65 results about "Sulfonosine" patented technology

The invention relates to the technical field of microbial treatment of antibiotic pollution, and discloses an antibiotic degrading bacterium with salt tolerance and capable of degrading sulfamethoxazole at low temperature and application, the strain degrades SMX in a wide temperature range of 10-40 DEG C, the degradation rate of 20mg / L SMX at 10-35 DEG C within 64 hours is greater than 70%, and the degradation rate of 20mg / L SMX at 20-30 DEG C reaches 100%; at the low temperature of 10 DEG C, low-concentration SMX is obviously degraded, and the SMX with the concentration of 5 mg / L can be completely degraded within 16 hours; the MJ2 can still effectively degrade SMX under the harsh conditions that the temperature is low and SMX serves as the unique carbon and nitrogen source, the degradation rate reaches 100% after 66h at the concentration of 5 mg / L, and it is proved that the MJ2 has the unique oligotrophic adaptability. Salinity tests show that the degradation rate of MJ2 to 20 mg / L SMX within 48 hours under the 0.1-2% NaCl concentration is 100%, the degradation rate is still kept at 50% even under the stress of 3% high salt, and remarkable salt tolerance is also shown. In conclusion, the strain MJ2 integrates wide temperature range adaptability, low-temperature high efficiency, oligotrophic tolerance and high salt stability, and has great application value in sulfonamide antibiotic pollution remediation in a complex environment.

The invention discloses a synthesis method of sulfachloropyrimidine, which comprises the following steps: taking paranitroaniline and 4, 6-dichloropyrimidine as raw materials, synthesizing acyl chloride by diazotization and sulfonylation of paranitroaniline, generating aminopyrimidine by ammonification of 4, 6-dichloropyrimidine, condensing aminopyrimidine and acyl chloride, and then synthesizing sulfachloropyrimidine by reduction. According to the method, chlorosulfonic acid is not used in the reaction process, the reaction treatment is simple, and the safety risk is reduced. Acid used in the chlorosulfonation process and ammonia used in the ammonification process can be recycled and reused, the product yield reaches 76.2%, and the quality meets the standard requirement. The process can improve the yield and reduce the production cost, the production process is easy to control, less three wastes are generated, and the environmental pollution is small.

The utility model relates to the technical field of material synthesis, and provides an efficient synthesis tank for sulfachlorpyridazine sodium raw material production, which comprises an equipment frame and a tank body, the tank body is arranged on the equipment frame, a transmission stirring component is arranged in the equipment frame and the tank body, a supporting component is arranged on the equipment frame, and a material receiving component is arranged on the surface of the equipment frame. The fixing shaft is fixed to the side surface of the equipment frame, the tank is rotationally connected to the fixing shaft, a driving motor is arranged on the side surface of the equipment frame, a transmission gear is arranged on the outer surface of the tank, and a driving gear is arranged at the output end of the driving motor. According to the technical scheme, the problems that when an existing sulfachlorpyridazine sodium synthesis tank in the related technology works, only materials are mixed, and the materials cannot be caked after being mixed with other substances are not considered, so that once the materials are caked with liquid when being mixed, the materials cannot be caked, and the materials cannot be caked are solved. And the problem that the mixing efficiency is reduced is solved.

A composition of stereoisomers of sulfoxaflor, where these stereoisomers are selected from diastereomers A and B at a selected A:B ratio, are provided as a mixture of crystal structures, and are water soluble with water solubility of at least about 0.7±0.07 mg / ml, methods for preparing them and insecticides and / or pesticides preparations comprising them.

The application discloses a method for removing trace sulfonamidochrysoidine in water by activating peracetic acid through complexation of manganese sulfate and 2-picolinic acid, wherein, (1) a homogeneous Mn(II)-PICA complex solution is prepared by mixing and stirring a manganese sulfate solution and a 2-picolinic acid solution; (2) peracetic acid solution and the homogeneous Mn(II)-PICA complex solution are added into water containing sulfonamidochrysoidine, and the mixture is fully stirred, and in the reaction process, high-valence manganese active species Mn(V)=O is generated; the system mainly adopts a non-radical oxidation path, has high selectivity to sulfonamidochrysoidine, and realizes degradation of the sulfonamidochrysoidine. The method has high activation efficiency and fast degradation speed, and the complex system significantly improves the activation efficiency of PAA, and the removal rate of sulfonamidochrysoidine can reach more than 90 % within 10 min, which is much higher than that of a single activation system.

