The invention relates to the field of medical care, and particularly relates to a medicine pillow and a making method thereof. The medicine pillow is applied widely and reliable in the treatment effect, and can be used for enhancing the effects of soothing nerves and benefiting brains. The medicine pillow comprises a pillow case, and a pillow core arranged in the pillow case; the pillow core is filled with traditional Chinese medicines; the traditional Chinese medicines comprise the following Chinese herbs in parts by weight: ginseng, platycodon grandiflorum, cistanche deserticola, radix peucedani, asarum, cynanchum atratum, Chinese angelica, ligusticum wallichii, seedlings of ligusticum wallichii, radix ligustici sinensis, radix angelicae, costustoot, agastache rugosus, eucommia ulmoides, flos magnoliae, Chinese honeylocust fruit, pericarpium zanthoxyli, pricklyash peel, dried ginger, aluminite, platycladi seed, common coltsfoot flower, monkshood, coix seed, black false hellebore, divaricate saposhnikovia root, negundo chastetree fruit, Chinese arborvitae branchlet, aconite, manglietia, alfalfa, cattail, and cedarwood.