64 results about "Phenylpropene" patented technology

The invention provides novel substituted phenylpropionaldehyde (benzylideneacetaldehyde) thiosemicarbazone compounds shown as the formula I and applications of the compounds as agricultural bactericides, wherein R is C1-C4 alkyl, C1-C4 alkoxy, halogen, trifluoromethyl, trifluoromethoxy and nitro; the substitution position of the R is mono-substituted, di-substituted or multi-substituted; the R refers in particular to 2-fluro, 4-bromo, 3-trifluoromethyl, 3-methyl and 3,4,5-trimethoxy, and -A- is -CH2-CH2- or -CH=CH-. Bactericidal activity tests show that the compounds shown in the formula I have good inhibition functions for four plant pathogens (botrytis cinerea, sclerotinia rot of colza, fusarium wilt of cotton and rice sheath blight disease), and can be used for controlling the plant pathogens as bactericides.

This invention relates to a cytotoxic phenylallyl phenylacrylate as shown in formula (1) and its analogs or phenylpropyl phenylpropionate as shown in formula (2), its analogs and its offcinal salts or solvates. This invention also relates to the preparation method for these compounds and the intermediates for preparation. Besides, this invention still relates to the pharmacological use of these compounds and their blended composites. The compounds in this invention have growth inhibitory activity towards tumor cells and are estimated to be used as antineoplastics.

The invention relates to a preparation method of lilial. The preparation method of lilial comprises the following steps that p-tert.-butyl-benzaldehyde, methanol and caustic soda flake solutions having different concentrations are added into a reactor; n-propanal is dropwisely added into the reactor at a certain temperature and undergoes a condensation reaction and after addition of n-propanal isfinished, the condensation reaction lasts for 0.5 to 2 hours under the condition of heat preservation; acidic materials are added into the reaction system to adjust a pH value and to stop the condensation reaction; after the condensation reaction is finished, methanol is recovered by distillation and a condensation product p-tert.-butyl-alpha-methyl phenyl acrolein is obtained by film evaporator distillation; methanol, p-tert.-butyl-alpha-methyl phenyl acrolein and a hydrogenation catalyst are added into a hydrogenation reactor; hydrogen is fed into the hydrogenation reactor and the mixture in the hydrogenation reactor undergoes a hydrogen reaction; and after the hydrogen reaction is finished, the reaction products are subjected to filter pressing, solvent removal and rectification so that a finished product lilial is obtained. Lilial obtained by the preparation method is a colorless and transparent liquid, and has a refractive index (nd20) of 1.504 to 1.506, the specific gravity (25 DEG C, mg / mL) of 0.942 to 0.946, an acid value (mgKOH / g) of 2.0(max.), the GC content (determined by an area normalization method) of m-LLY less than 2.0%, p-LLY great than or equal to 97.0% and m-LLY+p-LLY great than or equal to 98.0%, and the moisture content less than or equal to 0.25%.

Compounds for use in the treatment or prophylaxis of an affective disorder are provided. Compound is represented by formula I in which the dotted line represents a single or a double bond; and R5 and R5' are independently -H, -OH or -OR6, where R6 is a linear or branched C1-C4 alkyl; X is -CH2O-; Z is -CH2OmicronEta2O-,-CH(CH3)CH2O- or -CH2CH(CH3)O-; m is 1; and n is an integer of 1-5; or a pharmaceutically acceptable salt, prodrug, metabolite, or hydrate thereof.

The invention discloses the application of phenylacrylic compounds to the preparation of Shp2-specific inhibitors and pharmaceutical application thereof. The invention finds that two phenylacrylic compounds, namely isoferulic acid and cinnamic acid, have a specific inhibitory effect on Shp2 and the isoferulic acid and the cinnamic acid can be prepared into the Shp2-specific inhibitors. The invention further verifies that both the isoferulic acid and the cinnamic acid can inhibit EGF-induced phosphorylation of Erk by inhibiting the activity of the Shp2 in the cellular level, the cinnamic acid can also inhibit EGF-induced migration of MDA-MB-468 cells, and the isoferulic acid and the cinnamic acid are expected to be developed into medicines for preventing or treating of Shp2-related diseasesand are of a great significance on the development of the medicines targeting the Shp2.

