Hyaluronic acid lubricant with low osmotic pressure and preparation method thereof

Abstract

The invention relates to the technical field of lubricants, in particular to a low-osmotic-pressure hyaluronic acid lubricant and a preparation method thereof. The low-osmotic-pressure hyaluronic acid lubricant disclosed by the invention is prepared from the following materials in parts by weight: 88.35 to 92.97 parts of purified water, 4 to 6 parts of modified polyvinyl alcohol, 2 to 5 parts of 1, 2-propylene glycol, 0.1 to 1 part of sodium hyaluronate, 0.01 to 0.1 part of aloe extract, 0.01 to 0.1 part of snail stock solution, 0.01 to 0.1 part of herba centellae extract, 0.05 to 0.06 part of phenoxyethanol, 0.45 to 0.55 part of ethylhexylglycerin and 0.01 to 0.03 part of lactic acid. The lubricant obtained by the preparation method disclosed by the invention can effectively improve the lubricating property and prolong the service life; by means of accurately controlling the dosage and proportion of each component, optimizing the preparation process and the like, multiple advantages of low osmotic pressure, moisturizing and lubrication, skin friendliness, stability, safety and the like are realized, the requirements of different crowds can be met, and comfortable use experience is provided.

Description

Technical Field

[0001] The present invention relates to the technical field of lubricants, and in particular to a low-osmotic pressure hyaluronic acid lubricant and a preparation method thereof. Background Art

[0002] The osmotic pressure of a solution refers to the attraction of solute particles in the solution to water. The magnitude of the osmotic pressure of a solution depends on the number of solute particles in a unit volume of solution: the more solute particles there are, that is, the higher the concentration of the solution, the greater the attraction to water, and the higher the osmotic pressure of the solution; conversely, the fewer solute particles, that is, the lower the concentration of the solution, the smaller the attraction to water, and the lower the osmotic pressure of the solution; that is, it is related to the content of inorganic salts and proteins. The unit of osmotic pressure is usually expressed in osmotic pressure molar concentration (osmolality), which refers to the number of moles of solute per kilogram of solvent. The normal value of human osmotic pressure is between 280-310mmol / L. Within this range, it is called isotonic, below this range is called hypotonic, and similarly, above the range is hypertonic. Osmotic pressure plays a very important role in the exchange of fluid inside and outside the blood vessels and blood volume. Its stability is mainly regulated by the neuroendocrine system. The osmotic pressure receptors are located in the hypothalamus and are particularly sensitive to changes in plasma osmotic pressure. As long as the osmotic pressure changes by 1%-2%, the receptors can sense it, and then affect the pituitary gland to secrete antidiuretic hormone.

[0003] The osmotic pressure of a human lubricant depends primarily on the concentration of solutes, especially salts, sugars, and other soluble substances. The ideal osmotic pressure of a human lubricant should not exceed 380mOsm / kg. However, if such a limit is set at this time, it may severely limit the range of available products. The World Health Organization (WHO) has clear safety recommendations on the osmotic pressure of human lubricants: In 2012, after synthesizing a number of scientific studies, the WHO put forward a recommendation document on the procurement of human lubricants. The document states that lubricants with high osmotic pressure may affect the safety of users. Specifically, solutions with an osmotic pressure higher than that of body fluids can cause dehydration of body cells and may cause the body to feel a stinging or burning sensation. This not only weakens the body's sensitive mucosal protective layer, but may also increase the risk of bacteria and viruses invading the body. Therefore, the WHO recommends that the osmotic pressure of lubricants should be controlled at (less than 1200mOsm / kg) and a low pH value to reduce the risk of damage to the mucosa. A study pointed out that most vaginal lubricants widely used in the United States and internationally have high osmotic pressures, with osmotic pressures 4 to 30 times that of healthy vaginal fluids. These high osmotic pressure formulations have been shown to be significantly toxic to human colonic epithelial cells and significantly increase the risk of vaginal transmission of genital herpes infection in the peri / HSW model. They also cause toxicity to in vitro and cultured vaginal epithelial cells and increase HIV susceptibility in cell culture. Studies have also found that the osmotic pressure of healthy vaginal fluid is 370±40mOsm / kg, while lubricants with an osmotic pressure greater than 4 times that of vaginal fluid (>1500mOsm / kg) significantly reduce epithelial barrier function and show damage to tissue structure. At the same time, studies have also shown that excessive osmotic pressure may cause damage to vaginal epithelial cells and increase the risk of infection. Therefore, the osmotic pressure level of human lubricants should be considered when selecting and using them to ensure the safety and effectiveness of the product. The formulation of human lubricants needs to consider safety and biocompatibility to ensure that they are harmless to the human body during use.

