Litsea lancilimba Merr. fruit extract, and extraction method, preparation method and application thereof

A technology of Ginger japonica and an extraction method, which are applied in directions such as drug combination, separation/purification of carbonyl compounds, non-central analgesics, etc., can solve problems such as chemical components of Ginger japonica fruit and its pharmacological activity, etc., and achieve Rich variety of effects

Active Publication Date: 2020-05-29
GUIZHOU JINGCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are no literature reports on the chemical constituents and pharmacological activity of Zingiber officinale fruit at home and abroad, and there are no reports related to the preparation method and use of the Zingiber officinale fruit extract in the present invention.

Method used

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  • Litsea lancilimba Merr. fruit extract, and extraction method, preparation method and application thereof
  • Litsea lancilimba Merr. fruit extract, and extraction method, preparation method and application thereof
  • Litsea lancilimba Merr. fruit extract, and extraction method, preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0075] Embodiment 1 Gingeria japonica sesquiterpene A, B, C, their structural formula and absolute configuration are respectively as follows:

[0076] 1) Gingeria sesquiterpene A:

[0077]

[0078] 2) Gingeria sesquiterpene B:

[0079]

[0080] 3) Gingeria sesquiterpene C:

[0081]

Embodiment 2

[0082] The extraction method of embodiment 2 large fruit tree ginger sesquiterpene A, B, C

[0083] 1) Dried the fruit of Zingiber officinalis, crushed, soaked and extracted with 5 times the amount of 95% ethanol at 20°C for 2 times, each time for 24 hours, combined to obtain the extract, and concentrated under reduced pressure;

[0084] 2) Concentrate the extract under reduced pressure until there is no alcohol smell, and obtain a water-suspended liquid extract, add 2 to 6 times of water to dilute, and sequentially use 2 to 6 times of petroleum ether, ethyl acetate, and n-butanol to extract twice respectively, The solvent is recovered under reduced pressure to obtain petroleum ether, ethyl acetate and n-butanol parts respectively;

[0085] 3) Chromatography on the 100-200 mesh normal-phase silica gel column on the above-mentioned ethyl acetate part, and sequentially use petroleum ether: ethyl acetate to carry out gradient elution, and the specific ratio is: 100% petroleum eth...

Embodiment 3

[0087] The extraction method of embodiment 3 large fruit tree ginger sesquiterpene A, B, C

[0088] 1) Dried the fruit of Zingiber officinalis, crushed, soaked and extracted with 15 times the amount of 95% ethanol at 30°C for 5 times, each time for 12 hours, combined to obtain the extract, and concentrated under reduced pressure;

[0089] 2) Concentrate the extract under reduced pressure until there is no alcohol smell to obtain a water-suspended liquid extract, add 2 to 6 times of water to dilute, and sequentially extract 4 times with 2 to 6 times of petroleum ether, ethyl acetate, and n-butanol, respectively, The solvent is recovered under reduced pressure to obtain petroleum ether, ethyl acetate and n-butanol parts respectively;

[0090] 3) Chromatography on the 100-200 mesh normal-phase silica gel column on the above-mentioned ethyl acetate part, and sequentially use petroleum ether: ethyl acetate to carry out gradient elution, and the specific ratio is: 100% petroleum eth...

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Abstract

The invention relates to a Litsea lancilimba Merr. fruit extract, and an extraction method, a preparation method and an application thereof. Systematic and deep chemical component research is carriedout on the Litsea lancilimba Merr. fruits, and three sesquiterpene components are separated from the Litsea lancilimba Merr. fruits and are all sesquiterpene new framework compounds. The extraction method and the preparation method of the extract and the application of the extract in anti-inflammatory and antibacterial activity aspects are clarified. The Litsea lancilimba Merr. fruit extract is disclosed for the first time. The Litsea lancilimba Merr. fruit extract comprises Litsea lancilimba Merr. fruit sesquiterpenes A, B and C; the extraction and separation method and a new skeleton structure confirmation process of the sesquiterpenes are provided, the research on the chemical components of Litsea lancilimba Merr. plants are perfected, and the provided sesquiterpenes have a novel framework structure, and enrich the diversity of the sesquiterpenes.

Description

technical field [0001] The invention relates to the field of natural medicine inventions, in particular to a fruit extract of Zingiber officinalis, an extraction method, a preparation method and an application. Background technique [0002] There are about 200 species of plants in the genus Litsea of ​​the family Lauraceae, which are distributed in tropical and subtropical Asia and America. For deciduous or evergreen trees or shrubs. There are about 72 species, 18 varieties and 3 varieties in my country. It is one of the genus with more species and wider distribution in Lauraceae in China. It is distributed from 18° north latitude of Hainan Island, Guangdong Province to 34° north latitude of Henan Province, north of the Yangtze River. But it is mainly produced in the warm regions of the south and southwest, and it is a common tree in the forests of this region. (Editorial Committee of Flora of China, Chinese Academy of Sciences, Flora of China [M], Beijing: Science Press, 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/20C07D313/18C07C45/79C07C45/80C07C49/733A61P29/00
CPCA61P29/00C07C45/79C07C45/80C07C49/733C07D313/18C07D493/20C07C2602/30
Inventor 马贤鹏肖雪屠国丽郁华军金慧子肖永振
Owner GUIZHOU JINGCHENG PHARMA
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