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69 results about "Glycopolymer" patented technology
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Glycopolymer is synthetic polymer with pendant carbohydrates. Glycopolymers play an important role in many biological recognition events such as cell–cell adhesion, development of new tissues and infectious behavior of virus and bacteria. They have high potential in targeted drug delivery, tissue engineering and synthesis of bio-compatible materials.
Superabsorbent polymer
InactiveUS7291674B2Organic detergent compounding agentsPharmaceutical non-active ingredientsPolymer resinWater insoluble
The invention relates to a superabsorbent polymer comprising a composition comprising a polymeric resin composition comprising from about 55 to about 99.9 wt. % of polymerizable unsaturated acid group containing monomers, from about 0.001 to about 5.0 wt. % of internal crosslinking agent and from 0 to 25 wt % of a preneutralizing agent; wherein the polymeric resin composition is preneutralized from 0 to about 50 mole %; and a water swellable, water-insoluble aminopolysaccaride polymer wherein when the superabsorbent polymer is contacted with an aqueous solution, the polymeric resin composition is neutralized by the aminopolysaccaride polymer so that the superabsorbent polymer has a degree of neutralization of about 20 mole % or more than the preneutralization degree of the polymeric resin composition.
Owner:EVONIK CORP
Cross-linkable amphiphilic natural polysaccharide and application thereof
The invention discloses a cross-linkable amphiphilic natural polysaccharide and application thereof. Specifically, in particular, a double-bond and a hydrophobic chain are employed for dual modification of a natural polysaccharide polymer to obtain cross-linkable amphiphilic natural polysaccharide, and the cross-linkable amphiphilic natural polysaccharide is applied to loading and delivery of protein drugs. The amphiphilic natural polysaccharide provided by the invention can self-assemble into nanogel with protein loading capacity in an aqueous solution, and then an initiator is employed to activate the double-bond modifying natural polysaccharide to generate a free radical, thus triggering mutual crosslinking of the double-bond to form a new covalent bond, and the stable action force of the covalent bond is utilized to obtain the preparation so as to achieve efficient delivery of protein drugs.
Owner:CHINA PHARM UNIV
Methods, assays and kits for cancer diagnosis and screening utilizing glycan-binding and glycan epitopes
InactiveUS20100075344A1Highly reproducible resultImprove signal-to-noise ratioDisease diagnosisBiological testingCancer cellCancers diagnosis
The invention relates to the diagnosis, monitoring, prognosis, and / or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are utilized in bioanalytical systems, methods and kits for detecting neoplasia and methods related thereto and based thereon. In an exemplary embodiment glycans or glycopolymers are carried in an array, on beads or in a microfluidic system for diagnostic screening for risk of neoplasia, the existence of neoplasia in a patient, or for treatment monitoring. In such an embodiment, the bioanalytic system identifies binding interactions between molecules in a patient test sample (e.g., glycan compositions) and the glycans or glycopolymers. The glycan-binding compositions may be used to generate an immune response against cancer cell epitopes. Alternatively, antibody therapeutics can be developed that are useful for binding to glycan compositions on a cell surface.
