Acne-removing composition capable of fading acne marks and preventing relapse and application of acne-removing composition

Abstract

The invention relates to an acne-removing composition for fading acne marks and preventing relapse and application thereof. The acne-removing composition comprises a first functional component, an olive leaf extract and a lactobacillus / rye fine powder fermentation product, the first functional component comprises centella asiatica extract, madecassoside and glucose. The centella asiatica extract, madecassoside and the lactobacillus / rye fine powder fermentation product in the composition disclosed by the invention contain various active chemical substances, so that the composition can help to support a skin barrier function, reduce skin sensitivity, improve skin moisture retention capacity, inhibit various inflammatory factors and play a soothing role; the olive leaf extract is rich in natural antioxidants and natural antibacterial components, free radicals can be removed, and the inflammation problem caused by lipid peroxidation is inhibited. The components can be mutually matched and synergistically interacted, so that the acne cream has excellent effects of relieving, resisting oxidation, improving the sensitive and red phenomenon of the acne skin, improving the skin barrier capability of the acne skin and lightening acne marks, has a lasting effect and can prevent relapse.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and relates to an anti-acne composition for lightening acne marks and preventing recurrence, and an application thereof, and an anti-acne composition for lightening acne marks and preventing recurrence, and an application thereof in cosmetics. Background Art

[0002] Acne is one of the common skin problems, which is more common in adolescents. It is related to factors such as increased secretion of sex hormones in adolescents, abnormal keratinization of the sebaceous gland ducts of the hair follicles, and inflammatory response.

[0003] Common topical medicines for acne removal include retinoic acid, benzoyl peroxide, and antibiotics. However, retinoic acid can increase the photosensitivity of the skin and cause it to become red; benzoyl peroxide is somewhat irritating, and some patients may experience skin redness and peeling; antibiotics can cause bacterial resistance, and the course of treatment should not be too long. Compared with topical medicines, acne-removing skin care products, especially those from natural sources, have advantages in terms of skin irritation or safety, and are more easily accepted by consumers. Summary of the invention

[0004] In view of the deficiencies in the prior art, the object of the present invention is to provide an acne-removing composition for lightening acne marks and preventing recurrence and its application, in particular to provide an acne-removing composition for lightening acne marks and preventing recurrence and its application in cosmetics.

[0005] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0006] In a first aspect, the present invention provides an acne-removing composition for lightening acne marks and preventing recurrence, the acne-removing composition comprising a first effective ingredient, an olive leaf extract, and a lactobacillus / rye powder fermentation product;

[0007] The first effective ingredient includes Centella asiatica extract, madecassoside and glucose.

[0008] The Centella asiatica extract, madecassoside, and lactobacillus / rye powder fermentation product in the composition of the present invention contain a variety of active chemical substances, which can help support the skin barrier function, which helps to reduce skin sensitivity, improve skin moisture retention, inhibit a variety of inflammatory factors, and play a soothing role; the main component of the olive leaf extract is olive leaf, which is rich in natural antioxidants and natural antibacterial ingredients, can remove free radicals in the body, and can inhibit inflammation caused by lipid peroxidation. These components can cooperate with each other and synergize, have excellent soothing, anti-oxidation, improve acne skin sensitive redness, enhance acne skin barrier ability, lighten acne marks, and have a lasting effect to prevent recurrence.

[0009] Preferably, the first effective ingredient consists of 0.05-1% of Centella asiatica extract, 1-10% of madecassoside and 90-99% of glucose in terms of mass percentage.

[0010] The content of the Centella asiatica extract can be selected from 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5% and the like; the content of the hydroxymadecassoside can be selected from 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% and the like; the content of the glucose can be selected from 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 99% and the like.

[0011] Preferably, the anti-acne composition comprises, by mass, 1-20 parts of the first effective ingredient, 1-20 parts of olive leaf extract, and 1-20 parts of lactobacillus / rye powder fermentation product.

[0012] The 1-20 parts means that 1 part, 2 parts, 3 parts, 5 parts, 7 parts, 8 parts, 10 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 20 parts, etc. can be selected independently.

