Bear-ball total bound cholic acid injection, its production and usage

A bile acid injection and injection technology, applied in the preparation of the total bear bile combined bile acid injection, bear bile total combined bile acid injection field, can solve the problems of no reports, no research reports and publications, etc., to achieve preparation Good safety, the effect of treating cardiovascular and cerebrovascular diseases, and low production cost

Inactive Publication Date: 2007-06-20
王静
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, encouraging progress has been made in the chemical and pharmacological research of drainage bear bile powder, and it has been proved that the main active ingredient is total bound cholic acid mainly composed of tauroursodeoxycholic acid and taurourchenodeoxycholic acid. , but about the extraction and purification process suitable for industrial production of the total bound bile acid of the active part, especially the extraction and purification process that can make the content of the active part reach more than 80% and meet the raw material requirements for intravenous injections, there are no research reports and Publicly, there is no report on the injection made from the total conjugated bile acid of the effective part of bear bile

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bear-ball total bound cholic acid injection, its production and usage
  • Bear-ball total bound cholic acid injection, its production and usage

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0126] Preparation of reference substance solution Precisely weigh an appropriate amount of tauroursodeoxycholic acid, taurourchenodeoxycholic acid, taurocholic acid, and taurodeoxycholic acid reference substance, and add methanol to make each 1ml of tauroursodeoxycholic acid. Deoxycholic acid 0.1mg, taurochenodeoxycholic acid 0.1mg, taurocholic acid 0.003mg, taurodeoxycholic acid 0.003mg solution, ready to use.

[0127] Preparation of the test solution Take an appropriate amount of this product, accurately weigh it, add methanol to dissolve and dilute, and obtain.

[0128] Determination method Precisely draw 5 μl of the above-mentioned reference substance solution and 10 μl of the test solution, inject it into the liquid chromatograph, measure it, and obtain it.

Embodiment 1

[0130] Embodiment 1: the preparation of bear bile total bound bile acid extract

[0131] Get bear bile powder 1Kg, add 5 times of amount of water heating and dissolving, filter, get bear bile aqueous solution, pass through 30 liters of pretreated D 101 Macroporous adsorption resin column, add 60L of water to elute, discard the aqueous solution, continue to elute with 70% ethanol, collect the 70% ethanol eluate, recover ethanol under reduced pressure and concentrate to a relative density of about 1.08-1.12 (60°C ) clear paste, spray-dried to obtain 700g of bear bile total combined acid extract. Determined by high-performance liquid chromatography, the extract of total bound cholic acid of bear bile contains 89.4% of total bound cholic acid of bear bile, including 46.2% of tauroursodeoxycholic acid, 40.5% of taurochenodeoxycholic acid, taurine Sulfocholic acid 2.2%, taurodeoxycholic acid 0.5%.

Embodiment 2

[0132] Embodiment 2: Preparation of small volume bear bile total combined bile acid injection

[0133] Take 100g of bear bile total bound cholic acid extract (calculated as total bound cholic acid), add 5000ml of water for injection to dissolve, add 10g of sodium bisulfite, 10g of sodium citrate, heat to boil, add 5g of activated carbon, stir well, and boil After 30 minutes, filter, add water for injection to the filtrate to 10000ml, fine filter, pack in 10ml ampoules, make 1000 tubes, melt seal, sterilize, check clarity, pack, and get ready.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A Chinese medicine in the form of injection for treating infectious disease, the diseases in hepatobiliary system, and cardiovascular and cerebrovascular diseases is prepared from bear gall powder through extracting general cholalic acid and mixing it with additives. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an injection of the effective parts of traditional Chinese medicine, especially the extract of the total combined bile acid of bear bile obtained by extracting and purifying the effective parts of bear bile powder by artificial drainage, which is compatible with auxiliary materials in an appropriate proportion and can be used for intravenous injection. The total bound bile acid injection of bear bile for use, and the present invention also relates to the method for preparing the total bound bile acid injection of bear bile and the pharmaceutical use. Background technique [0002] Bear bile is a traditional rare and valuable medicinal material. Although its curative effect is definite, it is not widely used clinically. In recent years, the success of artificial drainage of bear bile has opened up a wealth of drug sources. A large number of research results have proved that artificial drainage of bear bile powder has antibacterial...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/08A61K9/19A61P31/00A61P1/16A61P9/00
Inventor 张良杨奎
Owner 王静
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap