Rapid hemostatic

A hemostatic agent and rapid technology, applied in the field of hemostatic agent and rapid hemostatic agent, can solve the problems of temperature rise, achieve the effects of avoiding pain, sterilizing and promoting wound healing, and avoiding pollution

Active Publication Date: 2017-03-15
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing hemostatic agents with microporous starch as the main body will produce different degrees of temperature rise during the hemostasis process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment provides a kind of rapid hemostatic agent, its preparation raw material comprises microporous starch, calcium ion and chitosan or chitin, in every 100g microporous starch, chitosan or chitin add-on amount is 30g, and calcium ion adds The amount is 20 μmol, wherein chitosan or chitin can be added alone or in combination.

[0036] The preparation method of the rapid hemostatic agent of the present embodiment is:

[0037] (1) Activation of corn microporous starch

[0038] Weigh 1.0 kg of corn microporous starch, leave it in a vacuum desiccator at room temperature for 24 hours, then wash it twice with 5 times the volume of absolute ethanol and three times with 12 times the volume of acetone, and pump it out with a G2 sand core funnel. Filter until dry, leave it in a vacuum desiccator at 45°C for 24 hours, and transfer it to a container previously filled with high-purity nitrogen.

[0039] (2) Addition of chitin and / or chitosan

[0040] Add 300 grams of ch...

Embodiment 2

[0100] This embodiment provides a kind of rapid hemostatic agent, its preparation raw material comprises microporous starch, calcium ion and chitosan or chitin, in every 100g microporous starch, chitosan or chitin add-on amount is 1g, and calcium ion adds The amount is 10 μmol, wherein chitosan or chitin can be added alone or in combination.

[0101] The test method of present embodiment rapid hemostatic agent is identical with embodiment 1, and obtained result is as follows:

[0102] The average time for complete hemostasis of rabbit ear wounds in self-made hemostatic agent group, Yunnan Baiyao group and negative control group were (94±3)s, (217±4)s and (300±6)s respectively, and the average time for complete hemostasis of rabbit liver wounds were respectively For (50±2)s, (131±3)s and (210±5)s. The hemostatic effect is significantly better than the commercially available Yunnan Baiyao, and the hemostatic time for wounds of different animals is also within 100 seconds, the h...

Embodiment 3

[0104] The present embodiment provides a kind of rapid hemostatic agent, its preparation raw material comprises microporous starch, calcium ion and chitosan or chitin, in every 100g microporous starch, chitosan or chitin addition is 50g, and calcium ion adds The amount is 500 μmol, wherein chitosan or chitin can be added alone or in combination.

[0105] The test method of present embodiment rapid hemostatic agent is identical with embodiment 1, and obtained result is as follows:

[0106] The average time for the self-made hemostatic agent group, the Yunnan Baiyao group and the negative control group to complete hemostasis of the rabbit ear wound and the rabbit liver wound were (91±3)s and (51±1)s, (216±2)s and (133±1)s, respectively. 4) s, (303 ± 4) s and (213 ± 4) s, the hemostatic effect is significantly better than that of the commercially available Yunnan Baiyao, and the hemostatic time for different animal wounds is also within 100 seconds. In addition, compared with Ex...

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Abstract

The invention relates to a rapid hemostatic. Preparation raw materials of the rapid hemostatic comprise microporous starch, calcium ions or zinc ions, chitosan or chitin. In every 100 g of the microporous starch, the addition amount of the chitosan or chitin is 1 to 50 g, the addition amount of the calcium ions is 10 to 500 micromoles, or the addition amount of the zinc ions is 6 to 80 micromoles. When the rapid hemostatic disclosed by the invention is not used, the temperature of skin at a wound cannot be increased obviously, and sharp temperature rise of the wound during hemostasis can be effectively prevented, so that pains of a patient due to the fact that the temperature of the wound is increased when an existing hemostatic is used are avoided, and the novel hemostatic can be used for hemostasis of internal and external wounds under various middle and small arteries.

Description

technical field [0001] The invention belongs to the technical field of new hemostatic materials, and relates to a hemostatic agent, in particular to a rapid hemostatic agent capable of preventing wound temperature from rising. Background technique [0002] At present, the traditional hemostatic materials commonly used in surgery include oxidized cellulose, absorbable gelatin sponge, collagen sponge, and zeolite, etc. Although they can all be used as local hemostatic materials, each has major disadvantages that limit its clinical application. For example, during the application of zeolite hemostatic agents, a large amount of heat energy is released to increase the local temperature, which may cause side effects of tissue thermal burns, which seriously restricts its application. [0003] Experimental studies have found that during the process of hemostasis, the hemostatic agent absorbs a large amount of water in the blood. If the process is completed instantaneously, the hemos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02
CPCA61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/08A61L2300/232A61L2300/404A61L2400/04C08L3/02C08L5/08
Inventor 边文海李倩陈秀王超展边六交
Owner NORTHWEST UNIV(CN)
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