[0004] Lubricants are widely used in the medical and consumer product fields, especially in sexual health and joint lubrication. Hyaluronic acid (HA), also known as hyaluronic acid, is a natural polysaccharide with good moisturizing and lubricating properties. It is widely present in various tissues and body fluids of the human body. Due to its unique physical and chemical properties, hyaluronic acid is widely used as the main component of lubricants.

[0005] Traditional hyaluronic acid lubricants usually use sodium hyaluronate as the main ingredient, supplemented with water and other regulators such as sodium chloride to adjust the solubility and stability of the product. However, this type of lubricant may have the problem of too high osmotic pressure in some applications, which may cause discomfort to some sensitive people, especially in vaginal lubrication and eye lubrication. Based on this, the present invention proposes a low osmotic pressure hyaluronic acid lubricant and a preparation method thereof. Summary of the invention

[0006] The purpose of the present invention is to provide a low osmotic pressure hyaluronic acid lubricant and a preparation method thereof, which can effectively improve the lubrication performance and extend the service life, and also achieve multiple advantages such as low osmotic pressure, moisturizing and lubricating, skin-friendly, stable and safe.

[0007] In the first aspect, the present invention provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 88.35-92.97 parts of purified water, 4-6 parts of modified polyvinyl alcohol, 2-5 parts of 1,2-propylene glycol, 0.1-1 parts of sodium hyaluronate, 0.01-0.1 parts of aloe extract, 0.01-0.1 parts of snail stock solution, 0.01-0.1 parts of Centella asiatica extract, 0.05-0.06 parts of phenoxyethanol, 0.45-0.55 parts of ethylhexylglycerin and 0.01-0.03 parts of lactic acid.

[0008] Furthermore, the viscosity of the low osmotic pressure hyaluronic acid lubricant is 4000-5000 mPa.s.

[0009] Furthermore, the molecular weight of the sodium hyaluronate is 1 million to 1.8 million Daltons.

[0010] Furthermore, the aloe extract is an aloe vera extract, and the aloe vera extract has an aloe polysaccharide content of not less than 8% and an O-acetyl content of not less than 5%.

[0011] Furthermore, the preparation method of the modified polyvinyl alcohol includes: swelling the polyvinyl alcohol in a water bath at a temperature of 40-50°C for 3-4 hours, adding glycerol and stirring in a water bath at 80-90°C for 3.5-4.5 hours until the polyvinyl alcohol is completely dissolved, then adding seaweed extract and calcium silicate when the temperature is lowered to 55-65°C, and continuing to stir for 50-60 minutes until the mixture is completely mixed.

[0012] Furthermore, the weight ratio of the polyvinyl alcohol, glycerol, seaweed extract and calcium silicate is 100:(4-6):(2-3):(8-10).

[0013] Furthermore, the degree of polymerization of the polyvinyl alcohol is 1600-1700, and the degree of alcoholysis is 97-99%.

[0014] In a second aspect, the present invention provides a method for preparing a low osmotic pressure hyaluronic acid lubricant, comprising the following steps: (1) mixing a formula amount of purified water and a formula amount of sodium hyaluronate, stirring, and homogenizing once, and then heating and homogenizing twice to obtain a uniform transparent gel; (2) mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail stock solution, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin uniformly, adding the mixture to the obtained gel, stirring uniformly, and finally adding a formula amount of lactic acid to adjust the pH of the product, and filtering the product with a 200-mesh filter.

[0015] Furthermore, in the step (1), after homogenization once, the temperature is raised to 80-85° C., and the insulation time is 15-20 minutes.

[0016] Furthermore, the temperature is lowered to 38-42° C. during stirring in step (2).

