Traditional Chinese medicine sustained-release tablet and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine sustained-release tablet which is prepared from the following raw materials in parts by weight: 20-25 parts of cortex eucommiae, 18-22 parts of rhizoma gastrodiae, 15-20 parts of folium apocyni veneti, 8-10 parts of green tea, 5-8 parts of semen cassiae, 8-10 parts of fiveleaf gynostemma herb, 8-10 parts of lucid ganoderma, 5-8 parts of herba bulbophylli levinei, 3-5 parts of poria cocos, 3-5 parts of fructus gardeniae, 3-5 parts of s.confusum, 20-22 parts of grape seed oil, 10-15 parts of seabuckthorm seed oil, 4-6 parts of lactose, 15-18parts of hydroxypropyl methylcellulose, 1-2 parts of glutamine, 1-2 parts of alanine and 1-2 parts of magnesium stearate. Meanwhile, the invention also provides a preparation method of the traditionalChinese medicine sustained-release tablet. The preparation method comprises the following steps of performing superfine grinding, being supplemented by ultrasonic treatment during extraction with anethanol solution, performing extraction with a supercritical carbon dioxide fluid, and preparing an extract obtained by extraction into the traditional Chinese medicine sustained-release tablet. The traditional Chinese medicine sustained-release tablet provided by the invention can effectively lower blood pressure, has good blood pressure stabilization effect and can also improve blood lipid metabolism of a human body.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine preparation. More specifically, the invention relates to a traditional Chinese medicine sustained-release tablet for treating hypertensive diseases accompanied by hyperlipidemia, which belongs to the technical field of traditional Chinese medicine preparations. Background technique

[0002] Hypertension is a disease characterized by increased systemic arterial blood pressure (systolic blood pressure and / or diastolic blood pressure) (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney and other organs. Systemic disease with functional or organic damage. Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. It is caused by the joint action of many factors such as genetics, spirit, environment, age, and living habits. In recent years, there have been ...

Examples

Embodiment 1

[0028] Weigh 25 parts of Eucommia ulmoides, 20 parts of Gastrodia elata, 18 parts of apocynum, 10 parts of green tea, 6 parts of cassia seed, 10 parts of Gynostemma pentaphyllum, 10 parts of Ganoderma lucidum, 5 parts of Orchid chinensis, 4 parts of Poria cocos, 3 parts of gardenia and seaweed by weight. Artemisia 3 parts, pulverize, mix, pass 100 mesh sieves to obtain coarse powder, carry out superfine pulverization to coarse powder, pass 500 mesh sieves again to obtain fine powder, then fine powder and volume fraction are 85% ethanol solution by mass Mixed at a ratio of 1:3, treated at 50°C with a frequency of 300MHz ultrasonic waves for 60 minutes, during ultrasonic treatment, every 3 minutes of ultrasonic treatment, paused for 1 minute, and then carried out suction filtration to obtain the first filtrate and the first filter residue; the first filtrate was reduced Pressure distillation, concentration to a relative density of 1.30, and then at 50°C and 25MPa, fluid extractio...

Embodiment 2

[0030]Weigh 22 parts of Eucommia ulmoides, 18 parts of Gastrodia elata, 20 parts of apocynum, 8 parts of green tea, 5 parts of cassia seed, 8 parts of Gynostemma pentaphyllum, 8 parts of ganoderma lucidum, 6 parts of tooth blue, 3 parts of poria cocos, 4 parts of gardenia and seaweed by weight. 4 parts of artemisia, pulverized, mixed, passed through a 100-mesh sieve to obtain a coarse powder, the coarse powder was ultrafinely pulverized, and then passed through a 500-mesh sieve to obtain a fine powder, and then the fine powder was mixed with an ethanol solution with a volume fraction of 85%. Mixed at a ratio of 1:3, treated at 50°C with a frequency of 300MHz ultrasonic waves for 60 minutes, during ultrasonic treatment, every 3 minutes of ultrasonic treatment, paused for 1 minute, and then carried out suction filtration to obtain the first filtrate and the first filter residue; the first filtrate was reduced pressure distillation, concentrated to a relative density of 1.28, and ...