[0013] Further preferably, the anti-acne composition further comprises guaiaczul and purslane extracts.

[0014] Guaichuanxiu can soothe and repair acne-prone skin, accelerate the healing of damaged skin, prevent recurrence of acne, reduce sebum secretion, prevent acne formation, strengthen the skin barrier, and resist microorganisms and external stimuli. Purslane extract is rich in vitamin E and vitamin C, which help eliminate free radicals and stimulate cell growth and metabolism, thereby improving skin condition.

[0015] The present invention also found that adding guaiazulene and purslane extracts to the above composition can promote synergistically with other components, further improving the product's soothing, anti-oxidation, improving acne skin sensitive redness, improving acne skin barrier, fading acne marks, and preventing recurrence. And the effect of adding guaiazulene and purslane extracts at the same time is better than adding guaiazulene or purslane extracts alone.

[0016] Preferably, the anti-acne composition further comprises 0.5-10 parts of guaiaczul and 1-20 parts of purslane extract by weight.

[0017] The mass proportion of the guaiaczulene can be selected from 0.5 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 10 parts, etc.; the mass proportion of the purslane extract can be selected from 1 parts, 2 parts, 3 parts, 5 parts, 7 parts, 8 parts, 10 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 20 parts, etc.

[0018] Preferably, the anti-acne extract is prepared by a preparation method comprising the following steps:

[0019] The olive leaf extract, lactobacillus / rye powder fermentation product, optional guaiazulene and optional purslane extract are mixed at 25-45° C., and then mixed with the first effective ingredient at 20-30° C. to prepare the preparation method.

[0020] In a second aspect, the present invention provides use of the anti-acne composition according to the first aspect in preparing cosmetics.

[0021] Preferably, the cosmetics include lotions, emulsions, creams, essences, facial masks, cleansing products, and make-up removers.

[0022] Preferably, the content of the anti-acne composition in the cosmetic is 0.5-10%, for example 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 8%, 9%, 10%, etc.

[0023] In a third aspect, the present invention provides a facial cream with soothing, repairing and acne scar fading effects, wherein the components of the facial cream include the anti-acne composition described in the first aspect, a moisturizer, an antioxidant, an emollient, a thickener, an emulsifier, a skin conditioner and water.

[0024] Preferably, the components of the facial cream include, by mass percentage, 0.5-10% of the anti-acne composition described in the first aspect, 10-15% of a moisturizer, 0.05-0.5% of an antioxidant, 0.1-5% of an emollient, 0.1-1% of a thickener, 1-5% of an emulsifier, 0.1-3% of a skin conditioner, and 60-90% of water.

[0025] The content of the acne-removing composition can be selected from 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 8%, 9%, 10%, etc.; the content of the moisturizer can be selected from 10%, 11%, 12%, 13%, 14%, 15%, etc.; the content of the antioxidant can be selected from 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, etc.; the content of the emollient can be selected from 0.1%, 0.5 %, 1%, 2%, 2.5%, 3%, 3.5%, 4%, 5% and the like; the content of the thickener can be selected from 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.7%, 0.8%, 0.9%, 1% and the like; the content of the emulsifier can be selected from 1%, 2%, 3%, 4%, 5% and the like; the content of the skin conditioner can be selected from 0.1%, 1%, 1.5%, 2%, 2.5%, 3% and the like; the content of water can be selected from 60%, 65%, 70%, 75%, 80%, 85%, 90% and the like.

[0026] Preferably, the moisturizing agent includes any one of glycerin, 1,3-propylene glycol, panthenol, 1,2-hexanediol, butylene glycol, trehalose, squalane or betaine, or a combination of at least two thereof.

[0027] Preferably, the thickener includes any one of sodium polyacrylate, sodium polyacrylate grafted starch, ammonium acryloyldimethyltaurate / VP copolymer or xanthan gum, or a combination of at least two thereof.

