Formula of feed additive capable of reducing acid and protecting kidney

Abstract

The invention discloses a feed additive formula capable of reducing acid and protecting kidney. The feed additive formula comprises the following components: yucca extract, silymarin, chitosan, potassium citrate, medicinal charcoal, vitamin C, vitamin and bentonite. The invention belongs to the technical field of feed additive formulas, and particularly relates to a feed additive formula for reducing acid and protecting kidney.

Description

Technical Field

[0001] The invention belongs to the technical field of feed additive formula, and specifically refers to a feed additive formula for reducing acid and protecting kidneys. Background Art

[0002] In modern animal husbandry, with the continuous expansion of breeding scale and the increase of breeding density, the health of livestock has received increasing attention. Due to the influence of unreasonable feed matching, environmental factors and various stress factors in the breeding process, acid-base imbalance often occurs in livestock, resulting in the accumulation of acidic metabolites, causing damage to organs such as the kidneys, affecting the growth and development and production performance of livestock. At the same time, if the nutrients in the feed cannot be fully absorbed and utilized, it will not only cause waste of resources, but also increase breeding costs. In addition, the quality and safety of feed are also important factors affecting the development of animal husbandry. Unqualified feed may cause livestock to be infected with diseases and even affect food safety. Therefore, it is of great practical significance to develop a feed additive that can effectively regulate the acid-base balance in livestock, protect kidney function, provide balanced nutrition, and improve feed utilization and safety. Traditional feed additives often have problems such as single function, insignificant effect, and unstable quality, and cannot meet the development needs of modern animal husbandry.

[0003] The acid-reducing and kidney-protecting feed additive formula and preparation method of the present invention came into being in such a background, aiming to provide an efficient, safe and reliable feed additive solution for animal husbandry, promote the healthy development of animal husbandry, and improve breeding efficiency and product quality. Summary of the invention

[0004] The technical problem to be solved by the present invention is that acid-base imbalance often occurs in livestock, resulting in accumulation of acidic metabolites, causing damage to organs such as the kidneys, and affecting the growth, development and production performance of livestock.

[0005] In order to achieve the above functions, the technical scheme adopted by the present invention is as follows: a feed additive formula for reducing acid and protecting the kidneys, comprising the following components by weight: yucca extract: 10-15 parts, silymarin: 8-12 parts, chitosan: 10-15 parts, potassium citrate: 20-30 parts, medicinal charcoal: 10-15 parts, vitamin C: 8-12 parts, vitamin E4-8 parts and bentonite: 10-15 parts.

[0006] The present invention also discloses a method for preparing a feed additive formula for reducing acid and protecting kidneys, comprising the following steps:

[0007] S1. Crushing and sieving: Putting raw materials with relatively high hardness such as potassium citrate, medicinal charcoal and bentonite into a jet mill for crushing to obtain a mixture A, and crushing soft gel raw materials such as yucca extract, silymarin and chitosan into a universal crusher to obtain a mixture B; the crushed raw materials are screened through an 80-100 mesh sieve, and all the raw materials pass through the sieve smoothly to obtain powders with uniform particle size;

[0008] S2. Vitamin premixing: Select a suitable carrier, mix the vitamins with the carrier, put vitamin C and vitamin E into a small high-speed mixer with the carrier respectively, stir at high speed for 5-8 minutes under an environment of 20-25°C and relative humidity of 40%-60%, so that the vitamins are evenly adsorbed on the surface of the carrier to form a premixed material, and seal it for storage;

[0009] S3, mixing and stirring: Add mixture A into a double cone mixer, stir at low speed for 3-5 minutes for preliminary mixing, slowly add the vitamin premix, continue stirring at low speed for 8-10 minutes, and then stir at medium speed for 10-15 minutes. During the mixing process, sample and test to ensure that the mixing uniformity is qualified;

[0010] S4. Quality inspection: Take samples from different parts of the double cone mixer, and use instrumental analysis (such as vitamin HPLC) to test the mixing uniformity, calculate the coefficient of variation, and it is qualified if it does not exceed 5%. Otherwise, adjust the mixing parameters and retest; Microbial index detection, test the total number of bacteria, total number of molds, Escherichia coli, Salmonella, etc. according to standard methods, which should meet the hygiene standards; Check whether the appearance is uniform, without impurities, agglomeration and discoloration, and whether the particle size meets the requirements of 80-100 mesh sieve. The fluidity is measured by the angle of repose meter. If it is unqualified, add flow aids or optimize the process;

[0011] S5. Packaging and storage: Use food-grade plastic composite bags or aluminum foil bags and other packaging materials.

[0012] Preferably, the carrier in step S3 is microcrystalline cellulose.

