60 results about "Phenylpropene" patented technology

The invention relates to a thermosetting resin composition and prepreg and laminate prepared therefrom. The thermosetting resin composition contains the following ingredients in parts by weight: 50-150 parts of cyanate, 30-120 parts of epoxy resin, 20-70 parts of allyl benzene-maleic anhydride, 20-100 parts of polyphenyl ether, 30-100 parts of halogen-free flame retardant, 0.05-5 parts of curing accelerator and 50-200 parts of filler. The prepreg and the laminate, which are manufactured from the thermosetting resin composition, have the comprehensive properties of low dielectric constant, low dielectric loss, excellent flame retardance, heat resistance and wet resistance and the like, and are suitable for being applied to halogen-free high-frequency multilayer circuit boards.

The invention relates to a preparation method of lilial. The preparation method of lilial comprises the following steps that p-tert.-butyl-benzaldehyde, methanol and caustic soda flake solutions having different concentrations are added into a reactor; n-propanal is dropwisely added into the reactor at a certain temperature and undergoes a condensation reaction and after addition of n-propanal isfinished, the condensation reaction lasts for 0.5 to 2 hours under the condition of heat preservation; acidic materials are added into the reaction system to adjust a pH value and to stop the condensation reaction; after the condensation reaction is finished, methanol is recovered by distillation and a condensation product p-tert.-butyl-alpha-methyl phenyl acrolein is obtained by film evaporator distillation; methanol, p-tert.-butyl-alpha-methyl phenyl acrolein and a hydrogenation catalyst are added into a hydrogenation reactor; hydrogen is fed into the hydrogenation reactor and the mixture in the hydrogenation reactor undergoes a hydrogen reaction; and after the hydrogen reaction is finished, the reaction products are subjected to filter pressing, solvent removal and rectification so that a finished product lilial is obtained. Lilial obtained by the preparation method is a colorless and transparent liquid, and has a refractive index (nd20) of 1.504 to 1.506, the specific gravity (25 DEG C, mg / mL) of 0.942 to 0.946, an acid value (mgKOH / g) of 2.0(max.), the GC content (determined by an area normalization method) of m-LLY less than 2.0%, p-LLY great than or equal to 97.0% and m-LLY+p-LLY great than or equal to 98.0%, and the moisture content less than or equal to 0.25%.

The present invention provides microwave assisted rapid and economical process for the preparation of substituted phenylaldehydes from trans and cis-phenylpropene, a commercial utilization of toxic cis-isomer of the general formula (I)using meta-periodate and osmium tetraoxide (catalytic amount) as an efficient oxidizing agent in the presence of catalyst namely amberlite IRA-410 and quaternary ammonium salt.

The invention provides a phenylacrylate compound as well as a preparation method and application thereof. The phenylacrylate compound has the structure shown in a formula I. The phenylacrylate compound and pharmaceutically acceptable salt, solvent compound, predrug, tautomer or stereoisomer or medicinal composition thereof have good anti-inflammatory and antiplatelet effects, have a long treatmenttime window, do not have remarkable side effect, is safe and effective, can serve as antithrombus, anti-inflammatory and stroke-treating medicines and have wide application prospects.

The invention discloses an environment-friendly plastic material. The material is prepared from, by weight, 50-120 parts of nylon, 42-78 parts of cis-hexenyl dicarboxylic anhydride-allyl benzene copolymer, 35-65 parts of 2-hydroxyl-4-octyl oxyl phenylbutyrophenone, 20-38 parts of butenyl distearamide, 15-30 parts of polybutylene terephthalate, 12-25 parts of polyether glycerol, 10-20 parts of brominated paraffin, 10-15 parts of olive oil, 8-14 parts of AR glass fiber, 6-12 parts of carboxyethyl cellulose, 15-25 parts of filler, 8-12 parts of addition agent, 4-6 parts of fire retardant, 3-5 parts of antismoke agent, 1-3 parts of ultraviolet light absorber, 1-3 parts of tackifier and 1-2 parts of softening agent. The environment-friendly plastic material is good in flame retardant effect, high in anti-impact capacity, high in toughness and good in performance, is low in preparation cost, can be applied and popularized and has remarkable economic and social benefits.

Disclosed are a substituted phenylpropenylpyridine derivative, a preparation method therefor and the use thereof as a PD-1 / PD-L1 inhibitor. In particular, disclosed are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method therefor and the use thereof. The definition of each group in the formula is detailed in the description and claims.

The invention relates to the field of flotation, in particular to phenylpropenyl hydroxamate, a preparation method thereof and application thereof to tungsten ore flotation. The preparation method ofphenylpropenyl hydroxamate comprises the following steps: preparing raw materials; preparing hydroxylamine hydrochloride and a sodium hydroxide solution; preparing a crude product of phenylpropenyl hydroxamate; and purifying phenylpropenyl hydroxamate. The optimum pH of phenylpropenyl hydroxamate in ore pulp is close to neutral, so that the flotation is easy to operate, the burden on workers is lowered, chemicals are saved, and the flotation cost is decreased.

The invention discloses a method for synthesizing isoquinolinone compounds or pyridone compounds. The reaction is carried out in a solvent, and after the reaction is completed, the isoquinolinone compound or the pyridone compound is obtained through post-treatment. The method has simple and easy-to-obtain raw materials, mild conditions, high conversion efficiency, high regioselectivity, high atom utilization and simple operation.

