133 results about "Sulfonosine" patented technology

The invention provides a preparation method of a novel heterogeneous Fenton-like catalytic material, i.e., a water-insoluble beta-cyclodextrin polymer is formed by esterification, polycondensation and crosslinking of citric acid and beta-cyclodextrin, and is combined with an iron-copper bimetallic catalytic active center through a metal coordination effect; a novel iron-copper beta-cyclodextrin polymeric material is successfully prepared and is used for catalyzing and activating H2O2 oxidized sulfonamide antibiotics SAs. Under the conditions that the temperature is 35 DEG C, the pH value is 3, the adding amount of the iron-copper beta-cyclodextrin polymeric material is 1.2 g / L, the adding amount of H2O2 is 10 mM, and the rotating speed of a stirrer is 500 r / min, the removal capacity of the iron-copper beta-cyclodextrin polymeric material Fenton-like system to 1 mg / L sulfameracil (SMR) is close to 90% within 10 min. The method provided by the invention has the characteristics of low cost, good effect, no generation of a large amount of iron mud, environmental protection and the like, is helpful for promoting the development of beta-cyclodextrin in the field of Fenton-like environment treatment, and provides an effective reference and a new thought for treatment of sulfonamide antibiotics in a water environment.

The invention discloses a preparation method of a high-temperature-resistant benzidine yellow pigment, and belongs to the technical field of pigment synthesis, and the high-temperature-resistant benzidine yellow pigment is prepared by diazotizing 3, 3 '-dichlorobenzidine, coupling the diazotized 3, 3'-dichlorobenzidine with a sulfonimide modified acetoacetanilide derivative to obtain a pigment compound, and finally compounding the obtained pigment compound with sulfanilamide group grafted polyethersulfone. According to the high-temperature-resistant benzidine yellow pigment prepared by the preparation method disclosed by the invention, the high-temperature-resistant performance of the benzidine yellow pigment is remarkably improved and the use performance of the benzidine yellow pigment is improved by introducing the sulfonimide group and the polyethersulfone grafted with the sulfanilamide group for synergistic modification.

The invention discloses a sulfanilamide thiazolyl resorcinol derivative and application of the sulfanilamide thiazolyl resorcinol derivative in preparation of a tyrosinase inhibitor and whitening cosmetics. The structural formula of the derivative is # imgabs0 #, in the formula, R represents a fat (aromatic) group substituent, and R'represents a hydrogen atom or methyl; the preparation method comprises the following steps: taking 2-chloro-1-(2, 4-dimethoxyphenyl) ethanone as an initial raw material, carrying out cyclization condensation on the 2-chloro-1-(2, 4-dimethoxyphenyl) ethanone and thiourea to obtain 4-(2-amino-1, 3-thiazole-4-yl) benzene-1, 3-dimethanol, carrying out reaction on 2-amino of thiazole and different fat (aromatic) sulfonyl chloride, and then removing methyl to prepare the 4-(2-amino-1, 3-thiazole-4-yl) benzene-1, 3-dimethanol. Pharmacological activity tests show that the compound has good inhibitory activity on tyrosinase, which indicates that the sulfanilamide thiazolyl resorcinol derivative can be researched and utilized as a novel tyrosinase inhibitor and whitening cosmetics.

The invention discloses a P.megaterium strain with stress resistance, growth promotion and environmental restoration functions and application thereof, and belongs to the technical field of microorganisms. According to the present invention, the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M 2025912, and the preservation number of the Pristeria megaterium XT106 provided by the invention is CCTCC NO: M 2025912; the Pristia megaterium XT106 provided by the invention is a strain capable of oxidizing manganese to form a biological manganese oxide, and the biological manganese oxide can adsorb and remove heavy metals (Cu, Sb, Pb, Zn, Cd and Cr) and degrade antibiotics (tetracycline and ciprofloxacin). The strain can move, tolerate acid-base, high-salt, phenanthrene and sulfamethoxazole environments, has the capability of generating a biological membrane, and can generate hydrogen sulfide, adsorb / fix and remove heavy metals (Cd, Pb, Zn, Sb and Cu) and promote plant growth.