[0017] The beneficial effects of the present invention are:

[0018] The present invention relates to a low osmotic pressure hyaluronic acid lubricant formula, which uses a large amount of purified water as a base solvent, and selects low osmotic pressure moisturizers (such as 1,2-propylene glycol, sodium hyaluronate) and other functional ingredients. The osmotic pressure formed by these ingredients in the solution is low, which helps to reduce the osmotic pressure stimulation to skin cells. By accurately controlling the amount and proportion of each component, especially the molecular weight selection and concentration adjustment of sodium hyaluronate, and the addition of low osmotic pressure substances such as functional ingredients, the overall osmotic pressure is reduced. The formula avoids the use of highly irritating ingredients, such as high-concentration inorganic salts, and at the same time adds aloe extract with a soothing effect, which helps to reduce the discomfort during use.

[0019] In the preparation process of modified polyvinyl alcohol, calcium silicate is used as an inorganic lubricant, and its fine particle structure helps to disperse evenly in polyvinyl alcohol and seaweed extract. The hydroxyl groups on the surface of calcium silicate may form hydrogen bonds with the hydroxyl groups in polyvinyl alcohol, thereby enhancing the interaction between the three. The addition of calcium silicate can increase the lubricity of the modified polyvinyl alcohol system, reduce its viscosity, and improve the actual coating thickness and coating uniformity. The interaction between calcium silicate, polyvinyl alcohol and seaweed extract helps to form a more stable structure, prevent the lubricant from stratification or precipitation during storage and use, and improve the overall stability.

[0020] In modified polyvinyl alcohol, calcium silicate is a porous inorganic material with good hygroscopicity and water retention. When added to polyvinyl alcohol lubricants, calcium silicate can absorb and retain a portion of the water, forming a tiny moisture reservoir. During the drying process, the water in the calcium silicate is gradually released, slowing down the evaporation rate of the water in the lubricant, thereby extending the drying time. The particle shape and surface properties of calcium silicate may help form a lubricating film on the friction surface, reducing direct contact between the friction surfaces. The addition of calcium silicate can also reduce the viscosity of the lubricant, making it easier for the lubricant to flow and distribute on the friction surface, thereby reducing the dynamic friction coefficient.

[0021] In addition, calcium silicate, as an inorganic modified material, has good biological activity and cell compatibility, which makes it have broad application prospects in the biomedical field. When calcium silicate is used to modify polyvinyl alcohol, it can give the composite material better biocompatibility and activity.

[0022] In modified polyvinyl alcohol, seaweed extracts are rich in a variety of active ingredients, such as polysaccharides and amino acids, which can form chemical bonds or hydrogen bonds with polyvinyl alcohol molecules. These interactions may increase the cohesion between lubricant molecules, making it more difficult for water to escape from the material and also help to extend the drying time. These active ingredients can also form a tight bond with polyvinyl alcohol molecules, enhancing the weather resistance and stability of the lubricant. DETAILED DESCRIPTION

[0023] The technical solution of the present invention is described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] It should be noted that aloe extract CAS number: 85507-69-3, purchased from Nanjing Songguan Biotechnology Co., Ltd., Centella asiatica extract CAS number: 84696-21-9, purchased from Wuhan Kemik Biomedical Technology Co., Ltd., seaweed extract CAS number: 92128-82-0, purchased from Nanjing Shunchi Biotechnology Co., Ltd.

[0025] Example 1

[0026] This embodiment provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of modified polyvinyl alcohol, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of aloe extract, 0.5 parts of snail stock solution, 0.5 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin, and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500 mPa.s;

[0027] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0028] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 45°C for 3.5 hours, adding glycerol and stirring in a water bath at 85°C for 4 hours until polyvinyl alcohol is completely dissolved, then adding seaweed extract and calcium silicate when the temperature is lowered to 60°C, and stirring for 55 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, seaweed extract and calcium silicate is 100:5:2.5:9; the degree of polymerization of polyvinyl alcohol is 1650, and the degree of alcoholysis is 98%;

[0029] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 40°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0030] Example 2

[0031] This embodiment provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 88.35 parts of purified water, 4 parts of modified polyvinyl alcohol, 2 parts of 1,2-propylene glycol, 0.2 parts of sodium hyaluronate, 0.03 parts of aloe extract, 0.01 parts of snail stock solution, 0.02 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.01 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4000 mPa.s;

