96results about How to "Has anti-inflammatory activity" patented technology

The invention discloses a nutrition meal replacement composition, which is prepared from the following components in parts by weight: 10-300 parts of euglenophyta powder, 60-500 parts of quinoa powder, 100-400 parts of chia seed powder, 40-450 parts of collagen powder, 50-520 parts of a carbohydrate compound, 0-200 parts of vitamin and 0-500 parts of mineral substances. The invention further discloses a nutrition meal replacement refresher. The refresher is prepared from the nutrition meal replacement composition and a food additive. The nutrition meal replacement composition has the effects of regulating intestinal tracts, dual-directionally regulating blood glucose and providing abundant nutrient substances needed for a human body while losing weight and controlling the weight.

The invention provides a compound feed capable of improving the fatty liver and body colour of the marine fish. The compound feed comprises a premixed feed, a bile acid, curcumin and betaine, wherein the premixed feed comprises fish meal, soya bean meal, corn gluten meal, high protein flour, corn, shrimp shell meal, monocalcium phosphate, fish oil, liquid phosphatide, vitamin premixes, mineral premixes, and the like. Artificial marine-fish breeding experiments prove that the compound feed provided by the invention can meet the nutritional needs of marine-fish growth, effectively enhance the physique of the marine fish, improve the immunity of the marine fish, reduce the incidence of a fatty liver disease, and improve the body color of the marine fish, so that the body color of the marine fish is bright-colored and close to a wild natural color, thereby enhancing the quality of artificially cultured marine fish.

The invention discloses thiazole Schiff base (I, II) containing nitryl with a chemical structural formula on the right. A method for preparing the thiazole Schiff base containing the nitryl comprises the steps as follows: nitrobenzene formaldehyde takes reflux reaction with 5-(4-chlorobenzyl)-4-tert-butyl-2-amido thiazole in ethanol to prepare and obtain the thiazole Schiff base [I with chemical name of 5-(4-chlorobenzyl)-4-tert-butyl-2-(nitrobenzyl imino) thiazole] containing the nitryl; or salicylaldehyde takes reflux reaction with 4-(nitrophenyl)-2-amido thiazole in the ethanol to prepare and obtain the thiazole Schiff base [II with chemical name of 4-( nitrophenyl)-2-(2-hydroxy benzyl imino) thiazole] containing the nitryl. The thiazole Schiff base containing the nitryl can be used for preparing anti-inflammatory analgesics.

The invention relates to crowfoot crack resistant cream for infants and a preparing method thereof. The cream comprises solid grease, liquid grease, a solid emulsifier, a plant anti-allergy component, a humectant, a plant extract and an antiseptic. The cream is suitable for skin dryness, peeling, crowfoot cracks in severe cases of infants which are caused by dry weather in autumn and winter. The cream is particularly nourishing and mild, and is extremely high in safety requirements and good in grease compatibility and compatibleness. Oat glucan having high moisturizing effects and the polyol type humectant are adopted so that moisturizing effects are good. The liquorice root extract and natural bisabolol are added further to solve a sensitive skin problem.

The invention provides a kudzu vine root anti-alcoholism beverage, and belongs to the technical field of non-alcoholic beverages. The provided beverage is mainly composed of a kudzu vine root extract, a licorice extract, a raisin tree seed extract, an emblic leafflower fruit extract, and dark plum condensed juice. The beverage is mainly composed of extracts of traditional Chinese herbals and plants, and thus has little side and toxic effect on human body. The beverage can relieve the symptoms of dizziness, headache, uncomfortable stomach, and bad breath after drunkenness, and is capable of protecting the liver and stomach. Moreover, the provided beverage does not contain any antiseptic, has a sour-sweet, fresh, and palatable taste, and is welcome by vast population.

