Temozolomide intravenous injection fat emulsion and preparation method thereof

A technology of temozolomide and fat emulsion, which is applied in the field of medicine and biology, can solve the problems of unsuitability and poor solubility of temozolomide, and achieve the effects of enhancing compliance, improving drug efficacy, and strong controllability
CN103405385AInactive Publication Date: 2013-11-27SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2013-11-27
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a temozolomide intravenous injection fat emulsion which comprises the following components in percentage by weight: 0.01-5% of temozolomide, 5-30% of oil for injection, 0.2-5% of emulgator, 0.2-3% of stabilizer, 1-5% of isoosmotic adjusting agent and the balance of water for injection. The prepared temozolomide intravenous injection fat emulsion is uniform in appearance, narrower in distribution, high in drug loading capacity (1 mg / ml), stable in quality, used for intravenous injection, simple and practical in production process, high in controllability, and liable to large-scale industrial production; the average grain diameter is about 200 nm, the Zeta electric potential is about -40 mV, and the pH is 5.0-9.0; the temozolomide intravenous injection fat emulsion has excellent biocompatibility, can provide energy for an organism, and can realize therapeutic action to various tumours.
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Description

technical field

[0001] The invention relates to a temozolomide intravenous injection fat emulsion and a preparation method thereof, belonging to the field of medical biotechnology. Background technique

[0002] In recent years, the incidence of malignant brain tumors is not optimistic. Statistics show that about 60% of primary brain tumors are malignant brain tumors, which have a high incidence and great harm. The standard treatment for malignant brain tumors is surgical resection of the tumor followed by postoperative radiation therapy. Temozolomide has good anti-tumor activity, and has been evaluated as the "gold standard" for the treatment of malignant brain tumors by the American and European medical circles, and has been defined as the first-line drug for the treatment of malignant brain tumors by international medicine.

[0003] Temozolomide was approved by the FDA on August 11, 1999, and was launched in the United States. Its chemical name is 3,4-dihydro-3-methyl-4...

Claims

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