Whitening and anti-aging composition suitable for sensitive skin and application of whitening and anti-aging composition

Abstract

The invention relates to a whitening and anti-aging composition suitable for sensitive skin and application of the whitening and anti-aging composition, and belongs to the technical field of cosmetics. The composition comprises bakuchiol, hydrolyzed royal jelly protein, a radix pseudostellariae extract and a golden camellia flower extract as active ingredients. The bakuchiol has the effects of resisting aging, resisting oxidation, resisting inflammation and the like; the hydrolyzed royal jelly protein can help to relieve skin discomfort, preserve moisture, enhance the skin barrier function and the like; the golden camellia flower extract has the effects of resisting light aging, whitening skin, fading spots, resisting inflammation and relieving allergy, and the radix pseudostellariae extract has the effects of resisting inflammation, resisting oxidation, resisting aging and the like. According to the composition disclosed by the invention, through reasonable blending of the components, synergistic interaction can be realized, the effects of resisting inflammation, whitening and delaying senescence are remarkably improved, and the composition contains natural components, is mild and non-irritant, is suitable for sensitive skin and can be applied to various cosmetics.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a whitening and anti-aging composition suitable for sensitive skin and applications thereof. Background Art

[0002] As consumers continue to demand more refined skin care, skin care products with both whitening and anti-aging effects have become an important segment of the cosmetics market. However, traditional whitening and anti-aging products are mostly designed for healthy skin, and their active ingredients (such as high concentrations of vitamin C, retinol, and fruit acids) are often highly irritating, easily causing adverse reactions such as redness, stinging, and peeling in people with sensitive skin. According to statistics, approximately 50% of consumers worldwide describe themselves as having sensitive skin or occasionally sensitive skin. Among them, Asians have a thinner stratum corneum and a relatively fragile skin barrier function, and the demand for mild and effective skin care products is particularly urgent.

[0003] In the existing technology, the whitening and anti-aging solutions for sensitive skin have the following main defects:

[0004] Balancing efficacy and mildness is difficult. Traditional whitening ingredients (such as hydroquinone and kojic acid) and anti-aging ingredients (such as retinoic acid and its derivatives) work by inhibiting tyrosinase activity or promoting collagen regeneration. However, their potent mechanisms of action can easily damage the already fragile skin barrier of sensitive skin, inducing inflammatory responses. While some products use low-concentration formulas or encapsulation techniques to reduce irritation, their efficacy is significantly weakened, making it difficult to meet consumer demand for results.

[0005] Insufficient ingredient synergy: Existing technologies focus on optimizing single-functional ingredients (e.g., nano-sized vitamin C derivatives, sustained-release retinol), but lack multi-target synergistic design for both whitening and anti-aging pathways. For example, whitening ingredients may only act on melanin production without simultaneously inhibiting skin damage caused by oxidative stress or inflammatory mediators; anti-aging ingredients may only promote collagen synthesis without repairing DNA damage or basement membrane degradation caused by photoaging.

[0006] Incompatibility between soothing systems and active ingredients. To alleviate irritation, some products incorporate soothing ingredients like bisabolol and ceramides. However, these substances have poor compatibility with active ingredients (such as vitamin C, which requires an acidic pH), which can easily lead to inactivation of active ingredients or reduced formula stability. Furthermore, traditional soothing ingredients focus primarily on immediate soothing effects and lack intervention for long-term skin barrier repair.

[0007] Due to the contradiction between permeability and safety, in order to improve the transdermal absorption of effective ingredients, existing technologies often use chemical transdermal absorption enhancers (such as propylene glycol, ethanol) or physical penetration-enhancing methods (such as microneedles, iontophoresis), but such methods may further damage the stratum corneum structure of sensitive skin and aggravate skin sensitivity.

[0008] The neglect of the unique physiological mechanisms of sensitive skin, along with its inflammatory response, increased transepidermal water loss (TEWL), and neurological hyperreactivity, requires whitening and anti-aging formulas to combine anti-inflammatory, moisturizing, and neurological calming properties. The development of sensitive skin is primarily related to a compromised skin barrier function. Excessive cleansing, frequent exfoliation, the use of irritating cosmetics or skincare products, and long-term exposure to environmental factors such as pollution and ultraviolet rays can all damage the skin barrier, leading to water loss and increased penetration of external irritants, which can cause sensitive symptoms such as redness, stinging, and itching.