The invention discloses a naphthalene sulfonamide compound and preparation methods and applications thereof. The naphthalene sulfonamide compound provided by the invention can interfere with Keap1-Nrf2 binding and activate Nrf2 so as to alleviate inflammatory damage and improve inflammatory microenvironment, has potential anti-inflammatory activity, and can be used for preparing anti-inflammatory medicine for the inflammatory damage of many inflammation-related diseases. The diseases include chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal inflammation, rheumatoid arthritis and the like.

The invention relates to the technical field of medicine, and in particular relates to a cucoline derivative as well as salts, a preparation method and application thereof. According to the invention, 1, 4, 6 and 17 positions in a cucoline structure are modified so as to obtain the cucoline derivative the structural general formula of which is as follows (shown in the specification); the salts of the cucoline derivative comprise hydrochloride, sulfate, bisulfate, hydrobromide, oxalate, citrate and mesylate; and the inhibition activity of partial compounds of the invention on NF-kappa B are obviously superior to that of cucoline, and the cucoline derivative and salts thereof are used for preparing anti-inflammatory medicaments.

The invention discloses a compound for treating pneumonia and application thereof, and relates to the technical field of medicines. The compound for treating pneumonia is a heterocyclic compound, a pharmaceutically acceptable salt of the heterocyclic compound and / or a pharmaceutically acceptable carrier of the heterocyclic compound. The compound for treating pneumonia has a significant improvementeffect on bacterial pneumonia, viral pneumonia, fungal pneumonia, immune pneumonia, mycoplasma pneumonia, chlamydia pneumonia and other pathogen pneumonia, and especially can significantly improve pathological damage of viral bacterial pneumonia. The heterocyclic compound involved in the compound for treating pneumonia is simple in synthesis method, is suitable for industrial production, and is more stable than natural analogues; the activity of the compound is remarkably superior to that of ribavirin, oseltamivir, cefazolin and penicillin G which are clinically first-line medicines, and theactivity of the compound is also remarkably superior to that of purine analogues A, B and C.

The invention discloses a sulfonamide compound with tetrahydroquinoline as a core and a preparation method and application of the sulfonamide compound. The sulfonamide compound with tetrahydroquinoline as the core is novel in structure and simple in preparation method, is capable of reducing mature secretion of interleukin IL-1beta by specifically inhibiting activation of NLRP3 inflammasome, thenalleviating inflammatory injury and improving inflammatory microenvironments, has remarkable anti-inflammation activity, and meanwhile has no conspicuous toxicity for THP-1 cells. The compound disclosed by the invention can be prepared as an anti-inflammation medicine for treating inflammation related diseases, including purpurin-related periodic syndromes, inflammatory intestine problems, chronicretardant lung diseases, diabetes, rheumatic arthritis, rheumatoid arthritis, gout, non-alcoholic fatty liver diseases, chronic kidney diseases, atherosclerosis, neurodegenerative diseases and the like.

The invention provides a method for preparing a lucid ganoderma drink powder mixed with ginseng and ginger, and the formula of the raw materials is as follows in parts by weight: 28-42 parts of raw ginger powder, 1.4-2.1 parts of dry ginseng with water content being not more than 7%, 1.6-2.4 parts of liquorice, 1.4-2.1 parts of dry lucid ganoderma with water content being not more than 1.3% and 80-120 parts of white granulated sugar. Nutrient components in the raw materials are extracted by alcohol, are mixed and dried to obtain the finished product. The drink powder has rich nutritions, and nutrient solutions of the four raw materials are compatible mutually in health care function with a synergistic effect and significant health care function.

The invention provides a lindenane sesquiterpenoid dimer with a 1,3-dioxolane linking unit. The structural formula of the lindenane sesquiterpenoid dimer is shown in the description. The invention also provides a preparation method of the lindenane sesquiterpenoid dimer with the 1,3-dioxolane linking unit and an application of the lindenane sesquiterpenoid dimer with the 1,3-dioxolane linking unitin preparation of drugs for treating inflammation. The lindenane sesquiterpenoid dimer (Chlojapolactone B) with the rare 1,3-dioxolane linking unit is separated from an ethanol extract of all grass of chloranthaceae chloranthus plant chloranthus japonicus, and it is found that the compound has potential anti-inflammatory activity.