[0028] Preferably, the emollient includes any one of white meadowfoam seed oil, sunflower seed oil, mango seed esters, grape seed oil, sweet almond oil, avocado tree butter, jojoba seed oil, avocado oil, caprylic / capric triglyceride, polydimethylsiloxane, isononyl isononanoate, cetyl ethylhexanoate or hydrogenated polyisobutene, or a combination of at least two thereof.

[0029] Preferably, the emulsifier includes any one or a combination of at least two of PEG-100 stearate, potassium cetyl phosphate, polysorbate-60, methyl glucose sesquistearate, sorbitan stearate, sorbitan polyether-30 tetraoleate, polysorbate-20, PEG-20 glyceryl triisostearate, cetearyl olive oil ester, sorbitan olive oil ester or cetyl PEG / PPG-10 / 1 polydimethylsiloxane.

[0030] Preferably, the skin conditioning agent includes Sophora flavescens extract and Cornus officinalis extract.

[0031] The facial cream involved in the present invention uses the above-mentioned acne-removing composition as the main effective ingredient. If two skin conditioners, namely, Sophora flavescens extract and Cornus officinalis extract, are additionally added, the antioxidant effect of the product can be further improved, thereby further enhancing the product's effect of improving acne-prone skin sensitivity and redness.

[0032] Preferably, the antioxidant comprises p-hydroxyacetophenone.

[0033] Preferably, the facial cream is prepared by a preparation method comprising the following steps:

[0034] The emollient and the emulsifier are mixed at 40-70°C for 5-30 minutes to obtain an oil phase; the moisturizer, the thickener and water are mixed at 40-60°C for 5-30 minutes to obtain an aqueous phase; the oil phase and the aqueous phase are mixed and emulsified at 40-60°C for 5-30 minutes, and then mixed with the anti-acne composition, the antioxidant and the skin conditioner at 20-35°C for 5-30 minutes to obtain the product.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] The Centella asiatica extract, madecassoside, and lactobacillus / rye powder fermentation product in the composition of the present invention contain a variety of active chemical substances, which can help support the skin barrier function, which helps to reduce skin sensitivity, improve skin moisture retention, inhibit a variety of inflammatory factors, and play a soothing role; the main component of the olive leaf extract is olive leaf, which is rich in natural antioxidants and natural antibacterial ingredients, can remove free radicals in the body, and can inhibit inflammation caused by lipid peroxidation. These components can cooperate with each other and synergize, have excellent soothing, anti-oxidation, improve acne skin sensitive redness, enhance acne skin barrier ability, lighten acne marks, and have a lasting effect to prevent recurrence.

[0037] The present invention also found that adding guaiazulene and purslane extracts to the above composition can promote synergistically with other components, further improving the product's soothing, anti-oxidation, improving acne skin sensitive redness, improving acne skin barrier, fading acne marks, and preventing recurrence. And the effect of adding guaiazulene and purslane extracts at the same time is better than adding guaiazulene or purslane extracts alone. DETAILED DESCRIPTION

[0038] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0039] The sources of the effective ingredients contained in the products involved in the following embodiments, comparative examples, application examples, and comparative application examples are as follows (only the effective ingredients are reflected, and other necessary auxiliary ingredients contained in commercially available raw materials are not repeated).

[0040] Centella X is a self-developed product of Guangzhou Turtle Dad Biotechnology Co., Ltd. under the trade name Centella X, which contains Centella asiatica extract, madecassoside and glucose (0.5% Centella asiatica extract, 5% madecassoside, and the balance is glucose);

[0041] The lactobacillus / rye powder fermentation product is a product of Shanghai Aoyuan New Material Technology Co., Ltd. model WoresanaSerum;

[0042] Olive leaf extract was purchased from Guangzhou Bio-Technology Co., Ltd. BT products;

[0043] Guaichuanzulone is a product of Guangzhou Tianna Biotechnology Co., Ltd.;

[0044] Purslane extract is a product of Guangzhou Sicoxi Biotechnology Co., Ltd.;

[0045] Cornus officinalis extract is a product of Xi'an Tianyi Biotechnology Co., Ltd.;

[0046] Sophora flavescens extract is a product of Guangzhou Luojie Biotechnology Co., Ltd.;

[0047] Polydimethylsiloxane is a product of Guangzhou Shengkaisi Chemical Technology Co., Ltd. with model number KF-6017;

[0048] Xanthan gum is a product of Guangzhou Wanlu Chemical Co., Ltd. with model number ClariXan TM RXC-PCM;

[0049] PEG-100 stearate is a product of Foshan Xin'an Chemical Trading Co., Ltd. with model number Emulgade 165CN.