[0009] In response to the refined demands of people with sensitive skin for skin care products, there is an urgent need to develop whitening and anti-aging compositions suitable for sensitive skin. Summary of the Invention

[0010] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a whitening and anti-aging composition suitable for sensitive skin and its application. The composition provided by the present invention can significantly improve the dullness of sensitive skin, have significant whitening and anti-aging effects, and is mild and non-irritating. It has multiple functions such as anti-photoaging, moisturizing, anti-inflammatory and soothing. It is suitable for long-term use on sensitive skin and can protect and repair the skin barrier.

[0011] To achieve the above object, the technical solution adopted by the present invention is:

[0012] In a first aspect, the present invention provides a whitening and anti-aging composition suitable for sensitive skin, the composition comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract and Camellia chrysantha extract as active ingredients.

[0013] Preferably, the weight ratio of bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract and Camellia chrysantha extract in the composition provided in the first aspect is (5-8): (10-15): (15-20): (10-20).

[0014] Further preferably, the weight ratio of bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract and Camellia chrysantha extract in the composition provided in the first aspect is (6-8): (11-14): (16-18): (14-16), and further preferably 7:12:16:15.

[0015] Preferably, the preparation method of the Camellia chrysantha extract comprises the following steps: mixing Camellia chrysantha powder with an ethanol aqueous solution with a volume fraction of 55-75%, ultrasonic extraction at 30-45°C for 0.5-1h, with an ultrasonic power of 80-120W, filtering, concentrating, and freeze-drying after the extraction to obtain the Camellia chrysantha extract, wherein the material-liquid ratio of the Camellia chrysantha powder to the ethanol aqueous solution is 1g:(10-20)mL.

[0016] In a second aspect, the present invention further provides a method for preparing a whitening and anti-aging composition suitable for sensitive skin, comprising: mixing the components to obtain the composition.

[0017] In a third aspect, the present invention further provides a use of a whitening and anti-aging composition suitable for sensitive skin in the preparation of cosmetics.

[0018] In a fourth aspect, the present invention further provides a cosmetic comprising the whitening and anti-aging composition suitable for sensitive skin described in the first aspect.

[0019] Preferably, the cosmetics described in the fourth aspect further include excipients acceptable in cosmetics, and the excipients include at least one of an emulsifier, a moisturizer, a thickener, a preservative, a flavoring agent, and a transdermal absorption enhancer.

[0020] Preferably, the amount of the whitening and anti-aging composition described in the first aspect added to the cosmetic described in the fourth aspect is 0.1-10 wt %.

[0021] More preferably, the cosmetic is any one of an aqueous solution, an essence, an essence lotion, a facial mask or a cream.

[0022] Bakuchiol (CAS No. 10309-37-2) is a natural terpenoid compound extracted from the seeds of the leguminous plant Psoralea corylifolia. It is a prenylphenol derivative. Its chemical structure is unique, with a molecular formula of C 18 H 24 O, molecular weight 256.38, easily oxidized. Bakuchiol can stimulate the synthesis of type I collagen and other collagen in the dermis by activating retinol receptors, improving skin elasticity and reducing wrinkles. It inhibits the activity of matrix metalloproteinases (MMP-1, MMP-3), reduces collagen degradation, and improves wrinkle depth. Clinical studies have shown that 0.5% bakuchiol cream is as effective as retinol in improving photoaging within 12 weeks. Bakuchiol can promote healthy metabolism of the epidermal stratum corneum, smooth the skin, improve tolerance, and has no side effects such as stinging and peeling. It is suitable for people with sensitive skin and those who are anti-aging.