The invention discloses a protective spray, which consists of the following components in percentage by weight: 0.9-1.5% of an emulsifier, 0.4-0.8% of an emulsion stabilizer, 0.2-0.4% of cetostearyl alcohol, 5-10% of glycerol, 3-5% of squalane, 2-4% of caprylic / capric triglyceride, 3-8% of a protective composition, 0.5-1.0% of a preservative and the balance of de-ionized water. The protective spray provided by the invention aims at relieving harm to environmental pollution and residual makeup to skin, and the protective spray is applicable to various skins, in particular sensitive skin; the spray is convenient to use; the spray has the advantages of being free from a propellant, good in spray effect, good in stability, strong in adsorption resistance and good in moisturizing effect; and the spray is capable of protecting the skin in a long-acting mode.

The invention relates to a mixed-source terpenoid and application thereof in preparing an anti-inflammatory drug. The structure of the mixed-source terpenoid is as shown in the formula I, a preparation method of the mixed-source terpenoid comprises the steps that marine-derived aspergillus terreus ML-44 ferment is subjected to extraction, separation and purification to obtain the mixed-source terpenoid. The mixed-source terpenoid has the effect of restraining LPS from inducing RAW 264.7 cell NO production, and the effect is not achieved by restraining cell proliferation or toxicity, so that the mixed-source terpenoid has anti-inflammatory activity, therefore, the mixed-source terpenoid can be used for curing inflammatory diseases as the anti-inflammatory drug, and a lead compound is provided for developing a novel anti-inflammatory drug. The formula I is shown in the description.

The invention relates to the technical field of application of artemisia scoparia extracts, and relates to application of an artemisia scoparia extract for preparing a medicine for treating pneumonia caused by streptococcus pneumonia or / and beta hemolytic streptococcus. The invention discloses the application of the artemisia scoparia extract for preparing the medicine for treating pneumonia caused by streptococcus pneumonia or / and beta hemolytic streptococcus for the first time. In-vitro antibacterial tests show that the artemisia scoparia extract has a function of remarkably inhibiting growth of streptococcus pneumonia and beta hemolytic streptococcus, anti-inflammatory tests show that the artemisia scoparia extract has anti-inflammatory activity, and meanwhile, the artemisia scoparia extract has a protection function on mouse lung injury models, so that the result shows that the artemisia scoparia extract has a treatment effect on pneumonia caused by streptococcus pneumonia or / and beta hemolytic streptococcus, and thus novel ways are provided for treatment on pneumonia caused by streptococcus pneumonia or / and beta hemolytic streptococcus.

The invention discloses chromone glycoside compounds separated and purified from scindapsus officinalis schott and an extraction method. Six chromone glycoside compounds are separated from scindapsus officinalis schott, namely 5-hydroxy-2-methyl-7-O-alpha-L-rhamnose chromone glycoside, 5-hydroxy-2-methyl-7-O-beta-D-xylose chromone glycoside, 5-hydroxy-2-methyl-7-O-[6-OAc-beta-D-glucosyl-(1-3)]-alpha-L-rhamnose chromone glycoside, 5-hydroxy-2-methyl-7-O-[beta-D-glucosyl-(1-2)]-alpha-L-rhamnose chromone glycoside, 2-hydroxymethyl-5,7-dyhydroxy-11-O-beta-D-arabinose chromone glycoside, 2-hydroxymethyl-5,7-dyhydroxy-11-O-beta-D-arabinose chromone glycoside, and 5,7-dyhydroxy-2-methyl-8-C-beta-D-glucose chromone glycoside. The extraction method is wide in raw material source, simple in preparation process, economic and safe and high in yield, and the six novel compounds all have anti-inflammation activity, are low in toxic and side effect and have good medicinal prospects.