The invention relates to the technical field of microbial treatment of antibiotic pollution, and discloses an antibiotic degrading bacterium with salt tolerance and capable of degrading sulfamethoxazole at low temperature and application, the strain degrades SMX in a wide temperature range of 10-40 DEG C, the degradation rate of 20mg / L SMX at 10-35 DEG C within 64 hours is greater than 70%, and the degradation rate of 20mg / L SMX at 20-30 DEG C reaches 100%; at the low temperature of 10 DEG C, low-concentration SMX is obviously degraded, and the SMX with the concentration of 5 mg / L can be completely degraded within 16 hours; the MJ2 can still effectively degrade SMX under the harsh conditions that the temperature is low and SMX serves as the unique carbon and nitrogen source, the degradation rate reaches 100% after 66h at the concentration of 5 mg / L, and it is proved that the MJ2 has the unique oligotrophic adaptability. Salinity tests show that the degradation rate of MJ2 to 20 mg / L SMX within 48 hours under the 0.1-2% NaCl concentration is 100%, the degradation rate is still kept at 50% even under the stress of 3% high salt, and remarkable salt tolerance is also shown. In conclusion, the strain MJ2 integrates wide temperature range adaptability, low-temperature high efficiency, oligotrophic tolerance and high salt stability, and has great application value in sulfonamide antibiotic pollution remediation in a complex environment.

The invention relates to the technical field of organic pollutant removal application, and particularly discloses a preparation method and application of a Co and N loaded Ti3Al C2 composite catalyst, and the preparation method comprises the step of successfully doping N and Co into the surface of Ti3Al C2 to synthesize a Co-N-Ti3Al C2 composite material by adopting a simple hydrothermal combined high-temperature carbonization method. Compared with a double combination of the materials, the Co-N-Ti3Al C2 has higher PMS activation and sulfonamide isoxazole (S IZ) degradation capability, and 98.6% of S IZ simulation wastewater with the concentration of 10 mg / L can be removed within 30 minutes by combining the Co-N-Ti3Al C2 with a PMS system. The high catalytic activity of the material is attributed to the strong interaction between pyridine N and Co atoms on the surface of Ti3AlC2, and meanwhile, the strong interaction is also beneficial for inhibiting leaching of Co ions in the material. The Co-N-Ti3Al C2 composite material has the advantages that the Co-N-Ti3Al C2 composite material is high in interference resistance, high in activity in natural water and high in practical applicability.

The invention relates to a high-entropy eutectic electrolyte, a preparation method thereof and an electrochemical device, and the high-entropy eutectic electrolyte is mainly formed by mixing a lithium salt, a solvent and a diluent, the solvent is at least one of sulfone, sulfanilamide, dinitrile and carbonate. The invention further comprises the preparation method of the high-entropy eutectic electrolyte. The electrochemical device comprises a high-entropy eutectic electrolyte, a positive electrode, a negative electrode and a diaphragm. According to the invention, the defects of high viscosity and poor wettability of an aprotic eutectic solvent can be overcome, the diluent is added to form a local eutectic solvent, and the obtained electrolyte has the characteristics of better solubility, low viscosity, wide electrochemical stability, low flammability or inflammability, wide temperature range, high lithium ion transfer number, good ionic conductivity and the like; the method has practical application value in electrochemical devices such as supercapacitors, batteries and sensors.

The invention discloses a monatomic covalent organic framework material with adjustable iron loading capacity, a preparation method of the monatomic covalent organic framework material and a sulfamethoxazole degradation method. COFs containing bipyridine groups are used as a framework, an anchoring point is provided for iron loading, the iron loading capacity can be regulated and controlled by controlling the adding amount of an iron precursor, and a degradation path is successfully regulated and controlled to be close to 100% high-valence iron; and after calcination, the spinning state of iron is changed, and the PMS utilization rate and the electron transmission efficiency of iron sites are improved, so that the degradation efficiency of new pollutants is remarkably improved. The preparation process has the core advantages of simple equipment, simplicity and convenience in operation, low production cost and the like, and has outstanding environmental compatibility, social and economic values and industrial mass production feasibility while practicing a green synthesis concept.