[0013] Preferably, in step S2, the vitamins and the carriers are mixed in a ratio of 1:5-1:8.

[0014] The present invention adopts the above structure to achieve the following beneficial effects: the additive of the present invention helps to regulate the acid-base balance in the livestock body, maintains the pH of urine within an appropriate range, reduces the stimulation and damage of acidic substances to the kidneys, thereby reducing the risk of diseases such as urinary stones, promotes the excretion of metabolic waste such as uric acid, reduces the filtration burden of the kidneys, helps to improve the functional state of the kidneys, and at the same time regulates the balance of intestinal flora, reduces the production and absorption of intestinal endotoxins, reduces the potential damage of these toxins to the kidneys, and protects the kidneys from the aspect of intestinal health. DETAILED DESCRIPTION

[0015] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] Embodiment 1:

[0017] A feed additive formula for reducing acid and protecting kidneys comprises the following components by weight: 10 parts of silymarin, 12 parts of chitosan, 25 parts of potassium citrate, 12 parts of medicinal charcoal, 10 parts of vitamin C, 6 parts of vitamin E and 13 parts of bentonite.

[0018] The present invention also discloses a method for preparing a feed additive formula for reducing acid and protecting kidneys, comprising the following steps:

[0019] S1. Crushing and sieving: Use a jet mill and a universal mill to crush the raw materials and pass through an 80-mesh sieve;

[0020] S2, vitamin premix: 10 parts of vitamin C are mixed with 50 parts of microcrystalline cellulose, and 6 parts of vitamin E are mixed with 30 parts of microcrystalline cellulose, and stirred at high speed for 6 minutes at 23° C. and relative humidity of 50%;

[0021] S3, mixing and stirring: add the solid raw materials into the double cone mixer and stir at low speed for 4 minutes, add the vitamin premix and stir at low speed for 9 minutes, stir at medium speed for 12 minutes, and the mixing uniformity is qualified;

[0022] S4. Quality inspection: qualified in mixing uniformity inspection, qualified in microbiological index, and good in physical properties;

[0023] S5. Packaging and storage: Use food-grade plastic composite bags, 500g per bag, and store in a warehouse with a temperature of 20℃ and a relative humidity of 50%.

[0024] Embodiment 2:

[0025] A feed additive formula for reducing acid and protecting the kidneys comprises the following components by weight: 10 parts of yucca extract, 8 parts of silymarin, 10 parts of chitosan, 20 parts of potassium citrate, 10 parts of medicinal charcoal, 8 parts of vitamin C, 4 parts of vitamin E and 10 parts of bentonite.

[0026] The present invention also discloses a method for preparing a feed additive formula for reducing acid and protecting kidneys, comprising the following steps:

[0027] S1. Crushing and sieving: crush the raw materials and sieve them as required;

[0028] S2, vitamin premix: 8 parts of vitamin C are mixed with 40 parts of microcrystalline cellulose, and 4 parts of vitamin E are mixed with 20 parts of microcrystalline cellulose, and stirred at high speed for 5 minutes at 22°C and relative humidity of 45%;

[0029] S3, mixing and stirring: first stir at a low speed for 3 minutes, then add the vitamin premix and stir at a low speed for 8 minutes, then stir at a medium speed for 10 minutes to mix evenly;

[0030] S4. Quality inspection: qualified in mixing uniformity inspection, qualified in microbiological index, and good in physical properties;

[0031] S5. Packaging and storage: Packed in aluminum foil bags, 1 kg per bag, stored in a warehouse with a temperature of 18°C ​​and a relative humidity of 55%.

[0032] Embodiment 3:

[0033] A feed additive formula for reducing acid and protecting the kidneys comprises the following components by weight: 15 parts of yucca extract, 12 parts of silymarin, 15 parts of chitosan, 30 parts of potassium citrate, 15 parts of medicinal charcoal, 12 parts of vitamin C, 8 parts of vitamin E and 15 parts of bentonite.

[0034] The present invention also discloses a method for preparing a feed additive formula for reducing acid and protecting kidneys, comprising the following steps:

[0035] S1. Crushing and screening: crushing and screening of raw materials;

[0036] S2, vitamin premix: 12 parts of vitamin C are mixed with 60 parts of microcrystalline cellulose, and 8 parts of vitamin E are mixed with 40 parts of microcrystalline cellulose, and stirred at high speed for 8 minutes at 24° C. and relative humidity of 55%;

[0037] S3, mixing and stirring: the solid raw materials are first stirred at a low speed for 5 minutes, and then the vitamin premix is ​​added and stirred at a low speed for 10 minutes, and then stirred at a medium speed for 15 minutes, and the mixing uniformity is good;

[0038] S4. Quality inspection: qualified in mixing uniformity inspection, qualified in microbiological index, and good in physical properties;

[0039] S5. Packaging and storage: Use plastic composite bags, 2kg per bag, and store in a warehouse with a temperature of 22℃ and a relative humidity of 45%.