[0032] The molecular weight of sodium hyaluronate is 1 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0033] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 40°C for 3 hours, adding glycerol and stirring in a water bath at 80°C for 3.5 hours until polyvinyl alcohol is completely dissolved, then adding seaweed extract and calcium silicate when the temperature is lowered to 55°C, and stirring for 50 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, seaweed extract and calcium silicate is 100:4:2:8; the degree of polymerization of polyvinyl alcohol is 1600, and the degree of alcoholysis is 97%;

[0034] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 80°C, keeping the temperature for 15 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 38°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0035] Example 3

[0036] This embodiment provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 92.97 parts of purified water, 6 parts of modified polyvinyl alcohol, 5 parts of 1,2-propylene glycol, 1 part of sodium hyaluronate, 0.1 parts of aloe extract, 0.1 parts of snail stock solution, 0.1 parts of Centella asiatica extract, 0.55 parts of phenoxyethanol, 0.6 parts of ethylhexylglycerin and 0.03 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 5000 mPa.s;

[0037] The molecular weight of sodium hyaluronate is 1.8 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0038] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 50°C for 4 hours, adding glycerol and stirring in a water bath at 90°C for 4.5 hours until polyvinyl alcohol is completely dissolved, then adding seaweed extract and calcium silicate when the temperature is lowered to 65°C, and stirring for 60 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, seaweed extract and calcium silicate is 100:6:3:10; the degree of polymerization of polyvinyl alcohol is 1700, and the degree of alcoholysis is 99%;

[0039] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 85°C, keeping the temperature for 20 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 42°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0040] Example 4

[0041] This embodiment provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 88.35 parts of purified water, 6 parts of modified polyvinyl alcohol, 2 parts of 1,2-propylene glycol, 1 part of sodium hyaluronate, 0.03 parts of aloe extract, 0.1 parts of snail stock solution, 0.02 parts of Centella asiatica extract, 0.45 parts of phenoxyethanol, 0.6 parts of ethylhexylglycerin and 0.01 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 5000 mPa.s;

[0042] The molecular weight of sodium hyaluronate is 1 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0043] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 40°C for 4 hours, adding glycerol and stirring in a water bath at 80°C for 4.5 hours until polyvinyl alcohol is completely dissolved, then adding seaweed extract and calcium silicate when the temperature is lowered to 55°C, and stirring for 60 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, seaweed extract and calcium silicate is 100:4:3:8; the degree of polymerization of polyvinyl alcohol is 1700, and the degree of alcoholysis is 97%;

[0044] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 85°C, keeping the temperature for 15 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 42°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, and filtering the product through a 200-mesh sanitary filter.

[0045] Comparative Example 1

[0046] This comparative example provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of modified polyvinyl alcohol, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of seaweed extract, 0.5 parts of snail stock solution, 0.5 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500 mPa.s;

[0047] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0048] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 45°C for 3.5 hours, adding glycerol and stirring in a water bath at 85°C for 4 hours until polyvinyl alcohol is completely dissolved, then adding aloe extract and calcium silicate when the temperature is lowered to 60°C, and stirring for 55 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, aloe extract and calcium silicate is 100:5:2.5:9; the degree of polymerization of polyvinyl alcohol is 1650, and the degree of alcoholysis is 98%;

[0049] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 40°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0050] Comparative Example 2

[0051] This comparative example provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of modified polyvinyl alcohol, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of aloe extract, 0.5 parts of snail stock solution, 0.5 parts of seaweed extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500mPa.s;

[0052] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0053] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 45°C for 3.5 hours, adding glycerol and stirring in a water bath at 85°C for 4 hours until polyvinyl alcohol is completely dissolved, then adding Centella asiatica extract and calcium silicate when the temperature is lowered to 60°C, and stirring for 55 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, Centella asiatica extract and calcium silicate is 100:5:2.5:9; the degree of polymerization of polyvinyl alcohol is 1650, and the degree of alcoholysis is 98%;

[0054] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 40°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0055] Comparative Example 3

[0056] This comparative example provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of modified polyvinyl alcohol, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of aloe extract, 0.5 parts of snail stock solution, 0.5 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500 mPa.s;