The invention relates to adhesive hydrogel and a preparation method and application thereof, and belongs to the technical field of hydrogel, the adhesive hydrogel comprises a double-network structure formed by interpenetrating a first network and a second network, the first network structure is formed by physical crosslinking of tannic acid and polyvinyl alcohol through multiple hydrogen bonds, and the second network structure is formed by interpenetrating of tannic acid and polyvinyl alcohol through multiple hydrogen bonds. The second network structure is a covalent cross-linked network formed by metacrylic acid ester monomers and sulfanilamide betaine under the action of free radical polymerization; wherein the second network structure is connected with the first network structure through substitution reaction; a rigid brittle first network with high crosslinking density is formed through interpenetration of two networks with different chemical compositions and crosslinking mechanisms, is supported by a high-strength structure and has a synergistic effect with a flexible and high-toughness second network with low crosslinking degree, and high strength and self-repairing capability are combined, so that the self-repairing performance is improved under the action of external stimulation; the rigid first network structure serves as a framework to provide structural support for the hydrogel, and meanwhile the flexible second network structure enhances the toughness of the hydrogel while dissipating energy.

The application discloses an iron-manganese complex graphene carbon catalyst supported on a zeolite, and a preparation and application thereof, and belongs to the technical field of water treatment. The catalyst is a GC@Mn-Fe3O4 / Zeolite catalyst, which is made of nitrogen-doped graphene carbon, Fe3O4, Mn3O4 and a zeolite, and a preparation method thereof is provided. The GC@Mn-Fe3O4 / Zeolite catalyst prepared in the application can drive the metabolism of microorganisms in water to antibiotics, and effectively removes three mixed antibiotics, i.e., ciprofloxacin, sulfamethoxazole and tetracycline, in water under the condition that no external energy is input, and the removal rate can reach more than 95%. In addition, the iron-manganese complex graphene carbon catalyst is supported on the zeolite, so that the stability of the catalyst is improved, and the catalyst has a good application prospect.

This invention discloses a piperazine-containing seven-membered cyclic sulfonamide derivative and its electrochemical synthesis method. The method employs an electrochemical oxidation process, using electrons as a clean oxidant, to achieve a dehydrogenation cross-coupling reaction between the seven-membered cyclic sulfonamide and piperazine compounds, synthesizing a series of piperazine-modified seven-membered cyclic sulfonamide derivatives with anti-inflammatory activity. This synthetic method has significant advantages in green chemistry, requiring no noble metal catalysts, stoichiometric oxidants, or strong bases. The reaction conditions are mild and the process is easily controlled. Furthermore, this invention achieves Csp... 2 The direct oxidative cross-dehydrogenation coupling between -H and N-H constructs a C-N bond in one step, which is highly atom-economical and avoids the drawbacks of substrate prefunctionalization and multi-step reactions in traditional synthesis, thus improving the synthesis efficiency.

This application relates to the field of biotechnology, and particularly to primer pairs, primer-probe compositions, PCR premixes, kits, and methods for detecting multiple respiratory pathogens. Nucleic acid sequences are shown in primer pairs as indicated by SEQ ID NO: 1-2, 4-5, 7-8, 10-11, 13-14, 16-17, 19-20, 22-23, 25-26, 28-29, 31-32, 34-35, 37-38, and 40-41. For target respiratory pathogens, this application designs specific amplification primer pairs, paired with suitable probes, enabling the simultaneous detection of eight targets. Furthermore, the detection process avoids interference from heme, trimethoprim, sulfamethoxazole, amphotericin B, itraconazole, fluconazole, azithromycin, adrenaline, and lidocaine hydrochloride in the test sample. It exhibits good anti-interference properties and shows no cross-reactivity with *Rhodococcus equi*, *Candida tropicalis*, and *Candida krusei*.