Owner:VUSKOVIC MARKO +1
Monosaccharide polymer enriching material and preparation thereof, and application of the monosaccharide polymer enriching material to enrichment of glycopeptides
InactiveCN106861661AHigh selectivityImprove throughputOther chemical processesPreparing sample for investigationPolymer scienceHydrolysate
The invention relates to a monosaccharide polymer enriching material and preparation thereof, and application of the monosaccharide polymer enriching material to enrichment of glycopeptides. Functional monosaccharide monomers are copolymerized onto a main polymer chain by using a Schiff-base condensation method and are further grafted onto a matrix material so as to obtain a sugar-responsive polymeric material. The monosaccharide polymer enriching material is applied to enrichment and / or selective separation of glycopeptides. The matrix material modified by a polymer is used for contacting with enzymatic glycoprotein hydrolysate for enrichment of glycopeptides. Specifically, a solid-phase extraction (SPE) mode or a dispersive solid-phase extraction mode is employed; and in a SPE mode, when the matrix material modified by the monosaccharide polymer is used for enriching glycopeptides, the enzymatic glycoprotein hydrolysate is loaded into a SPE instrument with the matrix material modified by the monosaccharide polymer as a filling material, then an eluent is used for flushing to remove non-glycopeptides, and glycopeptides are separated from eluate. The monosaccharide polymer enriching material prepared in the invention has the characteristics of high selectivity, high flux and the like in separation and enrichment of glycopeptides and can realize selective enrichment of glycopeptides.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI +1
Method for preparing xylooligosaccharide from corncobs through microwave-assisted hydrothermal treatment
The invention discloses a method for preparing xylooligosaccharide from corncobs through microwave-assisted hydrothermal treatment. The xylooligosaccharide is a functional glycopolymer formed by combining 2-6 xylose molecules by beta-1,4 glucosidic bonding; the method of the microwave-assisted hydrothermal treatment is that water is taken as a reaction solvent, and a complex three-dimensional network structure of cell walls of the corncobs is efficiently and rapidly broken by virtue of a microwave-assisted technology, so that hemicelluloses are dissolved out and subjected to hydrolysis reaction to generate the xylooligosaccharide; the specific steps for preparing xylooligosaccharide from the corncobs through the microwave-assisted hydrothermal treatment are as follows: crushing the corncobs into small granules, extracting by an organic solvent, filtering, washing by purified water, drying, and then carrying out ball-milling; adding a sample subjected to the ball-milling and the water in a reaction kettle, carrying out ultrasonic treatment and reacting in a microwave; and concluding the reaction, cooling, carrying out suction filtration to obtain filtrate, distilling and concentrating the filtrate, and carrying out freeze-drying to obtain the xylooligosaccharide. The method for preparing xylooligosaccharide from the corncobs through the microwave-assisted hydrothermal treatment has the advantages of being rapid, efficient, environmentally friendly, and the like.
Owner:SOUTH CHINA UNIV OF TECH
Method for preparing double-channel hydrophilic bicontinuous polymer monolithic column
ActiveCN109651572AGuaranteed uniformityGuaranteed PenetrationOther chemical processesEmulsionEmulsion polymerization
The invention relates to the field of polymer monolithic column preparation, in particular to a double-channel hydrophilic bicontinuous polymer monolithic column and a preparation method thereof. A self-made amphiphilic diblock sugar-containing polymer is used as a surfactant to control a continuous phase emulsion, and the block polymer is also involved in the preparation of an initiator or a chain transfer agent for the polymerization of the monolithic column. With the combination of a small molecular pore-forming agent and through one-step polymerization of an active emulsion, the double-channel hydrophilic bicontinuous polymer monolithic column is obtained. According to the prepared double-channel hydrophilic bicontinuous polymer monolithic column, the skeleton of the monolithic columnis polystyrene, which has high mechanical strength and good chemical stability, and the outer surface of the skeleton is a sugar-containing polymer and has hydrophilicity and is easy to derive. The monolithic column pores penetrate, have two pores of super macropores and mesopores, and have wide application space in the fields of cell culture, enzyme immobilization and rapid separation and purification of proteins.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Sugar-containing polymer compound film with blocked pore and preparation thereof
InactiveCN101301590AImprove mechanical propertiesFix stability issuesSemi-permeable membranesPolymer scienceIn situ polymerization
The present invention discloses a production method of sugar-containing polymer hole-blocking compound membrane and the application in permeation vaporization and dehydration of organic solvent. The said method comprises the following steps: mixing sugar-contained monomer, comonomer, cross linker, evocating agent and solvent to formulate polymerized solution; performing in-situ polymerization by adopting photo-initiation or thermal initiation mode after the polypropylene microporous membrane is immersed in polymerization solution for a special time; getting sugar-contained polymer hole-blocking compound membrane after cleaning and drying. The sugar-containing polymer hole-blocking compound membrane prepared by the invention can be used for organic solvent dehydration, has advantages of high separation factor, large separation flux, good mechanical properties, good chemical stability and thermostability, and has utility value in separation and purification of organic solvent.
