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2 results about "Placental cell" patented technology
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Placental stem cells are a type of perinatal stem cell derived from the placental blood or tissue. The placenta is an organ that connects the developing fetus to the uterine wall, allowing a flow of nutrients, gases, and hormones between the mother and the fetus during pregnancy.
A method for constructing a preeclampsia animal model based on down-regulation of HAPLN1 to induce abnormal placental cell aging and application thereof
The application discloses a kind of based on HAPLN1 down-regulation induced preeclampsia animal model construction method and application of placental cell abnormal aging, belong to the field of biological medicine technology.The application can stably induce the animal model with typical preeclampsia clinical characteristics by reducing the expression level of HAPLN1 in pregnant mice, while reproducing the abnormal phenotype of placental cell aging.The method has strong controllability in operation process, and the model has good reproducibility, which can provide effective experimental tools for in-depth study of the pathogenesis of preeclampsia and development of new diagnosis and treatment strategies.
Owner:THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
Soluble placental ECM
The invention is directed to a composition of soluble placental ECM in storage solution and the methods of manufacture related thereto. The solubilized placental ECM solution is manufactured through a process of partitioning placental ECM from the placental tissue in a high acidic pH environment and performing an ultrafiltration step and diafiltration step through a tangential flow filtration system to increase the pH. The soluble placental ECM retains the native characteristics of placental ECM components and includes collagens (types I, III, V, VI, IX, and X), elastin, laminin, and fibronectin.
Owner:REGENTX PARTNERS LLC