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Synthetic method of 4-fluorobenzaldehyde

A technology for p-fluorobenzaldehyde and a synthesis method, which is applied in chemical instruments and methods, preparation of carbon-based compounds, preparation of organic compounds, etc., can solve the problems of high technical difficulty, complex process, and difficulty in obtaining cerium salts, and achieves a synthesis route. The effect of short, cheap, and cheap raw materials

Inactive Publication Date: 2009-01-28
王俊华
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the process is complex and technically difficult, and the cerium salt is not easy to obtain, so it is difficult to realize industrial production

Method used

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  • Synthetic method of 4-fluorobenzaldehyde
  • Synthetic method of 4-fluorobenzaldehyde

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In a 500ml autoclave, put 50g of p-chlorobenzaldehyde, 40g of anhydrous potassium fluoride, 5g of cetyltrimethylammonium chloride, and 250g of dimethylformamide, and then raise the temperature to 200°C for reaction. After the reaction is completed, the temperature is lowered and filtered, and the filtrate is first decompressed to recover the solvent dimethylformamide, and then the product is collected.

Embodiment 2

[0018] In a 500ml four-necked bottle, put 50g of p-chlorobenzaldehyde, 80g of anhydrous potassium fluoride, 5g of tetraphenylphosphonium bromide, and 200g of sulfolane, and then raise the temperature to 210°C for reaction. After the reaction is completed, filter, and the filtrate is first decompressed to obtain the product, and then the solvent sulfolane is recovered.

Embodiment 3

[0020] In a 500ml four-necked bottle, put 50g of p-chlorobenzaldehyde, 75g of anhydrous potassium fluoride, 4g of benzyltriphenylphosphonium bromide, 3g of polyethylene glycol dimethyl ether, and 300g of o-nitrotoluene, and then raise the temperature to 220°C reaction. After the reaction is completed, filter, and the filtrate is first decompressed to obtain the product, and then the solvent o-nitrotoluene is recovered.

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Abstract

The invention relates to a synthetic method of p-flurobenzaldehyde, which belongs to the chemical and pharmaceutical field. In the synthetic method, the p-chlorobenzaldehyde and potassium fluoride react under the condition of a solvent and a catalyst at high temperature, wherein, the solvent is one of sulfolane, dimethyl sulfoxide, dimethylformamide, dimethylacetamide, hexamethyl phosphoramide, nitrobenzene and ortho-nitrotoluene; the catalyst is one of or the mixture of two or more than two of benzyl triethyl amine chloride, tetrabutylammonium bromide, hexadecyltrimethylammonium chloride, methyltrioctylammonium chloride, tetraphenylphosphonium bromide, methyltriphenylphosphonium bromide, benzyl triphenyl phosphonium bromide and polyethylene glycol dimethyl ether. Compared with the conventional preparation method, the synthetic method of the invention has the advantages of cheap raw materials, short synthetic route and little 'three wastes' discharge. As the amount of the catalyst used is reduced and the price of the solvent is low, the production cost of the p-flurobenzaldehyde is decreased.

Description

technical field [0001] The invention relates to a synthesis method of p-fluorobenzaldehyde, which belongs to the field of chemical pharmacy. Background technique [0002] In the chemical and pharmaceutical field, due to the introduction of fluorine atoms, most fluorine-containing organic compounds have characteristics that other organic compounds cannot match. The unique and excellent properties of fluorine-containing organic compounds have aroused people's great interest in it. In recent years, fine chemical products such as fluorine-containing medicines, pesticides, dyes, and surfactants have attracted great attention from many countries. As an important intermediate of pesticides, p-fluorobenzaldehyde has seen a sharp increase in demand in recent years, and the market is in short supply. [0003] The synthesis methods reported can be mainly divided into the following categories: [0004] 1. Halogen exchange method, using sulfolane, dimethyl sulfoxide, dimethylformamide...

Claims

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Application Information

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IPC IPC(8): C07C47/55C07C45/63B01J31/02
Inventor 王俊华
Owner 王俊华
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