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Plant based dietary supplement for improving the duration and quality of sleep

A technology of pills, lozenges, applied in the field of unique compositions for the treatment or prevention of insomnia or insomnia, capable of solving problems such as dangers of action

Inactive Publication Date: 2006-11-01
ACCESS BUSINESS GRP INT LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All of these drugs cause drowsiness and can suppress breathing, making the combined effect even more dangerous

Method used

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  • Plant based dietary supplement for improving the duration and quality of sleep
  • Plant based dietary supplement for improving the duration and quality of sleep
  • Plant based dietary supplement for improving the duration and quality of sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1: Ability of Valerian Extract to Bind Potently to GABA Receptors

[0093] Valerian, an herb known to produce anxiolytic and sedative effects, binds to GABA receptors and thereby potentiates the sedative effects of anesthetics and other drugs that act on GABA receptors. See Yuan, Chun-Su et al., 2004 "Gamma-aminobutyric acid Acidergic effects of valerian and pentenoic acid on the activity of rat brainstem neurons" Anesth. Analg. 98:35-8.

[0094] Those skilled in the art will appreciate that there are many methods for determining the ability of a substance to bind a GABA receptor. An example of such methods is as follows and described in Yuan, Chun-Su et al., 2004 "Gamma-aminobutyric acid Acidergic effects of valerian and pentenoic acid on the activity of rat brainstem neurons" Anesth.Analg.98 : 35-8, which is incorporated herein by reference in its entirety. Yuan et al demonstrated the anxiolytic and sedative effects of valerian due to its binding to GABA rec...

Embodiment 2

[0103] Example 2: Ability of Jujube Extract, Radix Paeoniae Alba Extract, Polygala Extract, Passiflora Extract and Valerian Root Extract to Strongly Bind to GABA Receptor

[0104] The GABA receptor agonist binding assay was used to test the biological activity of the extracts of Paeoniae Alba, Jujube, Polygala, Passiflora, Valeriana or their derivatives. These GABA-A agonist assays were performed by NovaScreen Biosciences (Hanover, Maryland) and are described in: Falch E. et al., 1986 "Effects of GABA-A and GABA-B receptor sites and GABA uptake using rat meningeal preparations Comparative stereostructure-activity studies performed" - J.Neurochem.47(3):898-903; and Enna S.J. et al., 1977 "Stereospecificity and structure-activity requirements for GABA receptor binding in the rat brain" - BrainRes .124(1):185-190, which is hereby incorporated by reference in its entirety.

[0105] In particular, the GABA-A agonist binding assay used bovine cerebellum as a source of GABA-A recept...

Embodiment 3

[0110] Example 3: Ability of different formulations of the present invention to strongly bind to GABA receptors

[0111] sample discription

IC in μg / ml 50

Formula 1 (434mg Paeoniae Alba, 200mg Passiflora)

0.74

Formula 2 (375mg Paeoniae Alba, 134mg Passiflora)

1.19

Formula 3 (650mg Paeoniae Alba, 200mg Passiflora)

5.3

Formula 4 (400mg Paeoniae Alba, 200mg Passiflora)

4.04

Formula 5 (525mg Paeoniae Alba, 200mg Passiflora)

3.89

Formula 6 (250mg Radix Paeoniae Alba, 500mg Wild Jujube)

1.84

Formula 7 (650mg Radix Paeoniae Alba, 200mg Wild Jujube)

2.41

Formula 8 (700mg wild jujube, 134mg passion fruit)

1.67

Formula 9 (500mg wild jujube, 134mg passion fruit)

0.89

Formula 10 (375mg Paeoniae Alba, 500mg Wild Jujube, 134mg Passiflora)

1.92

Formula 11 (650mg Paeoniae Alba, 200mg Wild Jujube, 200mg Passiflora)

3.6...

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PUM

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Abstract

The present invention relates to compositions for treating insomnia or sleeplessness. The compositions of the present invention comprise jujube extract and at least one of white peony extract, radix polygala extract, and passion flower extract. The extracts used in the compositions of the present invention bind strongly to GABA receptors and work synergistically to shorten the time needed to fall asleep and to improve the quality of sleep by reducing awakenings during sleep and increasing the duration of sleep.

Description

Background technique [0001] Insomnia, or insomnia, is a common disorder caused by mental and / or physical overstimulation in general. Factors such as stress, poor dietary habits, lack of physical activity and psychological influences are the main causes of insomnia. The inability to sleep is an important problem because sleep is essential for survival and good health. [0002] How long a person sleeps and how rested a person feels when they wake up can be influenced by many factors, including excitement or sadness. Medications can also play a part; some drugs can make you drowsy, while others make it difficult to fall asleep. Even certain food ingredients or additives, such as caffeine, stimulant seasonings, and monosodium glutamate (MSG) can affect sleep. [0003] Intermittent use of sleep medications, such as sedatives or sleeping pills, may be helpful when sleep disturbances interfere with a person's normal activities and sense of well-being. Sedatives reduce activity, r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A23L1/30A61K9/00A61K9/14A61K9/20A61P25/20
CPCA61K36/185A61K36/65A61K36/69A61K36/725A61P25/20A61K2300/00
Inventor C·伊康特董美仙M·黄D·J·法斯特A·佐内伊Y·李
Owner ACCESS BUSINESS GRP INT LLC
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