Mitochondrion-targeted micelle material and curcumin micelle preparation prepared from material

A technology of mitochondria and curcumin, applied in the directions of non-active ingredients medical preparations, anti-tumor drugs, emulsion delivery, etc., can solve the problems of poor light resistance and heat resistance, restricted application, insolubility of curcumin, etc. High sealing rate, obvious slow release effect, small particle size effect

Inactive Publication Date: 2017-01-25
YANTAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Although curcumin has many advantages, it is insoluble in water, sensitive to light and heat, and has poor light resistance and heat resistance. Applications in the field of medicine

Method used

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  • Mitochondrion-targeted micelle material and curcumin micelle preparation prepared from material
  • Mitochondrion-targeted micelle material and curcumin micelle preparation prepared from material
  • Mitochondrion-targeted micelle material and curcumin micelle preparation prepared from material

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Embodiment Construction

[0051] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0052] Polymeric micelles are formed from amphiphilic block copolymers, which are thermodynamically stable systems. During the formation process, the hydrophobic segment of the copolymer is subjected to H 2 The exclusion of O molecules, self-association and aggregation form the hydrophobic core of this particle dispersion system, while its hydrophilic H 2 The O segment forms the H-philic 2 O outer layer makes it in H 2 Stable in O.

[0053]Polymer micelle belongs to a kind of particle dispersion system, which has many incomparable features of other substances. The particle size is small and the degree of dispersion is large, which can make the difficult-to-dissolve drug achieve a better dissolution rate, speed u...

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Abstract

The invention relates to a mitochondrion-targeted micelle material which is formed by bonding one hydroxyl on a hyaluronate oligomer with 5-carboxyl of (5-carboxylamyl)-triphenyl phosphonium bromide through an ester bond. The general formula is disclosed in the specification, wherein n is a positive integer, and the molecular weight of the hyaluronate oligomer is less than 10000 Da. The invention also relates to a preparation method of the mitochondrion-targeted micelle material, and a curcumin micelle preparation prepared from the micelle material and a preparation method thereof. The micelle material has tumor and mitochondrion targeting properties; and the curcumin micelle preparation prepared from the micelle material can precisely guide the curcumin into the tumor cells and mitochondrions thereof, thereby better displaying the antitumor function.

Description

technical field [0001] The invention relates to the field of targeted drug carriers and preparations, and more particularly relates to a mitochondria-targeted micelle material and a curcumin micelle preparation prepared from the material. Background technique [0002] Malignant tumor is a common and frequently-occurring disease, which affects our quality of life and is the "killer" of our health. From the saying "Talking about cancer, you can see the degree of fear that people have about it." For humans, the death rate caused by malignant tumors ranks second in the death rate caused by all diseases. How to solve the thorny social public problem of tumor is the most serious issue that people are facing at present. [0003] At this stage, there are various treatment methods for tumors, as well as various therapeutic drugs, so we will not repeat them here. Let me focus on drug therapy. Drug therapy is a common method for tumor treatment. Compared with other therapies, drug t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/36A61K31/12A61P35/00C08B37/08
CPCA61K31/12A61K9/0002A61K9/1075A61K47/36C08B37/0072
Inventor 郭春静陈大全殷军港
Owner YANTAI UNIV
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