The present invention belongs to the field of biomedicine technology, and specifically relates to a combination drug combination and application for inhibiting the proliferation of NPM1 mutant leukemia cells. The combination drug combination includes RAS selective lethal molecule 3 and sulfonamide antibiotics; and anti-tumor small molecule drugs. The sulfonamide antibiotics include sulfasalazine; the anti-tumor small molecule drugs are selected from one or more of cytarabine, daunorubicin and venetoclax. The present invention also provides the application of the pharmaceutical composition in the combination drug combination in the preparation of an NPM1 mutant leukemia ferroptosis effect evaluation reagent.

The invention discloses a preparation method of an MXene-based electro-polymerization molecularly imprinted polymer and application of the MXene-based electro-polymerization molecularly imprinted polymer in detection of sulfadimethoxine content. The preparation method comprises the steps of synthesis of an MXene-MOF composite material, preparation of the MXene-based electro-polymerization molecularly imprinted polymer and the like. The electrochemical detection of the SDM is realized by electrically polymerizing a layer of molecularly imprinted polymer on the surface of the MXene-based composite material. When SDM exists in a detection environment, an imprinting cavity with specific recognition capability is combined with the SDM through acting forces such as hydrogen bonds and the like, so that the electron transfer rate is hindered, and the current value is reduced. The quantitative detection of the SDM is realized by analyzing the relationship between the logarithm of the concentration of the SDM and the delta I current change value. The method has a wide concentration detection range and a low detection limit, and has a wide application prospect.

The invention discloses a synthesis method of sulfachloropyrimidine, which comprises the following steps: taking paranitroaniline and 4, 6-dichloropyrimidine as raw materials, synthesizing acyl chloride by diazotization and sulfonylation of paranitroaniline, generating aminopyrimidine by ammonification of 4, 6-dichloropyrimidine, condensing aminopyrimidine and acyl chloride, and then synthesizing sulfachloropyrimidine by reduction. According to the method, chlorosulfonic acid is not used in the reaction process, the reaction treatment is simple, and the safety risk is reduced. Acid used in the chlorosulfonation process and ammonia used in the ammonification process can be recycled and reused, the product yield reaches 76.2%, and the quality meets the standard requirement. The process can improve the yield and reduce the production cost, the production process is easy to control, less three wastes are generated, and the environmental pollution is small.

The utility model relates to the technical field of material synthesis, and provides an efficient synthesis tank for sulfachlorpyridazine sodium raw material production, which comprises an equipment frame and a tank body, the tank body is arranged on the equipment frame, a transmission stirring component is arranged in the equipment frame and the tank body, a supporting component is arranged on the equipment frame, and a material receiving component is arranged on the surface of the equipment frame. The fixing shaft is fixed to the side surface of the equipment frame, the tank is rotationally connected to the fixing shaft, a driving motor is arranged on the side surface of the equipment frame, a transmission gear is arranged on the outer surface of the tank, and a driving gear is arranged at the output end of the driving motor. According to the technical scheme, the problems that when an existing sulfachlorpyridazine sodium synthesis tank in the related technology works, only materials are mixed, and the materials cannot be caked after being mixed with other substances are not considered, so that once the materials are caked with liquid when being mixed, the materials cannot be caked, and the materials cannot be caked are solved. And the problem that the mixing efficiency is reduced is solved.

A composition of stereoisomers of sulfoxaflor, where these stereoisomers are selected from diastereomers A and B at a selected A:B ratio, are provided as a mixture of crystal structures, and are water soluble with water solubility of at least about 0.7±0.07 mg / ml, methods for preparing them and insecticides and / or pesticides preparations comprising them.

The drying device comprises a shell, the upper end of the shell fixedly communicates with a feeding port, the tail end of the shell fixedly communicates with a discharging port, the space in the shell is divided into a drying area, a transmission area and a storage area, and a plurality of vibration plates are slidably connected into the drying area; a material cooling assembly capable of cooling materials is arranged in the transmission area, and the transmission area is further provided with a frequency assembly capable of changing the vibration frequency of each vibration plate at the position of the corresponding vibration plate. High-temperature materials are recycled into the drying equipment again, the heating equipment is turned off at the moment, and meanwhile, dry cold air is injected into the drying equipment, so that the materials can be cooled in the original drying equipment, the equipment investment cost is reduced, and the production line space is saved; and meanwhile, the device can independently adjust the vibration frequency of one vibration plate, so that the vibration frequency of the materials at the caking position is high, the original vibration frequency of other positions is kept, and uniform discharging is achieved.