Owner:ZHEJIANG UNIV
Sugar-containing photodynamic therapy nano particles with blood stability and target ability and preparing method of sugar-containing photodynamic therapy nano particles
ActiveCN105412924ASimple and fast operationMaintain stabilityPowder deliveryEnergy modified materialsPhotodynamic therapyPhotosensitizer
The invention discloses sugar-containing photodynamic therapy nano particles with blood stability and target ability and a preparing method of the sugar-containing photodynamic therapy nano particles. The nano particles are formed by wrapping photosensitizer micromolecules with a synthesized copolymer of DMA and DMAEMA, and wrapping the outer layers of nano particles with glycopolymer layers, wherein the average particle size of the nano particles ranges from 180 nm to 300 nm. The preparing method of the sugar-containing photodynamic therapy nano particles comprises the steps that the copolymer of DMA and DMAEMA is subjected to self-assemblage in water to wrap the photosensitizer micromolecules to form the nano particles, the nano particles are mixed with a glycopolymer solution with an end group serving as carboxyl, and the glycopolymer is aggregated on the surfaces of the nano particles through electrostatic interaction to form the sugar-containing photodynamic therapy nano particles. According to the method, operation is easy and convenient, and various photodynamic reagents can be wrapped. The adopted polymer shows electropositivity and can be combined with various glucide polymers with negative electricity, meanwhile, the glycopolymer is aggregated on the surfaces of the nano particles, and thus blood stability, target ability and biocompatibility are achieved.
Owner:SUZHOU UNIV
Methods, assays and kits for cancer diagnosis and screening utilizing glycan-binding and glycan epitopes
InactiveUS8298773B2Highly reproducible resultImprove signal-to-noise ratioDisease diagnosisBiological testingEpitopeCancer cell
The invention relates to the diagnosis, monitoring, prognosis, and / or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are utilized in bioanalytical systems, methods and kits for detecting neoplasia and methods related thereto and based thereon. In an exemplary embodiment glycans or glycopolymers are carried in an array, on beads or in a microfluidic system for diagnostic screening for risk of neoplasia, the existence of neoplasia in a patient, or for treatment monitoring. In such an embodiment, the bioanalytic system identifies binding interactions between molecules in a patient test sample (e.g., glycan compositions) and the glycans or glycopolymers. The glycan-binding compositions may be used to generate an immune response against cancer cell epitopes. Alternatively, antibody therapeutics can be developed that are useful for binding to glycan compositions on a cell surface.
Owner:VUSKOVIC MARKO +1
Surface adsorption antibacterial glycopolymer and preparation method thereof
The invention discloses a surface adsorption antibacterial glycopolymer and a preparation method thereof. A chain transfer agent is added into raw materials including methacrylamide sugar-containing monomers, carboxylic acid monomers and dopamine monomers to prepare the glycopolymer under solar light or simulated solar light with similar wavebands according to a one-step method. The glycopolymer is high in water solubility, great in surface adsorption performance, available for surface in-situ reduction of silver ions and applicable to preparation of functional antibacterial glycopolymer materials and later-stage surface antibacterial treatment of inorganic, organic and metal materials and the like. The dopamine monomers have catechol functional groups, and the glycopolymer forms covalentbonds or strong non-covalent bonds along with material surfaces through the catechol functional groups to be adsorbed on the material surfaces; carboxylic acid is chelated with silver ions to fix thesilver ions on a substrate; the sugar-containing monomers and the dopamine monomers have reducibility and capable of realizing in-situ reduction of the silver ions to achieve an antibacterial effect.