The invention relates to imidazolone-morphinan and an application thereof. A research result indicates that imidazolone-morphinan has anti-inflammatory activity in an inhibition model experiment for inflammatory factors released by LPS (lipopolysaccharide) activated microglia BV2, does not show up cytotoxicity, is expected to be a candidate drug for prophylactic treatment of Parkinson's disease and has good development prospect.

The invention discloses a curcumin derivative as shown in formula (I) as well as a preparation method and application of the curcumin derivative. The invention provides a novel curcumin derivative, and the derivative has an anti-inflammatory activity and can be used as an active ingredient in anti-inflammatory drugs or anti-inflammatory pharmaceutical compositions. Furthermore, the invention also provides a preparation method of the curcumin derivative as shown in formula (I). The invention belongs to the technical field of chemical drugs; the curcumin derivative is better than curcumin in stability, and the curcumin derivative is low in preparation cost and good in realizability.

The invention discloses a compound with an indoline skeleton, and a preparation method and medical application of the compound. The compound containing the indoline skeleton provided by the inventioncan interfere with Keap1-Nrf2 interaction activate Nrf2 and a downstream factor, reduce cell inflammatory factors and enhance cell oxidation resistance; and therefore, the compound can reduce inflammatory injuries, has potential anti-inflammatory activity, and can be used for preparing anti-inflammatory drugs for treating inflammatory injuries caused by a plurality of inflammation-related diseases, including myocarditis, chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal inflammation, rheumatoid arthritis and the like.

The invention discloses an application of an alpha-mangostin derivative alpha-mangostin derivative in preparation of drugs for resisting and treating BPH (benign prostatic hyperplasia) and anti-BPH drug composition. The effective ingredient of the anti-BPH BPH drug composition is the alpha-mangostin derivative. The alpha-mangostin derivative can be absorbed by prostate tissue, still has anti-inflammatory activity, can improve the SOD activity and reduce MDA content and relieves enlargement of a prostate gland, therefore, the alpha-mangostin derivative can be used for treating BPH and has broad application prospects in preparation of the drugs for treating the BPH.

The invention relates to novel strains, namely, irpex lacteus (Irpex lacteus PCV1) and schizophyllum commune (schizophyllum commune SCF1) for preparing active dietary fibers by fermenting potato dregs, and a method for converting the potato dregs to synthesize the active dietary fibers through degradation of irpex lacteus PCV1 and schizophyllum commune SCF1. The Irpex lacteus PCV1 is the strain belonging to the polyporales, polyporaceae and the irpex lacteus genus; the Irpex lacteus PCV1 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 6, 2016,and is assigned with the accession number of CGMCC NO.12529. The schizophyllum commune SCF1 is the strain belonging to the agaricales, schizophyllaceae and the schizophyllum; the schizophyllum commune SCF1 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 6, 2016, and is assigned with the accession number of CGMCC NO.12530. The method comprises thefollowing steps: inoculating Irpex lacteus PCV1 into a liquid fermentation culture medium containing the potato dregs, brain and inorganic salt for fermentation culture, after culture is finished, inactivating the fermentation liquor, after inactivating, inoculating the schizophyllum commune SCF1 for fermentation culture, carrying out homogenization treatment on the fermentation final product, and thus the active dietary fiber product is obtained.

The invention discloses chromon-substituted 2-hydroxypyrrole derivatives, and a synthesis method and an application thereof, and belongs to the technical field of medicinal chemistry. The structural formula of the chromon-substituted 2-hydroxypyrrole derivatives is shown in the description; and in the formula, n is 0 or 1, R is hydrogen, fluorine, chlorine or a methyl group, R<1> is hydrogen or fluorine, R<2> is hydrogen, fluorine, chlorine or bromine, and EWG is a benzoyl group, a p-methylbenzoyl group, a p-fluorobenzoyl group, a p-chlorobenzoyl group or a p-bromobenzoyl group. The target compounds with an anti-inflammatory activity, which are the chromon-substituted 2-hydroxypyrrole derivatives, are prepared from benzoylformaldehyde derivatives, coumarin derivatives and heterocyclic ketene aminals through a one-pot cascade reaction. The method has the advantages of easily available synthesis raw materials, simple synthesis process, no metal catalyst in the reaction, and low synthesis cost, and realizes the catalyst-free, simple and efficient one-pot process synthesis of the complex and diverse chromon-substituted 2-hydroxypyrrole derivatives.

