Composition for treating brain injury and neurodegenerative disease and application thereof

Abstract

The invention relates to the technical field of neurology, in particular to a composition for treating brain injury and neurodegenerative lesion and application thereof, the composition is composed of an antioxidant and an anti-inflammatory drug, the antioxidant comprises vitamins, flavonoids, polysaccharides, saponins and active peptides according to the mass ratio of 4: 3: 1: 4: 2, and the content of the antioxidant is 60-80 parts; the anti-inflammatory drug comprises a non-steroidal anti-inflammatory drug NSAIDs, and the number of the components of the anti-inflammatory drug is 20-40 parts. By utilizing the synergistic effect of various active ingredients, the traditional Chinese medicine composition can comprehensively improve the symptoms of a patient, relieve pain, improve sleep and improve the cognitive function, thereby delaying neurodegenerative diseases and being beneficial to improving the functional state of neurons.

Description

Technical Field

[0001] The present invention relates to the technical field of neurology, and in particular to a composition for treating brain damage and neurodegenerative diseases and application thereof. Background Art

[0002] Neurological diseases, especially brain injury and neurodegenerative diseases, pose a serious threat to human health. These diseases often lead to serious consequences such as cognitive decline and limb movement disorders, which seriously affect the quality of life of patients. The treatment of brain injury and neurodegenerative diseases is a complex and multifaceted field. Because these diseases often involve complex pathophysiological processes, the development of effective treatments requires a deep understanding of the mechanisms of the disease and the search for strategies that can intervene in these mechanisms.

[0003] In the prior art, many drugs can only relieve symptoms but cannot prevent or reverse the degeneration process of neurons; they only improve cognitive function based on current symptoms. Due to the complexity and diversity of the pathogenesis of neurodegenerative diseases, some compositions are difficult to fully cover their types of diseases, and there are certain defects in the repair of neurons, which affects the stability and efficacy of the drug action.

[0004] In summary, how to solve the problem that the drugs in the prior art can only relieve symptoms but have certain defects in repairing neurons has become a difficult problem that needs to be solved urgently in this field. Therefore, it is necessary to propose a composition for treating brain injury and neurodegenerative diseases and its application. Summary of the invention

[0005] To solve the above problems, the present invention provides a composition for treating brain injury and neurodegenerative diseases and its application, which utilizes the synergistic effect of multiple active ingredients to comprehensively improve the patient's symptoms, relieve pain, improve sleep, and enhance cognitive function, thereby delaying neurodegenerative diseases and helping to improve the functional state of neurons.

[0006] In order to achieve the above-mentioned purpose, the technical scheme of the present invention is as follows: a composition for treating brain damage and neurodegenerative diseases, consisting of an antioxidant and an anti-inflammatory drug, the antioxidant comprising vitamins, flavonoids, polysaccharides, saponins and active peptides in a mass ratio of 4:3:1:4:2, and the antioxidant component is 60-80 parts; the anti-inflammatory drug comprises non-steroidal anti-inflammatory drugs NSAIDs, and the anti-inflammatory drug component is 20-40 parts.

[0007] Furthermore, the vitamins are selected from one or more of β-carotene, vitamin C and vitamin E.

[0008] Furthermore, the flavonoids are selected from one or more of chlorogenic acid, soy isoflavones and cucurbitacin.

[0009] Furthermore, the polysaccharide is selected from one or more of angelica polysaccharide, ganoderma lucidum polysaccharide, yam polysaccharide, astragalus polysaccharide and wolfberry polysaccharide.

[0010] Furthermore, the saponins are selected from one or more of ginsenosides, notoginseng saponins and total saponins of Ilex pubescens.

[0011] Furthermore, the active peptides are selected from one or more of corn peptides, rice bran antioxidant peptides, wheat germ antioxidant peptides, glutathione, deer antler polypeptides and sea cucumber peptides.

[0012] Further, the preparation method of the composition comprises the following steps:

[0013] Step 1, raw material extraction: extracting active ingredients from raw materials containing antioxidants; after extraction, separating, purifying and concentrating to obtain antioxidant extracts.

[0014] Step 2, grinding and sieving: weigh the antioxidant extract and the anti-inflammatory drug in proportion, put them into a grinding and stirring device for grinding; after grinding, sieve to obtain the composite powder.

[0015] Step three, stirring and mixing: stirring and mixing the composition powder, and the stirring and mixing is carried out in a grinding and stirring device.

[0016] Step 4, drug preparation: placing the stirred and mixed composition into a drug carrier, and encapsulating the drug carrier with a capsule.

