Preparation method of cassia twig and poria cocos pills

A technology of Guizhi Fuling Pills and Guizhi, which is applied to medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, and can solve the unsolved problems of stability and dissolution of active ingredients, incomplete extraction of active ingredients, pills, etc. The problem of unstable properties of skin phenol can be solved, and the effect of improving bioavailability, controlling the dissolution time limit and rapid disintegration can be achieved.

Inactive Publication Date: 2017-11-03
SHANXI SHUANGREN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain technical defects in the production process. First, the traditional extraction method is used to extract the active ingredients in the drug incompletely, resulting in low bioavailability; second, the prescription contains both volatile and fat-soluble active ingredients and water-soluble active ingredients. ingredients, so that the prescription is easy to be lost in the process of extraction, concentration, and pellet drying, especially the active ingredient paeonol in Moutan cortex is unstable, and it will decompose and lose when the temperature is higher than 60-65°C, resulting in a decrease in its active ingredients. Affect the curative effect of the drug, and at the same time, when the pill making pro

Method used

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  • Preparation method of cassia twig and poria cocos pills
  • Preparation method of cassia twig and poria cocos pills
  • Preparation method of cassia twig and poria cocos pills

Examples

Experimental program
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Example Embodiment

[0024] Example 1

[0025] A preparation method of Guizhi Fuling Pills includes the following steps:

[0026] Weigh 280g Guizhi, 280g Poria, 280g Moutan Bark, 280g Red Peony, and 280g Peach Kernel;

[0027] 1) Take Moutan Bark and Poria cocos and crush them into fine powder, and pass through an 80-mesh sieve for use;

[0028] 2) Extraction and concentration: Take cassia twig, peach kernel and red peony root and add 6 times the weight of 95% ethanol to extract twice, 1.5 hours each time, combine the extracts, filter, and concentrate under reduced pressure into an alcohol extract; use the remaining residue Extract 2 times with 6 times the amount of water, 1 hour each time, combine the extracts and concentrate under reduced pressure into a water-extracted extract; mix the two extracts evenly to obtain the total extract;

[0029] 3) Powder making: spray drying the total extract, air inlet temperature: 150°C, air outlet temperature: 55°C to concentrate and dry into fine powder, then add Mout...

Example Embodiment

[0033] Example 2

[0034] Weigh 480g of Guizhi, 480g of Poria, 480g of Moutan Bark, 480g of Red Peony Root, and 480g of Peach Kernel;

[0035] 1) Take Moutan Bark and Poria cocos and crush them into fine powder, pass through a 100-mesh sieve for use;

[0036] 2) Extraction and concentration: Take cinnamon sticks, peach kernels and red peony roots and add 8 times the weight of 95% ethanol to extract 3 times, 2 hours each time, combine the extracts, filter, and concentrate under reduced pressure into an alcohol extract; use the remaining residue Extract 3 times with 10 times the amount of water for 2 hours each time, combine the extracts and concentrate under reduced pressure into a water-extracted extract; mix the two extracts evenly to obtain the total extract;

[0037] 3) Flour milling: the total extract is dried into fine powder by microwave vacuum, vacuum degree: -0.07Mpa, temperature: 50℃, the dried paste is crushed through a 100-mesh sieve, and then the peony bark and tuckahoe po...

Example Embodiment

[0041] Example 3

[0042] A preparation method of Guizhi Fuling Pills includes the following steps:

[0043] Weigh 380g of Guizhi, 380g of Poria cocos, 380g of Cortex Moutan, 380g of Red Peony, and 380g of Peach Kernel;

[0044] 1) Take cassia twig and poria cocos into fine powder, pass through a 90-mesh sieve for use;

[0045] 2) Extraction and concentration: Take tree peony bark, peach kernel, red peony root and 7 times the weight of 95% ethanol to extract twice for 1.5 hours each time, combine the extracts, filter, and concentrate under reduced pressure into an alcohol extract; use the remaining residue Extract 3 times with 8 times the amount of water for 1.5 hours each time, combine the extracts and concentrate under reduced pressure to form a water-extracted extract; mix the two extracts evenly to obtain the total extract;

[0046] 3) Powder making: spray drying the total extract, air inlet temperature: 190°C, air outlet temperature: 65°C, dry into fine powder, then add cassia twi...

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Abstract

The invention discloses a preparation method of cassia twig and poria cocos pills and belongs to the technical field of traditional Chinese medicines. By adopting the technical scheme, the preparation method comprises the following steps: crushing poria cocos into fine powder respectively; then carrying out alcohol extraction and water extraction on peach kernels and red paeony roots in sequence; or crushing cassia twigs and coxtex moutan into fine powder or extracting and concentrating to prepare concentrated water-paste pills or water-honeyed pills by adopting different blending technologies; carrying out a subsequent pill preparation technology to prepare the cassia twig and poria cocos pills. According to the preparation method of the cassia twig and poria cocos pills, a complete technical scheme is formed by powdering, concentration, blending and pelleting, so that the extract yield is improved, effective components are sufficiently extracted, the bioavailability is improved and the dissolution time limit is effectively controlled; the preparation method has the advantages of short production period, stable preparation quality, high effective component content, rapidness in disintegration, high bioavailability, small oral administration dosage, convenience for oral administration and the like, and can be applied to preparation of cassia twig and poria cocos water-paste pill and water-honeyed pill dosage forms.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, in particular to a preparation method of Guizhi Fuling Pills. Background technique [0002] Guizhi Fuling Pills originated from "Synopsis of the Golden Chamber" by Zhang Zhongjing in Eastern Han Dynasty. Symptom block, or amenorrhea due to blood stasis, abdominal pain during menstruation, endless lochia after delivery. [0003] Among the cinnamon twigs and poria cocos, the cinnamon twig is the king of the prescription, and its chemical composition is mainly volatile oils, and its active ingredient is cinnamic aldehyde. In addition, cinnamic acid in the ethanol extract is also one of the active ingredients of this product: Moutan bark The main chemical components are paeonol, paeonol glycoside, paeonol protoside, paeoniflorin, hydroxy paeoniflorin, etc.; the main active ingredients in Radix Paeoniae Rubra are paeoniflorin, paeoniflorin, paeonol, etc.; The ing...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/20A61P15/00A61P29/00
CPCA61K9/20A61K9/2068A61K36/076A61K36/54A61K36/65A61K36/71A61K36/736A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 霍五奎聂广洪穆景龙辛俊伟
Owner SHANXI SHUANGREN PHARMA
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