability, high precision and the like.

The invention discloses a detection method for the fingerprint spectrum of an instant spina date seed heart calming solid beverage. The method comprises the following steps of: step 1, preparing a test solution; step 2, preparing a mixed reference substance solution; step 3, respectively and precisely sucking the mixed reference substance solution and the test solution, injecting the mixed reference substance solution and the test solution into a liquid chromatograph, and recording chromatograms; step 4, exporting the fingerprint spectrum of the test solution from an instrument, importing the fingerprint spectrum into a traditional Chinese medicine chromatographic fingerprint spectrum similarity evaluation system, and selecting chromatographic peaks existing in chromatograms of different batches of instant spina date seed heart-calming drink solid beverages as common peaks; generating a control fingerprint spectrum of the instant spina date heart-calming drink solid beverages by using an average value calculation method; calculating the relative retention time and the relative peak area of each common peak; and comparing with the spectrum with the spectrum of the mixed standard product, and identifying main component peaks. The fingerprint spectrum can comprehensively and objectively characterize the quality of the instant spina date seed heart-calming drink solid beverage. The detection method has the advantages of simplicity, stability, high precision, good reproducibility and the like.

The invention belongs to the technical field of spectrum detection, and relates to a fingerprint spectrum detection method for Ganshuang granules, which comprises: 1) carrying out ultrasonic extraction on Ganshuang granules by using methanol to obtain a to-be-detected test solution; (2) carrying out high performance liquid chromatography detection on the test solution by adopting ultra-high performance liquid chromatography, and recording chromatographic data within 40 minutes; and generating the fingerprint spectrum of the Ganshuang granules from the chromatographic data according to the 'Traditional Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System A'. The detection method provided by the invention has the characteristics of high accuracy, high stability and good repeatability, can comprehensively reflect the quality of the Ganshuang granules, and ensures the product quality.

The invention provides the establishment method of the lipid-soluble fingerprint diagram for the evodia and its standard fingerprint diagram which includes: making of the trying aqua, making of the comparing aqua, detecting by the HPLC, using fingerprint diagram software to treat the data and diagram and then get the lipid-soluble fingerprint diagram of the evodia. Compared with the existing technique, the invention is simple, stability, the precision is so much high and re-appear is good; The method to withdraw the lipid-soluble composition is brief and the time is short; the peak of lipid-soluble fingerprint diagram is many and the peak form is good, so it is easy to discriminate; The standard fingerprint diagram built up can be availably token by the quality of the evodia. Therefore, it provides a new standard for appraising the evodia.

The invention relate to quality control method of compound Danshen root drops. The method comprises: measuring the fingerprint pattern of the compound Danshen root drops control sample by high efficiency liquid chromatography; measuring the fingerprint pattern of product to be measured of the compound Danshen root drops by the same method and in the same condition; comparing two results. When the absorption peak numbers of two results achieve the value described in the invention, the product to be measured is qualified.