96results about How to "Has anti-inflammatory activity" patented technology

The invention discloses a nutrition meal replacement composition, which is prepared from the following components in parts by weight: 10-300 parts of euglenophyta powder, 60-500 parts of quinoa powder, 100-400 parts of chia seed powder, 40-450 parts of collagen powder, 50-520 parts of a carbohydrate compound, 0-200 parts of vitamin and 0-500 parts of mineral substances. The invention further discloses a nutrition meal replacement refresher. The refresher is prepared from the nutrition meal replacement composition and a food additive. The nutrition meal replacement composition has the effects of regulating intestinal tracts, dual-directionally regulating blood glucose and providing abundant nutrient substances needed for a human body while losing weight and controlling the weight.

The invention provides a compound feed capable of improving the fatty liver and body colour of the marine fish. The compound feed comprises a premixed feed, a bile acid, curcumin and betaine, wherein the premixed feed comprises fish meal, soya bean meal, corn gluten meal, high protein flour, corn, shrimp shell meal, monocalcium phosphate, fish oil, liquid phosphatide, vitamin premixes, mineral premixes, and the like. Artificial marine-fish breeding experiments prove that the compound feed provided by the invention can meet the nutritional needs of marine-fish growth, effectively enhance the physique of the marine fish, improve the immunity of the marine fish, reduce the incidence of a fatty liver disease, and improve the body color of the marine fish, so that the body color of the marine fish is bright-colored and close to a wild natural color, thereby enhancing the quality of artificially cultured marine fish.

The invention relates to crowfoot crack resistant cream for infants and a preparing method thereof. The cream comprises solid grease, liquid grease, a solid emulsifier, a plant anti-allergy component, a humectant, a plant extract and an antiseptic. The cream is suitable for skin dryness, peeling, crowfoot cracks in severe cases of infants which are caused by dry weather in autumn and winter. The cream is particularly nourishing and mild, and is extremely high in safety requirements and good in grease compatibility and compatibleness. Oat glucan having high moisturizing effects and the polyol type humectant are adopted so that moisturizing effects are good. The liquorice root extract and natural bisabolol are added further to solve a sensitive skin problem.

The invention discloses a compound for treating pneumonia and application thereof, and relates to the technical field of medicines. The compound for treating pneumonia is a heterocyclic compound, a pharmaceutically acceptable salt of the heterocyclic compound and/or a pharmaceutically acceptable carrier of the heterocyclic compound. The compound for treating pneumonia has a significant improvementeffect on bacterial pneumonia, viral pneumonia, fungal pneumonia, immune pneumonia, mycoplasma pneumonia, chlamydia pneumonia and other pathogen pneumonia, and especially can significantly improve pathological damage of viral bacterial pneumonia. The heterocyclic compound involved in the compound for treating pneumonia is simple in synthesis method, is suitable for industrial production, and is more stable than natural analogues; the activity of the compound is remarkably superior to that of ribavirin, oseltamivir, cefazolin and penicillin G which are clinically first-line medicines, and theactivity of the compound is also remarkably superior to that of purine analogues A, B and C.

The invention provides a method for preparing a lucid ganoderma drink powder mixed with ginseng and ginger, and the formula of the raw materials is as follows in parts by weight: 28-42 parts of raw ginger powder, 1.4-2.1 parts of dry ginseng with water content being not more than 7%, 1.6-2.4 parts of liquorice, 1.4-2.1 parts of dry lucid ganoderma with water content being not more than 1.3% and 80-120 parts of white granulated sugar. Nutrient components in the raw materials are extracted by alcohol, are mixed and dried to obtain the finished product. The drink powder has rich nutritions, and nutrient solutions of the four raw materials are compatible mutually in health care function with a synergistic effect and significant health care function.

