Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for large-scale preparation of pramiracetam

A technology of pramiracetam hydrate and tetrahydrofuran, which is applied in the field of fine chemical product production to achieve the effects of low environmental pollution, low cost and high purity

Inactive Publication Date: 2013-04-03
KAMP PHARMA
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to overcome the deficiencies of the existing pramiracetam synthesis process, to provide a high yield, safe, pollution-free, low cost, easy to operate The preparation method for obtaining high-purity pramiracetam is suitable for large-scale production and can meet the requirements of the pharmaceutical field

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for large-scale preparation of pramiracetam
  • Method for large-scale preparation of pramiracetam
  • Method for large-scale preparation of pramiracetam

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The following implementation is only to illustrate the present invention in more detail, but does not limit the present invention in any form.

[0028] The preparation method of pramiracetam:

[0029] (1) Synthesis of N-(2-(diisopropyl)ethyl)-2-chloroacetamide hydrochloride (Intermediate A):

[0030] Take a dry 1000ml three-neck bottle, install mechanical stirring, dropping funnel, and thermometer. Add 72g (0.5mol) of diisopropylethylenediamine and 500ml of dry tetrahydrofuran, and stir the reaction at about 315 rpm. Ice bath, starting at 2°C. Slowly add 45ml (0.56mol) of chloroacetyl chloride dropwise. When the dropwise addition was carried out for about one hour, a yellow sticky substance formed on the wall. Speed ​​up the rotating speed to about 350 rpm, and continue the dropwise addition reaction. The temperature of the whole reaction process was controlled within 15°C. After about one hour and forty minutes, the dropwise addition was completed, and th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for large-scale preparation of pramiracetam. The method comprises the following steps of: carrying out a condensation reaction, dissolving and filtering, re-dissolving and extracting, refluxing, freezing and suction-filtering. The method provided by the invention has simple process operation, is safe and pollution-free. Moreover, the prepared pramiracetam has high yield, high purity, easily obtained materials, and low production cost, and is suitable for large-scale production of the enterprises.

Description

technical field [0001] The invention belongs to the production field of fine chemical products, and in particular relates to a preparation process of pramiracetam, which is used for producing medicines for improving brain function. Background technique [0002] Pramiracetam was first listed in Italy in 1993. Its chemical name is N-(2-(diisopropylamino)ethyl)-2-oxo-1-pyrrolidineacetamide. Tan analogues, new pyrrolidone-like brain function improvers, suitable for memory and recognition impairment, language disorders and Alzheimer's syndrome (Alzheimer's disease), its chemical structure is shown in Figure I . [0003] In the literature [Peng Zhenyun, Sun Yongju, Qi Chao, Synthesis of Pramiracetam, China Pharmaceutical Industry, 1998, 29 (8): 344] obtained by reacting ethyl pyrrolidone acetate and N,N-diisopropylethylenediamine . Pyrrolidone ethyl acetate is obtained from the sodium salt of pyrrolidone according to the Gabriel synthesis. In the ammonolysis reaction, an exces...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D207/27
Inventor 曾培安张浩吴锋刘娟张静吴健民贺莲
Owner KAMP PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com