[0050] Example 1

[0051] This embodiment provides an anti-acne composition, which includes, by mass, 15 parts of a first effective ingredient (Centella X), 10 parts of an olive leaf extract, and 15 parts of a lactobacillus / rye powder fermentation product.

[0052] The preparation method comprises the following steps: mixing olive leaf extract and lactobacillus / rye powder fermentation product at 40°C for 20 minutes, and then mixing with the first effective ingredient at 25°C for 20 minutes to obtain the product.

[0053] Example 2

[0054] This embodiment provides an acne-removing composition, which includes, by mass, 10 parts of a first effective ingredient (Centella X), 20 parts of an olive leaf extract, and 10 parts of a lactobacillus / rye powder fermentation product.

[0055] The preparation method comprises the following steps: mixing olive leaf extract and lactobacillus / rye powder fermentation product at 35°C for 20 minutes, and then mixing with the first effective ingredient at 20°C for 20 minutes.

[0056] Example 3

[0057] This embodiment provides an anti-acne composition, which includes 20 parts of a first effective ingredient (Centella X), 15 parts of an olive leaf extract, and 5 parts of a lactobacillus / rye powder fermentation product by mass.

[0058] The preparation method comprises the following steps: mixing olive leaf extract and lactobacillus / rye powder fermentation product at 35°C for 20 minutes, and then mixing with the first effective ingredient at 30°C for 20 minutes.

[0059] Example 4

[0060] This embodiment provides an anti-acne composition, which includes, by mass, 12 parts of a first effective ingredient (Centella X), 8 parts of an olive leaf extract, 12 parts of a lactobacillus / rye powder fermentation product, 6 parts of guaiazulene, and 2 parts of a purslane extract.

[0061] The preparation method is as follows: olive leaf extract, lactobacillus / rye powder fermentation product, guaiac azulene and purslane extract are mixed at 40°C for 20 minutes, and then mixed with the first effective ingredient at 25°C for 20 minutes to obtain the product.

[0062] Example 5

[0063] The present embodiment provides an anti-acne composition, which includes, by mass, 12 parts of a first effective ingredient (Centella X), 8 parts of an olive leaf extract, 12 parts of a lactobacillus / rye powder fermentation product, 2 parts of guaiazulene, and 6 parts of a purslane extract.

[0064] The preparation method is as follows: olive leaf extract, lactobacillus / rye powder fermentation product, guaiac azulene and purslane extract are mixed at 40°C for 20 minutes, and then mixed with the first effective ingredient at 25°C for 20 minutes to obtain the product.

[0065] Example 6

[0066] This embodiment provides an anti-acne composition, which includes, by mass, 12 parts of a first effective ingredient (Centella X), 8 parts of an olive leaf extract, 12 parts of a lactobacillus / rye powder fermentation product, and 8 parts of guaiacyl cyanide.

[0067] The preparation method is as follows: olive leaf extract, lactobacillus / rye powder fermentation product and guaiacyl palmitate are mixed at 40°C for 20 minutes, and then mixed with the first effective ingredient at 25°C for 20 minutes to obtain the product.

[0068] Example 7

[0069] This embodiment provides an anti-acne composition, which includes, by mass, 12 parts of a first effective ingredient (Centella X), 8 parts of an olive leaf extract, 12 parts of a lactobacillus / rye powder fermentation product, and 8 parts of a purslane extract.

[0070] The preparation method is as follows: olive leaf extract, lactobacillus / rye powder fermentation product and purslane extract are mixed at 40°C for 20 minutes, and then mixed with the first effective ingredient at 25°C for 20 minutes to obtain the product.