The invention discloses a protective spray, which consists of the following components in percentage by weight: 0.9-1.5% of an emulsifier, 0.4-0.8% of an emulsion stabilizer, 0.2-0.4% of cetostearyl alcohol, 5-10% of glycerol, 3-5% of squalane, 2-4% of caprylic/capric triglyceride, 3-8% of a protective composition, 0.5-1.0% of a preservative and the balance of de-ionized water. The protective spray provided by the invention aims at relieving harm to environmental pollution and residual makeup to skin, and the protective spray is applicable to various skins, in particular sensitive skin; the spray is convenient to use; the spray has the advantages of being free from a propellant, good in spray effect, good in stability, strong in adsorption resistance and good in moisturizing effect; and the spray is capable of protecting the skin in a long-acting mode.

The invention relates to a mixed-source terpenoid and application thereof in preparing an anti-inflammatory drug. The structure of the mixed-source terpenoid is as shown in the formula I, a preparation method of the mixed-source terpenoid comprises the steps that marine-derived aspergillus terreus ML-44 ferment is subjected to extraction, separation and purification to obtain the mixed-source terpenoid. The mixed-source terpenoid has the effect of restraining LPS from inducing RAW 264.7 cell NO production, and the effect is not achieved by restraining cell proliferation or toxicity, so that the mixed-source terpenoid has anti-inflammatory activity, therefore, the mixed-source terpenoid can be used for curing inflammatory diseases as the anti-inflammatory drug, and a lead compound is provided for developing a novel anti-inflammatory drug. The formula I is shown in the description.

The invention relates to the technical field of application of artemisia scoparia extracts, and relates to application of an artemisia scoparia extract for preparing a medicine for treating pneumonia caused by streptococcus pneumonia or/and beta hemolytic streptococcus. The invention discloses the application of the artemisia scoparia extract for preparing the medicine for treating pneumonia caused by streptococcus pneumonia or/and beta hemolytic streptococcus for the first time. In-vitro antibacterial tests show that the artemisia scoparia extract has a function of remarkably inhibiting growth of streptococcus pneumonia and beta hemolytic streptococcus, anti-inflammatory tests show that the artemisia scoparia extract has anti-inflammatory activity, and meanwhile, the artemisia scoparia extract has a protection function on mouse lung injury models, so that the result shows that the artemisia scoparia extract has a treatment effect on pneumonia caused by streptococcus pneumonia or/and beta hemolytic streptococcus, and thus novel ways are provided for treatment on pneumonia caused by streptococcus pneumonia or/and beta hemolytic streptococcus.

The invention discloses chromone glycoside compounds separated and purified from scindapsus officinalis schott and an extraction method. Six chromone glycoside compounds are separated from scindapsus officinalis schott, namely 5-hydroxy-2-methyl-7-O-alpha-L-rhamnose chromone glycoside, 5-hydroxy-2-methyl-7-O-beta-D-xylose chromone glycoside, 5-hydroxy-2-methyl-7-O-[6-OAc-beta-D-glucosyl-(1-3)]-alpha-L-rhamnose chromone glycoside, 5-hydroxy-2-methyl-7-O-[beta-D-glucosyl-(1-2)]-alpha-L-rhamnose chromone glycoside, 2-hydroxymethyl-5,7-dyhydroxy-11-O-beta-D-arabinose chromone glycoside, 2-hydroxymethyl-5,7-dyhydroxy-11-O-beta-D-arabinose chromone glycoside, and 5,7-dyhydroxy-2-methyl-8-C-beta-D-glucose chromone glycoside. The extraction method is wide in raw material source, simple in preparation process, economic and safe and high in yield, and the six novel compounds all have anti-inflammation activity, are low in toxic and side effect and have good medicinal prospects.

The invention relates to imidazolone-morphinan and an application thereof. A research result indicates that imidazolone-morphinan has anti-inflammatory activity in an inhibition model experiment for inflammatory factors released by LPS (lipopolysaccharide) activated microglia BV2, does not show up cytotoxicity, is expected to be a candidate drug for prophylactic treatment of Parkinson's disease and has good development prospect.