[0023] Hydrolyzed royal jelly protein is a complex of small molecule peptides and amino acids obtained by enzymatic hydrolysis of royal jelly. It combines the nutritional activity of royal jelly with better skin permeability. The large molecular proteins in royal jelly are hydrolyzed into low molecular weight peptides by proteases, significantly improving the efficiency of transdermal absorption. The core active ingredients of royal jelly (such as royal jelly acid, amino acids, and vitamins) are retained, but the problems of poor stability and sensitization of natural royal jelly are avoided. It promotes collagen regeneration and anti-aging, stimulates fibroblast proliferation, and upregulates the expression of collagen (type I / III) and elastic fiber synthesis genes; it has anti-inflammatory and soothing effects, stimulates fibroblast proliferation, upregulates the expression of collagen (type I / III) and elastic fiber synthesis genes, inhibits histamine release, relieves lactic acid-mediated stinging reactions (suitable for sensitive skin), blocks the MAPK / NF-κB inflammatory signaling pathway, and reduces the release of pro-inflammatory factors such as TNF-α and IL-6. Antioxidant, rich in superoxide dismutase and small molecule peptides, which can effectively clear ROS free radicals, reduce lipid peroxidation, and maintain the integrity of the stratum corneum lipid barrier; the hydrolyzate is rich in hydrophilic amino acids such as proline and lysine, which enhance the hydration capacity of the stratum corneum and reduce the transepidermal water loss rate (TEWL); indirectly inhibit tyrosinase activity (by downregulating MITF transcription factor), reduce melanin synthesis, and the effect is better than kojic acid.

[0024] Pseudostellaria heterophylla extract is derived from the dried root tuber of Pseudostellaria heterophylla, a plant in the Caryophyllaceae family. Its main active ingredients include triterpenoid saponins (such as Pseudostellaria heterophylla saponin A, which has antiviral and anti-inflammatory properties), polyphenols and polysaccharides (such as Pseudostellaria heterophylla polysaccharides, which can enhance immunity and lower blood sugar), and flavonoids (such as Pseudostellaria heterophylla flavonoids, which have antioxidant and antibacterial properties). It fights photoaging by increasing skin SOD activity, reducing the lipid peroxidation product MDA, and increasing the content of hydroxyproline, a collagen marker. It also whitens and reduces dark spots by inhibiting tyrosinase activity, inhibiting pigment synthesis, and synergizing with antioxidants to reduce oxidative stress-induced pigmentation.

[0025] Camellia chrysantha extract is rich in active ingredients such as polyphenols (such as flavanols, phenolic acids), flavonoids (such as quercetin, kaempferol), saponins, polysaccharides, amino acids, volatile oils, etc., which can exert strong antioxidant and anti-inflammatory effects, regulate skin immunity and promote cell renewal, form a moisturizing film to repair the skin barrier, and reduce sensitive symptoms such as redness, swelling, and itching.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] Sensitive skin is prone to common problems such as dryness, redness, itching, and allergies in response to different substances, and therefore requires special cosmetics to improve skin condition. The present invention provides a composition of bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract, and Camellia chrysantha extract, which has anti-inflammatory and soothing, antioxidant, whitening, skin barrier repair, and anti-aging effects. The composition is compounded by specific components and dosages so that each ingredient can fully exert its efficacy and form a synergistic effect with each other. Specific experiments in the specific embodiments have demonstrated that the composition can effectively achieve skin care effects through anti-inflammatory and soothing, antioxidant, whitening, and anti-aging effects, and is suitable for sensitive skin.

[0028] The compositions of the present invention all use natural and mild plant extracts as raw materials, so that the compositions have significant efficacy while also being mild and non-irritating, suitable for people with sensitive skin, and can be applied to various cosmetics, with good market application prospects.

[0029] Figures in the specification

[0030] Figure 1 Comparative Example 5: Mild irritation image of skin irritation test on 3 nude mice in the low-dose group. DETAILED DESCRIPTION

[0031] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0032] It should be understood that the present invention is not limited to the specific compositions, methods or protocols described herein. In addition, unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the present invention belongs. It should also be understood that the terminology used herein is only for the purpose of describing specific embodiments and is not intended to limit the scope of the present invention, which is defined solely by the claims.

[0033] In the following examples, experimental methods without specific conditions are generally performed under conventional conditions or those recommended by the manufacturer. Unless otherwise specified, the materials, reagents, and instruments used are commercially available.

[0034] Some of the raw materials and their sources are as follows:

[0035] Bakuchiol: purchased from Nanjing Longze Pharmaceutical Chemical Co., Ltd.