[0071] Comparative Example 1

[0072] This comparative example provides an anti-acne composition, the formula of which differs from that of Example 1 only in that the first effective ingredient (Centella X) is missing, and its reduced mass is proportionally distributed to the mass fractions of the olive leaf extract and the lactobacillus / rye powder fermentation product. The preparation method thereof is referred to Example 1.

[0073] Comparative Example 2

[0074] This comparative example provides an anti-acne composition, the formula of which differs from that of Example 1 only in that the olive leaf extract is missing, and the reduced mass thereof is proportionally distributed to the mass fractions of the first effective ingredient (Centella X) and the lactobacillus / rye powder fermentation product. The preparation method thereof is referred to Example 1.

[0075] Comparative Example 3

[0076] This comparative example provides an anti-acne composition, the formula of which is different from that of Example 1 only in that the lactobacillus / rye powder fermentation product is missing, and the reduced mass thereof is proportionally distributed to the mass fractions of the first effective ingredient (Centella X) and the olive leaf extract. The preparation method thereof is referred to Example 1.

[0077] Application Examples 1-3

[0078] This application example provides three types of facial creams, the formulas of which are shown in the following table:

[0079]

[0080] The preparation method is:

[0081] The emollient and the emulsifier are mixed at 60°C for 15 minutes to obtain an oil phase; the moisturizer, the thickener and water are mixed at 50°C for 15 minutes to obtain an aqueous phase; the oil phase and the aqueous phase are mixed and emulsified at 50°C for 25 minutes, and then mixed with the anti-acne composition, the antioxidant and the skin conditioner at 30°C for 25 minutes to obtain the product.

[0082] Application Example 4-7

[0083] This application example provides four types of facial creams, the formulas of which differ from those of application example 1 only in that the composition of example 1 is replaced by the compositions of examples 4-7 in equal amounts, and the other components and contents remain unchanged. The preparation method thereof is the same as that of application example 1.

[0084] Application Example 8

[0085] This application example provides a facial cream, the formula of which is different from that of application example 1 only in that the extract of Sophora flavescens is missing and the portion of the extract of Cornus officinalis is 0.2 parts, and the other components and contents remain unchanged. The preparation method thereof is the same as that of application example 1.

[0086] Application Example 9

[0087] This application example provides a facial cream, the formula of which differs from that of application example 1 only in that the cornus officinalis extract is missing and the portion of the sophora flavescens extract is 0.2 portions, and the other components and contents remain unchanged. The preparation method thereof is the same as that of application example 1.

[0088] Application Example 10

[0089] This application example provides a facial cream, the formula of which differs from that of application example 1 only in that the extract of Cornus officinalis and the extract of Sophora flavescens are missing, the mass fractions of which are supplemented by water, and the other components and contents remain unchanged. The preparation method thereof is the same as that of application example 1.

[0090] Comparative Application Examples 1-3

[0091] This comparative application example provides three types of facial creams, the formulas of which differ from those of application example 1 only in that the composition of example 1 is replaced by the compositions of comparative examples 1-3 in equal amounts, and the other components and contents remain unchanged. The preparation method thereof is the same as that of application example 1.

[0092] Test Example 1

[0093] Evaluation of irritation soothing effect:

[0094] The composition products obtained in Examples 1-7 and Comparative Examples 1-3 were subjected to a chicken embryo chorioallantoic membrane test (HET-CAM), and the specific operation was as follows:

[0095] (1) Chicken embryos at day 0 of embryonic age were placed in an incubator at a temperature of 37.5°C ± 0.5°C and a relative humidity of 55%-70% and incubated until day 9; the air chamber position was determined using an egg candling device and a small hole was drilled, the eggshell at the air chamber end was carefully removed using serrated curved tweezers, and after the eggshell membrane was completely exposed, 2 mL of physiological saline was added to moisten it, the physiological saline was removed, and the eggshell membrane was carefully peeled off using serrated curved tweezers to expose the chicken embryo chorioallantoic membrane (CAM).

