18 results about "Glycopolymer" patented technology

The invention discloses a modified polylactic acid-glycolic acid copolymer composite material scaffold and a preparation method and application thereof, the polylactic acid-glycolic acid copolymer composite material scaffold has a porous structure, pores in the surface and the interior are communicated with each other, and the pore diameter from the surface to the interior is increased in a gradient manner; a metal organic framework material is loaded on the surface of the polylactic acid-glycolic acid copolymer composite material bracket. The printing stent of the modified polylactic acid-glycolic acid copolymer composite material stent has macroscopic macropores and microscopic pores at the same time, so that the surface roughness of the stent can be improved, the purpose of remarkably promoting stent cell adhesion is achieved, the specific surface area of the stent can be remarkably increased, and the stability of the stent is improved. The polylactic acid-glycolic acid copolymer is accelerated to degrade and release more acidic degradation products, so that the degradation of the polydopamine is accelerated, the release of the medicine embedded in the polydopamine is accelerated, and the problem of slow degradation of the polydopamine in vivo and in vitro is solved.

Surfactant compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous fluid in the presence of a hydroxide base and a neutral surfactant or a reaction product form thereof, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. One or more zwitterionic surfactants may be combined with the surfactant composition in a ratio sufficient to render the resulting combined surfactant composition brine-tolerant, even when both the reaction product and one or more of the zwitterionic surfactant(s) are brine-intolerant. The one or more zwitterionic surfactants may be further selected to render the combined surfactant composition non-emulsifying toward oleaginous fluids.

This invention belongs to the field of glycopolymer technology, and particularly relates to a tetraphenylethylene mono-arm thiomannose polymer with a side chain, its preparation method, and its application. The chemical structural formula of the tetraphenylethylene mono-arm thiomannose polymer is shown in formula (I). Wherein, n is an integer ≥2. The glycopolymer of this invention exhibits high biocompatibility and fluorescent recognition properties, and innovatively utilizes efficient and rapid RAFT polymerization and click chemistry to prepare the tetraphenylethylene mono-arm thiomannose polymer.

The present invention discloses platelet-targeted glycosylated polymer micelle nanoparticles and a method for preparing the same, belonging to the field of polymer materials. The present invention utilizes a RAFT polymerization reaction to prepare an amphiphilic block copolymer: different glycosylated monomers, an initiator, and a chain transfer agent are first reacted in DMF, followed by the addition of N-alkyl acrylamide and an initiator, followed by continued reaction. The resulting glycosylated polymer is dialyzed and freeze-dried, and then dispersed in water to obtain nanomicelles. The glycosylated polymer is simple and controllable to prepare, and the resulting glycosylated polymer micelles have a particle size of less than 200 nm and are uniformly dispersed, exhibiting good affinity for platelets.

The invention belongs to the technical field of glycopolymer, and particularly relates to a single-arm mercaptan mannose polymer with a side chain containing tetraphenyl ethylene as well as a preparation method and application of the single-arm mercaptan mannose polymer. The chemical structural formula of the mercaptan mannose polymer containing the tetraphenyl ethylene single arm on the side chain is shown as a formula (I). Wherein n is an integer greater than or equal to 2. The saccharide polymer has high biocompatibility and fluorescence recognition characteristics, and the tetraphenyl ethylene-containing single-arm mercaptan mannose polymer is prepared by innovatively applying efficient and rapid RAFT polymerization and click chemistry reaction.

Provided is lipid nanoparticle functionalised with a glycopolymer. The glycopolymer comprises at least four carbohydrate units, wherein each carbohydrate unit is independently selected from a monosaccharide, a disaccharide and an oligosaccharide. The lipid nanoparticle can be used for inducing an immune response in a subject.

The invention belongs to the technical field of biological medicine, and particularly relates to glycopolymer nanoparticles and application thereof. The anti-cancer drug AMG510 is wrapped in mannose, the tumor microenvironment can be reprogrammed, and the permeation effect of the drug on tumors is improved. The synthesized glycopolymer nanoparticle AMG510 (at) M-NP has hydrophilicity and is easy to absorb in vivo, the actual dosage is reduced under the theoretical dosage, and the adverse drug reaction is further relieved. Mannose and AMG510 have a synergistic effect, so that the anti-cancer effect is improved. The raw material mannose is easily available, the preparation process is simple, the cost is reduced, and the method is suitable for mass production.