The invention discloses a compound with an indoline skeleton, and a preparation method and medical application of the compound. The compound containing the indoline skeleton provided by the inventioncan interfere with Keap1-Nrf2 interaction activate Nrf2 and a downstream factor, reduce cell inflammatory factors and enhance cell oxidation resistance; and therefore, the compound can reduce inflammatory injuries, has potential anti-inflammatory activity, and can be used for preparing anti-inflammatory drugs for treating inflammatory injuries caused by a plurality of inflammation-related diseases, including myocarditis, chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal inflammation, rheumatoid arthritis and the like.

The invention relates to novel strains, namely, irpex lacteus (Irpex lacteus PCV1) and schizophyllum commune (schizophyllum commune SCF1) for preparing active dietary fibers by fermenting potato dregs, and a method for converting the potato dregs to synthesize the active dietary fibers through degradation of irpex lacteus PCV1 and schizophyllum commune SCF1. The Irpex lacteus PCV1 is the strain belonging to the polyporales, polyporaceae and the irpex lacteus genus; the Irpex lacteus PCV1 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 6, 2016,and is assigned with the accession number of CGMCC NO.12529. The schizophyllum commune SCF1 is the strain belonging to the agaricales, schizophyllaceae and the schizophyllum; the schizophyllum commune SCF1 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 6, 2016, and is assigned with the accession number of CGMCC NO.12530. The method comprises thefollowing steps: inoculating Irpex lacteus PCV1 into a liquid fermentation culture medium containing the potato dregs, brain and inorganic salt for fermentation culture, after culture is finished, inactivating the fermentation liquor, after inactivating, inoculating the schizophyllum commune SCF1 for fermentation culture, carrying out homogenization treatment on the fermentation final product, and thus the active dietary fiber product is obtained.

The invention discloses chromon-substituted 2-hydroxypyrrole derivatives, and a synthesis method and an application thereof, and belongs to the technical field of medicinal chemistry. The structural formula of the chromon-substituted 2-hydroxypyrrole derivatives is shown in the description; and in the formula, n is 0 or 1, R is hydrogen, fluorine, chlorine or a methyl group, R<1> is hydrogen or fluorine, R<2> is hydrogen, fluorine, chlorine or bromine, and EWG is a benzoyl group, a p-methylbenzoyl group, a p-fluorobenzoyl group, a p-chlorobenzoyl group or a p-bromobenzoyl group. The target compounds with an anti-inflammatory activity, which are the chromon-substituted 2-hydroxypyrrole derivatives, are prepared from benzoylformaldehyde derivatives, coumarin derivatives and heterocyclic ketene aminals through a one-pot cascade reaction. The method has the advantages of easily available synthesis raw materials, simple synthesis process, no metal catalyst in the reaction, and low synthesis cost, and realizes the catalyst-free, simple and efficient one-pot process synthesis of the complex and diverse chromon-substituted 2-hydroxypyrrole derivatives.

The invention provides a large yellow tea polysaccharide with anti-inflammatory activity, a preparation method and application of the large yellow tea polysaccharide and an anti-inflammatory pharmaceutical composition, and belongs to the technical field of application of active substances of large yellow tea. The large yellow tea polysaccharide with the anti-inflammatory activity is novel in structure, has a definite chemical structure, is uniform in composition, has an obvious anti-inflammatory function, can remarkably reduce expression of inflammatory factors in bone marrow-derived macrophages caused by lipopolysaccharide, and has no toxic or side effect on normal macrophages. As the polysaccharide with natural anti-inflammatory activity, the problem that the Huangdan tea lacks an active component with a single composition and a clear structure in the aspect of research and development of new anti-inflammatory drugs is solved, and a reliable material basis is laid for research on the structure-function relationship of the anti-inflammatory action of the Huangdan tea polysaccharide and research and development of the anti-inflammatory drugs.

