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Rifampicin nano-grade suspension and preparation method thereof

A technology of nanosuspension and rifampicin, which is applied in the field of veterinary medicine to achieve the effects of improving bioavailability, increasing saturated solubility and reducing waste

Inactive Publication Date: 2012-03-14
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The object of the present invention is to provide a rifampicin nanosuspension and preparation method thereof, to solve its convenient administration, reduce waste and ensure dosage

Method used

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  • Rifampicin nano-grade suspension and preparation method thereof
  • Rifampicin nano-grade suspension and preparation method thereof
  • Rifampicin nano-grade suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The prescription of rifampin nanosuspension:

[0028] Component Dosage

[0029] Rifampicin 3% (W / V)

[0030] Ethanol 3% (V / V)

[0031] Sodium Lauryl Sulfate 0.06% (W / V)

[0032] Sodium Carboxymethyl Cellulose 0.5% (W / V)

[0033] Sodium Bicitrate 2% (W / V)

[0034] Polyvinylpyrrolidone 1.0% (W / V)

[0035] Thiourea Dioxide 0.1% (W / V)

[0036] Purified water Add to 100% (V / V)

[0037] The preparation method of rifampin nanosuspension:

[0038] (1) First dissolve sodium bicitrate into a small amount of purified water, then add rifampicin, ethanol and sodium lauryl sulfate, and stir to obtain solution A.

[0039] (2) Take an appropriate amount of purified water, adjust the pH value between 10.5 and 11.5 with 20% sodium hydroxide solution, add thiourea dioxide, heat to dissolve and place it at room temperature, then add polyvinylpyrrolidone and sodium carboxymethylcellulose, and stir Dissolve solution B.

[0040] (3) Pour solution B into solution A, stir and mix even...

Embodiment 2

[0044] The prescription of rifampin nanosuspension:

[0045] Component Dosage

[0046] Rifampicin 15% (W / V)

[0047] Glycerin 6% (V / V)

[0048] Sodium dodecyl sulfonate 0.05% (W / V)

[0049] Sodium Carboxymethyl Cellulose 0.5% (W / V)

[0050] Sodium Bicitrate 2% (W / V)

[0051] Polyvinylpyrrolidone 1.5% (W / V)

[0052]Thiourea Dioxide 0.5% (W / V)

[0053] Purified water Add to 100% (V / V)

[0054] The preparation method of rifampin nanosuspension:

[0055] (1) First dissolve sodium bicitrate into a small amount of purified water, then add rifampicin, glycerin and sodium lauryl sulfate, and stir to obtain solution A.

[0056] (2) Take an appropriate amount of purified water, adjust the pH value between 10.5 and 11.5 with 20% sodium hydroxide solution, add thiourea dioxide, heat to dissolve and place it at room temperature, then add polyvinylpyrrolidone and sodium carboxymethylcellulose, and stir Dissolve solution B.

[0057] (3) Pour solution B into solution A, stir and mix...

Embodiment 3

[0061] The prescription of rifampin nanosuspension:

[0062] Component Dosage

[0063] Rifampicin 30% (W / V)

[0064] Ethanol 10% (V / V)

[0065] Sodium Lauryl Sulfate 0.05% (W / V)

[0066] Sodium Carboxymethyl Cellulose 0.5% (W / V)

[0067] Sodium Bicitrate 2% (W / V)

[0068] Polyvinylpyrrolidone 2.0% (W / V)

[0069] Thiourea Dioxide 0.2% (W / V)

[0070] Purified water Add to 100% (V / V)

[0071] The preparation method of rifampin nanosuspension:

[0072] (1) First dissolve sodium bicitrate into a small amount of purified water, then add rifampicin, ethanol and sodium lauryl sulfate, and stir to obtain solution A.

[0073] (2) Take an appropriate amount of purified water, adjust the pH value between 10.5 and 11.5 with 20% sodium hydroxide solution, add thiourea dioxide, heat to dissolve and place it at room temperature, then add polyvinylpyrrolidone and sodium carboxymethylcellulose, and stir Dissolve solution B.

[0074] (3) Pour solution B into solution A, stir and mix ev...

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Abstract

The invention relates to a rifampicin nano-grade suspension and a preparation method thereof. The rifampicin nano-grade suspension provided by the invention can be taken with drinking water. The stock solution of the suspension can be uniformly dispersed in water after being diluted, and a stable suspending state is maintained. The rifampicin nano-grade suspension provided by the invention is advantaged in convenient administration, reduced wasting, ensured dosage, high medicine dissolution rate, and increased saturated solubility of the medicine. With the nano-grade suspension and the preparation method, effects of rifampicin can be fully performed in the treatments of diseases such as poultry escherichia coli, salmonella, and duck serositis.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and in particular relates to a preparation method of a rifampicin nano-suspension for treating diseases such as avian Escherichia coli, salmonella and duck serositis. Background technique [0002] Rifampicin, also known as Meperiplex, Mepericomycin, Lifuping. A semi-synthesized derivative of rifamycin SV, rifampicin is an extended-spectrum antibacterial drug, easily soluble in chloroform and methanol, slightly soluble in ethanol, acetone or ether, and hardly soluble in water. It is stable at room temperature and heat, and it is easy to deteriorate when exposed to light. Its molecular structural formula is as follows: [0003] [0004] The antibacterial mechanism of rifampicin is to specifically bind to the β subunit of RNA polymerase, which is dependent on bacteria, prevent mRNA synthesis, stop the synthesis of DNA and protein, and achieve bactericidal effect. In therapeutic doses, it only i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/496A61P31/04
Inventor 聂丽娜刘爱玲刘桂兰孙俊王伟颖
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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