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Novel piracetam synthetic method

A technology of piracetam and a new method, which is applied in the field of synthesizing piracetam, can solve the problems of high production cost, and achieve the effects of simple production operation, reduced production cost, and short reaction steps

Inactive Publication Date: 2012-10-10
SHANGHAI MODERN HASEN SHANGQIU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since electrolytic reduction is still in the research stage in my country, the production cost of this method is relatively high

Method used

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  • Novel piracetam synthetic method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A kind of synthetic new method of piracetam, it comprises the following steps:

[0022] Add 30.0g (0.2mol) ethyl 4-chloro-n-butyrate, 24.3g (0.22mol) glycinamide hydrochloride, 21.2g (0.2mol) sodium carbonate and 300ml absolute ethanol into a three-necked flask, heat to reflux After 20 hours, cool slightly, heat filter, evaporate the solvent dehydrated alcohol under reduced pressure, and the residue is recrystallized, filtered and dried to obtain 15.9g white crystals, which are piracetam, and the yield is 55.9% (with 4- Ethyl chloro-n-butyrate, the same below).

Embodiment 2

[0024] A kind of synthetic new method of piracetam, it comprises the following steps:

[0025] Add 30.0g (0.2mol) ethyl 4-chloro-n-butyrate, 33.2g (0.3mol) glycinamide hydrochloride, 31.8g (0.3mol) sodium carbonate and 180ml absolute ethanol into a three-necked flask, heat to reflux After 25 hours, cool slightly, heat filter, and distill off the solvent absolute ethanol under reduced pressure. The residue is recrystallized, filtered and dried to obtain 16.5 g of white crystals, namely piracetam, with a yield of 58.0%.

Embodiment 3

[0027] A kind of synthetic new method of piracetam, it comprises the following steps:

[0028] Add 30.0g (0.2mol) ethyl 4-chloro-n-butyrate, 39.8g (0.36mol) glycinamide hydrochloride, 42.4g (0.4mol) potassium carbonate and 90ml absolute ethanol into a three-necked flask, heat to reflux After 30 hours, cool slightly, heat filter, evaporate the solvent of absolute ethanol under reduced pressure, recrystallize the residue, filter and dry to obtain 16.8 g of off-white crystals, namely piracetam, with a yield of 59.1%.

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Abstract

The invention belongs to the field of chemical synthetic techniques, in particular relates to a novel piracetam synthetic method. The method comprises the following steps of: mixing ethyl-4-chloro-n-butanoate, glycinamide hydrochloride, alkaline and an alcohol organic solvent, and heating and reflowing for 20 to 30 hours, and thermally filtering, evaporating to remove the solvent under the reduced pressure, and then recrystallizing, filtering and drying the residues to obtain white or almost white crystal which is piracetam, wherein the mole ratio of ethyl-4-chloro-n-butanoate to glycinamide hydrochloride to alkaline is 1: (1.1-1.8): (1.0-2.0). The method is simple and short in reaction step, and mild in reaction condition, is convenient to operate for production; and moreover, the method is environment-friendly, and the synthetic raw materials and solvents are cheap and easy to obtain, thus the method is suitable for industrial production.

Description

technical field [0001] The technical field of chemical synthesis of the present invention particularly relates to a new method for synthesizing piracetam with ethyl 4-chloro-n-butyrate and glycinamide hydrochloride as raw materials. Background technique [0002] Piracetam (Piracetam, trade name Naofukang), also known as piracetam, chemical name 2-oxo-1-pyrrolidinylacetamide, molecular formula C 6 h 10 N 2 o 2 , molecular weight 142.16. Piracetam is a central stimulant and is mainly used clinically to treat memory and thinking disorders. The drug has a certain effect on senile memory loss, cerebral arteriosclerosis, cerebrovascular accident, brain trauma, sequelae of epilepsy, memory and thinking disorders caused by carbon monoxide, alcohol and drug poisoning, children's mental retardation and nocturia. [0003] There are many synthetic methods of piracetam, the main synthetic routes are: [0004] 1) Pyrrolidone method: For example, pyrrolidone and chloroacetamide are u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/27
Inventor 刁文瑞江正祥宋振峰于河先王紫华张峰
Owner SHANGHAI MODERN HASEN SHANGQIU PHARMA
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