Owner:SUZHOU UNIV
Light-weight composite corundum refractory aggregate, and preparation method for light-weight composite corundum refractory aggregate
The invention relates to a light-weight composite corundum refractory aggregate, and a preparation method for the light-weight composite corundum refractory aggregate. According to the technical scheme, the preparation method comprises the following steps: taking 80-95 wt% of gamma-Al2O3 fine powder, 1-10 wt% of Al(OH)3 micro powder, 1-10 wt% of a glycopolymer and 0.1-5 wt% of an antifreeze protein as raw materials, adding 20-60 wt% of water, and conducting wet grinding; pelleting slurry obtained after wet grinding into particles with the grain sizes being 1-2.5 mm through a disk, freezing, drying, and keeping the temperature for 3-6 h at the temperature of 300-800 DEG C to obtain porous corundum particles; then taking 80-97 wt% of alpha-Al2O3 micro powder, 2-10 wt% of nanometer aluminium oxide sol, and 1-5 wt% of MgO micro powder as mixtures, adding 30-50 wt% of organic alcohol, and conducting mixed grinding; pelleting the slurry obtained through mixed grinding and the porous corundum particles into particles of which the grain sizes are 3-10 mm, drying, and sintering for 1-5 h at the temperature of 1,700-1,900 DEG C, so as to obtain the light-weight composite corundum refractory aggregate. The light-weight composite corundum refractory aggregate product prepared by the invention is low in volume density, high in closed porosity, and high in slagging corrosion resistance.
Owner:WUHAN UNIV OF SCI & TECH
Preparation method of controlled release carrier of glucose-responsive drug
ActiveCN103191437AEasy to fixEffectively fixedMacromolecular non-active ingredientsControl releaseVinyl sulfone
The invention provides a preparation method of a controlled release carrier of a glucose-responsive drug, solves insufficiencies that ConA and sugar ligands thereof are needed to be modified in prior art. The method comprises: (1) dissolving sugar-containing polymer units in a lye, adding divinyl sulfone, adjusting a pH to stop reaction, and dialyzing to obtain a sugar-containing polymer with vinyl sulfone groups; (2) dissolving the prepared substances in a buffer solution, adding a ConA activating solution; (3) adjusting pH of the mixture obtained in step (2) by using the buffer solution, adjusting the pH, adding drop by drop the product into a mixed solution of cyclohexane and an emulsion stabilizer, reacting, removing an oil phase at an upper level, and depositing a lower level to obtain the glucose-responsive carrier. By introducing the divinyl sulfone into the ConA-sugar-containing polymer carrier, the preparation steps for the carrier can be simplified, the sugar-containing polymer can be directly crosslinked with the ConA, thereby being simple and high-efficiency to fix the ConA, low in cost, convenient to implement, and beneficial for large-scale production.
Owner:江阴智产汇知识产权运营有限公司
Preparation method of glycopolymer with lateral chains containing heterogeneous sugar units
ActiveCN110305238AMolecular weight controllableThe synthesis method is stableSugar derivativesSugar derivatives preparationSolubilityChemical reaction
The invention relates to a preparation method of glycopolymer with lateral chains containing heterogeneous sugar units. The preparation method includes: using 2-amino-2-methyl-1,3-propanediol as the raw material, using BOC to perform amino protection, then allowing the 2-amino-2-methyl-1,3-propanediol to have Williamson etherification reaction with propargyl bromide to prepare a compound with terminal alkyne, using an acetyl protected carbohydrate compound containing azido as the raw material to prepare a compound containing heterogeneous sugar through click chemical reaction, removing BOC protection, polymerizing with RAFT, using modification after polymerization to prepare glycopolymer with lateral chains containing heterogeneous sugar units, and then removing OAc protection to prepare glycopolymer containing heterogeneous sugar units. Compared with the prior art, the preparation method is simple in polymer monomer synthesizing method and controllable in polymer lateral chain structure, and the prepared glycopolymer is controllable in molecular weight, narrow in molecular weight distribution, good in water solubility and applicable to fields such as high polymer materials and biological medicine.