The application discloses a method for removing trace sulfonamidochrysoidine in water by activating peracetic acid through complexation of manganese sulfate and 2-picolinic acid, wherein, (1) a homogeneous Mn(II)-PICA complex solution is prepared by mixing and stirring a manganese sulfate solution and a 2-picolinic acid solution; (2) peracetic acid solution and the homogeneous Mn(II)-PICA complex solution are added into water containing sulfonamidochrysoidine, and the mixture is fully stirred, and in the reaction process, high-valence manganese active species Mn(V)=O is generated; the system mainly adopts a non-radical oxidation path, has high selectivity to sulfonamidochrysoidine, and realizes degradation of the sulfonamidochrysoidine. The method has high activation efficiency and fast degradation speed, and the complex system significantly improves the activation efficiency of PAA, and the removal rate of sulfonamidochrysoidine can reach more than 90 % within 10 min, which is much higher than that of a single activation system.

The invention relates to adhesive hydrogel and a preparation method and application thereof, and belongs to the technical field of hydrogel, the adhesive hydrogel comprises a double-network structure formed by interpenetrating a first network and a second network, the first network structure is formed by physical crosslinking of tannic acid and polyvinyl alcohol through multiple hydrogen bonds, and the second network structure is formed by interpenetrating of tannic acid and polyvinyl alcohol through multiple hydrogen bonds. The second network structure is a covalent cross-linked network formed by metacrylic acid ester monomers and sulfanilamide betaine under the action of free radical polymerization; wherein the second network structure is connected with the first network structure through substitution reaction; a rigid brittle first network with high crosslinking density is formed through interpenetration of two networks with different chemical compositions and crosslinking mechanisms, is supported by a high-strength structure and has a synergistic effect with a flexible and high-toughness second network with low crosslinking degree, and high strength and self-repairing capability are combined, so that the self-repairing performance is improved under the action of external stimulation; the rigid first network structure serves as a framework to provide structural support for the hydrogel, and meanwhile the flexible second network structure enhances the toughness of the hydrogel while dissipating energy.

The invention belongs to the technical field of aptamer hydrogel, and relates to a preparation method and application of bimetallic nano-enzyme aptamer hydrogel. The affinity of the aptamer and a target is accurately regulated and controlled through a flexible single chain with adjustable length and the gap width of a molecular tweezer region to obtain the aptamer with high affinity and binding stability, the aptamer hydrogel is constructed, and Pt-Ru bimetallic nano-enzyme is embedded in a polyacrylamide network in situ, so that the aptamer hydrogel is obtained. By doping metal, enzyme kinetic parameter optimization is realized, high-sensitivity signals are given to the hydrogel, structure-function integrated design of a sensing material is realized, and naked-eye rapid detection of sulfadimethoxine can be carried out.

The present invention discloses a compound solution of a sulfonamide and an antimicrobial synergist, its preparation method, and application. The compound solution further comprises a solvent, a pH buffer system, and a diluent; the solvent is N-methylpyrrolidone, and the pH buffer system is triethanolamine and an organic acid. The present invention discloses a stable, clear compound solution of a sulfonamide and an antimicrobial synergist, and its preparation method. The compound solution can be mixed with water for administration, exhibits excellent stability and lacks a distinctive odor after mixing with water, and eliminates problems such as uneven mixing of existing premixes and low intake of sick animals when their appetite decreases.

The invention belongs to the field of analysis and detection, and particularly relates to a sulfamethoxazole and trimethoprim combined trace detection method and application to drug monitoring after hematopoietic stem cell transplantation patient treatment. The detection method comprises the following steps: (1) pre-treating a sample: treating the sample by adopting a releasing agent containing an internal standard substance which comprises an isotope labeled compound; (2) carrying out qualitative and quantitative analysis by adopting liquid chromatography-tandem mass spectrometry, wherein a mobile phase A is an aqueous solution of formic acid; b is methanol. According to the invention, a micro method for detecting the blood concentration of sulfamethoxazole / trimethoprim in a hematopoietic stem cell transplanted child patient by a liquid chromatography-tandem mass spectrometry technology is established; combined determination of sulfamethoxazole and trimethoprim is achieved through a mass spectrum electrospray positive ion multi-reaction monitoring mode, selectivity, residue, accuracy, precision, stability and matrix effect are comprehensively evaluated, and the method is verified completely, stable and reliable.

