4results about How to "Improve functional status" patented technology

The present application relates to the field of cell therapy and regenerative medicine, and in particular to a kind of old age adipose tissue-derived mesenchymal stem cells pretreated by MK8722, its preparation method and application.The method comprises the following steps: the old age adipose tissue-derived mesenchymal stem cells are inoculated in culture solution containing MK8722 to carry out in vitro treatment, and first cells are obtained;The culture solution containing MK8722 is removed, and the first cells are washed to obtain second cells;Second cells are cultured using culture solution without MK8722, and the old age adipose tissue-derived mesenchymal stem cells pretreated by MK8722 are obtained.The cells obtained by the method, relative to the old age adipose tissue-derived mesenchymal stem cells without the in vitro treatment, show at least one improvement in proliferation capacity, continuous passage amplification capacity, adipogenic differentiation capacity or chondrogenic differentiation capacity, and can be used to prepare products for treating or alleviating osteoarthritis.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

The invention relates to the technical field of neurology, in particular to a composition for treating brain injury and neurodegenerative lesion and application thereof, the composition is composed of an antioxidant and an anti-inflammatory drug, the antioxidant comprises vitamins, flavonoids, polysaccharides, saponins and active peptides according to the mass ratio of 4: 3: 1: 4: 2, and the content of the antioxidant is 60-80 parts; the anti-inflammatory drug comprises a non-steroidal anti-inflammatory drug NSAIDs, and the number of the components of the anti-inflammatory drug is 20-40 parts. By utilizing the synergistic effect of various active ingredients, the traditional Chinese medicine composition can comprehensively improve the symptoms of a patient, relieve pain, improve sleep and improve the cognitive function, thereby delaying neurodegenerative diseases and being beneficial to improving the functional state of neurons.

The invention discloses a feed additive formula capable of reducing acid and protecting kidney. The feed additive formula comprises the following components: yucca extract, silymarin, chitosan, potassium citrate, medicinal charcoal, vitamin C, vitamin and bentonite. The invention belongs to the technical field of feed additive formulas, and particularly relates to a feed additive formula for reducing acid and protecting kidney.