11 results about "Glycopolymer" patented technology

Surfactant compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous fluid in the presence of a hydroxide base and a neutral surfactant or a reaction product form thereof, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. One or more zwitterionic surfactants may be combined with the surfactant composition in a ratio sufficient to render the resulting combined surfactant composition brine-tolerant, even when both the reaction product and one or more of the zwitterionic surfactant(s) are brine-intolerant. The one or more zwitterionic surfactants may be further selected to render the combined surfactant composition non-emulsifying toward oleaginous fluids.

This invention belongs to the field of glycopolymer technology, and particularly relates to a tetraphenylethylene mono-arm thiomannose polymer with a side chain, its preparation method, and its application. The chemical structural formula of the tetraphenylethylene mono-arm thiomannose polymer is shown in formula (I). Wherein, n is an integer ≥2. The glycopolymer of this invention exhibits high biocompatibility and fluorescent recognition properties, and innovatively utilizes efficient and rapid RAFT polymerization and click chemistry to prepare the tetraphenylethylene mono-arm thiomannose polymer.

The present invention discloses platelet-targeted glycosylated polymer micelle nanoparticles and a method for preparing the same, belonging to the field of polymer materials. The present invention utilizes a RAFT polymerization reaction to prepare an amphiphilic block copolymer: different glycosylated monomers, an initiator, and a chain transfer agent are first reacted in DMF, followed by the addition of N-alkyl acrylamide and an initiator, followed by continued reaction. The resulting glycosylated polymer is dialyzed and freeze-dried, and then dispersed in water to obtain nanomicelles. The glycosylated polymer is simple and controllable to prepare, and the resulting glycosylated polymer micelles have a particle size of less than 200 nm and are uniformly dispersed, exhibiting good affinity for platelets.

The invention belongs to the technical field of glycopolymer, and particularly relates to a single-arm mercaptan mannose polymer with a side chain containing tetraphenyl ethylene as well as a preparation method and application of the single-arm mercaptan mannose polymer. The chemical structural formula of the mercaptan mannose polymer containing the tetraphenyl ethylene single arm on the side chain is shown as a formula (I). Wherein n is an integer greater than or equal to 2. The saccharide polymer has high biocompatibility and fluorescence recognition characteristics, and the tetraphenyl ethylene-containing single-arm mercaptan mannose polymer is prepared by innovatively applying efficient and rapid RAFT polymerization and click chemistry reaction.

The present application provides a pyridyl cationic sugar-containing polymer, a preparation method thereof and an application thereof, belonging to the field of antibacterial technology. Insoluble polycaprolactone-b-poly(4-vinylpyridine) gradually undergoes an N-quaternization reaction with an unprotected halogen-functionalized monosaccharide in a solvent to form a sugar-containing copolymer micelle in a suspended form. The prepared pyridyl cationic sugar-containing polymer has high antibacterial activity, low hemolytic ability and good biocompatibility, and can be applied to the preparation of antibacterial drugs and the preparation of antibacterial medical devices. Moreover, the preparation method of the pyridyl cationic sugar-containing polymer of the present application is simple, and the prepared pyridyl cationic sugar-containing polymer has a stable structure.

Provided are a capsule and hollow particles based on particles formed from a glycopolymer containing glucose units in which at least one hydroxyl group is esterified with cinnamic acid to form a cinnamic acid ester (-OCO-CH = CH-C6H5).

A glycopolymer nanoparticle and an application thereof. Encapsulating an anticancer drug in a glycopolymer reprograms a tumor microenvironment, and increases drug penetration into tumors. The synthesized glycopolymer nanoparticle exhibits hydrophilicity and is easily absorbed in vivo, which reduces dosage and mitigates adverse drug reactions.

The invention belongs to the technical field of sugar polymers, and particularly relates to a mannose polymer with side chains containing tetraphenyl ethylene double-arm mercaptan as well as a preparation method and application of the mannose polymer. The chemical structural formula of the side chain containing tetraphenyl ethylene double-arm mercaptan mannose polymer is as shown in formula (I). Wherein n is an integer greater than or equal to 2. The glycopolymer disclosed by the invention has high biological compatibility and fluorescence recognition characteristics. # imgabs0 #

The present invention discloses a segmented glycopolymer, its preparation method, and application. The segmented glycopolymer uses commercially available fucose and lactose as raw materials. Through chemical enzymatic synthesis, it can controllably prepare fucose-sialyllactose segmented glycopolymers with varying degrees of polymerization, sugar densities, and linker arm lengths. This segmented glycopolymer can simultaneously act on the important viral proteins hemagglutinin and neuraminidase on the surface of influenza A virus, inhibiting influenza A virus infection through a dual-targeting mechanism. This has significant development and application value in the prevention and treatment of influenza A virus and can be used to develop drug-resistant anti-influenza drugs.

Surfactant compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous fluid in the presence of a hydroxide base and a neutral surfactant or a reaction product form thereof, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. One or more zwitterionic surfactants may be combined with the surfactant composition in a ratio sufficient to render the resulting combined surfactant composition brine-tolerant, even when both the reaction product and one or more of the zwitterionic surfactant(s) are brine-intolerant. The one or more zwitterionic surfactants may be further selected to render the combined surfactant composition non-emulsifying toward oleaginous fluids.

The application discloses an anti-tumor drug / autophagy inhibitor double-loading sugar polymer modified nanogel, a preparation method and application thereof, and belongs to the technical field of biomaterials. The method is as follows: firstly, a sugar polymer is coupled on the surface of nanogel through a "click" reaction between an azido group at the end of a sugar polymer chain and an alkyne group of the nanogel, so as to prepare a sugar polymer modified nanogel; then, an anti-tumor drug, an autophagy inhibitor and the sugar polymer modified nanogel are added into distilled water, and the mixture is incubated on a shaking table to prepare the anti-tumor drug / autophagy inhibitor double-loading sugar polymer modified nanogel. In the application, the sugar polymer chain is introduced on the surface of the nanogel, and galactose has specific recognition with asialoglycoprotein receptors overexpressed on the surface of liver cells. In particular, the sugar polymer brush has stronger recognition with lectin, and the drug-loaded nanogel can be targeted to liver cells, so that the application can be used for the treatment of hepatocellular carcinoma.