13 results about "Gold marker" patented technology

The invention discloses a gold label implant and positioning feature processing equipment thereof, and relates to the field of implantable medical instruments, a gold label is a cylinder, and the side wall of the gold label is provided with positioning features; positioning feature machining equipment comprises an electric spark machining device and a control piece. The control piece comprises a rotating assembly and a power connection assembly; the rotating assembly comprises a mounting frame, a motor arranged on the mounting frame, a first bevel gear connected with the motor, a second bevel gear meshed with the first bevel gear, a chuck piece fixed to the second bevel gear and a clamping piece arranged on the chuck piece. Positioning features are marked on the surface of the metal marker, friction force can be effectively increased, the implant is made of inert alloy materials and is easy to recognize and track, and conventional medical examination is not affected; the positioning feature machining equipment adopts electric spark machining, effectively fixes a gold-labeled raw material alloy thin wire, meanwhile, the gold-labeled raw material alloy thin wire is connected into an electrode, the rotating angle of the alloy wire can be controlled through a motor during machining, and positioning features are gradually punched on the side wall.

The invention discloses a real-time positioning method for a tumor target region and a gold label implant, and belongs to the technical field of tumor localization, and the method specifically comprises the following steps: implanting a gold label in a tumor region, constructing a gold label-tumor dynamic model through CT, and obtaining a respiratory phase feature vector; realizing space matching of the two-dimensional projection and the three-dimensional model by using an improved hybrid registration algorithm, and obtaining a tumor compound displacement vector; establishing a respiration-displacement correlation model through time sequence alignment, generating a tumor movement map containing a real-time position and a predicted trajectory, and updating the reference coordinate system; establishing a rigid safety boundary based on a gold label, analyzing soft tissue texture and a prediction trajectory in combination with a convolutional neural network to generate an elastic treatment boundary, and dynamically adjusting a dose weight of a non-label area; and finally, submillimeter-level dynamic tracking is executed through a multi-leaf collimator. The problems of tumor motion uncertainty and individual deformation difference are solved, and the target area coverage precision and the dose distribution reasonability are improved.

The invention relates to the technical field of gold-labeled implants, and discloses a pure gold-labeled implant with a positioning characteristic, the pure gold-labeled implant comprises at least two markers, and the markers are injected through a gold-labeled injector; the connecting line is a collagen chain and a fixation stripe group and is arranged on the marker, and after the marker is located in the target tissue, the fixation stripe group is extruded by the target tissue, so that the marker can be fixed in the target tissue; the fixing grain group comprises a fixing piece arranged on the marker; wherein the left view of the marker is of a circular structure, the top view of the marker is divided into four areas by two mutually perpendicular axial cross sections in the marker, the fixing pieces are located in the areas, and through a limiting groove, a connecting line, a mushroom-shaped third fixing piece and a multi-layer groove structure which are arranged in the pure gold label, the fixing pieces are fixed to the left side of the marker. Therefore, the human tissue can extend into the gold label implant to be matched with the barb to fix the gold label implant, and displacement of the implant is avoided.

The invention provides a kit for detecting natural musk as well as application and a method thereof. The kit for detecting the natural musk comprises an RPA (recombinase polymerase amplification) primer pair, a colloidal gold labeled detection probe and a lateral flow chromatography test strip, when the kit provided by the invention is used for detecting a to-be-detected sample, firstly, genome DNA of the to-be-detected sample is extracted, and room-temperature RPA amplification is performed on the genome DNA of the to-be-detected sample by adopting the RPA amplification primer pair, so that an amplification product is obtained; and secondly, mixing the amplification product with a colloidal gold labeled detection probe, dropwise adding the mixture on a lateral flow chromatography test strip, and judging whether the natural musk is contained in the sample to be detected or not according to a strip of the lateral flow chromatography test strip. The kit provided by the invention not only has the advantages of simplicity and convenience in operation, strong anti-interference capability, high sensitivity, strong specificity and the like, but also can realize on-site nondestructive detection, and is convenient for inspectors to master and operate.