The invention provides high-quality boat bottom antibacterial coating as well as preparation and application methods of the high-quality boat bottom antibacterial coating. The high-quality boat bottom antibacterial coating provided by the invention is prepared from phenol-formaldehyde resin, phthalic acid, graphite powder, titanium dioxide, beta-phenylacrolein, yellow lead, barium sulfate, copper chloride, rosin, heavy benzene and an addition agent. The high-quality boat bottom antibacterial coating provided by the invention has the advantages of reasonable components, special antibacterial property of the product, high stability and good effect. The preparation method of the high-quality boat bottom antibacterial coating is simple and feasible in process, high in production efficiency, low in utilization cost, simple to operate and easy to realize; the produced product is stable in quality, convenient to use and good in adaptability, and has relatively high popularization and application value.

The invention relates to the field of chemical synthesis, in particular to a preparation method of neoflavonoids. The preparation method is characterized by comprising the following steps of using substituted benzaldehyde as an initial raw material to be reacted with malonic acid to generate a substituted phenylacrylic acid compound; performing an addition reaction, an elimination reaction and the like on the substituted phenylacrylic acid compound, or performing acetylation so as to protect a phenolic hydroxyl group, then performing a bromination reaction and the elimination reaction so as to synthesize the substituted phenylpropiolic acid compound ; and using montmorillonite K-10 after being acidulated by sulfuric acid as a catalyst, enabling the substituted phenylpropiolic acid compound and a phenolic compound to perform a heating reaction so as to generate the neoflavonoids. Compared with the prior art, the preparation method of the neoflavonoids, disclosed by the invention, has the characteristics that raw materials are cheap, and easy to obtain, the operation is simple, the catalyst can be recovered for use, and the method is environmentally-friendly, the post-treatment is simple, and the production cost is low, and the method has a high popularization and application value.

The present invention is directed to anti-depressive activity of Crassulaceae special extracts, Carpediol, containing 2-(4-hydroxyphenyl)ethyl-β-d-glucopyranoside or 3-[6-o-(α-1-arabinopyranosyl)-β-d-glucopyranosyl]-oxy-1-phenylpropene in mammals, to method of preparation and analysis of these extract, as well to safety of their usage in combination with other drugs.

An outdoor glass fiber reinforced mildewproof and antibacterial poly carbonic acid resinous polymer is characterized by comprising the following materials in parts by weight: 60 parts of polycarbonate (PC), 30 parts of alkali-free short glass fiber, 1-20 parts of flexibilizer, 1-10 parts of flame retardant, 0.1-5 parts of a mildewproof and antimicrobial agent and 0.1-5 parts of an anti-oxidant; the mildewproof and antimicrobial agent is at least one of silicone quaternary ammonium salt, dual-benzene triadimenol, dibenzoyl peroxide and a-bromo-allyl acrolein; the anti-oxidant is at least oneof 4,4'-sulfo-dual(6-tertiary butyl-3-methylphenol), Beta-(3,5-tributyl-4-hydroxy phenyl)pseudacetic acid octadecanol ester, phosphorous acid trimester(2,4-dual tertiary butyl phenyl), dua l(2,4- dual tertiary butyl phenyl) pentaerythritol dual phosphite ester, and quadr-(Beta-(3,5 dual tertiary butyl-4-hydroxy phenyl)propionic acid)pentaerythritol ester. Comparing with the prior art, durability and mildewproof and antibacterial performance of the resinous polymer are improved.

The invention discloses a synthesis method of a polysubstituted beta-phenylallyl alcohol compound, and the method comprises the following steps: reacting polysubstituted propargyl alcohol with organicboric acid in an organic solvent under the actions of a rhodium catalyst, alkali and silver salt to directly construct the polysubstituted beta-phenylallyl alcohol compound in one step. The method issimple to operate, raw materials and reagents are easy to obtain, reaction conditions are mild, substrate universality is wide, functional group compatibility is good, and the reaction has high regioselectivity and stereoselectivity (single configuration). According to the method disclosed by the invention, the polysubstituted beta-phenylallyl alcohol compound can be directly obtained without using a protecting group. The invention also discloses application of the polysubstituted beta-phenylallyl alcohol compound in preparation of drugs for treating and / or preventing diabetes mellitus and antitumor drugs.

The invention provides a phenylacrylate compound as well as a preparation method and application thereof. The phenylacrylate compound has the structure shown in a formula I. The phenylacrylate compound and pharmaceutically acceptable salt, solvent compound, predrug, tautomer or stereoisomer or medicinal composition thereof have good anti-inflammatory and antiplatelet effects, have a long treatmenttime window, do not have remarkable side effect, is safe and effective, can serve as antithrombus, anti-inflammatory and stroke-treating medicines and have wide application prospects.

