An improved sleep anxiolytic botanical amino acid composition, method of making and use

Abstract

This invention discloses a plant-based amino acid composition for improving sleep and relieving anxiety, its preparation method, and its applications, relating to the fields of functional foods and nutritional health technology. The composition includes jujube seed extract, lily extract, poria cocos extract, polygonum multiflorum extract, arborvitae seed extract, clove extract, γ-aminobutyric acid (GABA), theanine, magnesium glycine, and L-glycine. This invention utilizes GABA to reduce nerve excitability; theanine to help improve relaxation; jujube seed extract to enhance sleep stability; glycine to lower core body temperature; and magnesium glycine to stabilize the nervous system. Its improving effects are manifested in: improving NREM sleep quality, enhancing sleep continuity, promoting deep sleep recovery, and reducing drowsiness the following day. It achieves the technical effects of shortening sleep onset time, increasing the proportion of deep sleep, reducing the number of nighttime awakenings, and improving the feeling of sleep recovery.

Description

Technical Field

[0001] This invention relates to the field of functional foods and nutritional health technology, specifically to a plant-based amino acid composition for improving sleep and relieving anxiety, its preparation method, and its application. Background Technology

[0002] In today's fast-paced society, the accumulated stress keeps many people's nervous systems in a state of constant tension, leading to a growing prevalence of neurotransmitter imbalances and posing a significant challenge to physical and mental health. Faced with this situation, existing solutions on the market each have their limitations and shortcomings: First, while common Western medicine treatments are relatively quick to take effect, they often come with strong dependence, and long-term use may lead to drug resistance or side effects; second, the safety and effectiveness of melatonin as a sleep regulator are still highly controversial in academia and practice, making it unsuitable as a routine treatment; third, while traditional Chinese medicine emphasizes holistic regulation and has relatively few side effects, it usually takes effect slowly, failing to meet modern people's need for rapid symptom relief; finally, while single-ingredient γ-aminobutyric acid (GABA) products can help soothe nerves, their mechanism of action is relatively simple, resulting in limited actual improvement and making it difficult to comprehensively address complex neuroregulatory issues. Summary of the Invention

[0003] The purpose of this invention is to provide a plant-based amino acid composition for improving sleep and relieving anxiety, its preparation method, and its application. This composition has high safety, multiple targets, synergistic effects, long-term applicability, and significant improvement in deep sleep.

[0004] To achieve the above objectives, the present invention provides the following technical solution:

[0005] A compound plant amino acid composition for improving sleep and relieving anxiety, the composition comprising the following components in parts by weight:

[0006] Ziziphus jujuba seed extract 10-40 parts,

[0007] Lily extract, 5-25 parts.

[0008] Poria cocos extract 5-25 parts,

[0009] Polygonum multiflorum extract 5-30 parts,

[0010] 3-20 parts of cypress seed extract,

[0011] Clove extract 0.5–10 parts,

[0012] 5-30 parts of γ-aminobutyric acid.

[0013] Theanine 5-30 parts,

[0014] 3-20 parts of magnesium glycine

[0015] 5-40 parts of L-glycine.

[0016] Furthermore, the total saponin content in the jujube seed extract is ≥2%.

[0017] Furthermore, the clove extract contains ≥5% eugenol.

[0018] Furthermore, the weight ratio of γ-aminobutyric acid to theanine is 1:0.6 to 1.2.

[0019] Furthermore, the composition further includes one or any combination of the following components, in parts by weight:

[0020] Maltodextrin 5-40 parts, erythritol 5-30 parts, xylitol 5-30 parts, microcrystalline cellulose 5-30 parts, magnesium stearate 5-30 parts.

[0021] Furthermore, the composition further includes one or any combination of the following components, in parts by weight:

[0022] Valerian extract 5-30 parts, chamomile extract 5-30 parts, passionflower extract 5-30 parts, DHA 5-40 parts, taurine 5-40 parts.

[0023] Further, the composition is prepared as follows:

[0024] Tablets, capsules, granules, gummies, oral liquids, solid beverages, sprays, or sublingual tablets.

[0025] Furthermore, the composition employs a microencapsulation process to encapsulate γ-aminobutyric acid, theanine, and clove extract.

[0026] Furthermore, the wall material of the microcapsule includes:

[0027] One or any combination of lecithin, gum arabic, β-cyclodextrin or whey protein.