The present invention discloses a dual-photoelectrode system and a method for photoelectrocatalytic degradation of organic pollutants thereof. TiO2NNs / Ti mesh is used as a photoanode and NCDs / Co3O4 / Ti mesh is used as a photocathode. A light-responsive dual-photoelectrode system (TiO2NNs-NCDs / Co3O4) is constructed to perform photoelectrocatalytic treatment on polluted water, thereby achieving high-efficiency and low-consumption photoelectrocatalytic oxidation degradation of pollutants such as sulfadiazine (98.54%), sulfadimethazine (98.17%), rhodamine B (99.03%), sulfathiazole (99.70%), 2,4-dichlorophenol (93.40%), and phenol (93.96%). Compared to existing technologies, the dual-photoelectrode system of the present invention features a new cathode material, NCDs / Co₃O₄, which is responsive to visible light, instead of the Pt sheet commonly used in traditional photoelectrocatalytic systems. This system leverages solar energy to generate a higher photovoltage between the photoanode and photocathode, enabling self-driven operation or low-power input operation. This reduces overall system energy consumption while further improving system efficiency and stability. The present invention boasts excellent light absorption performance and removal efficiency for difficult-to-degrade organic pollutants, along with good stability, long lifespan, and low energy consumption and cost, offering broad application prospects.

The application discloses an iron-manganese complex graphene carbon catalyst supported on a zeolite, and a preparation and application thereof, and belongs to the technical field of water treatment. The catalyst is a GC@Mn-Fe3O4 / Zeolite catalyst, which is made of nitrogen-doped graphene carbon, Fe3O4, Mn3O4 and a zeolite, and a preparation method thereof is provided. The GC@Mn-Fe3O4 / Zeolite catalyst prepared in the application can drive the metabolism of microorganisms in water to antibiotics, and effectively removes three mixed antibiotics, i.e., ciprofloxacin, sulfamethoxazole and tetracycline, in water under the condition that no external energy is input, and the removal rate can reach more than 95%. In addition, the iron-manganese complex graphene carbon catalyst is supported on the zeolite, so that the stability of the catalyst is improved, and the catalyst has a good application prospect.

The invention discloses a method for preparing bicyclo[1.1.1]pentanesulfonamide, which comprises taking N-substituted sulfonamide shown in formula (1), [1.1.1] propellerane shown in formula (2), and hydrogen / iodine / sulfur source reagent as raw materials, reacting in a solvent under the action of light and photocatalyst to obtain bicyclo[1.1.1]pentanesulfonamide shown in formula (3), and the reaction equation thereof is as follows: wherein, R 1 and R 2 The electron withdrawing group is a halogen, trifluoromethyl, nitro or cyano group, the electron donating group is an alkyl, alkenyl, alkynyl, alkoxy or aryl group, the Ar group is a phenyl, a substituted phenyl or pyridine, and the substituent of the substituted phenyl is an alkoxy or a halogen. The present invention uses cheap and readily available N-nitrososulfonamide as a nitrogen source, and has the advantages of simple operation, good substrate universality, high atomic utilization, etc.

Provided is a polycarbonate resin composition which contains 16-63 mass% of a repeating unit (a) represented by formula (1) and 37-84 mass% of a repeating unit (d) represented by formula (6), and which has a viscosity average molecular weight 15,000 or more. (In formula (1), R1 and R2 each independently denote a hydrogen atom or a methyl group.) (In formula (6), R15 to R18 each independently denote a hydrogen atom, an alkyl group having 1-10 carbon atoms, or a group which includes an aryl group and has 6-12 carbon atoms. W denotes at least one type selected from among a single bond, an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group and a divalent organic group.)