The invention relates to a class of phenylacryloyl 1,5-diaryl-1,2,4-triazole derivatives, a preparation method and medical application thereof, and belongs to the field of medicinal chemistry. The results of pharmacological experiments show that these compounds have good cyclooxygenase-2 (COX-2) / 5-lipoxygenase (5-LOX) inhibitory activity and good anti-tumor activity, and can be used to prepare and treat tumors and Drugs for other diseases or conditions related to COX‑2 and 5‑LOX pathways.

The invention relates to the discovery and application of a plurality of drug lead compounds, in particular to a bis-substituted allyl benzene compound with cytotoxic activity, the key intermediate and the pharmaceutical salt of the compound, also to the preparation method, the drug composition and the medicinal purpose of the allyl benzene derivative and the key intermediate of the allyl benzenederivative, belonging to the fields of organic chemistry, medicinal chemistry and pharmacology. The compound of the discovery in vitro inhibits the activity of six human tumor cell lines-human prostate cancer cells (PC-3), nasopharyngeal carcinoma cells (CNE), oral epithelial carcinoma cells (KB), human lung cancer cells (A549), human hepatoma cells (BEL-7404) and human cervical cancer cells (Hela), and can be expected for antitumor drug purpose.

The invention relates to the field of decorative paper production, provides environment-friendly decorative paper and a manufacturing method thereof, and is used for relieving the problem of indoor air pollution. According to the environment-friendly decorative paper, a negative ion layer is arranged on the decorative paper, and the negative ion layer is formed by coating negative ion powder on the decorative paper and then drying; the negative ion powder comprises 30-40 parts by mass of tourmaline powder; 1-3 parts by mass of medical stone powder, 2-4 parts by mass of hokutolite powder, 1-3 parts by mass of shell powder, 1-3 parts by mass of nano titanium dioxide, 2-3 parts by mass of nano manganese dioxide, 1-3 parts by mass of nano cerium oxide, 10-15 parts by mass of maleic anhydride,20-30 parts by mass of polyurethane, 10-12 parts by mass of diatomite and 5-7 parts by mass of allyl benzene. The negative ion layer can continuously release negative ions for a long time, and pollutants in the air can be continuously and effectively purified.

The invention belongs to the technical field of agriculture, and in particular relates to phenylacrylamide compounds. The extraction and separation method is as follows: take dried Solanum solanum and then concentrate under reduced pressure to obtain the extract; after suspending in distilled water, extract with petroleum ether and ethyl acetate respectively, and concentrate under reduced pressure to obtain the extract; Chromatography, eluting, collecting fractions, and silica gel thin-layer chromatography, to obtain four parts Fr.A ~ Fr.D; Fr.B is eluted by silica gel column chromatography, collecting fractions, silica gel thin-layer chromatography, Get Fr.B-1~Fr.B-6 six parts; .B-2-5 five parts; using high performance liquid chromatography, in Fr.B-2-2 ~ Fr.B-2-4 separation to obtain the target product. The extraction and separation method of the invention is simple, has good reproducibility and high extraction purity. The obtained compound has good antifeedant activity to cotton bollworm.

The invention discloses a small molecular inhibitor EE02 realizing targeted combination of EGFR and EPS8 and application thereof. The small molecular inhibitor has a molecular formula of C44H54N4O6S,the molecular weight being 767, and the Chinese name of 1-{4-[4-(2-hydroxyl-3-{4-[(2Z)-3-phenylpropyl-2-alkene-1-yl]piperazidine-1-yl}propoxyl)phenylsulfonyl]phenoxyl}-3-{4-[(2Z)-3-phenylpropyl-2-alkene-1-yl]piperazidine-1-yl}-2-propanol. The small molecular inhibitor can effectively inhibit the multiplication of EGFR and EPS8 positive tumor, can be used for preparing medicine for treating EGFR and EPS8 positive tumor, and has great potential of being developed into anti-tumor small molecular targeted medicine.

The invention relates to an efficient leather softener, which is prepared from the following raw materials by weight: 6-13 parts of turpentine oil, 4-11 parts of methylparaben, 2-7 parts of camphor oil, 1-4 parts of an auxiliary agent, 0.5-2 parts of an initiator, 4-7.5 parts of nitrocellulose, 7-9 parts of sodium dodecyl sulfonate, 3.5-10 parts of lemon essential oil, 4.2-8 parts of allylbenzene, 4-8.2 parts of sodium lauryl sulfate, 1-3 parts of chloroprene, 2-4 parts of a pearlescent pigment, 3-6 parts of grease, 8-11 parts of an alkyl pyridine hydrochloride, 2-6.5 parts of sodium silicate, and 6-9 parts of an organic acid. With the efficient leather softener of the present invention, the hand-feeling of the leather can be well improved while the permeability of the leather is increased, and the softener is nontoxic and harmless to human.

The invention discloses a preparation method of a phenylacrylamide compound shown in a general formula II in the technical field of organic chemistry. A substituent R of the phenylacrylamide compound is defined in the specification. The invention also relates to application of the compound shown in the general formula II in medicines for treating and / or preventing bacterial infection.

The present invention relates to methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX / ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and / or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.

The present invention provides microwave assisted rapid and economical process for the preparation of substituted phenylaldehydes from trans and cis-phenylpropene, a commercial utilization of toxic cis-isomer of the general formula (I) using meta-periodate and osmium tetraoxide (catalytic amount) as an efficient oxidizing agent in the presence of catalyst namely amberlite IRA-410 and quaternary ammonium salt.