According to the invention there is provided a pharmaceutical composition comprising N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, in which composition the C21 or salt thereof is protected by the presence of a coating comprising an enteric substance. Preferred dosage forms comprise capsules in which C21 or salt thereof is presented in the form of a dry powder mixture or a suspension of particles of C21 in a solvent in which it is insoluble. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.

The utility model relates to the technical field of metering tanks, and provides an alkali metering tank for sulfachloropyrazine sodium production, which comprises five groups of side plates, a metering column is arranged between two adjacent groups of side plates, the outer end of the metering column is fixedly connected with a connecting shaft, the connecting shaft is rotatably connected with the side plates, and the connecting shaft is fixedly connected with the side plates. A drying assembly is arranged in the metering column and comprises a storage cavity formed in the metering column. The stirring blades connected through the fulcrum shaft rotate in the storage cavity in the metering column, so that alkaline substances stored in the storage cavity are stirred, solid alkaline substances are prevented from being affected with damp and adhering to the inner wall of the metering pipe, and liquid alkaline substances can be prevented from being separated out and crystallized in a low-temperature environment; and in the process of stirring the alkaline substances, hot air flow passing through the interior of the air cavity achieves the effects of drying and heat preservation on the alkaline substances stored in the storage cavity.

According to the invention there is provided a method of improving (e.g. restoring) function in a patient having idiopathic pulmonary fibrosis, which method comprises perorally administering a therapeutically-effective amount of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically acceptable salt thereof, to said patient. Said treatment is capable of treating said IPF in a therapeutic, including a curative, fashion.

The utility model relates to the technical field of sulfachlorpyridazine sodium production devices, and provides an intelligent centrifugal machine for sulfachlorpyridazine sodium production, which comprises a base, and a support square rod is fixedly mounted in the middle of the top end of the base; firstly, a worker can place a test tube containing medicine in a placement box, then the test tube is clamped and fixed through a clamping plate, then a second motor can be started while a first motor arranged through a control panel is started to rotate at a low speed, and a linkage plate moves to a designated position while a supporting plate is driven to rotate; and along with rotation of a supporting plate, a rotationally-installed containing box makes intermittent contact with a rubber roller, so that the effect of promoting mixing of the medicine can be achieved, when centrifugal machining needs to be conducted, a second motor can be started to rotate reversely, a linkage plate descends, then a first motor is started to rotate at a high speed, and then centrifugal machining is conducted on the medicine. And the production efficiency of the sulfachlorpyridazine sodium is improved to a certain extent.

The invention discloses an MOF (Metal Organic Framework) immunochromatography test strip for detecting sulfadimidine and a preparation method thereof. According to the invention, a mouse hybridoma cell 1B12 is screened, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.46705, and the mouse hybridoma cell 1B12 is preserved in China General Microbiological Culture Collection Center on October 13, 2025. The mouse hybridoma cell 1B12 is secreted to obtain an anti-sulfadimidine monoclonal antibody, the anti-sulfadimidine monoclonal antibody is used for preparing an MOF immune probe, and finally the MOF immunochromatography test strip for detecting sulfadimidine is prepared. The prepared MOF immunochromatography test strip is short in determination time, easy to operate and low in cost, has excellent specificity and sensitivity, and can simply, conveniently and rapidly detect sulfadimidine.

Provided are aqueous pharmaceutical formulations comprising 4-((2-hydroxy-3-methoxybenzyl)amino)-benzenesulfonamide 12-LOX inhibitors with improved solubility. Also provides are aqueous parenteral pharmaceutical formulations comprising selective 12-LOX inhibitors with 2-hydroxyalkyl-β-cyclodextrins.

