The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a piracetam freeze-dried powder injection for injection. The preparation method of the piracetam freeze-dried powder injection for injection comprises the following steps: (1) putting 60% of water for injection based on the total volume into a mixing tank, adding piracetam in a stirring state, fully dissolving, adding the rest volume of water for injection, stirring, regulating the pH value, adding activated carbon for injection, stirring, filtering, decarbonizing, and continuously stirring, finely filtering, filling into a penicillin bottle, and performing semi-corking; S2) performing pre-freezing on the penicillin bottle in the step S1, starting a condenser, starting a vacuum pump when the temperature of the condenser is reduced to -40 DEG C or below, increasing the temperature to -18 DEG C, and keeping the temperature until the water line disappears; continuously raising the temperature to 35 DEG C, keeping the temperature, pumping out air, filling high-purity nitrogen, and pressing a penicillin bottle plug; and S3) rolling an aluminum-plastic cover, carrying out lightinspection, and packaging to obtain the injection. The piracetam freeze-dried powder injection for injection disclosed by the invention has the advantages that the appearance conforms to the specification, the redissolution is easy, the impurities are few, and the quality is stable.