Mitochondrion-targeted micelle material and curcumin micelle preparation prepared from material
A technology of mitochondria and curcumin, applied in the directions of non-active ingredients medical preparations, anti-tumor drugs, emulsion delivery, etc., can solve the problems of poor light resistance and heat resistance, restricted application, insolubility of curcumin, etc. High sealing rate, obvious slow release effect, small particle size effect
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[0051] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.
[0052] Polymeric micelles are formed from amphiphilic block copolymers, which are thermodynamically stable systems. During the formation process, the hydrophobic segment of the copolymer is subjected to H 2 The exclusion of O molecules, self-association and aggregation form the hydrophobic core of this particle dispersion system, while its hydrophilic H 2 The O segment forms the H-philic 2 O outer layer makes it in H 2 Stable in O.
[0053]Polymer micelle belongs to a kind of particle dispersion system, which has many incomparable features of other substances. The particle size is small and the degree of dispersion is large, which can make the difficult-to-dissolve drug achieve a better dissolution rate, speed u...
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