[0028] This invention also provides the following technical solutions:

[0029] A method for preparing a compound plant amino acid composition that improves sleep and relieves anxiety includes the following steps:

[0030] S1. Weigh each component according to the proportion;

[0031] S2. Crush and sieve the plant extract;

[0032] S3, mixed with γ-aminobutyric acid, theanine, magnesium glycine and L-glycine;

[0033] S4. Add auxiliary materials;

[0034] S5, granulation or mixing;

[0035] S6. Drying;

[0036] S7, tableting, filling or molding.

[0037] This invention also provides the following technical solutions:

[0038] The use of a complex plant-based amino acid composition for improving sleep and relieving anxiety in the preparation of products for at least one of the following purposes:

[0039] 1) Improve sleep;

[0040] 2) Shorten the time it takes to fall asleep;

[0041] 3) Increase the proportion of deep sleep;

[0042] 4) Relieves anxiety;

[0043] 5) Reduce nighttime awakenings;

[0044] 6) Improves the feeling of restorative sleep.

[0045] The beneficial effects of this invention are as follows: γ-aminobutyric acid (GABA) can reduce nerve excitability; theanine helps improve relaxation; jujube seed can enhance sleep stability; glycine can lower core body temperature; and magnesium glycine can stabilize the nervous system. Its improving effects are manifested in: improving NREM sleep quality, enhancing sleep continuity, promoting deep sleep recovery, and reducing drowsiness the following day. The synergistic effect of plant active ingredients, neurotransmitter regulatory components, and amino acid nutritional factors has the characteristics of high safety, multi-target action, significant synergistic effect, and long-term applicability, and can achieve the technical effects of shortening sleep onset time, increasing the proportion of deep sleep, reducing the number of nighttime awakenings, and improving the feeling of sleep recovery.

[0046] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, the preferred embodiments of the present invention are described in detail below. Detailed Implementation

[0047] The technical solutions of the present invention will now be clearly and completely described. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0048] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating orientation or positional relationships, are based on the shown orientation or positional relationships and are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0049] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0050] Furthermore, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0051] This application discloses a compound plant amino acid composition for improving sleep and relieving anxiety, the composition comprising the following components in parts by weight:

[0052] Ziziphus jujuba seed extract 10-40 parts,

[0053] Lily extract, 5-25 parts.

[0054] Poria cocos extract 5-25 parts,

[0055] Polygonum multiflorum extract 5-30 parts,

[0056] 3-20 parts of cypress seed extract,

[0057] Clove extract 0.5–10 parts,

[0058] 5-30 parts of γ-aminobutyric acid.

[0059] Theanine 5-30 parts,

[0060] 3-20 parts of magnesium glycine

[0061] 5-40 parts of L-glycine.

[0062] The total saponin content in jujube seed extract is ≥2%.

[0063] The eugenol content in clove extract is ≥5%.

[0064] The weight ratio of γ-aminobutyric acid to theanine is 1:0.6 to 1.2.

[0065] The composition also includes one or any combination of the following components, in parts by weight:

[0066] Maltodextrin 5-40 parts, erythritol 5-30 parts, xylitol 5-30 parts, microcrystalline cellulose 5-30 parts, magnesium stearate 5-30 parts.

[0067] The composition also includes one or any combination of the following components, in parts by weight:

[0068] Valerian extract 5-30 parts, chamomile extract 5-30 parts, passionflower extract 5-30 parts, DHA 5-40 parts, taurine 5-40 parts.

[0069] The composition is prepared as follows:

[0070] Tablets, capsules, granules, gummies, oral liquids, solid beverages, sprays, or sublingual tablets.

[0071] The composition employs a microencapsulation process to encapsulate γ-aminobutyric acid, theanine, and clove extract.

[0072] The wall materials of microcapsules include:

[0073] One or any combination of lecithin, gum arabic, β-cyclodextrin or whey protein.

[0074] This invention also provides the following technical solutions:

[0075] A method for preparing a compound plant amino acid composition that improves sleep and relieves anxiety includes the following steps:

[0076] S1. Weigh each component according to the proportion;

[0077] S2. Crush and sieve the plant extract;

[0078] S3, mixed with γ-aminobutyric acid, theanine, magnesium glycine and L-glycine;

[0079] S4. Add auxiliary materials;

[0080] S5, granulation or mixing;

[0081] S6. Drying;

[0082] S7, tableting, filling or molding.

[0083] This invention also provides the following technical solutions:

[0084] The use of a complex plant-based amino acid composition for improving sleep and relieving anxiety in the preparation of products for at least one of the following purposes:

[0085] 1) Improve sleep;

[0086] 2) Shorten the time it takes to fall asleep;

[0087] 3) Increase the proportion of deep sleep;

[0088] 4) Relieves anxiety;

[0089] 5) Reduce nighttime awakenings;

[0090] 6) Improves the feeling of restorative sleep.