[0057] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0058] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 45°C for 3.5 hours, adding glycerol and stirring in a water bath at 85°C for 4 hours until the polyvinyl alcohol is completely dissolved, then adding calcium silicate when the temperature is lowered to 60°C, and stirring for 55 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol and calcium silicate is 100:5:2.5:9; the degree of polymerization of polyvinyl alcohol is 1650, and the degree of alcoholysis is 98%;

[0059] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 40°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0060] Comparative Example 4

[0061] This comparative example provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of modified polyvinyl alcohol, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of aloe extract, 0.5 parts of snail stock solution, 0.5 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500 mPa.s;

[0062] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0063] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 45°C for 3.5 hours, adding glycerol and stirring in a water bath at 85°C for 4 hours until polyvinyl alcohol is completely dissolved, then adding seaweed extract and diatomaceous earth when the temperature is lowered to 60°C, and stirring for 55 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol, seaweed extract and diatomaceous earth is 100:5:2.5:9; the degree of polymerization of polyvinyl alcohol is 1650, and the degree of alcoholysis is 98%;

[0064] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 40°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0065] Comparative Example 5

[0066] This comparative example provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of modified polyvinyl alcohol, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of aloe extract, 0.5 parts of snail stock solution, 0.5 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500 mPa.s;

[0067] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0068] The preparation method of modified polyvinyl alcohol comprises: swelling polyvinyl alcohol in a water bath at a temperature of 45°C for 3.5 hours, adding glycerol and stirring in a water bath at 85°C for 4 hours until polyvinyl alcohol is completely dissolved, then adding seaweed extract when the temperature is lowered to 60°C, and stirring for 55 minutes until the mixture is completely mixed; the weight ratio of polyvinyl alcohol, glycerol and seaweed extract is 100:5:2.5; the degree of polymerization of polyvinyl alcohol is 1650, and the degree of alcoholysis is 98%;

[0069] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice until a uniform transparent gel is obtained; (2) after cooling to 40°C, uniformly mixing modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0070] Comparative Example 6

[0071] This comparative example provides a low osmotic pressure hyaluronic acid lubricant, comprising the following materials in parts by weight: 90 parts of purified water, 5 parts of polyvinyl alcohol, 0.125 parts of seaweed extract, 3.5 parts of 1,2-propylene glycol, 0.5 parts of sodium hyaluronate, 0.5 parts of aloe extract, 0.5 parts of snail stock solution, 0.5 parts of Centella asiatica extract, 0.05 parts of phenoxyethanol, 0.5 parts of ethylhexylglycerin and 0.02 parts of lactic acid; the viscosity of the low osmotic pressure hyaluronic acid lubricant is about 4500 mPa.s;

[0072] The molecular weight of sodium hyaluronate is 1.4 million Daltons; the aloe extract is a Curaçao aloe extract, wherein the content of aloe polysaccharide in the Curaçao aloe extract is not less than 8%, and the content of O-acetyl is not less than 5%;

[0073] The preparation method of the low osmotic pressure hyaluronic acid lubricant comprises the following steps: (1) adding a formula amount of purified water into an emulsification tank, adding a formula amount of sodium hyaluronate into the tank, stirring, homogenizing once, heating to 82°C, keeping the temperature for 17 minutes, and then homogenizing twice to obtain a uniform transparent gel; (2) cooling to 40°C, mixing polyvinyl alcohol, seaweed extract, 1,2-propylene glycol, aloe extract, snail concentrate, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, and adding the mixture to the obtained gel in the tank, stirring evenly, and finally adding a formula amount of lactic acid to adjust the pH of the product, filtering the product with a 200-mesh sanitary filter.

[0074] The lubricants prepared in Examples 1-4 and Comparative Examples 1-6 were tested, and the results are shown in Table 1 below:

[0075] 1. Lubricity test:

[0076] (1) Take 5g and 10g of the products of Examples 1-4 and Comparative Examples 1-6, respectively, and rub them back and forth on the arm at an average speed of 1 friction rub per second until the lubricant is completely smeared, and time and record;

[0077] (2) The dynamic friction coefficient of the lubricant obtained in each embodiment and comparative example was measured by using the method in GB 10006-2021 Determination of friction coefficient of plastic films and sheets;

[0078] 2. Stability study: The lubricating gel of each embodiment and comparative example was placed at 60°C for 10 days, and samples were taken on the 0th, 5th and 10th days. The samples placed on the 0th, 5th and 10th days were diluted to 5 times with water, and then the viscosity of each lubricating gel was tested at 25°C using the first method of the Pin capillary viscosity test method of Part IV 0633 of the 2020 edition of the Chinese Pharmacopoeia. The stability of the lubricating gel was evaluated by the viscosity reduction rate of each lubricating gel. The viscosity reduction rate = (η 0 -η n ) / η0 ×100%; where η 0 is the viscosity on day 0; η n is the viscosity on the nth day, n=5 or 10.

[0079] The test results are shown in Table 1.

[0080] Table 1 Test results

[0081]

[0082]

[0083] Finally, it should be noted that the above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Those skilled in the art should understand that the present invention can still be modified or replaced by equivalents. All technical solutions and improvements that do not depart from the spirit and scope of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A low osmotic pressure hyaluronic acid lubricant, characterized in that: The invention comprises the following materials in parts by weight: 88.35-92.97 parts of purified water, 4-6 parts of modified polyvinyl alcohol, 2-5 parts of 1,2-propylene glycol, 0.1-1 parts of sodium hyaluronate, 0.01-0.1 parts of aloe extract, 0.01-0.1 parts of snail stock solution, 0.01-0.1 parts of Centella asiatica extract, 0.05-0.06 parts of phenoxyethanol, 0.45-0.55 parts of ethylhexylglycerin and 0.01-0.03 parts of lactic acid.

2. A low osmotic pressure hyaluronic acid lubricant according to claim 1, characterized in that: The viscosity of the low osmotic pressure hyaluronic acid lubricant is 4000-5000 mPa.s.

3. The low osmotic pressure hyaluronic acid lubricant according to claim 1, characterized in that: The molecular weight of the sodium hyaluronate is 1 million to 1.8 million Daltons.

4. The method for preparing a low osmotic pressure hyaluronic acid lubricant according to claim 1, characterized in that: The aloe extract is a Curaçao aloe extract, in which the content of aloe polysaccharide is not less than 8% and the content of O-acetyl is not less than 5%.

5. The method for preparing a low osmotic pressure hyaluronic acid lubricant according to claim 1, characterized in that: The preparation method of the modified polyvinyl alcohol comprises: swelling the polyvinyl alcohol in a water bath at a temperature of 40-50° C. for 3-4 hours, adding glycerol and stirring in a water bath at a temperature of 80-90° C. for 3.5-4.5 hours until the polyvinyl alcohol is completely dissolved, then adding seaweed extract and calcium silicate when the temperature is lowered to 55-65° C., and continuing to stir for 50-60 minutes until the mixture is completely mixed.

6. The method for preparing a low osmotic pressure hyaluronic acid lubricant according to claim 5, characterized in that: The weight ratio of the polyvinyl alcohol, glycerol, seaweed extract and calcium silicate is 100:(4-6):(2-3):(8-10).

7. The method for preparing a low osmotic pressure hyaluronic acid lubricant according to claim 5, characterized in that: The polymerization degree of the polyvinyl alcohol is 1600-1700, and the alcoholysis degree is 97-99%.

8. A method for preparing the low osmotic pressure hyaluronic acid lubricant according to any one of claims 1 to 6, characterized in that: The steps include: (1) Mix the formulated amount of purified water and the formulated amount of sodium hyaluronate, start stirring, and homogenize once, and then start homogenizing twice after heating to obtain a uniform transparent gel; (2) Mix modified polyvinyl alcohol, 1,2-propylene glycol, aloe extract, snail extract, Centella asiatica extract, phenoxyethanol and ethylhexylglycerin, add them to the obtained gel, stir evenly, and finally add the formulated amount of lactic acid to adjust the pH of the product, and filter the product through a 200-mesh filter.

9. The method for preparing a low osmotic pressure hyaluronic acid lubricant according to claim 8, characterized in that: In the step (1), the temperature is raised to 80-85° C. after homogenization once, and the insulation time is 15-20 minutes.

10. The method for preparing a low osmotic pressure hyaluronic acid lubricant according to claim 8, characterized in that: During the stirring in step (2), the temperature is lowered to 38-42°C.

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