[0096] (2) Use physiological saline to dilute each group of composition products to prepare a 2% composition solution and mix it with an equal volume of 1% SDS solution as the test solution. At the same time, set physiological saline as a negative control and 0.5% SDS solution as a positive control. Use a disposable sterile syringe to take 0.3mL of the test substance and add it dropwise to the surface of the CAM. When adding, pay attention to make the sample cover the CAM evenly as much as possible. Observe the changes in the blood vessels in the CAM under a stereo microscope, and record the time when bleeding, vascular melting, and coagulation begin within 5 minutes. Perform 6 parallel experiments for each test substance.

[0097] The irritation score was calculated using the following formula:

[0098] IS=(301-tsecH)×5 / 300+(301-tsecL)×7 / 300+(301-tsecC)×9 / 300

[0099] Where: tsecH is the average time for bleeding to start on the CAM, s; tsecL is the average time for vascular melting to start on the CAM, s; tsecC is the average time for coagulation to start on the CAM, s. The eye irritation of the test substance is classified according to Table 1 based on the calculated IS value.

[0100] Table 1

[0101]

[0102] The results are shown in Table 2.

[0103] Table 2

[0104] Group tX t tC IS Value Stimulus Classification Negative control group 301 301 301 0 Non-irritating Positive control group 86 20 53 17.58 Intensity of stimulation Example 1 + 0.5% SDS 128 99 301 7.60 Moderate irritation Example 2 + 0.5% SDS 112 72 301 8.49 Moderate irritation Example 3 + 0.5% SDS 73 60 301 9.42 Moderate irritation Example 4 + 0.5% SDS 241 145 301 4.64 Mild irritant Example 5 + 0.5% SDS 249 178 301 3.74 Mild irritant Example 6 + 0.5% SDS 154 118 301 6.72 Moderate irritation Example 7 + 0.5% SDS 178 142 301 5.76 Moderate irritation Comparative Example 1 + 0.5% SDS 277 113 115 10.37 Intensity of stimulation Comparative Example 2 + 0.5% SDS 261 71 121 11.43 Intensity of stimulation Comparative Example 3 + 0.5% SDS 285 52 108 11.87 Intensity of stimulation

[0105] As can be seen from the data results in Table 2, there was no bleeding, vascular melting, or coagulation in the negative control group. After adding 0.5% SDS by mass, the bleeding time was 86s, the vascular melting time was 20s, the coagulation time was 53s, and the IS value was 17.58, which was a strong irritant. After adding different compositions respectively, the irritation symptoms caused by SDS were relieved to varying degrees. Compared with the samples of Comparative Examples 1-3, Examples 1-3 illustrate that the acne-removing composition of the present invention has a more excellent soothing effect on irritation, and Centella X, olive leaf extract, and lactobacillus / rye powder fermentation product synergize in soothing effect. Comparison of the samples of Examples 1-3 and 4-7 shows that the extracts of Guaiazulene and Portulaca oleracea can further improve the soothing effect of the composition.

[0106] Test Example 2

[0107] Evaluation of antioxidant effect:

[0108] The free radical (DPPH·) scavenging test was performed on the composition products obtained in Examples 1-7 and Comparative Examples 1-3. The specific operation is as follows:

[0109] Use anhydrous ethanol to dilute the combined products of each group and the single Centella X, olive leaf extract or lactobacillus / rye powder fermentation product to prepare a test solution with a concentration of 1%. Accurately weigh a certain amount of DPPH (1.1-diphenyl-2-trinitrophenylhydrazine) and prepare a 0.2mmol DPPH solution with anhydrous ethanol. Take 2mL of each group of test substances, add 2mL of DPPH solution respectively, react in the dark for 10min, and measure the absorbance of the reaction solution at 517nm. Use the following formula for calculation:

[0110] Free radical scavenging rate = 1-(A-A1) / (A2-A3)

[0111] Wherein: A is the absorbance at 517nm after the test solution is mixed with DPPH solution; A1 is the absorbance at 517nm after the test solution is mixed with anhydrous ethanol; A2 is the absorbance at 517nm after the blank solution is mixed with DPPH solution; A3 is the absorbance at 517nm after the blank solution is mixed with anhydrous ethanol.