[0017] Furthermore, the grinding and stirring device includes a shell, a controller and a driving member for providing bidirectional driving force, the controller is used to control the operation of the driving member; the output shaft on the driving member is rotatably matched with a cross plate, and the four ends of the cross plate are fixedly connected to the inner wall of the shell; the driving member is fixedly connected to the bottom of the middle position of the cross plate.

[0018] The output shaft on the driving member passes through the cross plate and is coaxially fixedly connected to a rotating disk, and a number of "ヘ"-shaped connecting rods are hinged along the circumference of the rotating disk; a grinding plate is hinged at one end of the connecting rod away from the rotating disk, and the side of the grinding plate away from the connecting rod is arc-shaped and in contact with the inner wall of the outer shell; a slider is fixedly connected to the bottom of the grinding plate, and a sliding groove that slides with the slider is opened on the cross plate; a screen is provided at the bottom of the cross plate, and the screen is fixedly connected to the inner wall of the outer shell.

[0019] The lower output shaft of the driving member is coaxially fixedly connected with a stirring shaft, and a plurality of S-shaped stirring blades are fixedly connected to the stirring shaft; a top cover is detachably connected to the top of the outer shell, and a plurality of supporting rods are fixedly connected to the bottom of the outer shell; a discharge port is opened at the bottom of the outer shell, and a one-way valve is fixedly connected to the discharge port, and a controller is used to control the operation of the one-way valve.

[0020] Furthermore, in step four, the drug carrier material is polylactic acid-glycolic acid copolymer, which has a thickness of 0.35-0.55 mm, an outer diameter of 6.05-6.85 mm, and a length of 7.15-8.35 mm; the capsule material is gelatin, which has a thickness of 0.55-0.65 mm, an outer diameter of 7.05-7.45 mm, and a length of 12.15-14.25 mm.

[0021] Furthermore, the application of any of the above compositions for treating brain damage and neurodegenerative diseases includes but is not limited to application in stroke, brain trauma, depression, Alzheimer's disease and Parkinson's disease.

[0022] The above scheme has the following beneficial effects:

[0023] 1. The present invention selects a combination of antioxidant components and anti-inflammatory drugs in a precise ratio. The antioxidant has a strong antioxidant activity, can effectively remove free radicals in the body, and reduce the damage of oxidative stress to nerve cells. Anti-inflammatory drugs can inhibit cyclooxygenase and reduce the generation of inflammatory mediators prostaglandins, thereby reducing inflammatory reactions and protecting nerve cells from further damage. By utilizing the synergistic effect of the composition, on the one hand, the damage of free radicals to nerve cells is reduced through antioxidant effects, and on the other hand, the inflammatory reaction is reduced through anti-inflammatory effects, and the repair and regeneration of nerve cells are jointly promoted.

[0024] Since the composition can reduce oxidative stress and inflammatory response, it helps to improve the functional state of neurons and improve the patient's cognitive ability and memory. In addition, the antioxidant component selected by the present invention promotes the activity of multiple enzymes in the body, helps to enhance the body's immunity, can promote the secretion of brain neurotransmitters, and helps to improve sleep quality; and has a certain regulatory effect on sleep and the nervous system, can help eliminate anxiety, promote sleep, and balance nervous disorders. Good sleep can provide them with more adequate rest time, help repair and regenerate the brain, thereby slowing down the progression of the disease and improving the quality of life.

[0025] 2. The polysaccharides selected by the present invention can inhibit neuronal apoptosis and oxidative stress by increasing the activity of antioxidant enzymes and the free radical scavenging rate. The selected flavonoids can reduce high-oxidation free radicals, improve the reduction of neurons induced by dopamine neurotoxins and the increase in propidium iodide absorption, and improve the delayed neuronal cell death and glial cell activation caused by ischemia. The selected saponins have antioxidant and anti-apoptotic effects; by reducing the reduction in the number of brain choline neurons and the reduction in the level of choline acetyltransferase induced by D-galactose, they have a protective effect on the neuropathological damage produced by brain choline. In addition, most of the selected ingredients are derived from daily food, which is easier to be digested and absorbed by the human body and has high safety.

[0026] 3. When preparing the composition of the present invention, an efficient grinding and stirring device is used to process the material, and the grinding plate is enabled to reciprocate through the driving member, thereby effectively grinding the material. This efficient grinding method can ensure that the antioxidant extract and the anti-inflammatory drug are fully refined, thereby improving their bioavailability. After grinding, the material falls to the bottom of the outer shell, and the S-shaped design of the stirring blade can achieve sufficient stirring and mixing of the material, ensuring that the antioxidant extract and the anti-inflammatory drug are evenly distributed, thereby improving the consistency and stability of the composition. Only one driving component is required to achieve multiple functions and reduce preparation costs; and the production cycle can be shortened, thereby improving production efficiency.