The invention relates to a preparation method of a metal molybdenum defect enhanced bismuth molybdate photocatalyst and an application of the metal molybdenum defect enhanced bismuth molybdate photocatalyst in removal of sulfamethoxazole in water, and belongs to the technical field of wastewater treatment.The preparation method comprises the steps that firstly, a molybdenum powder solution and a bismuth nitrate solution are subjected to a hydrothermal reaction to obtain a bismuth molybdate nanosheet precursor; then dispersing the synthesized bismuth molybdate nanosheet precursor in a sodium hydroxide solution, stirring, etching to obtain a metal molybdenum defect enhanced bismuth molybdate photocatalyst, adding the metal molybdenum defect enhanced bismuth molybdate photocatalyst into an aqueous solution containing sulfamethoxazole, stirring for a certain time to realize adsorption-desorption balance, then starting a 300W xenon lamp with a 420nm cut-off filter, and carrying out an illumination reaction, and continuously stirring to promote the photocatalytic degradation of the sulfamethoxazole. The prepared bismuth molybdate photocatalyst containing molybdenum defects is used for removing sulfamethoxazole in water, and the method has the advantages that the removal efficiency is high, materials are convenient to recycle and recycle, and the removal effect is slightly influenced by factors such as the pH value and various inorganic anions.

This invention discloses a tetracyclic analogue-sulfonamide hybrid of *Zanthoxylum bungeanum* alkaloids, possessing the following general formula. The invention also provides a method for preparing the tetracyclic analogue-sulfonamide hybrid of *Zanthoxylum bungeanum* alkaloids, comprising dissolving compound 10 or compound 11 and triethylamine in dichloromethane, adding benzenesulfonyl chloride derivative 12a-12e at low temperature, stirring, and then stirring at room temperature until the starting material spot disappears. The reaction is monitored by TLC. After the reaction is complete, the product 13a-13e or 14a-14e is obtained by column chromatography separation and purification. The tetracyclic analogue-sulfonamide hybrid of *Zanthoxylum bungeanum* alkaloids provided by this invention has been shown in in vitro antitumor experiments to exhibit strong inhibitory effects on human cervical cancer cells in leukemia cells, human liver cancer cells, human lung cancer cells, human cervical cancer cells, and normal human liver cells.

According to the sulfonamide-derived ionizable lipid compound and the application thereof, sulfonamide nitrogen atoms in the ionizable lipid compound lose protons in a neutral environment to form nitrogen anions, the nitrogen anions can be combined with quaternary ammonium salt positive ions to form a zwitterionic compound, and the biological safety is good; the negatively charged sulfonamide nitrogen atoms can obtain protons in an acid environment and lose negative charges, so that the sulfonamide can ionize the lipid compound with positive charges, and the combination with negatively charged RNA is facilitated; ionization constants of head groups R2 of the sulfanilamide lipid compounds are different, so that the sulfanilamide-derived ionizable lipid compounds with different R2 groups present different pKa, and components and contents of protein crowns adsorbed to the surfaces of the sulfanilamide-derived ionizable lipid compounds after being injected into a body are different. Different types of sulfanilamide-derived ionizable lipid compounds are made to target different organs or tissues.

The present invention relates to dihydrocyclopenta-isoquinoline-sulfonamide derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FcεRI receptor.

The present application relates to the technical field of TLR2 antagonists, and particularly relates to a compound with a ketoxime ether structure and application thereof.The compound has a structure shown in formula I: or a pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R5 are independently selected from any one of a hydrogen atom, a phenolic hydroxyl group, an amino group, a halogen, a C1-C4 alkyl group, a C1-C4 alkoxy group, a C3-C5 cycloalkyl group, a C2-C4 alkenyl group, a C2-C4 alkynyl group, an amide group, a sulfonamide group, an ester group, a cyano group, OCH2F, OCHF2, OCF3, SCF3 and N(CH3)2; ring A is one of a 6-14 membered aryl group and a 5-14 membered heteroaryl group; and R6 is any one of an ester group with 1-15 carbon atoms, an amide group, a sulfonamide group, an alkyl group, an alkoxy group, an oxazole, an isoxazole, a thiazole, an isothiazole, an oxadiazole, a thiadiazole, a substituted oxazole, a substituted isoxazole, a substituted thiazole, a substituted isothiazole, a substituted oxadiazole and a substituted thiadiazole.The compound can be used as a TLR2 antagonist.