The invention provides a large yellow tea polysaccharide with anti-inflammatory activity, a preparation method and application of the large yellow tea polysaccharide and an anti-inflammatory pharmaceutical composition, and belongs to the technical field of application of active substances of large yellow tea. The large yellow tea polysaccharide with the anti-inflammatory activity is novel in structure, has a definite chemical structure, is uniform in composition, has an obvious anti-inflammatory function, can remarkably reduce expression of inflammatory factors in bone marrow-derived macrophages caused by lipopolysaccharide, and has no toxic or side effect on normal macrophages. As the polysaccharide with natural anti-inflammatory activity, the problem that the Huangdan tea lacks an active component with a single composition and a clear structure in the aspect of research and development of new anti-inflammatory drugs is solved, and a reliable material basis is laid for research on the structure-function relationship of the anti-inflammatory action of the Huangdan tea polysaccharide and research and development of the anti-inflammatory drugs.

The invention provides a fermentation method of human intestinal flora and application. The method comprises the following steps of a, donor screening, wherein boys who are twelve to fourteen years old, are in good health, do not have the serious disease history or obvious gastrointestinal tract symptoms, do not take any antibiotics in at least six months and have a regular life are screened out;b, sample collection and treatment, wherein fresh excrement of the donors is collected, quickly transferred to an anaerobic working station and weighed, a pre-reduction sterile saline solution is added according to a proportion, and even mixing with sufficient vortex is conducted; then filtering is conducted, and an excrement suspension solution is collected; c, fermentation, wherein the excrementsuspension solution is transferred to a sterile serum bottle, sealed and placed in a culture box for standing fermentation. According to the fermentation method, the obtained pH-acidity fermentationproduct with multiple rich probiotics is a kind of optimized healthy human intestinal flora and can be applied to the excrement bacterium transplantation technology and development of medicines, health care products and the like with the human intestinal flora as a target point.

The invention provides a preparation process of a compound traditional Chinese medicine preparation so as to solve the problem that an existing compound traditional Chinese medicine preparation is insufficient in stability at high temperature. Through effective combination of an extraction separation process and a granulation coating technology, the stability of the existing compound traditional Chinese medicine preparation is improved, and the effect of the medicine for treating prostatitis is enhanced.

The invention discloses a composition for treating gynecological inflammation, a preparing method thereof and a suppository for treating gynecological inflammation.The composition comprises, by weight, 1-3 parts of adonis flowers, 2-4 parts of radix sophorae flavescentis, 1-3 parts of common cnidium fruits and 0-3 parts of broom cypress fruits.The composition and the suppository for treating gynecological inflammation have the remarkable anti-inflammatory effect and can efficiently act on the lesion target position, the toxic and side effects on the human body are reduced, use is convenient, the number of taking times is small, the action time is long, and the normal life and work of a patient can not be influenced; compared with a chemosynthetic antibiotic, the composition and the suppository have the remarkable advantages of being efficient, high in quality, safe and low in toxic and side effect.

The invention discloses a process method for extracting stevia rebaudiana polyphenol from stevia rebaudiana. The process method comprises the following steps: washing fresh stevia rebaudiana, weighing, and pulping with a beater to obtain slurry; standing the slurry in an acid solution having a certain pH value for a period, filtering with gauze to obtain slag; performing ultrasonic extraction on the slag by using alcohol as an extracting liquid to obtain crude extract; extracting the crude extract by using supercritical carbon dioxide extraction technology to obtain a stevia rebaudiana polyphenol extract; and purifying the stevia rebaudiana polyphenol extract to obtain stevia rebaudiana polyphenol powder. The process method can be used for singly and specifically extracting stevia rebaudiana polyphenol from stevia rebaudiana, has relatively high extracting purity and extraction rate, is simple in operation, and is suitable for industrial production for stevia rebaudiana polyphenol.

