5 results about "Glycopolymer" patented technology

Surfactant compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous fluid in the presence of a hydroxide base and a neutral surfactant or a reaction product form thereof, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. One or more zwitterionic surfactants may be combined with the surfactant composition in a ratio sufficient to render the resulting combined surfactant composition brine-tolerant, even when both the reaction product and one or more of the zwitterionic surfactant(s) are brine-intolerant. The one or more zwitterionic surfactants may be further selected to render the combined surfactant composition non-emulsifying toward oleaginous fluids.

This invention belongs to the field of glycopolymer technology, and particularly relates to a tetraphenylethylene mono-arm thiomannose polymer with a side chain, its preparation method, and its application. The chemical structural formula of the tetraphenylethylene mono-arm thiomannose polymer is shown in formula (I). Wherein, n is an integer ≥2. The glycopolymer of this invention exhibits high biocompatibility and fluorescent recognition properties, and innovatively utilizes efficient and rapid RAFT polymerization and click chemistry to prepare the tetraphenylethylene mono-arm thiomannose polymer.

Provided are a capsule and hollow particles based on particles formed from a glycopolymer containing glucose units in which at least one hydroxyl group is esterified with cinnamic acid to form a cinnamic acid ester (-OCO-CH = CH-C6H5).

A glycopolymer nanoparticle and an application thereof. Encapsulating an anticancer drug in a glycopolymer reprograms a tumor microenvironment, and increases drug penetration into tumors. The synthesized glycopolymer nanoparticle exhibits hydrophilicity and is easily absorbed in vivo, which reduces dosage and mitigates adverse drug reactions.

The application discloses an anti-tumor drug / autophagy inhibitor double-loading sugar polymer modified nanogel, a preparation method and application thereof, and belongs to the technical field of biomaterials. The method is as follows: firstly, a sugar polymer is coupled on the surface of nanogel through a "click" reaction between an azido group at the end of a sugar polymer chain and an alkyne group of the nanogel, so as to prepare a sugar polymer modified nanogel; then, an anti-tumor drug, an autophagy inhibitor and the sugar polymer modified nanogel are added into distilled water, and the mixture is incubated on a shaking table to prepare the anti-tumor drug / autophagy inhibitor double-loading sugar polymer modified nanogel. In the application, the sugar polymer chain is introduced on the surface of the nanogel, and galactose has specific recognition with asialoglycoprotein receptors overexpressed on the surface of liver cells. In particular, the sugar polymer brush has stronger recognition with lectin, and the drug-loaded nanogel can be targeted to liver cells, so that the application can be used for the treatment of hepatocellular carcinoma.