This application provides a method and system for recommending gold marker implantation sites, relating to the field of image-guided radiotherapy technology. The method includes acquiring a patient's CT image data; determining several gold marker implantation points based on the CT image data; combining the gold marker implantation points according to preset aggregation rules to construct several gold marker point sets; evaluating the three-dimensional geometric stability index and the two-dimensional observable stability index of each gold marker point set; combining the preset evaluation rules and the geometric stability index and observable stability index corresponding to each gold marker point set to select the optimal gold marker point set from all gold marker point sets; using the gold marker implantation points in the optimal gold marker point set as recommended gold marker implantation sites; and proactively recommending the optimal implantation point by quantitatively evaluating the geometric stability and observable stability of the gold marker based on CT images before implantation, thereby preventing distribution degradation problems, avoiding rework after implantation, and ensuring tracking accuracy and treatment efficiency from the source.

Described are a carbon-iodine conjugated polymer and preparation thereof, an imaging marker thereof, and uses thereof for preparing a localization marker, and belongs to the technical field of imaging markers. The conjugated structure enables the polymer to have strong absorption in a visible light region, and high iodine content of up to 84.1% corresponds to the strong imaging ability thereof. During surgery, on the basis of the dual guidance of a polymer-based image marker and naked eye observation, the marker can better facilitate determination of tumor resection margins, achieving precise resection of tumors and minimizing damage to surrounding normal tissues. During cyberknife-based treatment, the polymer can replace clinical gold markers to provide ray marker guidance. Absence of metal artifacts improves ray imaging quality and the accuracy of radiation dose distribution, good biocompatibility enhances the stability of the relative position of the marker, and radiotherapy side effects can be further reduced.

The embodiment of the invention belongs to the technical field of detection, and relates to a test strip and a kit for detecting lung cancer autoantibodies and application, the test strip comprises a first colloidal gold test paper, a second colloidal gold test paper, a third colloidal gold test paper, a fourth colloidal gold test paper, a fifth colloidal gold test paper, a sixth colloidal gold test paper and a seventh colloidal gold test paper, a p53 protein gold marker and a p53 recombinant antigen are arranged on the first colloidal gold test paper; a PGP9.5 protein gold marker and a PGP9.5 recombinant antigen are arranged on the second colloidal gold test paper; an SOX2 protein gold marker and an SOX2 recombinant antigen are arranged on the third colloidal gold test paper; a GAGE7 protein gold marker and a GAGE7 recombinant antigen are arranged on the fourth colloidal gold test paper; a GBU4-5 protein gold marker and a GBU4-5 recombinant antigen are arranged on the fifth colloidal gold test paper; an MAGEA1 protein gold marker and an MAGEA1 recombinant antigen are arranged on the sixth colloidal gold test paper; and a CAGE protein gold marker and a CAGE recombinant antigen are arranged on the seventh colloidal gold test paper. According to the invention, instant detection is realized while the detection sensitivity is ensured.

The present invention discloses a novel coronavirus detection test strip and a preparation method and a use method thereof, including a liner, a sample pad, a gold labeling pad, a detection pad and a water absorbing plate are sequentially arranged from one end to the other end of the liner, a nitrocellulose membrane is arranged on the surface of the detection pad, and a T line and a C line are arranged on the nitrocellulose membrane; the detection T line is coated with a sialic acid ligand fixed substance, and the sialic acid ligand fixed substance includes a sialic acid ligand molecule with high affinity; the quality control C line is coated with a control substance, and the control substance is a novel coronavirus S protein; the gold labeling pad is sprayed with a colloidal gold marker, and the colloidal gold marker is a gold nanoparticle with a sialic acid ligand molecule with medium affinity fixed on the surface. The present invention provides a test strip that can directly detect novel coronavirus particles, which can quickly and conveniently determine whether the sample contains virus particles, and then quickly determine whether the subject is infectious.

