The invention provides a method for calibrating a supersonic flow field density field. According to the method, a supersonic flow field density-nanoparticle-based planar laser scattering (NPLS) image gray curve is calibrated by adopting a comprehensive oblique shock wave and expansion wave calibration method based on an NPLS technology. The method comprises the following steps of: 1, uniformly scattering trace particles in supersonic incoming flow, and shooting a particle image according to the instruction of a computer by a charge coupled device (CCD); 2, continuously adjusting obliqueness of an attack angle alpha in a supersonic wind tunnel, and acquiring a group of (rhoi, Ii) (i=1, 2, L, n-1) data by changing the oblique attack angle alpha; 3, placing expansion wave generators in the supersonic wind tunnel, and acquiring the other group of (rhoi, Ii) (i=n, n+1, L, N) data by placing the expansion wave generators with different deflection angles; and 4, performing polynomial fitting on the two groups of data to obtain the supersonic flow field density-NPLS image gray relation curve, namely rho=alapha0+alpha1I+alpha2I2+alpha3I3+K. The method aims to solve the technical problems of low spatial resolution and low signal-noise ratio and high error on measurement of a low-density area.