The invention discloses a preparation method of a phenylallyl hydroxamic acid / acrylamide / methyl methacrylate copolymer for ore flotation, which comprises the following steps: S1: dissolving 3-phenylacryloyl chloride in 50 DEG C absolute ethyl alcohol, adding a hydroxamic acid agent and ammonia water, and carrying out water bath stirring reaction at 45-60 DEG C for 3-6 hours to obtain a reaction solution; s2, adding acrylamide, methyl methacrylate and distilled water into the reaction solution obtained in the step S1, uniformly stirring, and carrying out ultrasonic dispersion to obtain a mixedmonomer dispersion solution; and S3, heating the mixed monomer dispersion liquid to 50-65 DEG C, introducing nitrogen with the purity of more than or equal to 99.9% into the mixed monomer dispersion liquid, adjusting the pH value to 7.5-8.0, adding an initiator for induction to polymerize the monomer, reacting for 3 hours, concentrating and drying to obtain the terpolymer. According to the method,the hydroxylamine-acyl chloride method is used for hydroximation of the 3-phenyl acryloyl chloride, the hydroximation rate is high, the product yield is high, the flotation effect is good, and the beneficiation cost is low.

The invention discloses an environment-friendly plastic material. The material is prepared from, by weight, 50-120 parts of nylon, 42-78 parts of cis-hexenyl dicarboxylic anhydride-allyl benzene copolymer, 35-65 parts of 2-hydroxyl-4-octyl oxyl phenylbutyrophenone, 20-38 parts of butenyl distearamide, 15-30 parts of polybutylene terephthalate, 12-25 parts of polyether glycerol, 10-20 parts of brominated paraffin, 10-15 parts of olive oil, 8-14 parts of AR glass fiber, 6-12 parts of carboxyethyl cellulose, 15-25 parts of filler, 8-12 parts of addition agent, 4-6 parts of fire retardant, 3-5 parts of antismoke agent, 1-3 parts of ultraviolet light absorber, 1-3 parts of tackifier and 1-2 parts of softening agent. The environment-friendly plastic material is good in flame retardant effect, high in anti-impact capacity, high in toughness and good in performance, is low in preparation cost, can be applied and popularized and has remarkable economic and social benefits.

Compounds for use in the treatment or prophylaxis of pain, including acute and chronic pain (e.g., nociceptive pain, neuropathic pain, headaches, migraine), represented by general formula (I), in which: the dotted line represents a single or a double bond; and R5 and R5' are independently -H, -OH or -OR6, where R6 is a linear or branched C1-C4 alkyl; X is -CH2O-,; Z is -CH2CH2O-CH(CH3)CH2O- or -CH2CH(CH3)O-; m is 1; and n is an integer of 1- 5. The compounds of the invention are also effective for reducing inflammation and may be used alone or in combination with other analgesics.

The invention discloses a method for synthesizing isoquinolinone compounds or pyridone compounds. The method comprises the following step: reacting benzamide compounds or acrylamide compounds with allyl benzene compounds in an organic solvent under the action of a palladium catalyst and a cocatalyst, and after the reaction is finished, carrying out post-treatment to obtain the isoquinolinone compounds or the pyridone compounds. The method has the advantages of simple and easily available raw materials, mild conditions, efficient conversion, high regioselectivity, high atom utilization rate and simple operation.

Disclosed are a substituted phenylpropenylpyridine derivative, a preparation method therefor and the use thereof as a PD-1 / PD-L1 inhibitor. In particular, disclosed are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method therefor and the use thereof. The definition of each group in the formula is detailed in the description and claims.

Provided is a lemon juice-containing beverage which gives a fresh sensation typical of lemon regardless of its low fruit juice content. One ppb or more of at least one phenylpropene selected from the group consisting of safrole, methyleugenol, and myristicin is incorporated in a lemon juice-containing beverage having a fruit juice content of not less than 1% and not more than 30% and comprising at least one aroma component selected from the group consisting of linalool, nonanal, and decanal.

