Application of panaxadiol saponins fraction in preparing medicine for preventing epilepsia

A technology of ginseng diol saponin and ginsenoside, which is applied in the field of medicine, can solve problems such as insufficient curative effect of antiepileptic drugs, interference with the clinical treatment effect of ginseng or American ginseng, and reduced cognitive ability, so as to overcome insufficient curative effect and low safety, improve Anti-epileptic effect, effect of reducing toxic and side effects
CN102743401AActive Publication Date: 2012-10-24ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2012-10-24

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Abstract

The invention provides application of a panaxadiol saponins fraction in preparing a medicine for preventing epilepsia. The component comprises the following main constituents: ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rc and ginsenoside Rd, and the medicine is prepared from active constituents in the single panaxadiol saponins fraction or from the active constituents in the single panaxadiol saponins fraction and other medicines. By taking one of five panaxadiol saponins: ginseng, American ginseng rhizome medicinal materials, ginseng stems and leaves, American ginseng stem and leaf medicinal materials and total extractives or total saponins of the ginseng, the American ginseng rhizome medicinal materials, the ginseng stems and leaves and American ginseng stem and leaf medicinal materials as a starting raw material independently or taking a mixture which consists of two or more than two different raw materials as the starting raw material comprehensively, the medicine is prepared by establishing the chromatographic separation and purification technology. According to the medicine prepared from the panaxadiol saponins fraction provided by the invention, an anti-epileptic effect can be greatly improved, and moreover, the toxic and side effects, especially dermatitis and intelligence toxicity, of traditional anti-epileptic medicines can be resisted, therefore, long-standing defects that the anti-epileptic medicines are not enough in curative effect and low in safety are overcome. The structural formula of the panaxadiol saponin is shown in specification.
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Description

technical field

[0001] The invention belongs to the field of medicine, and relates to the preparation of a panaxadiol saponins active component (hereinafter referred to as panaxadiol saponins fraction, Panaxadiol Saponins Fraction, PDSF) and a drug containing panaxadiol saponins fraction (PDSF) in the prevention and treatment of epilepsy Applications. More specifically, a method of comprehensively utilizing ginseng, American ginseng medicinal materials and their stems and leaves and their extracts or total saponins to prepare panaxadiol saponins; and panaxadiol saponins alone or with other substances including known antiepileptic The drug, especially the drug preparation made together with lamotrigine, is used in the treatment and prevention of epilepsy, epilepsy complications, and the synergistic and attenuating effects of existing antiepileptic drugs. Background technique

[0002] 1. Existing antiepileptic drugs have many defects, and safer and more effective therapeutic...

Claims

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