The present invention provides a sulfonamide epoxy resin represented by Formula I and a method for preparing the same. Through ingenious process control, the present invention synthesizes a resin containing both epoxy and amino groups, enabling self-curing without the need for mixing with a curing agent or other components. Furthermore, the epoxy resin exhibits high and controllable reactivity, excellent physical and mechanical properties, and intrinsic flame retardancy, and has broad application prospects. #imgabs0#

The present invention relates to the technical field of pharmaceutical preparations, and discloses a levetiracetam oral solution and a preparation method thereof, the levetiracetam oral solution comprises the following raw material components by mass concentration: 80-120 mg / ml of an active component levetiracetam, a pH value regulator, 2.50-2.90 mg / ml of a bacteriostatic agent, 180-220 mg / ml of a cosolvent and 280-350 mg / ml of a flavoring agent, and the pH value of the levetiracetam oral solution is 5.0-5.6. The preparation method is carried out according to the following charging sequence: purified water and glycerol, methylparaben, propylparaben, mono-ammonium glycyrrhizinate S, acesulfame potassium, sodium acetate, liquid maltitol, levetiracetam, 1% acetic acid solution and essence. Compared with the prior art, the levetiracetam oral solution prepared by the preparation method disclosed by the invention is better in mouth feel and higher in stability; the adjustment of the preparation process greatly shortens the time required for preparation.

This invention discloses a piperazine-containing seven-membered cyclic sulfonamide derivative and its electrochemical synthesis method. The method employs an electrochemical oxidation process, using electrons as a clean oxidant, to achieve a dehydrogenation cross-coupling reaction between the seven-membered cyclic sulfonamide and piperazine compounds, synthesizing a series of piperazine-modified seven-membered cyclic sulfonamide derivatives with anti-inflammatory activity. This synthetic method has significant advantages in green chemistry, requiring no noble metal catalysts, stoichiometric oxidants, or strong bases. The reaction conditions are mild and the process is easily controlled. Furthermore, this invention achieves Csp... 2 The direct oxidative cross-dehydrogenation coupling between -H and N-H constructs a C-N bond in one step, which is highly atom-economical and avoids the drawbacks of substrate prefunctionalization and multi-step reactions in traditional synthesis, thus improving the synthesis efficiency.

This application relates to the field of biotechnology, and particularly to primer pairs, primer-probe compositions, PCR premixes, kits, and methods for detecting multiple respiratory pathogens. Nucleic acid sequences are shown in primer pairs as indicated by SEQ ID NO: 1-2, 4-5, 7-8, 10-11, 13-14, 16-17, 19-20, 22-23, 25-26, 28-29, 31-32, 34-35, 37-38, and 40-41. For target respiratory pathogens, this application designs specific amplification primer pairs, paired with suitable probes, enabling the simultaneous detection of eight targets. Furthermore, the detection process avoids interference from heme, trimethoprim, sulfamethoxazole, amphotericin B, itraconazole, fluconazole, azithromycin, adrenaline, and lidocaine hydrochloride in the test sample. It exhibits good anti-interference properties and shows no cross-reactivity with *Rhodococcus equi*, *Candida tropicalis*, and *Candida krusei*.

The invention relates to the technical field of preparation of imprinted polymers, and particularly discloses a magnetic molecularly imprinted polymer for sulfonamides and a preparation method of the magnetic molecularly imprinted polymer for sulfonamides. Tetraethyl orthosilicate is used for silanization of the surface of Fe3O4, then 3-(trimethoxysilyl) propyl methacrylate and silicon hydroxyl of Fe3O4 (at) SiO2 are used for condensation, and the magnetic molecularly imprinted polymer for sulfonamides is obtained. The preparation method comprises the following steps: carrying out vinyl modification on the surface of Fe3O4 (at) SiO2-CH = CH2 particles to obtain Fe3O4 (at) SiO2-CH = CH2 particles, and carrying out copolymerization on the Fe3O4 (at) SiO2-CH = CH2 particles and Fe3O4 (at) SiO2-CH = CH2 by adopting a surface imprinting method and taking sulfadimidine as a template molecule, methyl methacrylate as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent so as to prepare the Fe3O4 (at) SiO2-CH = CH2 molecularly imprinted polymer. The magnetic molecularly imprinted polymer obtained by the invention can quickly identify sulfadimidine under the action of an external magnetic field, is simple to prepare, good in adsorbability, relatively low in cost and convenient to recycle, can be repeatedly utilized, and has a relatively good application prospect.