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Preparation process of compound traditional Chinese medicine preparation

A compound traditional Chinese medicine and preparation process technology, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc. Reduce the use of auxiliary materials and reduce the effect of sticking and caking

Active Publication Date: 2021-01-15
YUNAN XITAO GREEN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the dosage of the content of the compound Chinese medicine preparation itself is relatively large (the average content of each capsule is 0.46g), and the composition is complex; if the embedding process is adopted, the dosage will be greatly increased, and the dissolution and absorption of this product may be affected. use

Method used

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  • Preparation process of compound traditional Chinese medicine preparation
  • Preparation process of compound traditional Chinese medicine preparation
  • Preparation process of compound traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]Example 1: Study on agglomeration of compound traditional Chinese medicine preparations

[0030]According to some existing drug moisture-proof measures to carry out research: according to the Ministry of Health issued the standard quality standard WS-10375(ZD-0375)-2002-2012Z, the preparation process of compound Chinese medicine preparations was prepared, and the contents of compound Chinese medicine preparations were prepared including "gelatin". Capsules for plant capsules, composite film bag packaging", "Add desiccant, composite film bag packaging", "gelatin capsules for plant capsules, aluminum-plastic for double aluminum", "content dry granulation 10 mesh", "dry content Method granulation 20 mesh, aluminum-plastic for double aluminum", "content dry granulation 15 mesh, 295K620008 type coating powder 80% ethanol coating", "content dry granulation 25 mesh, 295K620008 type coating powder 80% ethanol" Coating, aluminum-plastic for double aluminum", "content dry granulation 20 me...

Embodiment 2

[0037]Example 2: Preparation process one of compound traditional Chinese medicine preparation

[0038](1) According to the standard prescription amount, extract Hedyotis diffusa, Lysimachia, Houttuynia cordata, gentian grass and Bupleurum chinense with 45% ethanol at 55℃ for 1 hour, and filter to obtain filtrate and medicine residue;

[0039](2) Take step (1) medicinal residue, add gardenia, rehmannia glutinosa, purple salvia, astragalus, poria and decocting twice with water for 1.5 hours each time, recover the filtrate, combine with step (1) filtrate and concentrate to The clear ointment with a relative density of 1.18, cool to room temperature, add ethanol to 78% alcohol content, stir evenly, stand for 24 hours, filter, the filtrate recovers ethanol, concentrate and dry to obtain a compound Chinese medicine extract with a water content of 4%;

[0040](3) Take the compound Chinese medicine extract from step (2), mix it with bear bile powder and artificial bezoar according to the standard pr...

Embodiment 3

[0042]Example 3: Preparation process 2 of compound traditional Chinese medicine preparation

[0043](1) According to the standard prescription amount, extract Hedyotis diffusa, Lysimachia, Houttuynia cordata, gentian grass, and Bupleurum chinense with 30% ethanol at 60°C for 1 hour, and filter the filtrate and medicine residue;

[0044](2) Take the medicine residue from step (1), add gardenia, rehmannia glutinosa, purple salvia, astragalus, poria and decocting twice with water according to the standard prescription amount, 2h each time, collect the filtrate, and combine the filtrate with step (1) to concentrate. The cleansing cream with a density of 1.30, cool to room temperature, add ethanol to 80% alcohol content, stir evenly, stand for 18 hours, filter, the filtrate recovers ethanol, concentrate and dry to obtain a compound Chinese medicine extract with a water content of 2%;

[0045](3) Take the compound Chinese medicine extract from step (2), mix it with bear bile powder and artificial ...

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Abstract

The invention provides a preparation process of a compound traditional Chinese medicine preparation so as to solve the problem that an existing compound traditional Chinese medicine preparation is insufficient in stability at high temperature. Through effective combination of an extraction separation process and a granulation coating technology, the stability of the existing compound traditional Chinese medicine preparation is improved, and the effect of the medicine for treating prostatitis is enhanced.

Description

Technical field[0001]The invention belongs to the technical field of Chinese medicine pharmacy, and relates to a preparation process of a compound Chinese medicine preparation.Background technique[0002]The compound Chinese medicinal preparation is a Chinese patent medicine developed based on the traditional prescriptions of the Yi people in Yunnan. It is composed of bear gall powder, oldenlandia diffusa, Lysimachia, houttuynia cordata, gentian grass, Bupleurum bamboo, rehmannia, purple salvia, astragalus, Poria, artificial bezoar and gardenia, a total of twelve medicines; it has the effects of clearing heat and dampness, removing blood stasis and clearing leaching. It is used for damp heat and stasis caused by dampness, frequent urination, painful urination, prostatitis, For prostate hyperplasia, see the above syndromes.[0003]The quality standards for compound Chinese medicine preparations are included in the Pharmaceutical Standards issued by the Ministry of Health. The preparation...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/48A61P13/08A61P7/12A61P13/00A61K35/413
CPCA61K36/748A61K36/185A61K36/53A61K36/78A61K36/515A61K36/233A61K36/744A61K36/804A61K36/537A61K36/481A61K36/076A61K35/413A61K9/4858A61P13/08A61P7/12A61P13/00A61K2236/331A61K2236/333A61K2300/00
Inventor 陈蓬周祥来灿林徐洪明何厚洪王建方尚云龙吕丽丽
Owner YUNAN XITAO GREEN PHARMA
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