Owner:SHANGHAI INST OF TECH
Preparation method and application of glycopolymer
The invention discloses a preparation method and application of a glycopolymer. According to the preparation method, the combination of active ester exchange and active free-radical polymerization reaction at room temperature is utilized for the first time to successfully prepare the glycopolymer with controllable molecular weight and narrower molecular weight distribution by a one-step one-pot process. The invention provides a simple effective way for synthesizing the glycopolymer. The application method comprises the following steps: dialyzing the glycopolymer, carrying out freeze-drying, mixing the freeze-dried glycopolymer with an AgNO3 solution, and preparing the fluorescent sugar-containing silver nano cluster by using the glycopolymer as a stabilizer. The method for preparing the glycopolymer is also applicable to the preparation of glucose, galactose and other glycopolymers.
Owner:SUZHOU UNIV
Methods, assays and kits for cancer diagnosis and screening utilizing glycan-binding and glycan epitopes
InactiveUS20140087957A1Highly reproducible resultImprove signal-to-noise ratioSaccharide librariesLibrary screeningCancer cellCancers diagnosis
The invention relates to the diagnosis, monitoring, prognosis, and / or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are utilized in bioanalytical systems, methods and kits for detecting neoplasia and methods related thereto and based thereon. In an exemplary embodiment glycans or glycopolymers are carried in an array, on beads or in a microfluidic system for diagnostic screening for risk of neoplasia, the existence of neoplasia in a patient, or for treatment monitoring. In such an embodiment, the bioanalytic system identifies binding interactions between molecules in a patient test sample (e.g., glycan compositions) and the glycans or glycopolymers. The glycan-binding compositions may be used to generate an immune response against cancer cell epitopes. Alternatively, antibody therapeutics can be developed that are useful for binding to glycan compositions on a cell surface.
Owner:VUSKOVIC MARKO +1
Methods for detecting contaminants in solutions containing glucose polymers
ActiveUS20140051097A1Increase productionIncrease assayMetabolism disorderMicrobiological testing/measurementGlucose polymersGlycopolymer
The invention relates to a method for detecting contaminants of glucose polymers, said contaminants being capable of acting in synergy with one another so as to trigger an inflammatory reaction, characterized in that it comprises an in vitro inflammatory response test using modified cell lines.
Owner:ROQUETTE FRERES SA
Double-component high-strength hydrogel and preparation method thereof
ActiveCN105924685ARegulatory performanceHigh strengthAerosol deliveryOintment deliveryControlled releasePolymer science
The invention relates to the technical field of biopolymer, and provides a double-component high-strength hydrogel and a preparation method thereof. The double-component high-strength hydrogel is prepared through mixing a glycopolymer and an N-isopropylamine acrylamide-o-hydroxymethylbenzeneboronic acid half ester random copolymer. The repeating unit of the glycopolymer is galactose connected through 6-site hydroxyl. According to the preparation method, the hydrogel is prepared according to a principle that glycopolymer and o-hydroxymethylbenzeneboronic acid half ester polymer can form dynamic covalent bond. The preparation method is simple to operate. The prepared hydrogel has high strength, and the adopted polymers are easy to synthesize. The hydrogel has glucose responsiveness, and can be used as a controlled release carrier of insulin. Therefore, a novel idea is provided for painless treatments of diabetes.
Owner:NANJING UNIV OF POSTS & TELECOMM
Polyethylene Oxide Polymers Including Anti-Inflammatory Glycodendrons
Poly(ethylene oxide) (PEO) glycodendrimers can serve as multivalent inhibitors of selectin-mediated leukocyte recruitment regulating inflammatory response. Disclosed are compounds and methods relating to functionalized branched glycopolymers. In embodiments, the compounds are capable of modifying cell adhesion events and inflammatory conditions. In a particular embodiment, a multi-arm PEO polymer with sulfated lactose end groups can specifically inhibit interactions involving L-selectin. Also disclosed are methods of synthetic preparation and use.