[0036] Hydrolyzed royal jelly protein: purchased from Baoji Fangsheng Biological Development Co., Ltd.

[0037] Pseudostellariae Radix Extract: purchased from Gansu Yishengxiang Biotechnology Co., Ltd.

[0038] Centella asiatica extract: purchased from Gansu Yishengxiang Biotechnology Co., Ltd.

[0039] Honeysuckle extract: purchased from Gansu Yishengxiang Biotechnology Co., Ltd.

[0040] Hydrolyzed collagen: purchased from Dongguan Hengyi Biotechnology Co., Ltd.

[0041] Camellia chrysantha extract: homemade, the preparation method is: collect Camellia chrysantha flowers, wash them and put them into a constant temperature oven at 60℃ to dry to constant weight, grind them and pass them through a 100-mesh sieve, collect the sieve underflow to obtain Camellia chrysantha powder; add 70% ethanol aqueous solution with a volume fraction to the Camellia chrysantha powder at a material-liquid ratio of 1g:15mL, mix well, ultrasonically extract at 40℃ for 30min, and the ultrasonic power is 100W. After the extraction is completed, filter and collect the filtrate, and concentrate the filtrate by rotary evaporation at 50℃. After concentration, place it in an ultra-low temperature freeze dryer for freeze-drying to obtain Camellia chrysantha extract.

[0042] Example 1

[0043] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract, with the weight ratio of the components being 7:12:16:15.

[0044] Example 2

[0045] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract, with the weight ratio of the components being 6:14:17:13.

[0046] Example 3

[0047] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract, with the weight ratio of the components being 7:13:16:16.

[0048] Example 4

[0049] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract, with the weight ratio of the components being 8:11:18:18.

[0050] Comparative Example 1

[0051] A whitening and anti-aging composition suitable for sensitive skin, comprising hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract, and Camellia chrysantha extract, with the weight ratio of the components being 12:16:15; and the component bakuchiol is reduced compared with Example 1.

[0052] Comparative Example 2

[0053] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, pseudoginseng extract, and golden camellia extract, with the weight ratio of each component being 7:16:15; and the component hydrolyzed royal jelly protein is reduced compared with Example 1.

[0054] Comparative Example 3

[0055] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein and golden camellia flower extract, with the weight ratio of each component being 7:12:15; and the component Pseudostellariae Radix Extract is reduced compared with Example 1.

[0056] Comparative Example 4

[0057] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein and Pseudostellaria heterophylla extract, with the weight ratio of the components being 7:12:16; and the component Camellia chrysantha extract is reduced compared with Example 1.

[0058] Comparative Example 5

[0059] Compared with Example 1, the only difference is that in the composition of Comparative Example 5, an equal amount of retinol is used to replace bakuchiol.

[0060] Comparative Example 6

[0061] Compared with Example 1, the only difference is that in the composition of Comparative Example 6, an equal amount of hydrolyzed collagen is used to replace the hydrolyzed royal jelly protein.

[0062] Comparative Example 7

[0063] Compared with Example 1, the only difference is that in the composition of Comparative Example 7, an equal amount of Centella asiatica extract is used to replace the Pseudostellaria baicalensis extract.

[0064] Comparative Example 8

[0065] Compared with Example 1, the only difference is that in the composition of Comparative Example 8, an equal amount of honeysuckle extract is used to replace the golden camellia extract.

[0066] Comparative Example 9

[0067] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract, with the weight ratio of the components being 3:16:10:25.

[0068] Comparative Example 10

[0069] A whitening and anti-aging composition suitable for sensitive skin, comprising bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract, with the weight ratio of the components being 7:8:25:7.