[0027] 4. The present invention adopts precise ingredient ratios and combines multiple methods, has high extraction efficiency, is easy to operate, and can separate effective ingredients from impurities. In addition, biodegradable polymers are used as drug carriers, which have good sealing and biocompatibility. The composition can be gradually degraded in the body while slowly releasing the drug, thereby maintaining a longer period of therapeutic effect. The bioavailability of the drug can be improved, ensuring that the drug can effectively reach the target site and exert its therapeutic effect. Through the synergistic effect of multiple ingredients, the patient's symptoms can be comprehensively improved, pain can be relieved, sleep can be improved, and cognitive function can be improved, thereby delaying neurodegenerative lesions and helping to improve the functional state of neurons.

[0028] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The figure is a schematic diagram of a method for preparing a composition for treating brain injury and neurodegenerative diseases according to an embodiment of the present invention.

[0030] Figure 2 It is an axonometric view of the grinding and stirring device in an embodiment of the present invention.

[0031] Figure 3 It is an axonometric view of the driving member in the embodiment of the present invention.

[0032] Figure 4 It is a front cross-sectional view of the grinding and stirring device in an embodiment of the present invention.

[0033] The figure marks in the drawings of the specification include: 1. casing; 2. double-headed motor; 3. cross plate; 4. rotating disk; 5. connecting rod; 6. grinding plate; 7. screen; 8. stirring shaft; 9. stirring blade; 10. top cover; 11. support rod; 12. one-way valve. DETAILED DESCRIPTION

[0034] The following is further described in detail through specific implementation methods:

[0035] Embodiment 1:

[0036] As attached Figure 1 As shown: A composition for treating brain damage and neurodegenerative diseases, composed of antioxidants and anti-inflammatory drugs, the antioxidants include vitamins, flavonoids, polysaccharides, saponins and active peptides in a mass ratio of 4:3:1:4:2. In this embodiment, the vitamins are β-carotene, the flavonoids are chlorogenic acid, the polysaccharides are angelica polysaccharides, the saponins are ginsenosides, and the active peptides are corn peptides; the antioxidant component is 80 parts; the anti-inflammatory drugs include non-steroidal anti-inflammatory drugs NSAIDs, and the anti-inflammatory drug component is 20 parts. Through the synergistic effect of multiple ingredients, nerve cells are protected from oxidative damage from multiple angles. Effectively remove free radicals in the body and reduce the damage of oxidative stress to nerve cells.

[0037] The composition preparation method comprises the following steps:

[0038] Step 1, raw material extraction: the active ingredients are extracted from the raw materials containing antioxidants by alcohol extraction; the alcohol extraction method has the advantages of high extraction efficiency and simple operation. After extraction, the macroporous resin method is used for separation, purification and concentration, and the alcohol extraction method has the advantages of high extraction efficiency and simple operation to obtain antioxidant extracts.

[0039] Step 2, grinding and sieving: weigh the antioxidant extract and the anti-inflammatory drug in proportion, put them into a grinding and stirring device for grinding, so that the raw materials are mixed evenly and reach the required particle size; the ground mixture is sieved to obtain a composite powder that meets the requirements.

[0040] Step 3, stirring and mixing: stirring and mixing the powder of the composition, and the stirring and mixing is carried out in a grinding and stirring device to ensure that various components are evenly distributed.

[0041] Step 4, drug preparation: Place the stirred and mixed composition in a drug carrier, the drug carrier material is polylactic acid-glycolic acid copolymer, the thickness is 0.35mm, the outer diameter is 6.05mm, and the length is 7.15mm; and use a capsule to encapsulate the drug carrier, the capsule material is gelatin, the thickness is 0.55mm, the outer diameter is 7.05mm, and the length is 12.15mm. The use of biodegradable polymers to achieve sustained release of drugs and to precisely control the release of drugs can reduce the side effects of drugs; improve the bioavailability of drugs, and ensure that the drugs can effectively reach the target site and exert their therapeutic effects.

[0042] Embodiment 2:

[0043] As attached Figure 2-Figure 4As shown, the difference from the above embodiment is that the grinding and stirring device includes a shell 1, a controller and a driving member for providing a bidirectional driving force. In this embodiment, the driving member uses a double-headed motor 2, and the controller is used to control the operation of the double-headed motor 2; the output shaft on the double-headed motor 2 is rotated with a cross plate 3, and the four ends of the cross plate 3 are fixedly connected with the inner wall of the shell 1 by bolts; the double-headed motor 2 is fixedly connected to the bottom of the middle position of the cross plate 3 by bolts.