The invention relates to glyceride compounds with anti-inflammatory activity, and a preparation method and application thereof. The preparation method comprises the following steps: acquiring an extractive from propolis, conventionally carrying out silica gel reduced pressure column chromatography, carrying out gradient elution with a petroleum ether (60-90 DEG C)-acetone system, merging the eluates according to the analytic result of thin-layer chromatography, and separating to obtain the glyceride compounds. The in-vitro anti-inflammatory activity test proves that the glyceride compounds can obviously inhibit the expression levels of IL-1beta, IL-6 and COX-2mRNA in the mouse macrophage RAW 264.7 caused by lipopolysaccharide (LPS), and have a dosage dependency relationship, which indicates that the glyceride compounds have obvious anti-inflammatory activity. The invention can be used for preparing new anti-inflammatory activity medicines.

The invention provides shark composite short chain polypeptide having anti-inflammatory activity and a preparation method and application, and relates to the technical field of marine organisms. The preparation method comprises the steps of shearing sharks which are fresh or unfrozen after frozen storage and deboned into small blocks, removing fat with an alcohol solution, performing repeated rinsing until the sharks are tasteless, and performing draining; performing immersing and scalding treatment on the shark blocks with pure water; performing cooling to room temperature, performing homogenization treatment, performing enzymolysis with proteases to obtain enzymatic hydrolysate, and performing heating for ending a reaction; performing crude filtering on the enzymatic hydrolysate, performing centrifugation treatment, taking supernatant, performing filtering, removing solvents from filtrate, performing sterilization and drying, and obtaining the shark composite short chain polypeptide.The shark composite short chain polypeptide has anti-inflammatory activity, can be applied to functional foods and special medical formula foods as ingredients, and has notable biologic activity of resisting inflammatory, nourishing the liver, protecting the kidney and the like. Conventional complex working procedures for treating raw materials are simplified, the shark composite short chain polypeptide having favorable anti-inflammatory efficacy can be obtained, and industrial large-scale cost-effective production purpose can be achieved.

The invention discloses an Esculentoside A, EsA as well as a preparation method and application thereof. The general formula of the Esculentoside A, EsA is shown in the specification, wherein R is amino acid, polypeptide, piperazine base, substituted piperazine bases or substituted amido. An active ester intermediate formed by the Esculentoside A, EsA under the action of a condensation agent reacts with amine or piperazine or substituted piperazine or amino acid with the protected carboxyl or polypeptide; and the Esculentoside A, EsA is obtained by separation and purification. The Esculentoside A, EsA, as well as pharmaceutical salt and medical composite thereof can be used for preparing inflammatory medicaments.

The invention relates to a Litsea lancilimba Merr. fruit extract, and an extraction method, a preparation method and an application thereof. Systematic and deep chemical component research is carriedout on the Litsea lancilimba Merr. fruits, and three sesquiterpene components are separated from the Litsea lancilimba Merr. fruits and are all sesquiterpene new framework compounds. The extraction method and the preparation method of the extract and the application of the extract in anti-inflammatory and antibacterial activity aspects are clarified. The Litsea lancilimba Merr. fruit extract is disclosed for the first time. The Litsea lancilimba Merr. fruit extract comprises Litsea lancilimba Merr. fruit sesquiterpenes A, B and C; the extraction and separation method and a new skeleton structure confirmation process of the sesquiterpenes are provided, the research on the chemical components of Litsea lancilimba Merr. plants are perfected, and the provided sesquiterpenes have a novel framework structure, and enrich the diversity of the sesquiterpenes.