Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of Desheng tablet

A raw tablet and extraction technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of large dosage for patients, rough process, and many impurities, and achieve the effect of reducing dosage

Inactive Publication Date: 2013-03-27
章丘市妇幼保健院
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report of using supercritical and microwave technology in the extraction and preparation of raw tablets, but the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of Desheng tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 960g of Motherwort, 160g of Bupleuri, 320g of Angelica, 80g of Rhizoma Chuanxiong, 320g of Radix Paeoniae Alba, and 80g of Muxiang. Add Bupleuri, Angelica, and Rhizoma Chuanxiong to the CO2 supercritical extractor, and use ethanol as an entrainer, which accounts for the total extraction solvent. The volume percentage is 4%, extraction pressure is 15MPa, temperature is 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction is performed twice. Combine the extracts for 4 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to...

Embodiment 2

[0028] Take 960g of Motherwort, 160g of Bupleurum, 320g of Angelica, 80g of Chuanxiong, 320g of Paeoniae Alba, and 80g of Muxiang, and add Bupleurum, Angelica, and Chuanxiong into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave ex...

Embodiment 3

[0031] Take 960g of Motherwort, 160g of Bupleurum, 320g of Angelica, 80g of Chuanxiong, 320g of Paeoniae Alba, and 80g of Muxiang, and add Bupleurum, Angelica, and Chuanxiong into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method and applications of a Desheng tablet. The Desheng tablet is prepared from bulk drugs, including 960g of leonurus japonicus, 160g of radix bupleuri, 320g of angelica sinensis, 80g of ligusticum wallichii, 320g of white paeony root and 80g of costustoot, by supercritical extraction and microwave extraction. The invention also provides an application of the Desheng tablet in preparation of drugs for inhibiting proliferation of A-204 cells of rhabdomyosarcoma.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Desheng tablets. Background technique [0002] Desheng tablets are recorded in the standard WS3-B-0623-91 of the Ministry of Health. They are made of motherwort 960g, Bupleurum 160g, angelica 320g, Chuanxiong 80g, white peony 320g, and woody 80g as raw materials. phlegm. For irregular menstruation, abdominal pain during menstruation, blood stasis and qi stagnation, lump. [0003] In the prior art, there is no report of using supercritical and microwave technology in the extraction and preparation of raw tablets, but the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , Seriously affecting the clinical application of this product. Contents of the invention [0004] Object of the inv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/71A61K9/20A61P15/00A61P29/02A61P35/00
Inventor 不公告发明人
Owner 章丘市妇幼保健院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com