The invention discloses high-transmittance low-emissivity coated glass and a preparation process thereof. The low-emissivity coated glass comprises a glass substrate, a first dielectric film, a functional film and an outer dielectric film which are arranged in a stacked mode from bottom to top, the first dielectric film is composed of a tin oxide layer and a titanium dioxide layer, and the outer dielectric film is composed of a zinc oxide layer and a silicon-aluminum alloy layer; the functional film is prepared from the following raw materials by weight: polystyrene, phenol, 4-chloronitrobenzene, an anti-ultraviolet and anti-aging agent, a binding agent, a plasticizer and a dispersing agent. The polyphenyl propylene film has high transparency, is convenient to process and low in cost, doesnot emit toxic hydrogen chloride or other gases during incineration, can improve the high transparency and water resistance of the glass when being used on a glass film, ensures the visible light transmittance, is doped with polyphenol, can improve the wear resistance and corrosion resistance of the film, and the visible light transmittance of the glass is further improved.

The invention belongs to the technical field of chemical synthesis of medicines, and discloses a 3,5-pyrazoldione double bond compound of an N-substituted p-halobenzene ring with anti-tumor activity, and a synthesis method and application thereof. The compound disclosed by the invention has the structure shown by the general formula I; in the general formula I, X refers to F, Cl and Br respectively, and R1 refers to p-fluorophenyl, p-chlorphenyl, p-bromophenyl, 3-methoxy-4-hydroxyphenyl, 2,3-bis(p-methoxyphenyl), 3,4-difluorophenyl, phenylpropenyl and 2-furanpropenyl. In-vitro anti-tumor activity experiments prove that the compound has obvious effects on inhibiting and killing multiple tumor cells and can be used for preparing medicines for treating tumor diseases.

The invention relates to the field of decorative paper production, provides environment-friendly decorative paper and a manufacturing method thereof, and is used for relieving the problem of indoor air pollution. According to the environment-friendly decorative paper, a negative ion layer is arranged on the decorative paper, and the negative ion layer is formed by coating negative ion powder on the decorative paper and then drying; the negative ion powder comprises 30-40 parts by mass of tourmaline powder; 1-3 parts by mass of medical stone powder, 2-4 parts by mass of hokutolite powder, 1-3 parts by mass of shell powder, 1-3 parts by mass of nano titanium dioxide, 2-3 parts by mass of nano manganese dioxide, 1-3 parts by mass of nano cerium oxide, 10-15 parts by mass of maleic anhydride,20-30 parts by mass of polyurethane, 10-12 parts by mass of diatomite and 5-7 parts by mass of allyl benzene. The negative ion layer can continuously release negative ions for a long time, and pollutants in the air can be continuously and effectively purified.

The invention discloses a small molecular inhibitor EE02 realizing targeted combination of EGFR and EPS8 and application thereof. The small molecular inhibitor has a molecular formula of C44H54N4O6S,the molecular weight being 767, and the Chinese name of 1-{4-[4-(2-hydroxyl-3-{4-[(2Z)-3-phenylpropyl-2-alkene-1-yl]piperazidine-1-yl}propoxyl)phenylsulfonyl]phenoxyl}-3-{4-[(2Z)-3-phenylpropyl-2-alkene-1-yl]piperazidine-1-yl}-2-propanol. The small molecular inhibitor can effectively inhibit the multiplication of EGFR and EPS8 positive tumor, can be used for preparing medicine for treating EGFR and EPS8 positive tumor, and has great potential of being developed into anti-tumor small molecular targeted medicine.

The invention relates to an efficient leather softener, which is prepared from the following raw materials by weight: 6-13 parts of turpentine oil, 4-11 parts of methylparaben, 2-7 parts of camphor oil, 1-4 parts of an auxiliary agent, 0.5-2 parts of an initiator, 4-7.5 parts of nitrocellulose, 7-9 parts of sodium dodecyl sulfonate, 3.5-10 parts of lemon essential oil, 4.2-8 parts of allylbenzene, 4-8.2 parts of sodium lauryl sulfate, 1-3 parts of chloroprene, 2-4 parts of a pearlescent pigment, 3-6 parts of grease, 8-11 parts of an alkyl pyridine hydrochloride, 2-6.5 parts of sodium silicate, and 6-9 parts of an organic acid. With the efficient leather softener of the present invention, the hand-feeling of the leather can be well improved while the permeability of the leather is increased, and the softener is nontoxic and harmless to human.

The invention discloses a preparation method of a phenylacrylamide compound shown in a general formula II in the technical field of organic chemistry. A substituent R of the phenylacrylamide compound is defined in the specification. The invention also relates to application of the compound shown in the general formula II in medicines for treating and / or preventing bacterial infection.