Owner:EMORY UNIVERSITY +1
Methods and Compositions for Dectin-2 Stimulation and Cancer Immunotherapy
InactiveUS20200140556A1Enhance Dectin- signalingPeptide/protein ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsTLR8Infectious Disorder
Provided are methods and compositions for treating an individual with cancer or infectious disease. Multivalent Dectin-2 stimulating agents are provided that include: (a) an agent that binds to Dectin-2 and stimulates Dectin-2 signaling; and (b) an antibody and / or an immunomodulatory agent, wherein (a) and (b) are conjugated to one another. In some cases, (a) is a mannobiose glycopolypeptide that binds to Dectin-2. In some cases (b) is a stimulatory ligand for a TLR (e.g., TLR7, TLR8, TLR7 / 8, TLR2, and the like). Methods of treating an individual with cancer and / or an infectious disease can include administering to the individual an effective amount of a Dectin-2 stimulating composition. In some cases, the Dectin-2 stimulating composition comprises a Dectin-2 stimulating glycopolymer. In some cases the Dectin-2 stimulating composition comprises a multivalent Dectin-2 stimulating agent.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Three-arm mannose derivative and preparation method thereof through combination with double-click chemistry
ActiveCN113248550APromote aggregationClick chemical reaction is efficientSugar derivativesSugar derivatives preparationSide chainTert-Butyloxycarbonyl protecting group
The invention relates to a three-arm mannose derivative and a preparation method thereof through combination with double-click chemistry. Firstly, a three-arm terminal alkene / alkyne compound and [alpha]-D-azide mannose ([alpha]-Man-N3) are used for carrying out a CuAAC reaction between end group alkyne and azide to generate a rigid triazole group; then, the rigid triazole group and [alpha]-D-sulfydryl mannose ([alpha]-Man-SH) carry out a Thiol-ene reaction between end group alkene and the sulfydryl to generate a flexible thioether bond; and then, under an acidic condition of trifluoroacetic acid, protection of t-butyloxycarboryl is removed to obtain one series of three-arm mannose derivatives. Compared with the prior art, the invention utilizes the advantages of the click chemistry reaction to innovatively synthesize three kinds of three-arm mannose derivatives with different structures so as to be favorable for jointly utilizing RAFT polymerization in the later stage to prepare a sugar-containing polymer of which the side chain contains tri-functional mannose and perform an important guidance meaning for researching the influence of the rigidity and the flexibility of different branched chains of the polymer of which the side chain contains three-arm mannose for the biological characteristics.
Owner:SHANGHAI INST OF TECH
Preparation method of photo-controlled degradable hydrogel
ActiveCN108421042AHigh strengthImprove self-healing abilityDrug photocleavageAerosol deliverySelf-healingBiopolymer
The invention discloses a preparation method of a photo-controlled degradable hydrogel, and belongs to the technical field of biopolymers. The preparation method is simple to operate; the photo-controlled degradable hydrogel is prepared by mixing glycopolymer, benzeneboronic acid hemi-ester grafted sodium alginate, a photosensitizer and ascorbic acid, and has injectability and good biocompatibility; the properties of gel can be regulated by changing the content of each component; the strength of the hydrogel is changed by regulating the configuration of sugar in the glycopolymer, so that the prepared hydrogel has high strength and self-healing property; the hydrogel can be degraded rapidly under irradiation of near-infrared light, has photo-control degradability, provides a new carrier forcontrolled release of anticancer drugs, and has great significance in the field of biomedicine.