This invention relates to the field of immunology, and more particularly to a hybridoma cell line and its secreted monoclonal antibody against the metamizole residue marker 4-methylaminoantipyrine (MAA), and its applications. This invention uses 4-aminoantipyrine to react with methyl 4-bromomethylbenzoate, followed by alkaline hydrolysis to obtain a hapten (Formula I). ​​An immunogen is then synthesized and used to immunize mice. After cell fusion and screening, a hybridoma cell line capable of secreting a monoclonal antibody recognizing MAA is prepared, named Metamizole-6A4. This hybridoma cell line has a high efficiency in secreting monoclonal antibodies. The secreted monoclonal antibody can accurately detect MAA, IC50, and other markers. 50 The concentration is 4.06 ng / mL, with high specificity. Cross-reactivity with aminopyrine and its metabolites 4-aminoantipyrine, 4-formamidoantipyrine, 4-acetamidoantipyrine, sulfadiazine, norfloxacin, lincomycin, tylosin, penicillin G, streptomycin, and gentamicin is less than 5%. It can accurately detect MAA residues in food. Formula I.

The invention provides a bimetallic three-dimensional MOF (Metal Organic Framework) material based on a pyrazole ligand as well as a preparation method and application of the bimetallic three-dimensional MOF material, and belongs to the technical field of MOF materials. An organic ligand of the bimetallic three-dimensional MOF material based on the pyrazole ligand is a pyrazole organic monomer with a structure shown in a formula I, and coordination metals are two of Zn, Ni, Co and Mn; the bimetallic three-dimensional MOF material based on the pyrazole ligand is prepared by adopting a solvothermal method. According to the method, the molecular characteristics of specific organic pollutants (such as tetracycline, bisphenol A, sulfadiazine and methylene blue) are accurately matched by regulating and controlling the types of metal nodes, and efficient selective adsorption is realized. According to the invention, two metal ions are introduced to construct the bimetal MOF, and unique electron interaction and synergistic catalytic effect of bimetal centers are utilized to create more catalytic centers with higher activity, so that the redox degradation efficiency of target pollutants is fundamentally improved, and the effect of 1 + 1 > 2 can be realized.

The invention discloses a preparation method and application of a spherical nucleic acid-based nanoprobe and a paper-based chip thereof. The preparation method is characterized by comprising the following steps: preparing the spherical nucleic acid nanoprobe based on a sulfadiazine aptamer by adopting a microwave method; the paper-based chip is prepared by constructing a hydrophobic barrier by adopting a laser printing and high-temperature heating method, a to-be-detected water sample is dropwise added into a sample adding area of the paper-based chip, and the sample firstly reaches a detection area 1 through capillary action and is gathered after acting with a nano probe for detecting aminoglycoside antibiotics, so that the color of the paper-based chip is changed; after the sample continuously flows to a detection area 2 and reacts with the prepared spherical nucleic acid nanoprobe based on the sulfadiazine aptamer, a sodium chloride solution is dropwise added into the area to trigger a particle aggregation reaction, so that the color of the paper-based chip is changed, and simultaneous detection of aminoglycoside and sulfonamide antibiotics is realized. Compared with the prior art, the method has the characteristics of rapidness, convenience, economy and practicability, and is of great significance to environmental risk assessment, pollutant control and public health.

The application discloses a precise sulfonamide hapten, an artificial antigen and application thereof. The application provides two kinds of precise sulfonamide haptens, and an antibody of precise sulfonamide is prepared, which has high titer, high stability and high affinity, and provides core raw materials for establishing an immunodetection method of thiazide drugs. The application also establishes an indirect competitive ELISA immunological analysis method of a broad-spectrum thiazide drug, which has high sensitivity, the minimum detection limit (LOD) of the precise sulfonamide is 0.015 ng / mL, and the IC 50 of the six kinds of thiazide drugs ranges from 0.76 ng / ml to 358.76 ng / ml, and the method has a good application prospect in the residual detection of thiazide drugs.

