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Preparation technology and quality control method of preparation containing cassia twig and tuckahoe

A technology of Guizhi Fuling Pills and Poria cocos, which is applied in the fields of pill delivery, measuring devices, and pharmaceutical formulations, and can solve problems such as high labor intensity, difficult hygienic indicators, and impact on the clinical application of preparations

Inactive Publication Date: 2010-02-24
陈世忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the general manufacturing process adopted, there are problems such as low degree of mechanization, high labor intensity, long process, difficult control of hygienic indicators, long disintegration time limit, difficult control of pellet weight difference, and many tailings, which seriously affect to the clinical application of the preparation

Method used

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  • Preparation technology and quality control method of preparation containing cassia twig and tuckahoe
  • Preparation technology and quality control method of preparation containing cassia twig and tuckahoe
  • Preparation technology and quality control method of preparation containing cassia twig and tuckahoe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1. The preparation of Guizhi Fuling pill

[0033] 1. Prescription: Guizhi 60g, Poria cocos 60g, peony 60g, Moutan bark 60g, peach kernel 60g

[0034] 2. Preparation method: the above five flavors, cassia twig, poria cocos, and peony bark are crushed into fine powder, sieved, mixed, and set aside; peony and peach kernels are mixed and ground into fine powder, sieved, set aside; mix the above powders evenly, add Wet granulation of 5% starch slurry, drying in an oven at 50°C, granulation, adding 4% sodium carboxymethyl starch and 0.4% magnesium stearate by total weight, mixing evenly, pressing into 1000 pellets, coating with film, to obtain.

[0035] 3. Properties: This product is a pink film-coated pill, the core of which is light brown and white, with a specific gas and sweet taste.

[0036] 4. Specification: 0.3g / pill.

[0037] 5. Three batches of samples were prepared according to the above production process. The production process and physical and chemic...

Embodiment 2

[0042] Embodiment 2. Preparation of Guizhi Fuling Pills

[0043] 1. Prescription: Guizhi 60g, Poria cocos 60g, peony 60g, Moutan bark 60g, peach kernel 60g

[0044] 2. Preparation method: crush the above five flavors into fine powder, sieve, mix well, and set aside; take 45g Poria cocos and add 120ml deionized water, put it in a water bath and heat until Poria cocos dissolves and becomes a viscous liquid. The powder is mixed and granulated, dried, and granulated; add peony fine powder, paeonol fine powder, 13.5g PVP (K29 / 32), 1.5g magnesium stearate, and mix well. Compressed into 1000 pills, coated with film, to get ready.

[0045] 3. Properties: This product is a pink film-coated pill, the core of which is light brown and white, with a specific gas and sweet taste.

[0046] 4. Specification: 0.3g / pill.

[0047] 5. Three batches of samples were prepared according to the above production process. The production process and physical and chemical properties are as follows

[...

Embodiment 3

[0050] The determination of the content of cinnamon acid in embodiment 3 Guizhi Fuling pills

[0051] 1. The preparation of need testing solution takes the Guizhi Fuling pill prepared in Example 1, removes the coating, grinds into powder, accurately weighs 0.1g, puts in a 10ml measuring bottle, adds an appropriate amount of 50% methanol, and ultrasonically extracts for 30 minutes. Take it out, put it at room temperature, make up the solvent to the mark, shake it well, filter it with a 0.45 μm microporous membrane, and use the filtrate as the test solution, that is, ready.

[0052] 2. Preparation of reference substance solution Precisely weigh 1.68mg of cinnamic acid reference substance into a 100ml brown measuring bottle, dissolve it with 50% methanol and dilute to the mark, shake well, accurately measure 2ml, put it in a 5ml measuring bottle, add 50 Dilute with % methanol to the mark and shake well to obtain (each 1ml contains 7μg of cinnamic acid).

[0053] 3. Chromatograph...

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Abstract

The invention provides a new preparation method and a quality control method of a pill containing cassia twig and tuckahoe, The preparation method have the advantages of few production steps, short production cycle, high production mechanization, stable preparation quality, high content of effective ingredients, fast disintegration, high bioavailability, small dose, convenient administration and the like. The invention also provides the quality control method of cinnamyl aldehyde, cinnamic acid, paeonol, peoniflorin and amygdalin in the pill containing cassia twig and tuckahoe.

Description

technical field [0001] The invention relates to a preparation process and quality control method of cinnamon twig and poria cocos preparation. Background technique [0002] Guizhi Fuling Pill is recorded in Zhang Zhongjing's "Synopsis of the Golden Chamber" and treats the 20th pulse of women's pregnancy symptoms. It is good at treating women's persistent symptoms, pregnancy-fetal diseases, continuous leakage, and dysmenorrhea and amenorrhea caused by congestion. Block is a famous prescription for promoting blood circulation and removing blood stasis. In the prescription, Guizhi is used as the main drug to warm blood vessels; Poria cocos invigorates the spleen and eliminates dampness, strengthens the body and nourishes the fetus; peony nourishes blood and nourishes nutrition; peach kernel and paeonol eliminate blood stasis, break disease accumulation, remove stasis and regenerate; combined into a prescription, It is an effective prescription for promoting blood circulation a...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/28A61P15/00A61P15/06A61P15/08G01N30/36
Inventor 陈世忠
Owner 陈世忠
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