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Halloysite nanotube drug sustained-release material and preparation method thereof

A technology of halloysite nanotubes and slow-release materials, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc. It has universality and other issues, and achieves the effects of improving biological activity, increasing the probability of complications, and diversifying the way of administration

Inactive Publication Date: 2015-05-06
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the above-mentioned complexes can all play a certain sustained-release effect, they can only be used for the sustained-release of a certain specific drug and are not universally applicable.
[0004] In addition, although there are some sustained-release drug products, they still have problems such as low encapsulation efficiency, limited absorption, unstable preparation quality, and difficult dosage control.
And the cost of its preparation is high, and the operation of the preparation process is complicated

Method used

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  • Halloysite nanotube drug sustained-release material and preparation method thereof
  • Halloysite nanotube drug sustained-release material and preparation method thereof
  • Halloysite nanotube drug sustained-release material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Corrosion of halloysite nanotubes (HNTs)

[0041] Take 4g of halloysite powder and disperse it in 200mL of 3mol / L dilute sulfuric acid solution. After ultrasonic dispersion, stir magnetically in a water bath at 70°C for 12h, wash with a large amount of distilled water until neutral, and dry at 60°C in vacuum to obtain the partially corroded expansion of the inner wall. Halloysite nanotubes.

[0042] (2) Load of ibuprofen (IBU)

[0043] Take 1g of ibuprofen sample in a conical flask, dissolve it completely with 40mL of ethanol, then add 1g of expanded halloysite nanotubes for ultrasonic dispersion, and ensure that the system is in a vacuum environment, and shake at constant temperature for 24 hours to achieve drug loading. For the purpose, wash completely with ethanol and water, and vacuum-dry to obtain HNTs-IBU.

[0044] (3) Hydrophobic layer modification

[0045]a. Dissolve 0.5g of HNTs-IBU with 200mL of solvent (ethanol: water = 4:1) by ultrasound, stir magneti...

Embodiment 2

[0060] (1) Corrosion of halloysite nanotubes

[0061] Take 4g of halloysite powder and disperse it in 200mL of 5mol / L dilute sulfuric acid solution. After ultrasonic dispersion, stir magnetically in a water bath at 80°C for 12h, wash with a large amount of distilled water until neutral, and dry at 70°C in vacuum to obtain the partially corroded expansion of the inner wall. Halloysite nanotubes.

[0062] (2) Load of ofloxacin (OFL)

[0063] Take 1g ofloxacin sample in a conical flask, dissolve it completely with 30mL of dilute acetic acid solution with pH 3.0, then add 2g of expanded halloysite nanotubes for ultrasonic dispersion, and ensure that the system is in a vacuum environment and shake at constant temperature After 48 hours to achieve the purpose of drug loading, it was washed completely with dilute acetic acid solution and dried in vacuum to obtain HNTs-OFL.

[0064] (3) Hydrophobic layer modification

[0065] a. 0.5g of HNTs-OFL was ultrasonically dissolved with 20...

Embodiment 3

[0070] (1) Corrosion of halloysite nanotubes

[0071] Take 4g of halloysite powder and disperse it in 200mL of 4mol / L dilute sulfuric acid solution. After ultrasonic dispersion, stir magnetically in a water bath at 80°C for 12h, wash with a large amount of distilled water until neutral, and dry at 70°C in vacuum to obtain the partially corroded expansion of the inner wall. Halloysite nanotubes.

[0072] (2) Load of ibuprofen (IBU)

[0073] Take 2g of ibuprofen sample in a conical flask, dissolve it completely with 50mL of ethanol, then add 2g of expanded halloysite nanotubes for ultrasonic dispersion, and ensure that the system is in a vacuum environment, and shake at constant temperature for 24 hours to achieve drug loading. For the purpose, wash completely with ethanol and water, and vacuum-dry to obtain HNTs-IBU.

[0074] (3) Hydrophobic layer modification

[0075] a. Dissolve 0.5g of HNTs-IBU with 200mL of solvent (ethanol: water = 5:1) by ultrasound, stir magnetically ...

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Abstract

The invention relates to a halloysite nanotube drug sustained-release material and a preparation method thereof. The drug sustained-release material is prepared by the following steps: performing acid corrosion to a halloysite nanotube to obtain a dilated nanotube, loading the drug into an inner cavity of the halloysite nanotube, and coating an organosilane polymerized hydrophobic layer onto the surface of the drug-carried halloysite nanotube, wherein the during the coating of the organosilane polymerized hydrophobic layer, organosilane I is firstly used for modifying the outer surface of the halloysite nanotube, and then organosilane II is added to form the organosilane polymerized hydrophobic layer on the surface of the nanotube. Compared with the prior art, the sustained release material has universality on a hydrophobic drug and a hydrophile drug, the drug release time can be effectively prolonged, the encapsulation efficiency is high, and the administration safety of the drug can be improved.

Description

technical field [0001] The invention belongs to the field of drug sustained-release materials, in particular to a halloysite nanotube drug sustained-release material and a preparation method thereof. Background technique [0002] In recent years, the use of sustained-release drugs in my country has shown a steady growth trend. Sustained-release / controlled-release preparations are one of the commonly used dosage forms in clinical practice. Sustained-release preparations can reduce the number of times of administration, improve patient compliance, have small fluctuations in blood drug concentration, diversify administration routes, have little irritation, and have long-lasting curative effects. Safety and other advantages, so many drugs are trying to develop into sustained-release preparations, making it a research project with great practical value for pharmaceutical companies. Sustained-release materials are conducive to improving the efficacy of drugs, reducing toxic and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/34A61K31/192A61K31/5383A61K31/196A61K47/59
Inventor 钟世安李慧钟博俊朱小红彭伟陈建周成赟张小娜
Owner CENT SOUTH UNIV
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