Owner:NANJING UNIV OF POSTS & TELECOMM
Branched sugar-containing polymer-based nano particle as well as preparation method and application thereof
ActiveCN113583178AGood anti-tumor effectImprove pharmacological propertiesNanomagnetismNanomedicinePharmacometricsPharmaceutical drug
The invention provides a preparation method and application of a branched sugar-containing polymer nanoparticle as shown in a formula I. The branched sugar-containing polymer prepared by the preparation method disclosed by the invention has good self-assembly performance and tumor microenvironment responsiveness. The nanoparticle formed by self-assembly of the branched sugar-containing polymer can significantly improve the pharmacological properties of a small-molecule contrast agent, so that the nanoparticle has a longer blood half-life period, more tumor site accumulation, a higher tumor signal enhancement degree, a longer enhancement duration and better tumor enhancement specificity. The branched sugar-containing polymer nanoparticle prepared by the invention can be rapidly taken in by cells, release drugs in a tumor microenvironment, has long in-vivo circulation time and targeting property, and can significantly improve in-vivo distribution of small molecular drugs, so that the drugs are effectively accumulated at tumor sites, tumor growth is significantly inhibited, and the nanoparticle has good biological safety, and has huge development potential and wide application prospects in the field of tumor diagnosis and treatment integrated medicines.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
Polymeric compound comprising glycopolymer and a method for decomposing the same
InactiveUS6900295B2Easy to recycleEsterified saccharide compoundsSugar derivativesDecompositionEnzyme
The present invention is an enzyme-decomposable polymer compound having recyclable decomposition products. The polymeric compound is a glycopolymer of a saccharide having only glucopyranose rings and a second component. In addition, the glycopolymer may contain molecular chains having at least one type of repeating unit, which chains are crosslinked by a saccharide having only glucopyranose rings.
Owner:CANON KK
Pseudomonas aeruginosa detection membrane and preparation method thereof and method for detecting bacteria
InactiveCN108444961ADecreased fluorescence intensityDesorption does not occurFluorescence/phosphorescencePhenylboronic acidFluorescence
The invention relates to a Pseudomonas aeruginosa detection membrane and a preparation method thereof and a method for detecting bacteria, and belongs to the technical field of biological detection. The Pseudomonas aeruginosa detection membrane comprises a substrate layer, and comprises a detection layer, the detection layer is disposed on the substrate layer, the substrate layer comprises a nanofiber membrane, the detection layer comprises a fluoroboron fluorescent molecule functionalized glycopolymer and a phenylboronic acid polymer, wherein the fluoroboron fluorescent molecule functionalized glycopolymer and the phenylboronic acid polymer are uniformly and alternately assembled on the surface of the nanofiber membrane by layer-by-layer self-assembly. The detection membrane is not only low in cost but also capable of quantitatively detecting Pseudomonas aeruginosa.
Owner:WUHAN TEXTILE UNIV
Achyranthes bidentata glycopolymer as well as preparation method and application thereof
ActiveCN105037447ASimple preparation processEasy to operateOrganic active ingredientsSugar derivativesCelluloseAnti osteoporosis
The invention discloses a glycopolymer in achyranthes bidentata as well as a preparation method and application thereof. In the method, the achyranthes bidentata is used as a raw material, and is subjected to water-extraction alcohol precipitation and alkaline-extraction alcohol precipitation, so that polymers at all the parts of the achyranthes bidentata are obtained. The extraction method is implemented under a relatively gentle condition, and components of the glycopolymer are intactly preserved. The achyranthes bidentata glycopolymer has a remarkable effect at the aspect of anti-osteoporosis symptom; in addition, a glycopolymer pure product is obtained through separation and purification processes including Sevag method deproteinization, DEAE cellulose column chromatography, Sephacryl column chromatography and the like, and structural analysis shows that the achyranthes bidentata glycopolymer obtained through the method comprises polyose and oligose. Through the adoption of the achyranthes bidentata glycopolymer as well as the preparation method and application thereof, a basis is provided for the application of the achyranthes bidentata glycopolymer in the fields of health care products, medicines and the like.
Owner:GUANGDONG PHARMA UNIV
Antibodies for prevention and treatment of diseases caused by clostridium difficile
InactiveUS9815889B2Increase productionRapid immune responseOrganic active ingredientsImmunoglobulins against bacteriaDiseaseClostridium difficile toxin A
The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the Clostridium difficile glycopolymer PS-I: α-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[α-L-Rhap-(1→3)]-α-D-Glcp-(1→2)-α-D-Glcp or a fragment thereof. Said antibody is able to prevent and treat diseases caused by C. difficile. The present invention further pertains to a method of treating or preventing a disease caused by the pathogen Clostridium difficile, which comprises administering to a subject said antibody or a vaccine composition comprising said antibody.