The invention provides a colloidal gold marker for parathion pesticide based on nano-antibodies and its application. The present invention develops for the first time the combination of parathion nano-antibodies and colloidal gold to prepare parathion nano-antibody-colloidal gold markers for the detection of parathion pesticides. The detection stability and sensitivity of the parathion nano-antibody-colloidal gold marker are good; the nano-antibody colloidal gold test strips for parathion pesticides prepared therefrom have the advantages of high sensitivity, strong specificity, low cost, simple operation, short detection time, easy storage and long shelf life. The test strips provided by the present invention have a sensitivity of 0.0013-0.085 mg / kg for the detection of parathion pesticide residues, and a detection limit of 0.00069 mg / kg. They can be used for the rapid detection of parathion pesticides in agricultural products such as vegetables and fruits. The method is simple, fast, intuitive, accurate, widely applicable, low cost and easy to promote and use.

The utility model relates to a stabilizer and a gold label implanting device, belongs to the technical field of medical instruments, and solves the problems in the prior art that the spatial position is easy to change, the stability is poor and the accuracy of gold label implanting is easy to influence when a gold label is implanted in the gold label implanting device. The device comprises a supporting piece, a fixing plate and a telescopic adjusting mechanism. The supporting piece comprises a fixed body and at least one telescopic body, and the fixed body is fixedly connected with the gold label implanting device; one end of the telescopic body is slidably connected with the fixed body, and the other end is fixedly connected with the fixed plate; the telescopic adjusting mechanism comprises a driving unit, a reversing unit and a telescopic unit, one end of the telescopic unit is connected with the fixed body, and the other end is connected with the telescopic body; the reversing unit is arranged on the telescopic unit in a sleeving mode and connected with the driving unit. According to the utility model, the spatial position of the gold label implanting device is kept unchanged without being held by a medical worker, so that the stability and the gold label implanting precision of the gold label implanting device are improved, and the operation of the medical worker is facilitated.

This application provides a method and system for planning the implantation location of gold markers based on dual-channel X-ray imaging geometry, relating to the field of image-guided radiotherapy technology. The method includes acquiring a patient's CT image data; determining several gold marker implantation points based on the CT image data; combining the gold marker implantation points according to a preset aggregation rule to construct several gold marker point sets; evaluating the resolvability of the gold marker point set based on the projection distance between any two gold marker implantation points in the two-channel DR imaging; and evaluating the non-overlapping nature of the gold marker point set based on the projection position of each gold marker implantation point in the two-channel DR imaging. This invention uses CyberKnife dual-channel projection geometry to quantitatively evaluate resolvability and non-overlapping, enabling preoperative planning of optimal implantation schemes, avoiding tracking failures caused by two-dimensional projection issues, and significantly improving treatment safety and efficiency.

The application discloses a real-time positioning method of a tumor target area and a gold mark implant, and belongs to the technical field of tumor positioning, and specifically comprises the following steps: implanting a gold mark in a tumor area, constructing a gold mark-tumor dynamic model through CT and acquiring a respiratory phase feature vector; a two-dimensional projection is matched with a three-dimensional model in space by using an improved hybrid registration algorithm, and a tumor composite displacement vector is acquired; a respiratory-displacement correlation model is established through time sequence alignment, a tumor motion atlas containing a real-time position and a predicted trajectory is generated, and a reference coordinate system is updated; a rigid safety boundary is established based on the gold mark, an elastic treatment boundary is generated by combining convolutional neural network analysis of soft tissue texture and the predicted trajectory, and a non-marked area dose weight is dynamically adjusted; and finally, sub-millimeter dynamic tracking is executed through a multi-leaf collimator; the problems of tumor motion uncertainty and individual deformation difference are solved, and the target area coverage precision and dose distribution rationality are improved.

1. The name of the design product: positioning marker (radiotherapy). 2. The use of the design product: a metal marker for matching gold marker implanters for implanting into the human body, used for clinical routine treatment, physiotherapy and tumor radiotherapy and chemotherapy, and used for matching medical instruments and equipment to track and position specific lesion tissues. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view. 5. The reference diagram in use is the state of the product implanted into the lesion site by the gold marker implanter.