[0070] Table 1 Ingredients of Examples 1-4 and Comparative Examples 1-10 (parts by weight)

[0071]

[0072]

[0073] Performance test verification of Examples 1-4 and Comparative Examples 1-10

[0074] 1. Skin irritation test:

[0075] The whitening and anti-aging compositions for sensitive skin of Examples 1-4 and Comparative Examples 1-10 were prepared into deionized water solutions at three concentrations: low, medium, and high: 0.05 g / mL, 0.01 g / mL, and 0.15 g / mL. Skin irritation tests were conducted on 8 nude BALB / c mice per group (5 male and 5 female mice randomly selected). 50 μL of the composition was applied to the backs of the mice (0.5 cm × 0.5 cm) twice daily, once in the morning and once in the evening (8 hours apart). The mice were observed for behavior and skin condition every day for 4 consecutive weeks. Scoring was performed according to the following criteria:

[0076] Mouse skin condition Rating / points Normal skin 5 Mild irritation (redness, mild rash, dryness, peeling, etc.) 3 Rash, edema, ulcers, blisters, scratching 2 Poor activity, death 0

[0077] Table 2 Results of skin irritation test after 4 weeks

[0078]

[0079]

[0080]

[0081] As can be seen from the table above, after 4 weeks of skin irritation test, the three concentrations of the whitening and anti-aging compositions of Examples 1-4 did not produce any irritation reaction on the mice, and did not cause redness, slight rash, dryness, peeling and other minor irritation on the mouse skin. This shows that the whitening and anti-aging compositions of Examples 1-4 have good soothing properties. However, compared with Example 1, Comparative Example 5 uses retinol instead of bakuchiol. The low, medium and high concentration groups of Example 5 have different degrees of skin irritation. The skin of 3 mice in the low concentration group showed redness (see the attached figure of the specification). Figure 1 ), 6 and 8 mice in the medium and high concentration groups, respectively, developed rashes and scratching to varying degrees.

[0082] 2. Anti-inflammatory performance test

[0083] Experimental materials: The cell line used was RAW264.7 cells in the logarithmic growth phase (Wuhan Saios Biotechnology Co., Ltd.), and TNF-α and IL-6 inflammatory factor detection kits were used (Abcam).

[0084] The specific test methods are as follows:

[0085] (1) Inoculation: Cells were inoculated into culture flasks and 24-well culture plates at a culture density of 1×10 6 cells / mL, using DMEM culture medium (Gibco) containing 10% fetal bovine serum, and incubated in a 37°C, 5% CO2 incubator for 24 h;

[0086] (2) Modeling:

[0087] Control group: remove the supernatant from the 24-well plate, and add 0.5 μL of DMEM culture medium and 0.1 μL of PBS solution to each of the 6 wells in parallel;

[0088] Lipopolysaccharide (LPS) validation model group: remove the supernatant in the 24-well plate, and add 500 μL of DMEM culture medium and 100 μL of LPS solution to each of the 6 wells in parallel.

[0089] Experimental group: the supernatant in the 24-well plate was removed, and 500 μL of DMEM culture medium, 100 μL of a mixed solution of LPS and samples (example and comparative example samples) were added to each of 6 parallel wells.

[0090] (3) Detection: After incubation for 24 h at 37°C and 5% CO2, the supernatant was collected and the samples were centrifuged in centrifuge tubes. The supernatant was used for inflammatory factor concentration detection. Calculation: Inflammatory factor inhibition rate (%) = [(average inflammatory factor content in the model group - average inflammatory factor content in the treatment group) / (average inflammatory factor content in the model group - average inflammatory factor content in the blank control)] × 100%.

[0091] Table 3 Inflammatory factor inhibition rate

[0092]

[0093]

[0094] According to the results in Table 3, 1) the whitening and anti-aging compositions of Examples 1-4 had inhibition rates on inflammatory factors TNF-α and IL-6 of 85.6%-89.4% and 81.4%-84.1%, respectively, indicating that the compositions had significant anti-inflammatory and soothing effects. 2) Comparison of the experimental results of Example 1 with those of Comparative Examples 1-4 showed that the combination of the four components in the examples could achieve anti-inflammatory and soothing effects. After reducing a specific component, the inhibition rates on inflammatory factors TNF-α and IL-6 were reduced to 37.7%-55.9% and 42.7%-49.8%, respectively, and the anti-inflammatory effect of the composition was significantly reduced. 3) Compared with Example 1, in Comparative Examples 5-8, a component in the whitening and anti-aging composition was replaced with a functional analogue, and the inhibition rates on inflammatory factors TNF-α and IL-6 were reduced to 42.7%-56.4% and 43.9%-53.1%, respectively. 4) Comparative Examples 9 and 10, compared with Example 1, adjust the weight ratio of each component in the composition, resulting in a significant decrease in the inhibition rate of inflammatory factors TNF-α and IL-6. The above experimental results show that the bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract and Camellia chrysantha extract in the composition of the present invention can play a synergistic role in anti-inflammatory and soothing effects. Similar functional components cannot achieve the same or similar anti-inflammatory and soothing effects when compounded. At the same time, the dosage ratio of the four components in the present invention can also have a significant impact on the anti-inflammatory and soothing effects.

