N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress

a technology of n-acetylcysteine and n-acetylcysteine, which is applied in the field of n-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress, can solve the problems of reducing the oxidative capacity of hif-1. l
US20090234011A1Inactive Publication Date: 2009-09-17SAEGIS PHARMA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
SAEGIS PHARMA
Publication Date
2009-09-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods and compositions comprising N-acetylcysteine amide (NAC amide) and derivatives thereof are used in treatments and therapies for human and non-human mammalian diseases, disorders, conditions and pathologies. Pharmaceutically or physiologically acceptable compositions of NAC amide or derivatives thereof are administered alone, or in combination with other suitable agents, to reduce, prevent, or counteract oxidative stress and free radical oxidant formation and overproduction in cells and tissues, as well as to provide a new source of glutathione.
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Description

FIELD OF THE INVENTION

[0001] The present invention generally relates to the treatment of mammalian, including human, diseases with antioxidants. More particularly, the invention relates to treatments and therapies of a variety of diseases and conditions involving the administration of N-acetylcysteine amide (NAC amide) or a derivative thereof, alone or in combination with another agent, to a mammal in need thereof.BACKGROUND OF THE INVENTION

[0002] Oxidative stress plays an important role in the progression of neurodegenerative and age-related diseases, causing damage to proteins, DNA, and lipids. Low molecular weight, hydrophobic antioxidant compounds are useful in treating conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atherosclerotic cardiovascular disease, multiple organ dysfunctions and central nervous system neurodegenerative disorders, e.g., Parkinson's disease, Alzheimer's disease and Creutzfeldt-Jakob's disease. Ox...

Claims

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