Measuring method of agastache for dispelling turbidity soft capsules fingerprint
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A technology of Huoxiangzhengqi and fingerprints, which is used in measuring devices, testing pharmaceutical preparations, instruments, etc.
Active Publication Date: 2008-05-21
津药达仁堂集团股份有限公司达仁堂制药厂
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Embodiment 1
[0122] Example 1: Determination of Fingerprint of Huoxiangzhengqi Soft Capsules
[0123] 1. Preparation of the test product: Take 10 batches of different batches of Huoxiangzhengqi Soft Capsules (batch numbers are F292004, F292007, F292021, F2920076, F2920098, F2920159, E292003, D292014, D291015, E291656 respectively, and the serial numbers are 1 ~10), take about 10g of the contents of each batch of Huoxiangzhengqi soft capsules, weigh them accurately, add 2ml of n-hexane, heat slowly to boiling, keep boiling slightly for 3 hours, and let cool. Transfer the n-hexane solution into a 10ml stoppered graduated test tube, wash the extractor with a small amount of n-hexane for 2-3 times, put the cleaning solution into the graduated test tube, add 1ml of the reference solution (internal standard) precisely, and then dilute to volume with n-hexane To 5ml, mix well, that is.
[0124] 2. Preparation of reference solution: accurately measure an appropriate amount of n-tetradecane, add n...
[0137] 1. Preparation of the test sample: Take 8 batches of different batches of Huoxiangzhengqi Soft Capsules (the batch numbers are F292004, F292007, F292021, F2920076, F2920098, F2920159, E292003, D292014, and the sample numbers are 1 to 8 in sequence) , respectively take about 10g of the contents of each batch of Huoxiangzhengqi soft capsules, weigh them accurately, add 2ml of ethyl acetate, slowly heat to boiling, and keep boiling slightly for 3 hours, then let cool. Transfer the ethyl acetate solution into a 10ml stoppered graduated test tube, wash the extractor 2 to 3 times with a small amount of ethyl acetate, incorporate the cleaning solution into the graduated test tube, add 1ml of the reference solution (internal standard) precisely, and then use ethyl acetate Dilute the volume of the ester to 5ml, mix well, and obtain.
[0138] 2. Preparation of reference solution: accurately meas...
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Abstract
The present invention relates to a determining method for the fingerprint map of a pogostemi herba healthy energy soft capsule, which belongs to the field of Chinese medicine modernization. The determining method for the fingerprint map of the pogostemi herba healthy energy soft capsule comprises: the preparation of a sample; the preparation of reference object solution; chromatostrip condition: the chromatographic column is a plastic quartz capillary column; polysiloxane is stationary phase; procedure temperature: initial temperature is between 40 DEG C to 100 DEG C and raised to 230 DEG C to 280 DEG C at the speed of 2 DEG C to 6 DEG C per minute; the temperature in a vaporizer is between 230 DEG C to 280 DEG C; an interface temperature is between 230 DEG C to 280 DEG C; the range of mass charge ratio is 10 to 1000. The determining method: chromatogram maps in 1 hour are recorded by using GC-MS; taking the acreage of the patchouli alcohol as 1 to calculate the relative ratio of the peak area. The advantages of the present invention are that the fingerprint technique and the GC-MS equipment are combined to carry out nature and quantified determinations; the present invention can be taken as the standard fingerprint of the pogostemi herba healthy energy soft capsule content determination to discriminate active principles; the method is of stable, high accuracy and good reproducibility.
Description
technical field [0001] The invention relates to a method for determining the fingerprint of Huoxiangzhengqi soft capsule, in particular to a method for determining effective components in Huoxiangzhengqi soft capsule by gas chromatography-mass spectrometry fingerprint method, which belongs to the field of traditional Chinese medicine modernization. Background technique [0002] The prescription of Huoxiang Zhengqi comes from Huoxiang Zhengqi Powder contained in "Taiping Huimin Heji Bureau Prescription. Volume 2". Tangerine peel, bellflower, licorice. It has the effect of resolving the exterior, harmonizing the middle, and aromatizing the turbidity. It is mainly used for exogenous wind-cold, internal stagnation of dampness or feeling of heat-dampness, external symptoms such as cold and heat headache, internal chest and abdomen fullness, abdominal pain and diarrhea, and pale and greasy mouth. , slow pulse and other evidence of damp resistance. This prescription is often used...
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