[0040] When used specifically, a specific breed of livestock, such as pigs, cattle or sheep, which are similar in age and weight and in good health, are selected and randomly divided into three groups with equal numbers in each group, respectively marked as Group A, Group B and Group C. The livestock in Group A use the feed additive of Example 1, the livestock in Group B use the feed additive of Example 2, and the livestock in Group C use the feed additive of Example 3.

[0041] The experimental period was 60 days, during which the feeding environment, feed (except additives), feeding amount, drinking water, etc. were kept consistent.

[0042] Weigh before and after the experiment, calculate the average daily weight gain, record feed intake, calculate the average daily feed intake and feed conversion rate; draw blood in the middle and at the end to measure uric acid, creatinine, urea nitrogen, total protein, albumin, globulin and antioxidant indicators (SOD, GSH-Px, MDA); at the end of the experiment, slaughter (or non-lethal test) and obtain kidney tissue for pathological examination and gene expression detection.

[0043] Statistical software (such as SPSS) was used for analysis. The normality and homogeneity of variance of the data were tested first. Variance analysis was used for growth performance data. LSD multiple comparisons were performed if the differences were significant. Variance analysis or nonparametric tests were used for blood biochemistry and kidney health indicators according to their types. Chi-square test was used for categorical variables. The results were expressed as mean ± standard deviation. The differences were significant when P < 0.05.

[0044] The test results for 60 days showed that Example 3 was most effective in regulating the pH value of urine. Compared with Examples 1 and 2, it performed better in maintaining the acid-base balance toward a healthier weak alkaline direction. From the perspective of the decrease ratio of serum creatinine and urea nitrogen, the effect of Example 3 was also outstanding. Comprehensively comparing various indicators of health status and growth performance, Example 3 performed better than Examples 1 and 2.

[0045] The present invention and its implementation methods are described above, and such description is not restrictive. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A feed additive formula for reducing acid and protecting the kidney, characterized in that: The invention comprises the following components by weight: 10-15 parts of yucca extract, 8-12 parts of silymarin, 10-15 parts of chitosan, 20-30 parts of potassium citrate, 10-15 parts of medicinal charcoal, 8-12 parts of vitamin C, 4-8 parts of vitamin E and 10-15 parts of bentonite.

2. A method for preparing the acid-reducing and kidney-protecting feed additive formula according to claim 1, characterized in that: The steps include: S1. Grinding: Putting raw materials with relatively high hardness such as potassium citrate, medicinal charcoal, and bentonite into a jet mill for grinding to obtain a mixture A, and grinding soft gel raw materials such as yucca extract, silymarin, and chitosan into a universal grinder to obtain a mixture B; the ground raw materials are screened through an 80-100 mesh sieve, and all raw materials pass through the sieve smoothly to obtain powders with uniform particle size; S2. Vitamin premixing: Select a suitable carrier, mix the vitamins with the carrier, put vitamin C and vitamin E into a small high-speed mixer with the carrier respectively, stir at high speed for 5-8 minutes at 20-25°C and relative humidity of 40%-60%, so that the vitamins are evenly adsorbed on the surface of the carrier to form a premixed material, and seal it for storage; S3, mixing and stirring: Add mixture A into a double cone mixer, stir at low speed for 3-5 minutes for preliminary mixing, slowly add the vitamin premix, continue stirring at low speed for 8-10 minutes, and then stir at medium speed for 10-15 minutes. During the mixing process, sample and test to ensure that the mixing uniformity is qualified; S4. Quality inspection: Take samples from different parts of the double cone mixer, and use instrumental analysis (such as vitamin HPLC) to test the mixing uniformity, calculate the coefficient of variation, and it is qualified if it does not exceed 5%. Otherwise, adjust the mixing parameters and retest; Microbial index detection, test the total number of bacteria, total number of molds, Escherichia coli, Salmonella, etc. according to standard methods, which should meet the hygiene standards; Check whether the appearance is uniform, without impurities, agglomeration and discoloration, and whether the particle size meets the requirements of 80-100 mesh sieve. The fluidity is measured by the angle of repose meter. If it is unqualified, add flow aids or optimize the process; S5. Packaging and storage: Use food-grade plastic composite bags or aluminum foil bags and other packaging materials.

3. A feed additive formula for reducing acid and protecting kidneys according to claim 2, characterized in that: The carrier in step S3 is microcrystalline cellulose.

4. A feed additive formula for reducing acid and protecting kidneys according to claim 2, characterized in that: In step S2, the vitamins and the carriers are mixed in a ratio of 1:5-1:8.