[0044] The output shaft on the double-headed motor 2 passes through the cross plate 3 and is fixedly connected to the rotating disk 4 with coaxial bolts. The rotating disk 4 is hinged with a number of "ヘ"-shaped connecting rods 5 along its circumference; the connecting rods 5 are hinged with a grinding plate 6 at one end away from the rotating disk 4, and the side of the grinding plate 6 away from the connecting rods 5 is arc-shaped and in contact with the inner wall of the outer shell 1; a slider is fixedly welded to the bottom of the grinding plate 6, and a sliding groove that slides with the slider is opened on the cross plate 3; a screen 7 is provided at the bottom of the cross plate 3, and the screen 7 is fixedly bonded to the inner wall of the outer shell 1.

[0045] The lower output shaft of the double-head motor 2 is coaxially bolted and fixedly connected with a stirring shaft 8, and a plurality of S-shaped stirring blades 9 are bolted and fixedly connected with the stirring shaft 8; the top of the outer shell 1 is detachably connected with a top cover 10 by thread, and the bottom of the outer shell 1 is bolted and fixedly connected with a plurality of supporting rods 11; a discharge port is opened at the bottom of the outer shell 1, and a one-way valve 12 is bolted and connected at the discharge port, and a controller is used to control the operation of the one-way valve 12.

[0046] The specific implementation process is as follows: when grinding is required, the top cover 10 is removed and the raw materials are put into the housing 1 in proportion. Because a screen 7 is fixedly bonded to the inner wall of the housing 1, the material can only fall into the bottom of the housing 1 when it reaches a certain fineness. Since the inner wall of the housing 1 is bolted and fixedly connected with a cross plate 3, the double-headed motor 2 is bolted and fixedly connected to the bottom of the middle position of the cross plate 3, and the output shaft of the double-headed motor 2 passes through the cross plate 3 and is coaxially bolted and fixedly connected with the rotating disk 4; therefore, when the output shaft of the double-headed motor 2 rotates, it can drive the rotating disk 4 to rotate with it.

[0047] Since the rotating disk 4 is hinged with a number of "ヘ"-shaped connecting rods 5 along its circumference, the end of the connecting rod 5 away from the rotating disk 4 is hinged with a grinding plate 6; therefore, when the rotating disk 4 rotates forwards and backwards, it can drive the connecting rod 5 to perform corresponding reciprocating motion, and when the connecting rod 5 moves, it can drive the grinding plate 6 hinged thereto to perform reciprocating motion; since the bottom of the grinding plate 6 is fixedly welded with a slider, the cross plate 3 is provided with a sliding groove that slides with the slider; therefore, this slider sliding groove can make the movement range of the grinding plate 6 on the cross plate 3 always remain straight without deviation.

[0048] by Figure 3For example, when the output shaft on the double-headed motor 2 rotates forward, it can drive the connecting rod 5 to extend to both sides, and when extending, it drives the grinding plate 6 to move outward; conversely, when the output shaft on the double-headed motor 2 rotates reversely, it can drive the connecting rod 5 to contract inward, and when contracting, it drives the grinding plate 6 to move inward; in this way, the reciprocating motion of the grinding plate 6 inside the outer shell 1 is achieved. Since the side of the grinding plate 6 away from the connecting rod 5 is arc-shaped and contacts the inner wall of the outer shell 1, the grinding of the material can be achieved by the reciprocating motion of the grinding plate 6 on the inner wall of the outer shell 1. Since the cross plate 3 will not completely cover the screen 7, when the material is ground to a size corresponding to the screen 7, it can fall into the bottom of the outer shell 1, and in this way, efficient grinding of the material can be achieved.

[0049] Since the lower output shaft of the double-headed motor 2 is coaxially bolted and fixedly connected with the stirring shaft 8, and the stirring shaft 8 is bolted and fixedly connected with a plurality of S-shaped stirring blades 9, the material falls to the bottom of the screen 7 after being ground, and the double-headed motor 2 drives the stirring shaft 8 to rotate, and the stirring shaft 8 drives the stirring blades 9 to rotate, thereby achieving full stirring and mixing of the material. After the material processing is completed, the one-way valve 12 at the bottom is opened by the controller, and the material is taken out from the discharge port to obtain the desired product. In this way, only one double-headed motor 2 is needed to achieve grinding and stirring of the material, which is highly efficient and economical.