[0112] The results are shown in Table 3.

[0113] Table 3

[0114]

[0115]

[0116] From the data results in Table 3, it can be seen that compared with Comparative Examples 1-3 and single components Centella X, olive leaf extract or lactobacillus / rye powder fermentation product, the anti-acne composition of the present invention has significantly excellent antioxidant effect, and Centella X, olive leaf extract and lactobacillus / rye powder fermentation product have synergistic antioxidant effect. The effect of Examples 4-7 is better than that of Examples 1-3, indicating that guaiazulene and purslane extract can further synergistically improve the antioxidant effect of the composition.

[0117] Test Example 3

[0118] Human efficacy test evaluation:

[0119] (1) Subject selection:

[0120] 130 subjects who met the following conditions were selected: 18-35 years old, healthy Chinese men or women; >1 facial acne scar, >4 non-inflammatory acne (open comedones and closed comedones); able to cooperate well with the experimenter and maintain a regular life during the test; agreed not to use any cosmetics, drugs and health products that may affect the results during the trial; other subjects who were considered unsuitable for participation by clinical evaluation. This trial complies with the requirements of the Helsinki Declaration revised in 2013. All subjects understand the purpose and process of the entire trial and sign the informed consent.

[0121] (2) Test method:

[0122] This study adopted a self-control method, with 10 people in each group. The subjects applied the cream products prepared in Application Examples 1-10 and Comparative Application Examples 1-3 to their entire faces once every morning and evening for 21 consecutive days. The subjects cleaned their faces and sat quietly for 30 minutes in a test environment with a temperature of 20.5-21.5°C and a relative humidity of 50.5%-60.5% before using the cream (T0), after using it for 14 days (T1), 21 days (T2), after stopping using it for 14 days (T3), and after stopping using it for 28 days (T4), and the indicators were tested.

[0123] (3) Testing indicators:

[0124] (3.1) The transepidermal water loss value (TEWL) was measured using the Cutometer TewameterTM Hex transepidermal water loss test probe. The higher the value, the more severe the damage to the skin barrier function. The decrease rate (%) of the transepidermal water loss value of each group relative to T0 was calculated, and the results are shown in Table 4.

[0125] (3.2) Using the Skin-Colorimeter CL400 skin color probe, the a* value was measured. The higher the value, the more obvious the redness of the skin inflammation. The decrease rate (%) of the a* value of each group relative to T0 was calculated, and the results are shown in Table 5.

[0126] (3.3) The hemoglobin content was measured using the Mexameter MX 18 skin melanin and hemoglobin probe. The higher the value, the more obvious the redness of the skin inflammation. The decrease rate (%) of the hemoglobin content of each group relative to T0 was calculated, and the results are shown in Table 6.

[0127] Table 4

[0128]

[0129]

[0130] Table 5

[0131]

[0132]

[0133] Table 6

[0134] Group T1(％) T2(％) T3(％) T4(％) Application Example 1 22.84 25.68 28.96 28.12 Application Example 2 22.53 25.12 28.13 27.98 Application Example 3 21.87 24.9 27.39 27.51 Application Example 4 27.51 33.24 36.55 36.42 Application Example 5 27.12 32.98 36.44 36.49 Application Example 6 24.18 28.87 30.73 30.21 Application Example 7 24.33 27.66 29.87 30.01 Application Example 8 20.89 24.56 26.21 26.01 Application Example 9 21.13 24.99 27.35 27.11 Application Example 10 19.11 22.34 25.41 25.55 Comparative application example 1 17.62 20.56 22.89 22.56 Comparative Application Example 2 18.33 21.01 23.15 23.00 Comparative Application Example 3 17.30 20.44 22.43 22.52