The application discloses a cobalt-based Fenton-like catalyst and a preparation method and application thereof. The catalyst is prepared by the following steps: taking pyrrole as a monomer, dimethoxymethane as a crosslinking agent, methanesulfonic acid as a polymerization catalyst and a sulfonating agent, polymerizing by Friedel-Crafts alkylation to obtain a methanesulfonyl functionalized super-crosslinked polymer precursor, and then performing ultrasonic-assisted impregnation to load cobalt salt and high-temperature calcination. The active component of the catalyst is Co9S8 and elemental Co dual phases, which are highly dispersed in a porous carbon carrier in nanoscale, and no external sulfur source is needed. The phase controllable transformation is realized by adjusting the amount of the cobalt salt. The catalyst is used for Fenton-like reaction, and can quickly degrade a plurality of refractory organic pollutants such as sertraline, tetracycline, sulfamethoxazole and rhodamine B in the presence of PMS, and the removal rate reaches 100%. The catalyst has the advantages of simple preparation, high activity, good stability and wide application.

The invention discloses a sulfamethoxazole molecular imprinting ratio fluorescent paper-based sensor based on a rare earth complex fluorescent material as well as a preparation method and application of the sulfamethoxazole molecular imprinting ratio fluorescent paper-based sensor. The sulfamethoxazole molecularly imprinted ratiometric fluorescent paper-based sensor is prepared by the following steps: carrying out polymerization reaction on a red fluorescent material BCP-Eu, a green fluorescent material BCP-Tb, a template molecule sulfamethoxazole, a functional monomer and a cross-linking agent APTES on the surface of a paper base, eluting to remove the sulfamethoxazole template molecule, and detecting the sulfamethoxazole molecularly imprinted ratiometric fluorescent paper-based sensor. Finally, the sulfamethoxazole molecular imprinting ratio fluorescent paper-based sensor is obtained. According to the paper-based sensor, a molecular imprinting technology and a ratio fluorescence analysis method are organically combined, the paper-based sensor has the characteristics of high selectivity and high sensitivity, and specific recognition, rapid quantitative analysis and visual detection of sulfamethoxazole can be realized by further combining convenient imaging and signal reading functions of a smart phone; and an effective solution is provided for on-site instant detection of food safety.

The present invention relates to methods for treating and / or inhibiting the development or progression of diseases or disorders caused by, or associated with, herpes virus infection. In particular, provided are certain methods for treatment of a herpes virus infection, particularly a recurrent genital herpes infection associated with HSV-2, in a human subject, comprising oral administration of 2-(3-(2',5'-difluoro-[1, 1'-biphenyl]-4-yl)-2-oxotetrahydropyrimidin-1(2H)yl)-4-methylthiazole-5-sulfonamide (also referred to herein as 'Compound T).

The invention discloses an SMSI-enhanced MnOx / C nano-catalyst, which belongs to the field of nano-catalyst materials, and is specifically prepared by the following steps: reacting potassium permanganate with dopamine hydrochloride in an alkaline solution of tris (hydroxymethyl) aminomethane, and finally performing high-temperature pyrolysis to obtain the SMSI-enhanced MnOx / C nano-catalyst. The SMSI effect is utilized, the non-metal heteroatom doped carrier is promoted to effectively regulate and control the electronic structure of a metal active center through interface interaction, activation of peroxymonosulfate is promoted based on a free radical and non-free radical mixing path, the removal rate of sulfamethoxazole within 30 min is 97.9%, and the removal rate of sulfamethoxazole is 97.9%. The removal efficiency of rhodamine B, bisphenol A, tetracycline hydrochloride and p-nitrophenol is greater than 90.0%, the problem that a single path is limited by organic pollutant types is solved, and the practical application range of the catalyst is widened.