[0095] 3. Anti-aging performance test

[0096] The whitening and anti-aging compositions described in Examples 1-4 and Comparative Examples 1-10 were subjected to a DPPH free radical scavenging test.

[0097] Test method: 4.0 mL of 1×10 -4 mol / L DPPH solution and 0.5mL of deionized water with the same concentration of sample (0.01g / mL), seal with sealing film and shake to mix, immediately detect the absorbance A1 at 517nm, react in the dark for 30min, and detect the absorbance A2 at 517nm; add 4.0mL DPPH solution and 0.5mL sample dilution solvent (deionized water) into the test tube, shake to mix, and measure the absorbance value, which is recorded as A0.

[0098] DPPH free radical scavenging rate: Y = [1-(A2-A1) / A0] × 100%.

[0099] Table 4 DPPH free radical scavenging rate

[0100] Group DPPH free radical scavenging rate (%) Example 1 93.5％ Example 2 88.7％ Example 3 89.4％ Example 4 93.2％ Comparative Example 1 58.3％ Comparative Example 2 67.1％ Comparative Example 3 72.0％ Comparative Example 4 73.9％ Comparative Example 5 63.4％ Comparative Example 6 71.7％ Comparative Example 7 76.6％ Comparative Example 8 74.5％ Comparative Example 9 81.4％ Comparative Example 10 79.3％

[0101] According to the results in Table 4, the whitening and anti-aging compositions described in Examples 1-4 have significant anti-aging effects, and the DPPH free radical scavenging rates are in the range of 88.7%-93.5%, indicating significant anti-aging effects. Comparison of the experimental results of Comparative Examples 1-10 with Comparative Example 1 shows that the bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract and Camellia chrysantha extract in the composition of the present invention can play a synergistic role in anti-aging effects, and it is difficult to achieve the same or similar effects by compounding similar functional components or changing the dosage ratio of the four components.

[0102] Application Examples

[0103] Application Examples 1-4 and Comparative Application Examples 1-10 of the present invention provide a skin care lotion, the components (mass percentage) of which are shown in Table 5; wherein, Application Examples 1-4 and Comparative Application Examples 1-10 respectively use the whitening and anti-aging compositions suitable for sensitive skin prepared in Examples 1-4 and Comparative Examples 1-10.

[0104] Table 5 Ingredients of skin care lotion

[0105]

[0106] The preparation method of the skin care emulsion comprises the following steps:

[0107] Heat sterile deionized water to 50°C, add carbomer and sodium hyaluronate, and stir until completely dissolved; subsequently add arginine and the whitening and anti-aging composition provided in the examples or comparative examples and stir thoroughly; subsequently add glycerin, propylene glycol, cocoyl glucoside, and glyceryl glucoside and stir thoroughly, homogenize and emulsify with a high-pressure homogenizer, cool to room temperature, and discharge to obtain a skin care lotion.

[0108] 1. Application example: human patch test of skin care lotion

[0109] Experimental Method: A human patch test was used to verify the irritation of Application Examples 1-4 to sensitive skin. The specific test method was based on the "Technical Specifications for Safety of Cosmetics" (2015 edition). The grading standards for adverse skin reactions are shown in Table 6.

[0110] Forty volunteers were recruited, half male and half female, aged 19-55 years, with an average age of 32. First, a suitable patch tester was selected and, using the closed patch test method, an equal amount of the test substance, approximately 25 μL, was placed into the patch tester. The patch was then applied to the volunteer's arm using hypoallergenic tape, with gentle pressure applied to ensure even adhesion. After 24 hours, the test substance was removed. Skin reactions were observed 0.5, 24, and 48 hours after patch removal. Adverse skin reactions were recorded and the results are shown in Table 7.

