Drug combination containing etoricoxib and preparation method thereof
A technology of etoricoxib and composition, which is applied in the field of pharmaceutical compositions containing etoricoxib and its preparation, can solve the problems such as inability to effectively guarantee tablet hardness, low drug dissolution rate, and reduced drug dissolution rate.
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Embodiment 1
[0030] Prescription composition:
[0031] Name of raw material Percentage (%w / w) Amount of raw and auxiliary materials (g) etoricoxib 25.0% 50.0 Calcium hydrogen phosphate anhydrous 35.0% 70.0 microcrystalline cellulose 35.0% 70.0 Croscarmellose sodium (internal) 1.5% 3.0 Sodium carboxymethyl starch (inside) 0.5% 1.0 Magnesium stearate (inside) 0.5% 1.0 Croscarmellose sodium (external) 1.5% 3.0 Sodium carboxymethyl starch (external) 0.5% 1.0 Magnesium stearate (external) 0.5% 1.0 made into tablets 200mg / tablet Makes 1000 pieces
[0032] Preparation:
[0033] a) Weighing: Mix 50g etoricoxib, 70g anhydrous calcium hydrogen phosphate, 3g croscarmellose sodium, 1g carboxymethyl starch sodium and 70g microcrystalline cellulose, then add 1g stearin Magnesium acid mixed to obtain mixture I;
[0034] b) Granulation: Mixture I is granulated with a pressure roller dry granulator to obtain Mixtur...
Embodiment 2
[0039] Prescription composition:
[0040] Name of raw material Percentage (%w / w) Amount of raw and auxiliary materials (g) etoricoxib 30.0% 60.0 Calcium hydrogen phosphate anhydrous 16.5% 33.0 microcrystalline cellulose 49.5% 99.0 Croscarmellose sodium (internal) 1.125% 2.25 Carboxymethyl starch press (internal) 0.375% 0.75 Magnesium stearate (inside) 0.5% 1.0 Croscarmellose sodium (external) 1.125% 2.25 Carboxymethyl starch press (external) 0.375% 0.75 Magnesium stearate (external) 0.5% 1.0 made into tablets 200mg / tablet Makes 1000 pieces
[0041] Preparation:
[0042] a) Weighing: mix 60g etoricoxib, 33g anhydrous calcium hydrogen phosphate, 2.25g croscarmellose sodium, 0.75g carboxymethyl starch sodium and 99g microcrystalline cellulose, then add 1g Magnesium stearate is mixed to obtain mixture I;
[0043] b) Granulation: Mixture I is granulated with a pressure roller dry granulator...
Embodiment 3
[0048] Prescription composition:
[0049] Name of raw material Percentage (%w / w) Amount of raw and auxiliary materials (g) etoricoxib 40.0% 80.0 Calcium hydrogen phosphate anhydrous 42.0% 84.0 microcrystalline cellulose 14.0% 28.0 Croscarmellose sodium (internal) 0.975% 1.95 Sodium carboxymethyl starch (inside) 0.325% 0.65 Magnesium stearate (inside) 0.5% 1.0 Croscarmellose sodium (external) 0.975% 1.95 What about carboxymethyl starch (external) 0.325% 0.65 Magnesium stearate (external) 0.5% 1.0 made into tablets 200mg / tablet Makes 1000 pieces
[0050] Preparation:
[0051] a) Weighing: Mix 80g etoricoxib, 84g anhydrous calcium hydrogen phosphate, 2.25g croscarmellose sodium, 0.75g carboxymethyl starch sodium and 28g microcrystalline cellulose, then add 1g hardened Magnesium fatty acid is mixed to obtain mixture I;
[0052] b) Granulation: Mixture I is granulated with a pressure roller...
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