53results about How to "Does not cause rejection" patented technology

The invention discloses a hydrogel based on a gamma-polyglutamic acid and epsilon-polylysine cross-linked polymer. The hydrogel is prepared from crosslinking gamma-polyglutamic acid and epsilon-polylysine, and has a polymer with the following structural units, wherein m is a natural number ranging from 15 to 45, n is a natural number ranging from 3900-17000 and x is a natural number ranging from 5 to 40. The invention further discloses a preparation method of the hydrogel and an application of the hydrogel in preparing medical wound dressing. The hydrogel prepared by the method disclosed by the invention has good biocompatibility and can be widely applied to medical sanitary articles such as wound dressing.

The present invention relates to a polymer vesicle with the function of sugar sponge and its preparation method and application. Concanavalin on the above; its preparation method is: at first synthesizing the amphiphilic sugar-based polymer with at least initiator and polymerized monomer, then making the amphiphilic sugar-based polymer assemble into polymer vesicles, and finally Concanavalin is combined with polymer vesicles to form sugar-responsive polymer vesicles; the sugar-responsive polymer vesicles of the present invention can respond to changes in the concentration of glucose or mannose in the external environment and are not affected by the pH value. It has good stability and can be used as a buffer for glucose or mannose or a non-drug buffer for treating diabetes.

The invention discloses yak lactoprotein polypeptide nutrition powder applicable to rehabilitation of people after operations and a preparation method of the powder. The powder comprises the following main components: 20-24% of yak lactoprotein polypeptide powder, 6-10% of sodium caseinate, 18-20% of whey protein, 8-10% of defatted milk powder, 1-2% of bovine coloctrum, 0.02-0.03% of arginine, 0.11-0.14% of taurine, 8-12% of glucose, 1.1-1.5% of a silverweed cinquefoil extract, 0.1-1.4% of a lily extract, 1.5-2.5% of apple powder, 0.1-0.3% of vitamin C, 0.01-0.02% of vitamin E, 0.004-0.008% of group-B vitamins, 8-12% of polydextrose, 5-9% of fructo-oligose and 8-10% of maltodextrin. Through the organic combination of nutrients, energy and nutrient substances required by people after the operations can be comprehensively supplemented, and substances which are required by the people after the operations for the rehabilitation as soon as possible are provided.

The invention discloses a neuropeptide and a synthesis method and application thereof, wherein the neuropeptide has an amino acid sequence shown by SEQIDNO:1. According to the amino acid sequence represented by the SEQIDNO:1, valine is used as a first amino acid,-NH2 of the valine is exposed, then the-NH2 of the valine is condensed with-COOH of second amino acid-arginine to form an amide bond, other amino acids are sequentially connected, and finally tyrosine is to obtain the neuropeptide. Compared with the prior art, the neuropeptide has the following advantages: 1. the neuropeptide product can effectively improve defects of experimental animal social memory, and no adverse reaction is observed; 2. functional areas of the neuropeptide is a sequence on an endogenous protein, and cell rejection reaction may not be caused; 3. a signaling pathway activated by the neuropeptide is a known nervous system specific signaling pathway; 4. the product can effectively change the activity and state of neurons; and 5. the essence of the product is an amino acid sequence, is easy to degrade, and may not cause bodily organ loads.

The invention discloses a degradable and foldable biological amnion composite repair stent. The degradable and foldable biological amnion composite repair stent comprises a tube-shaped body with an axially extending through hole, an elastic balloon is arranged at the front end of the tube-shaped body, a one-way valve is connected to the tail end of the tube-shaped body, the one-way valve closes the through hole at the position, a foldable net-pipe-shaped polylactic acid bracket covers the outer surface of the elastic balloon, a biological amnion covers the outer surface of the foldable net-pipe-shaped polylactic acid bracket, a plurality of tiny holes are formed in net filaments of the foldable net-pipe-shaped polylactic acid bracket, and biological amnion powder fills the plurality of tiny holes; under the initial state, the elastic balloon, the foldable net-pipe-shaped polylactic acid bracket and the biological amnion are compressed to in the compact state; and under the use state, after the stent is implanted into the body and swelling occurs due to pressurizing, the tube-shaped or waterdrop-similar-shaped state can be formed complying with the lacrimal duct / uterine cavity, or the other spatial states adaptive to body cavity also can be formed.

A 3D printed artificial periosteum, artificial bone, artificial bone and preparation method thereof. The 3D printed artificial periosteum is made of calcium alginate composite nano-scale porcine cross-linked collagen fibers, and is made by 3D printing according to the shape of the periosteum required by the patient's bone defect; among them, calcium alginate and nano-scale porcine cross-linked collagen fibers are used. The mass ratio of 1:(1~5). The 3D printed artificial bone is made of artificial bone material printed by 3D printer according to the shape of the patient's bone defect; the artificial bone material is made of the following components: nano-scale porcine cross-linked collagen fibers, 1-6wt%; nano-scale hydroxyapatite , 3 to 4wt% and biodegradable carrier materials, 90 to 96wt%. The 3D printed artificial bone consists of 3D printed artificial bone and 3D printed artificial periosteum.

The present invention relates to a blood sugar regulating polymer vesicle which can be used for diabetes treatment and its preparation method and application. The polymer vesicle is assembled by amphiphilic sugar-containing polymer; transfer agent and polymerized monomers to synthesize amphiphilic sugar-containing polymers, and then self-assemble the amphiphilic sugar-containing polymers to form blood sugar-regulating polymer vesicles; the blood sugar-regulating polymer vesicles of the present invention can respond to glucose in the external environment The particle size changes with the change of concentration, it is not affected by temperature and has good stability, and can be used as a blood sugar detection reagent and a non-drug buffer for treating diabetes.