[0091] Example 1 (Standard Capsule)

[0092] Ingredient unit mg / capsule. In this example, each capsule contains: 50 mg of jujube seed extract, 20 mg of lily extract, 20 mg of poria cocos extract, 25 mg of polygonum multiflorum extract, 10 mg of arborvitae seed extract, 5 mg of clove extract, 150 mg of γ-aminobutyric acid, 180 mg of theanine, 60 mg of magnesium glycine, and 120 mg of L-glycine.

[0093] Preparation steps:

[0094] 1. Mixed plant extracts;

[0095] 2. Add amino acid components;

[0096] 3. Mix with a V-type mixer for 30 minutes;

[0097] 4. Add auxiliary materials;

[0098] 5. Filling capsules.

[0099] Example 2 (Gummy)

[0100] Based on Example 1, the following ingredients were added: erythritol, pectin, and citric acid.

[0101] Prepare sleep gummies.

[0102] Example 3 (Sublingual Immediate-Release Tablet)

[0103] Based on Example 2, the following were added: microcrystalline cellulose and a disintegrant.

[0104] The addition of microcrystalline cellulose and disintegrants enables rapid onset of action.

[0105] In summary, this invention provides a plant-based amino acid composition for improving sleep and relieving anxiety, its preparation method, and its applications. This composition utilizes γ-aminobutyric acid (GABA) to reduce nerve excitability; theanine to help enhance relaxation; jujube seed extract to enhance sleep stability; glycine to lower core body temperature; and magnesium glycine to stabilize the nervous system. Its improving effects include: improving NREM sleep quality, enhancing sleep continuity, promoting deep sleep recovery, and reducing drowsiness the following day. The synergistic effect of plant active ingredients, neurotransmitter regulatory components, and amino acid nutritional factors has the characteristics of high safety, multi-target action, significant synergistic effect, and long-term applicability, achieving the technical effects of shortening sleep onset time, increasing the proportion of deep sleep, reducing the number of nighttime awakenings, and improving the feeling of sleep recovery.

[0106] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0107] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A compound plant amino acid composition for improving sleep and relieving anxiety, characterized in that, The composition comprises the following components in parts by weight: Ziziphus jujuba seed extract 10-40 parts, Lily extract, 5-25 parts. Poria cocos extract 5-25 parts, Polygonum multiflorum extract 5-30 parts, 3-20 parts of cypress seed extract, Clove extract 0.5–10 parts, 5-30 parts of γ-aminobutyric acid. Theanine 5-30 parts, 3-20 parts of magnesium glycine 5-40 parts of L-glycine.

2. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 1, characterized in that, The total saponin content of the jujube seed extract is ≥2%. The clove extract contains ≥5% eugenol.

3. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 1, characterized in that, The weight ratio of γ-aminobutyric acid to theanine is 1:0.6 to 1.

2.

4. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 1, characterized in that, The composition further includes one or any combination of the following components, in parts by weight: Maltodextrin 5-40 parts, erythritol 5-30 parts, xylitol 5-30 parts, microcrystalline cellulose 5-30 parts, magnesium stearate 5-30 parts.

5. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 5, characterized in that, The composition further includes one or any combination of the following components, in parts by weight: Valerian extract 5-30 parts, chamomile extract 5-30 parts, passionflower extract 5-30 parts, DHA 5-40 parts, taurine 5-40 parts.

6. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 1, characterized in that, The composition is prepared as follows: Tablets, capsules, granules, gummies, oral liquids, solid beverages, sprays, or sublingual tablets.

7. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 1, characterized in that, The composition employs a microencapsulation process to encapsulate γ-aminobutyric acid, theanine, and clove extract.

8. The compound plant amino acid composition for improving sleep and relieving anxiety as described in claim 8, characterized in that, The wall material of the microcapsules includes: One or any combination of lecithin, gum arabic, β-cyclodextrin or whey protein.

9. A method for preparing the composition according to any one of claims 1 to 9, characterized in that, Includes the following steps: S1. Weigh each component according to the proportion; S2. Crush and sieve the plant extract; S3, mixed with γ-aminobutyric acid, theanine, magnesium glycine and L-glycine; S4. Add auxiliary materials; S5, granulation or mixing; S6. Drying; S7, tableting, filling or molding.

10. The use of the composition according to any one of claims 1 to 8 in the preparation of a product for at least one of the following uses, 1) Improve sleep; 2) Shorten the time it takes to fall asleep; 3) Increase the proportion of deep sleep; 4) Relieves anxiety; 5) Reduce nighttime awakenings; 6) Improves the feeling of restorative sleep.