[0050] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A composition for treating brain damage and neurodegenerative diseases, comprising an antioxidant and an anti-inflammatory drug, characterized in that: The antioxidant comprises vitamins, flavonoids, polysaccharides, saponins and active peptides in a mass ratio of 4:3:1:4:2, and the antioxidant component accounts for 60-80 parts; the anti-inflammatory drug comprises non-steroidal anti-inflammatory drugs (NSAIDs), and the anti-inflammatory drug component accounts for 20-40 parts.

2. The composition for treating brain damage and neurodegenerative diseases according to claim 1, characterized in that: The vitamins selected may include one or more of beta-carotene, vitamin C and vitamin E.

3. The composition for treating brain damage and neurodegenerative diseases according to claim 2, characterized in that: The flavonoids may be one or more of chlorogenic acid, soy isoflavones and cucurbitacin.

4. The composition for treating brain damage and neurodegenerative diseases according to claim 3, characterized in that: The polysaccharide is selected from one or more of angelica polysaccharide, ganoderma lucidum polysaccharide, yam polysaccharide, astragalus polysaccharide and wolfberry polysaccharide.

5. The composition for treating brain damage and neurodegenerative diseases according to claim 4, characterized in that: The saponins are selected from one or more of ginsenosides, notoginseng saponins and total saponins of Ilex pubescens.

6. The composition for treating brain damage and neurodegenerative diseases according to claim 5, characterized in that: The active peptides are selected from one or more of corn peptides, rice bran antioxidant peptides, wheat germ antioxidant peptides, glutathione, deer antler polypeptides and sea cucumber peptides.

7. The composition for treating brain damage and neurodegenerative diseases according to claim 6, characterized in that: The method for preparing the composition comprises the following steps: Step 1, raw material extraction: extracting active ingredients from raw materials containing antioxidants; separating, purifying and concentrating after extraction to obtain antioxidant extracts; Step 2, grinding and sieving: weigh the antioxidant extract and the anti-inflammatory drug according to a proportion, put them into a grinding and stirring device for grinding; after grinding, sieve to obtain a composite powder; Step 3, stirring and mixing: stirring and mixing the powder of the composition, and the stirring and mixing is performed in a grinding and stirring device; Step 4, drug preparation: placing the stirred and mixed composition into a drug carrier, and encapsulating the drug carrier with a capsule.

8. The composition for treating brain damage and neurodegenerative diseases according to claim 7, characterized in that: The grinding and stirring device comprises a housing (1), a controller and a driving member for providing a bidirectional driving force, wherein the controller is used to control the operation of the driving member; an output shaft on the driving member is rotatably matched with a cross plate (3), and the four ends of the cross plate (3) are fixedly connected to the inner wall of the housing (1); the driving member is fixedly connected to the bottom of the middle position of the cross plate (3); The output shaft on the driving member passes through the cross plate (3) and is coaxially fixedly connected to a rotating disk (4). The rotating disk (4) is hinged with a plurality of "ヘ"-shaped connecting rods (5) along its circumference; a grinding plate (6) is hingedly connected to one end of the connecting rod (5) away from the rotating disk (4); the side of the grinding plate (6) away from the connecting rod (5) is arc-shaped and contacts the inner wall of the outer shell (1); a slider is fixedly connected to the bottom of the grinding plate (6), and a sliding groove for slidingly cooperating with the slider is opened on the cross plate (3); a screen (7) is provided at the bottom of the cross plate (3), and the screen (7) is fixedly connected to the inner wall of the outer shell (1); The lower output shaft of the driving member is coaxially fixedly connected with a stirring shaft (8), and a plurality of S-shaped stirring blades (9) are fixedly connected to the stirring shaft (8); a top cover (10) is detachably connected to the top of the outer shell (1), and a plurality of support rods (11) are fixedly connected to the bottom of the outer shell (1); a discharge port is opened at the bottom of the outer shell (1), and a one-way valve (12) is fixedly connected to the discharge port, and a controller is used to control the operation of the one-way valve (12).

9. The composition for treating brain damage and neurodegenerative diseases according to claim 8, characterized in that: In step 4, the drug carrier material is polylactic acid-glycolic acid copolymer, which has a thickness of 0.15-0.35 mm, an outer diameter of 6.05-6.85 mm, and a length of 7.15-8.35 mm; the capsule material is gelatin, which has a thickness of 0.55-0.65 mm, an outer diameter of 7.05-7.45 mm, and a length of 12.15-14.25 mm.

10. An application of a composition for treating brain damage and neurodegenerative diseases, based on the composition for treating brain damage and neurodegenerative diseases according to any one of claims 1 to 9, characterized in that: Including but not limited to applications in stroke, brain trauma, depression, Alzheimer's disease and Parkinson's disease.

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