Chromone glycoside compounds separated and purified from scindapsus officinalis schott and extraction method

A technology for chromone glycosides and an extraction method, which is applied in the field of chromone glycosides and their preparation, can solve problems such as no research reports, and achieve the effects of simple preparation process, low toxicity and side effects, and good medicinal prospects.

Active Publication Date: 2017-11-07
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regarding the isolation and purification of new chromogen glycosides and extraction methods from green bamboo standard, no research report has been found after literature search

Method used

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  • Chromone glycoside compounds separated and purified from scindapsus officinalis schott and extraction method
  • Chromone glycoside compounds separated and purified from scindapsus officinalis schott and extraction method
  • Chromone glycoside compounds separated and purified from scindapsus officinalis schott and extraction method

Examples

Experimental program
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Embodiment

[0127] The preparation method of compound I-VI, the steps are as follows:

[0128] (1) Take 5kg of green bamboo standard medicinal material, pulverize, extract under reflux with 95% ethanol, the solid-to-liquid ratio is 1:3, extract three times, the time is 2h, 1h, 1h respectively, combine the filtrate, vacuum rotary steaming, freeze-drying, to obtain Green bamboo standard crude extract 1kg;

[0129] (2) Add an appropriate amount of water to the total crude extract and ultrasonically disperse it, extract it with petroleum ether, ethyl acetate and n-butanol respectively, filter the extract, concentrate under reduced pressure to obtain petroleum ether, ethyl acetate, n-butanol and water extraction respectively part;

[0130] (3) Dissolve 180 g of the obtained ethyl acetate portion in methanol, add 300 g of 200-300 mesh silica gel to mix the sample, evaporate the solvent, and use the volume ratio CH 2 Cl 2 -MeOH (100:1→50:1→25:1→15:1→10:1→5:1→1:1→0:1) for gradient elution to o...

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Abstract

The invention discloses chromone glycoside compounds separated and purified from scindapsus officinalis schott and an extraction method. Six chromone glycoside compounds are separated from scindapsus officinalis schott, namely 5-hydroxy-2-methyl-7-O-alpha-L-rhamnose chromone glycoside, 5-hydroxy-2-methyl-7-O-beta-D-xylose chromone glycoside, 5-hydroxy-2-methyl-7-O-[6-OAc-beta-D-glucosyl-(1-3)]-alpha-L-rhamnose chromone glycoside, 5-hydroxy-2-methyl-7-O-[beta-D-glucosyl-(1-2)]-alpha-L-rhamnose chromone glycoside, 2-hydroxymethyl-5,7-dyhydroxy-11-O-beta-D-arabinose chromone glycoside, 2-hydroxymethyl-5,7-dyhydroxy-11-O-beta-D-arabinose chromone glycoside, and 5,7-dyhydroxy-2-methyl-8-C-beta-D-glucose chromone glycoside. The extraction method is wide in raw material source, simple in preparation process, economic and safe and high in yield, and the six novel compounds all have anti-inflammation activity, are low in toxic and side effect and have good medicinal prospects.

Description

technical field [0001] The invention relates to the technical field of chromone glycoside compounds and preparation methods thereof, in particular to a chromone glycoside compound isolated and purified from green bamboo leaves and an extraction method. Background technique [0002] Chromone glycosides are a class of active substances widely distributed in various families and genera, which have anti-inflammatory, analgesic, anti-platelet aggregation, anti-oxidation, and inhibition of histamine release effects. The inflammatory response is a complex process involving the participation of various mediators, and the constant struggle between inflammatory factors and the body until a balance is reached. Traditional Chinese medicine exerts its anti-inflammatory effect through multiple channels and links. Traditional Chinese medicine has a variety of chemical components, a wide range of pharmacological activities, pleiotropic effects and less adverse reactions, and has very import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08C07D407/04C07H15/26A61P29/00
CPCC07D407/04C07H1/08C07H15/26C07H17/07
Inventor 王晓于金倩宋祥云王学勇郭兰萍
Owner SHANDONG ANALYSIS & TEST CENT
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