[0111] Table 6 Grading standards for adverse skin reactions

[0112]

[0113] Table 7 Record results of adverse reactions of skin

[0114]

[0115]

[0116] The patch test results show that no adverse skin reactions occurred in Application Examples 1-4, which is consistent with the results of the skin irritation test in Table 2 after 4 weeks. This shows that the whitening and anti-aging compositions suitable for sensitive skin prepared in Examples 1-4 of the present invention and the skin care lotions of Application Examples 1-4 prepared from the compositions have good skin affinity, are non-irritating, and are non-sensitizing.

[0117] 2. Application example: whitening performance test

[0118] 100 volunteers aged between 20 and 50 with whitening needs were selected as subjects and randomly divided into 10 groups, with 10 people in each group. Each group used the skin care lotion prepared by Application Examples 1-4 and Comparative Application Examples 1-10 respectively. The subjects applied the skin care lotion on their faces once in the morning and once in the evening every day for 4 weeks. The skin red-melanin tester HexameterMX18 was used to evaluate the changes in the melanin content of the subjects' skin before and after using the skin care lotion. The average melanin content before use was recorded as M1, and the average melanin content after 4 weeks of use was recorded as M2. Melanin inhibition rate T = (M1-M2) / M1×100%.

[0119] Table 8 Melanin inhibition rate results

[0120] Group Melanin inhibition rate T (%) Application Example 1 31.71％ Application Example 2 28.63％ Application Example 3 29.44％ Application Example 4 30.58％ Comparative Application Example 1 7.46％ Comparative Application Example 2 9.59％ Comparative Application Example 3 10.95％ Comparative Application Example 4 11.38％ Comparative Application Example 5 14.54％ Comparative Application Example 6 16.57％ Comparative Application Example 7 15.60％ Comparative Application Example 8 14.55％ Comparative Application Example 9 16.74％ Comparative Application Example 10 17.36％

[0121] According to the results in Table 8, the skin care lotions described in Application Examples 1-4 can significantly and effectively reduce the inhibition rate of melanin compared with Comparative Application Examples 1-4, which shows that the whitening and anti-aging compositions suitable for sensitive skin described in Examples 1-4 of the present invention have significant whitening effects.

[0122] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the content of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A whitening and anti-aging composition suitable for sensitive skin, characterized in that: The composition comprises bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract as active ingredients.

2. The whitening and anti-aging composition suitable for sensitive skin according to claim 1, characterized in that: The weight ratio of the bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria chinensis extract and Camellia chrysantha extract is (5-8): (10-15): (15-20): (10-20).

3. The whitening and anti-aging composition suitable for sensitive skin according to claim 1, characterized in that: The weight ratio of bakuchiol, hydrolyzed royal jelly protein, Pseudostellaria heterophylla extract and Camellia chrysantha extract is (6-8): (11-14): (16-18): (14-16).

4. The whitening and anti-aging composition suitable for sensitive skin according to any one of claims 1 to 3, characterized in that: The preparation method of the Camellia chrysantha extract comprises the following steps: mixing Camellia chrysantha powder with ethanol water solution, ultrasonically extracting, filtering, concentrating, and freeze-drying after the extraction to obtain the Camellia chrysantha extract.

5. The method for preparing the whitening and anti-aging composition suitable for sensitive skin according to any one of claims 1 to 4, characterized in that: The following steps are involved: The components are mixed to obtain the composition.

6. A cosmetic, characterized in that: A whitening and anti-aging composition suitable for sensitive skin comprising the composition according to any one of claims 1 to 4.

7. The cosmetic according to claim 6, characterized in that The cosmetics further include auxiliary materials acceptable in cosmetics, and the auxiliary materials include at least one of an emulsifier, a moisturizer, a thickener, a preservative, a flavoring agent, and a transdermal absorption enhancer.

8. The cosmetic according to claim 6, characterized in that The amount of the whitening and anti-aging composition added to the cosmetic is 0.1-10 wt %.

9. The cosmetic according to any one of claims 6 to 8, characterized in that The cosmetic is any one of an aqueous solution, an essence, an essence lotion, a facial mask or a cream.

10. Use of the whitening and anti-aging composition suitable for sensitive skin according to claims 1-4 in the preparation of cosmetics.

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