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A technology for lowering blood lipids and compositions, applied in the field of pharmaceutical compositions for lowering blood lipids, can solve problems such as lack of therapeutic drugs, and achieve a clear effect of lowering blood lipids
Inactive Publication Date: 2015-01-14
周玉萍
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Problems solved by technology
With the improvement of people's living standards and the increase of the elderly population, the incidence of this disease tends to increase, but there is still a lack of ideal therapeutic drugs
Method used
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Embodiment
[0012] Example Preparation of magnolia fruit extract
[0013] Take by weighing 1 kilogram of magnolia fruit, add the water that weight is 5 times of described magnolia fruit weight in magnolia fruit, heat 3 hours under the condition of reflux, cool to room temperature, filter, add absolute ethanol to alcohol in filtrate The content is 60% by volume, let it stand for 24 hours, filter, recover the ethanol in the filtrate, then centrifuge at 5500r / min for 5min, remove the supernatant, and vacuum-dry the precipitate obtained through centrifugation at 65°C to constant weight. Instantly.
experiment example
[0015] Establishment of hyperlipidemia animal model
[0016] Selection of Pharmacological Indicators
[0017] Select with high-fat feed (20% by weight of lard, 10% by weight of cholesterol, 2% by weight of pig bile salt, 0.2% by weight of propylthiouracil, 20% by weight of propylene glycol, 20% by weight of Tween-80, others are water) The hyperlipidemia model of SD rats was caused by feeding animals, and the drug effect of magnolia fruit extract was investigated with the blood lipid level as the pharmacological index.
[0018] Model building method
[0019] Under the conditions of room temperature 27 ℃ and humidity 60%, after raising the animals for one week, they were divided into blank control group, hyperlipidemia model group, and vehicle control group (DMSO aqueous solution, DMSO and water were mixed and shaken at a volume ratio of 1:4 to Di'ao Xinxuekang (purchased from Chengdu Di'ao Pharmaceutical Group Co., Ltd., approval number: Z10910051, product number: C1400000197...
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Abstract
The invention relates to a pharmaceutical composition for reducing blood fat. The pharmaceutical composition comprises a manglietia fruit extract and pharmaceutically acceptable carriers, wherein the manglietia fruit extract is prepared by the following steps: adding water of which the weight is 5 times that of manglietia fruits into manglietia fruits, heating under reflux conditions for 3 hours, cooling to room temperature, filtering, adding absolute ethyl alcohol into the filtrate until the content of alcohol is 60 volume percent, standing for 24 hours, filtering, recovering ethanol in the filtrate, centrifuging at a speed of 5500 revolutions per minute for 5 minutes, removing the supernatant, and performing vacuum drying on the centrifuged precipitate at the temperature of 65 DEG C to constant weight, thereby obtaining the manglietia fruit extract. The pharmaceutical composition disclosed by the invention is exact in effect of reducing the blood fat and is worthy of intensive study to develop novel drugs.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a blood lipid-lowering pharmaceutical composition. Background technique [0002] With the acceleration of the pace of life and the change of people's diet structure, cardiovascular and cerebrovascular diseases have become the world's number one health killer. In China, the mortality rate of cardiovascular diseases is on the rise, and the number of deaths from cardiovascular diseases is about 3 million every year. The most important risk factors for cardiovascular and cerebrovascular diseases are hypertension, hyperlipidemia, diabetes, obesity and smoking. Hyperlipidemia is a disorder of lipid metabolism in the body, resulting in an increase in blood lipid levels. It has a very close relationship with atherosclerosis (As), and is one of the main risk factors for coronary heart disease. With the improvement of people's living standards and the increase of the elderly population, the inci...
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