[0135] From the data results of Tables 4 to 6, it can be seen that the facial cream product involved in the present invention has excellent effects of repairing the barrier function of the facial acne scar area, improving the redness of the facial acne scar area, and preventing repeated acne. Centella X, olive leaf extract and lactobacillus / rye powder fermentation product synergistically enhance the above effects. Guaichuansu and Portulaca oleracea extract can further synergistically improve the above effects of the composition of Centella X, olive leaf extract and lactobacillus / rye powder fermentation product. At the same time, further adding skin conditioners Sophora flavescens extract and Cornus officinalis extract to the facial cream can further improve the effect of the facial cream in repairing the barrier function of the facial acne scar area, improving the redness of the facial acne scar area, and preventing repeated acne.

[0136] The applicant declares that the present invention illustrates the technical solution of the present invention through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0137] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0138] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. An anti-acne composition for fading acne marks and preventing recurrence, characterized in that: The acne-removing composition comprises a first effective ingredient, olive leaf extract, and a lactobacillus / rye powder fermentation product; The first effective ingredient includes Centella asiatica extract, madecassoside and glucose.

2. The anti-acne composition according to claim 1, characterized in that: The anti-acne composition comprises, by weight, 1-20 parts of a first effective ingredient, 1-20 parts of an olive leaf extract, and 1-20 parts of a lactobacillus / rye powder fermentation product.

3. The anti-acne composition according to claim 1 or 2, characterized in that: The anti-acne composition also includes guaiazulene and purslane extracts.

4. The anti-acne composition according to claim 3, characterized in that: The anti-acne composition further comprises 0.5-10 parts of guaiaczul and 1-20 parts of purslane extract by weight.

5. Use of the anti-acne composition according to any one of claims 1 to 4 in the preparation of cosmetics.

6. The use according to claim 5, characterized in that: The cosmetics include lotions, emulsions, creams, essences, facial masks, cleansing products, and makeup removal products; Preferably, the content of the anti-acne composition in the cosmetic is 0.5-10%.

7. A facial cream with soothing, repairing and acne scar fading effects, characterized in that: The components of the facial cream include the anti-acne composition according to any one of claims 1 to 4, a moisturizer, an antioxidant, an emollient, a thickener, an emulsifier, a skin conditioner and water.

8. The facial cream according to claim 7, characterized in that The components of the facial cream include, by mass percentage, 0.5-10% of the anti-acne composition according to any one of claims 1 to 4, 10-15% of a moisturizer, 0.05-0.5% of an antioxidant, 0.1-5% of an emollient, 0.1-1% of a thickener, 1-5% of an emulsifier, 0.1-3% of a skin conditioner, and 60-90% of water.

9. The facial cream according to claim 7 or 8, characterized in that The moisturizing agent includes any one or a combination of at least two of glycerin, 1,3-propylene glycol, panthenol, 1,2-hexanediol, butylene glycol, trehalose, squalane or betaine; Preferably, the thickener includes any one of sodium polyacrylate, sodium polyacrylate grafted starch, ammonium acryloyldimethyltaurate / VP copolymer or xanthan gum, or a combination of at least two thereof.

10. The facial cream according to claim 7 or 8, characterized in that The emollient comprises any one or a combination of at least two of white meadowfoam seed oil, sunflower seed oil, mango seed ester, grape seed oil, sweet almond oil, avocado tree butter, jojoba seed oil, avocado oil, caprylic / capric triglyceride, dimethicone, isononyl isononanoate, cetyl ethylhexanoate or hydrogenated polyisobutene; Preferably, the emulsifier includes any one of PEG-100 stearate, potassium cetyl phosphate, polysorbate-60, methyl glucose sesquistearate, sorbitan stearate, sorbitan polyether-30 tetraoleate, polysorbate-20, PEG-20 glyceryl triisostearate, cetearyl olive oil ester, sorbitan olive oil ester or cetyl PEG / PPG-10 / 1 polydimethylsiloxane or a combination of at least two thereof; Preferably, the skin conditioning agent comprises Sophora flavescens extract and Cornus officinalis extract; Preferably, the antioxidant comprises p-hydroxyacetophenone.

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