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Traditional Chinese medicine substance standard preparation method comprehensively controlled by dynamism and transitivity and product thereof

A comprehensive control and delivery technology, applied in the field of medicine and chemistry, to achieve the effect of accurate control, strong pertinence, simple and convenient operation

Pending Publication Date: 2019-07-19
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the quality of the controlled substance standards, decoction pieces, and preparations is uniform, stable, and highly traceable. Therefore, this method is a universal method for Chinese herbal medicines, decoction pieces, substance standards, and preparations that are "following nature" and is highly targeted. , strong comprehensiveness, wide applicability, accurate control, stable control, simple and convenient operation, etc., it solves the international problems that cannot be solved by other methods at present

Method used

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  • Traditional Chinese medicine substance standard preparation method comprehensively controlled by dynamism and transitivity and product thereof
  • Traditional Chinese medicine substance standard preparation method comprehensively controlled by dynamism and transitivity and product thereof
  • Traditional Chinese medicine substance standard preparation method comprehensively controlled by dynamism and transitivity and product thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Example 1: Determination of Topological Index of "Imprinted Template" of Sangyuan Medicinal Ingredients

[0127] Using the UPLC-Q-TOF / MS analysis method, according to the quasi-molecular ion peaks in the first-order mass spectrum of the existing reference substance and the fragment ion information in the multi-level mass spectrum, combined with literature and self-made databases, analyze mulberry branches, mulberry leaves, and Morus alba Topological index of "imprinted template" chemical composition of mulberry medicinal materials such as bark and mulberry.

[0128] 1) Instruments and reagents: ① Instrument: Ultra-high performance liquid chromatography tandem quadrupole / time-of-flight mass spectrometer (UPLC-H-CLASS / XEVO G2-XS Qtof) coupled instrument (Waters, USA), equipped with Masslynx4.1 Data processing system; ACQUITY UPLC BEHC18 chromatographic column (Waters, USA); RE52 series rotary evaporator (Shanghai Yarong Biological Equipment Instrument Co., Ltd.); CP114 el...

Embodiment 2

[0140] Example 2: Topological index and total statistical moment parameter, information entropy and information amount of "imprinted template" of 11 batches of Houttuynia cordata fingerprint volatile oil.

[0141] 1) Samples: from various places in Hunan Province, determined by GC / MS according to the classical method, conditions: chromatographic column SE-30 (30m×0.25mm×0.25μm) quartz capillary column. Heating program: keep at 60°C for 1min, rise to 103°C at 15°C / min, then rise to 104°C at 0.2°C / min, then rise to 140.7°C at 37°C / min, then rise to 141°C at 0.02°C / min , then raised to 168°C at 40°C / min, kept for 1min, then raised to 200°C at 7°C / min, kept for 7min, and the injection volume was 1μl. Mass spectrometry conditions The ion source is an EI source; the ion source temperature is 230°C; the quadrupole temperature is 150°C; the electron energy is 70eV; the interface temperature is 280°C; the solvent delay is 2.5min; the mass range is 40~500amu(m / z) .

[0142] 2) Compone...

Embodiment 3

[0149] Embodiment 3: The one-time steady-state feeding quantity of Houttuynia cordata injection: The GC fingerprint spectrum measurement of Houttuynia cordata injection preparation, volatile component is according to embodiment 2, and its information volume is calculated by formula (4), as can be seen from Table 3, The RSD of the information content of 11 batches of Houttuynia cordata is 24.66%. Since the unit dosage is 2Kg, according to formula (3) or formula (6), it can be calculated that the steady-state dosage of Houttuynia cordata as an injection is 1418.3Kg. Therefore, the production of Houttuynia cordata injection needs a large extraction tank to extract once to meet the requirements.

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Abstract

The invention discloses a traditional Chinese medicine substance standard preparation method comprehensively controlled by dynamism and transitivity and a product thereof. The traditional Chinese medicine substance standard preparation method is based on autonomic effects of a supramolecular imprinting template of traditional Chinese medicine and diversity regulation of medical materials; and molecular topological indexes, feeding quantity at a time, precise processing and preparation and an evaluation technology are adopted, the quality control in the whole process is carried out from the part and entirety, the static state and dynamic state, the measurement and calculation, the design and experiment, the fixation and transmission, and the method has universality and integrity. The preparation and the quality control are carried out on the basis that the traditional Chinese medicine substance standard and the dynamism and the transitivity in the whole preparation process of the product of the traditional Chinese medicine substance standard are mastered, and the substance standard and the product are high in security and stability; comprehensive technological information which is of great concern to the quality control over the preparation, and the quality has credibility; the traditional Chinese medicine substance standard preparation method is suitable for all traditional Chinese medicine substance standards and the preparation of the products, and is especially suitable for research of compound preparations of ancient classic famous prescriptions; and the product can beflexibly distributed, is suitable for a whole pharmaceuticals industry, and has wide market prospects.

Description

technical field [0001] The invention belongs to the field of combination of medicine and chemistry, belongs to the interdisciplinary subject of traditional Chinese medicine and biosupramolecular chemistry, and relates to a preparation method of a Chinese medicine material standard with comprehensive control of dynamics and transmissibility and a product thereof. Background technique [0002] Traditional Chinese medicine is the quintessence of China, among which Chinese medicinal materials, decoction pieces and compound preparations (collectively referred to as products) are the three major material bases of traditional Chinese medicine for clinical treatment of diseases, and are the precious heritage of the motherland's medicine. It has a long history of more than 3,000 years in our country. Traditional Chinese medicine and its preparations have definite curative effects and high safety, and have been passed down for thousands of years and are enduring. In particular, the cl...

Claims

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Application Information

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IPC IPC(8): G01N33/15G01N1/28
CPCG01N1/28G01N33/15
Inventor 贺福元樊启猛贺鹏刘润南李海英梁慧慧石继连周逸群邓凯文刘文龙肖美凤杨岩涛唐宇唐昱潘雪
Owner HUNAN UNIV OF CHINESE MEDICINE
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