The invention provides a fermentation method of human intestinal flora and application. The method comprises the following steps of a, donor screening, wherein boys who are twelve to fourteen years old, are in good health, do not have the serious disease history or obvious gastrointestinal tract symptoms, do not take any antibiotics in at least six months and have a regular life are screened out;b, sample collection and treatment, wherein fresh excrement of the donors is collected, quickly transferred to an anaerobic working station and weighed, a pre-reduction sterile saline solution is added according to a proportion, and even mixing with sufficient vortex is conducted; then filtering is conducted, and an excrement suspension solution is collected; c, fermentation, wherein the excrementsuspension solution is transferred to a sterile serum bottle, sealed and placed in a culture box for standing fermentation. According to the fermentation method, the obtained pH-acidity fermentationproduct with multiple rich probiotics is a kind of optimized healthy human intestinal flora and can be applied to the excrement bacterium transplantation technology and development of medicines, health care products and the like with the human intestinal flora as a target point.

The invention provides a preparation process of a compound traditional Chinese medicine preparation so as to solve the problem that an existing compound traditional Chinese medicine preparation is insufficient in stability at high temperature. Through effective combination of an extraction separation process and a granulation coating technology, the stability of the existing compound traditional Chinese medicine preparation is improved, and the effect of the medicine for treating prostatitis is enhanced.

The invention relates to glyceride compounds with anti-inflammatory activity, and a preparation method and application thereof. The preparation method comprises the following steps: acquiring an extractive from propolis, conventionally carrying out silica gel reduced pressure column chromatography, carrying out gradient elution with a petroleum ether (60-90 DEG C)-acetone system, merging the eluates according to the analytic result of thin-layer chromatography, and separating to obtain the glyceride compounds. The in-vitro anti-inflammatory activity test proves that the glyceride compounds can obviously inhibit the expression levels of IL-1beta, IL-6 and COX-2mRNA in the mouse macrophage RAW 264.7 caused by lipopolysaccharide (LPS), and have a dosage dependency relationship, which indicates that the glyceride compounds have obvious anti-inflammatory activity. The invention can be used for preparing new anti-inflammatory activity medicines.

The invention provides shark composite short chain polypeptide having anti-inflammatory activity and a preparation method and application, and relates to the technical field of marine organisms. The preparation method comprises the steps of shearing sharks which are fresh or unfrozen after frozen storage and deboned into small blocks, removing fat with an alcohol solution, performing repeated rinsing until the sharks are tasteless, and performing draining; performing immersing and scalding treatment on the shark blocks with pure water; performing cooling to room temperature, performing homogenization treatment, performing enzymolysis with proteases to obtain enzymatic hydrolysate, and performing heating for ending a reaction; performing crude filtering on the enzymatic hydrolysate, performing centrifugation treatment, taking supernatant, performing filtering, removing solvents from filtrate, performing sterilization and drying, and obtaining the shark composite short chain polypeptide.The shark composite short chain polypeptide has anti-inflammatory activity, can be applied to functional foods and special medical formula foods as ingredients, and has notable biologic activity of resisting inflammatory, nourishing the liver, protecting the kidney and the like. Conventional complex working procedures for treating raw materials are simplified, the shark composite short chain polypeptide having favorable anti-inflammatory efficacy can be obtained, and industrial large-scale cost-effective production purpose can be achieved.

The invention discloses an Esculentoside A, EsA as well as a preparation method and application thereof. The general formula of the Esculentoside A, EsA is shown in the specification, wherein R is amino acid, polypeptide, piperazine base, substituted piperazine bases or substituted amido. An active ester intermediate formed by the Esculentoside A, EsA under the action of a condensation agent reacts with amine or piperazine or substituted piperazine or amino acid with the protected carboxyl or polypeptide; and the Esculentoside A, EsA is obtained by separation and purification. The Esculentoside A, EsA, as well as pharmaceutical salt and medical composite thereof can be used for preparing inflammatory medicaments.