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Medicine for retarding breast cancer cell division and preparation method thereof

A breast cancer cell and drug technology, applied in the field of drugs for slowing the division of breast cancer cells and its preparation, and the field of drugs for slowing the division of cancer cells, can solve the problems of slow curative effect and insufficient inhibitory effect, and achieve significant curative effect and inhibit breast cancer. Cell proliferation, no toxic side effects

Pending Publication Date: 2021-07-13
张媛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although most of them have inhibitory or therapeutic effects on breast cancer, the inhibitory effect is not significant enough, and the curative effect is very slow. Compared with the rapid spread and development of cancer cells, the inhibitory or therapeutic effects are insufficient.

Method used

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  • Medicine for retarding breast cancer cell division and preparation method thereof
  • Medicine for retarding breast cancer cell division and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of a drug for slowing down breast cancer cell division.

[0026] A medicine for slowing down the division of breast cancer cells. Its raw material components include 10.2 parts of silver thread grass, 2.2 parts of onion, 21.2 parts of poplar buds or bud scales, 6.3 parts of Sperantosporum, and 17.6 parts of mimosa.

[0027] Weigh each component according to the above parts by mass, and pretreat each component to obtain its extract or modified extract. The specific preparation method of each component extract or modified extract is as follows:

[0028] Preparation of Silvertracea extract: Extract Silvertracea with reflux of 95% ethanol, recycle ethanol to obtain its ethanol extract, then degrease the extract with petroleum ether and perform AB-8 macroporous resin column chromatography, and then use Silverwort extract was obtained by elution with 50% ethanol.

[0029] Preparation of onion extract: wash the onion and put it into a pulverizer to crush it, boil ...

Embodiment 2

[0038] Effect of the pharmaceutical composition of the present invention on transplanted breast cancer.

[0039] (1) Preparation of transplanted breast cancer mouse model

[0040] 36 SPF female healthy TA2 mice, 6 weeks old, body weight 16g-18g. Take the MA-891 mouse breast cancer cells in logarithmic growth phase cultured in vitro, and adjust the concentration of MA-891 cells with sterile PBS to 1×10 7 / mL. Under sterile conditions, MA-891 mouse breast cancer cells were inoculated subcutaneously in the right axilla of TA2 mice, with an inoculation volume of 0.2ml / mouse (the number of cells was 2×10 6 / only). The entire inoculation process must be carried out in a sterile hood with aseptic operation, and the inoculation should be completed within 1 hour. The volume of the subcutaneous transplanted tumor reaches 60mm 3 Around time (about l0d), the model is successfully manufactured.

[0041] (2) Grouping and administration

[0042] According to the principle of tumor vol...

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Abstract

The invention provides a medicine for retarding breast cancer cell division. The medicine is prepared by mixing plant extracts or modified extracts. The plants comprise chloranthus japonicus, allium plants, poplar plants, garden balsam stems and mimosa pudica. Through experimental research of the inventor, the pharmaceutical composition has an extremely remarkable curative effect in the aspect of treating breast cancer, can inhibit breast cancer cell proliferation, and can avoid toxic and side effects caused by chemical drugs.

Description

technical field [0001] The invention belongs to the technical field of anticancer drugs, and relates to a drug for slowing down the division of cancer cells, in particular to a drug for slowing down the division of breast cancer cells and a preparation method thereof. Background technique [0002] Breast cancer is a cancer that originates from breast tissue, mammary ducts and lobules, and occurs in humans and other mammals. The vast majority of human breast cancers occur in women, but they can also occur in men. Breast cancer is the disease with the highest cancer mortality after lung cancer in the world today, accounting for 32% of female malignant tumors, and it is on the rise. It has obviously become one of the most important diseases that threaten women's health. [0003] The treatment of breast cancer includes surgery, radiation therapy and drug therapy, which mainly includes hormone therapy, chemotherapy and immunotherapy. Surgery is still the most important treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P35/00
CPCA61K36/185A61K36/8962A61K36/76A61K36/47A61K36/48A61P35/00A61K2236/333A61K2236/51A61K2300/00
Inventor 张媛
Owner 张媛
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