Owner:MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV
Synthesis method of highly ordered dendronized heterogeneous glycopolymer containing various glycosyl groups
ActiveCN112940162AStructure orderMolecular weight controllableBulk chemical productionSodium methoxideCombinatorial chemistry
The invention relates to a synthesis method of a highly ordered dendronized heterogeneous glycopolymer containing various glycosyl groups. The method comprises the following steps: (1) adding anhydrous triethylamine into a dichloromethane solution of pentafluorophenol under an ice bath condition, then adding acryloyl chloride for reaction, and after the reaction is finished, washing, drying and purifying to obtain a compound PFPA; (2) carrying out polymerization reaction on the compound PFPA, a chain transfer agent and an initiator to obtain a polymer pPFPA; (3) mixing the polymer pPFPA with dendronized glycosamine, and carrying out ammonolysis reaction to obtain a glycopolymer; and (4) adding the glycopolymer into a sodium methoxide / methanol solution to react, and purifying after the reaction is finished, thereby obtaining the target product, namely the dendronized heterogeneous glycopolymer containing various glycosyl groups. Compared with the prior art, the method has the advantages that the advantages of RAFT polymerization and post-modification are combined, the glycopolymer with the ordered structure is obtained, particularly the regular heterogeneous glycopolymer is obtained, and a universal platform and the like are provided for preparation of the functional glycopolymer.
Owner:SHANGHAI INST OF TECH
Sugar-containing porphyrin complexation photosensitizer and preparation method thereof
InactiveCN103285403BGood water solubilityImprove the effect of photodynamic therapyEnergy modified materialsPharmaceutical non-active ingredientsReceptorPorphyrin
The present invention discloses a sugar-containing porphyrin complexation photosensitizer and a preparation method thereof. The preparation method comprises the following steps: 1) adopting a sugar-containing monomer, an initiator and a chain transfer agent to carry out a reversible addition fragmentation chain transfer polymerization reaction to obtain a sugar-containing polymer with a regular structure and a controllable molecular weight; and 2) mixing the sugar-containing polymer obtained in the step 1) and porphyrin, adding a catalyst, and then adopting a one-pot method to synthesize to obtain the sugar-containing porphyrin complexation photosensitizer. According to the present invention, water solubility of the sugar-containing porphyrin complexation photosensitizer prepared by using the method is substantially increased, and specific interactions of the sugar-containing component and protein receptors over-expressed on the surface of pathological cells can be adopted to achieve a targeting purpose so as to improve a photodynamic treatment effect.
Owner:SUZHOU UNIV
Biological assay of peptidoglycans
ActiveUS9857355B2Not affect capacityLarge storageBiological material analysisBiological testingSignal PathwaysBiology
The present invention relates to a biological method for assaying peptidoglycans (PGN) in a sample, particularly a sample of glucose polymers. The PGN assay includes: a) treating the glucose polymer sample by sonication, heating, and / or alkalizing; b) placing the treated sample or a dilution thereof in contact with a recombinant cell expressing an exogenous TLR2 (toll-like receptor 2) and a reporter gene directly dependent on the signaling pathway associated with the TLR2. The reporter gene codes for a colored or fluorescent protein or for a protein the activity of which is measurable with or without a substrate; c) measuring the reporter gene signal; and d) determining the amount of PGN in the sample using a standard curve of the correlation between the amount or PGN and the strength of the reporter gene signal.
Owner:ROQUETTE FRERES SA
A kind of hydrophilic ultra-macroporous polymer microsphere and preparation method thereof
ActiveCN104558350BHigh mechanical strengthGood hydrophilicity on the outer surfaceIon-exchange process apparatusOther chemical processesPolymer sciencePolyvinyl alcohol
Owner:ZIBO KANGBEI MEDICAL DEVICES
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