Embodiment 3

[0032] Weigh 20 parts of Eucommia ulmoides, 22 parts of Gastrodia elata, 15 parts of apocynum, 9 parts of green tea, 8 parts of cassia seed, 9 parts of Gynostemma pentaphyllum, 9 parts of Ganoderma lucidum, 8 parts of Orchid chinensis, 5 parts of Poria cocos, 5 parts of gardenia and seaweed by weight. 5 parts of artemisia, pulverized, mixed, passed through a 100-mesh sieve to obtain a coarse powder, the coarse powder was ultrafinely pulverized, and then passed through a 500-mesh sieve to obtain a fine powder, and then the fine powder and an ethanol solution with a volume fraction of 85% were mixed by mass Mixed at a ratio of 1:3, treated at 50°C with a frequency of 300MHz ultrasonic waves for 60 minutes, during ultrasonic treatment, every 3 minutes of ultrasonic treatment, paused for 1 minute, and then carried out suction filtration to obtain the first filtrate and the first filter residue; the first filtrate was reduced pressure distillation, concentrated to a relative density...

technical field

[0001] The invention relates to a traditional Chinese medicine preparation. More specifically, the invention relates to a traditional Chinese medicine sustained-release tablet for treating hypertensive diseases accompanied by hyperlipidemia, which belongs to the technical field of traditional Chinese medicine preparations. Background technique

[0002] Hypertension is a disease characterized by increased systemic arterial blood pressure (systolic blood pressure and / or diastolic blood pressure) (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney and other organs. Systemic disease with functional or organic damage. Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. It is caused by the joint action of many factors such as genetics, spirit, environment, age, and living habits. In recent years, there have been ...

Examples

Embodiment 1

[0028] Weigh 25 parts of Eucommia ulmoides, 20 parts of Gastrodia elata, 18 parts of apocynum, 10 parts of green tea, 6 parts of cassia seed, 10 parts of Gynostemma pentaphyllum, 10 parts of Ganoderma lucidum, 5 parts of Orchid chinensis, 4 parts of Poria cocos, 3 parts of gardenia and seaweed by weight. Artemisia 3 parts, pulverize, mix, pass 100 mesh sieves to obtain coarse powder, carry out superfine pulverization to coarse powder, pass 500 mesh sieves again to obtain fine powder, then fine powder and volume fraction are 85% ethanol solution by mass Mixed at a ratio of 1:3, treated at 50°C with a frequency of 300MHz ultrasonic waves for 60 minutes, during ultrasonic treatment, every 3 minutes of ultrasonic treatment, paused for 1 minute, and then carried out suction filtration to obtain the first filtrate and the first filter residue; the first filtrate was reduced Pressure distillation, concentration to a relative density of 1.30, and then at 50°C and 25MPa, fluid extractio...

Embodiment 2

[0030]Weigh 22 parts of Eucommia ulmoides, 18 parts of Gastrodia elata, 20 parts of apocynum, 8 parts of green tea, 5 parts of cassia seed, 8 parts of Gynostemma pentaphyllum, 8 parts of ganoderma lucidum, 6 parts of tooth blue, 3 parts of poria cocos, 4 parts of gardenia and seaweed by weight. 4 parts of artemisia, pulverized, mixed, passed through a 100-mesh sieve to obtain a coarse powder, the coarse powder was ultrafinely pulverized, and then passed through a 500-mesh sieve to obtain a fine powder, and then the fine powder was mixed with an ethanol solution with a volume fraction of 85%. Mixed at a ratio of 1:3, treated at 50°C with a frequency of 300MHz ultrasonic waves for 60 minutes, during ultrasonic treatment, every 3 minutes of ultrasonic treatment, paused for 1 minute, and then carried out suction filtration to obtain the first filtrate and the first filter residue; the first filtrate was reduced pressure distillation, concentrated to a relative density of 1.28, and ...

Embodiment 3

[0032] Weigh 20 parts of Eucommia ulmoides, 22 parts of Gastrodia elata, 15 parts of apocynum, 9 parts of green tea, 8 parts of cassia seed, 9 parts of Gynostemma pentaphyllum, 9 parts of Ganoderma lucidum, 8 parts of Orchid chinensis, 5 parts of Poria cocos, 5 parts of gardenia and seaweed by weight. 5 parts of artemisia, pulverized, mixed, passed through a 100-mesh sieve to obtain a coarse powder, the coarse powder was ultrafinely pulverized, and then passed through a 500-mesh sieve to obtain a fine powder, and then the fine powder and an ethanol solution with a volume fraction of 85% were mixed by mass Mixed at a ratio of 1:3, treated at 50°C with a frequency of 300MHz ultrasonic waves for 60 minutes, during ultrasonic treatment, every 3 minutes of ultrasonic treatment, paused for 1 minute, and then carried out suction filtration to obtain the first filtrate and the first filter residue; the first filtrate was reduced pressure distillation, concentrated to a relative density...

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