The present application provides a pyridyl cationic sugar-containing polymer, a preparation method thereof and an application thereof, belonging to the field of antibacterial technology. Insoluble polycaprolactone-b-poly(4-vinylpyridine) gradually undergoes an N-quaternization reaction with an unprotected halogen-functionalized monosaccharide in a solvent to form a sugar-containing copolymer micelle in a suspended form. The prepared pyridyl cationic sugar-containing polymer has high antibacterial activity, low hemolytic ability and good biocompatibility, and can be applied to the preparation of antibacterial drugs and the preparation of antibacterial medical devices. Moreover, the preparation method of the pyridyl cationic sugar-containing polymer of the present application is simple, and the prepared pyridyl cationic sugar-containing polymer has a stable structure.

Provided are a capsule and hollow particles based on particles formed from a glycopolymer containing glucose units in which at least one hydroxyl group is esterified with cinnamic acid to form a cinnamic acid ester (-OCO-CH = CH-C6H5).

A substrate coated with a polymer obtained by grafting an aqueous monomer grafting solution comprising a mixture that includes sodium styrene sulphonate (NaSS) and methacrylic acid (MA) or acrylic acid (AA). The mixture has 10 to 90 mol % of sodium styrene sulphonate and 10 to 90 mol % of methacrylic acid or acrylic acid. The substrate is selected from among polyesters, vinyl polymers, polyacrylics and polymethacrylics, PEEK, silicones, natural polymers, natural or artificial celluloses, collagens, glycopolymers, ceramics, metals and metal alloys, and in particular Ti and alloys thereof and Ni—Ti alloys. The aqueous grafting solution has, in addition to the mixture which represents 90 to 99 mol % of the aqueous grafting solution, 1 to 10 mol % of hydroxyethylmethacrylate (HEMA).

The invention relates to localized surface plasmon resonance (LSPR) detection and analysis of mannose-binding lectin (MBL) using gold nanorods (GNR) coated with lectin-binding glycopolymer. The linker between the mannose and the gold nanorod comprises PEG (polyethylene glycol)-alkane-sulfydryl. Colloidal stability required by LSPR is provided by preventing particle aggregation.

A glycopolymer nanoparticle and an application thereof. Encapsulating an anticancer drug in a glycopolymer reprograms a tumor microenvironment, and increases drug penetration into tumors. The synthesized glycopolymer nanoparticle exhibits hydrophilicity and is easily absorbed in vivo, which reduces dosage and mitigates adverse drug reactions.

The invention belongs to the technical field of sugar polymers, and particularly relates to a mannose polymer with side chains containing tetraphenyl ethylene double-arm mercaptan as well as a preparation method and application of the mannose polymer. The chemical structural formula of the side chain containing tetraphenyl ethylene double-arm mercaptan mannose polymer is as shown in formula (I). Wherein n is an integer greater than or equal to 2. The glycopolymer disclosed by the invention has high biological compatibility and fluorescence recognition characteristics. # imgabs0 #

The present invention discloses a segmented glycopolymer, its preparation method, and application. The segmented glycopolymer uses commercially available fucose and lactose as raw materials. Through chemical enzymatic synthesis, it can controllably prepare fucose-sialyllactose segmented glycopolymers with varying degrees of polymerization, sugar densities, and linker arm lengths. This segmented glycopolymer can simultaneously act on the important viral proteins hemagglutinin and neuraminidase on the surface of influenza A virus, inhibiting influenza A virus infection through a dual-targeting mechanism. This has significant development and application value in the prevention and treatment of influenza A virus and can be used to develop drug-resistant anti-influenza drugs.

This disclosure relates to an invitro gut model, including an integral layer of intestinal epithelial cells, an artificial mucus atop the integral layer of intestinal epithelial cells, wherein the artificial mucus comprises a silk glycopolymer and optionally a silk polymer lacking sugar substituents, the artificial mucus having a degree of substitution of the silk glycopolymer, a location of substitution of the silk glycopolymer, a concentration of the silk glycopolymer, an overall polymer concentration, an overall silk polymer concentration, an optional concentration of the silk polymer lacking sugar substituents, an optional ratio by weight of the silk glycopolymer and the silk polymer lacking sugar substituents, and / or a silk glycopolymer silk backbone molecular weight is tailored to maintain the integral layer of intestinal epithelial cells for a predetermined length of time, and growth media accessible to the intestinal epithelial cells and tailored to maintain viability of the intestinal epithelial cells.

Surfactant compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous fluid in the presence of a hydroxide base and a neutral surfactant or a reaction product form thereof, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. One or more zwitterionic surfactants may be combined with the surfactant composition in a ratio sufficient to render the resulting combined surfactant composition brine-tolerant, even when both the reaction product and one or more of the zwitterionic surfactant(s) are brine-intolerant. The one or more zwitterionic surfactants may be further selected to render the combined surfactant composition non-emulsifying toward oleaginous fluids.

Compositions comprising a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be obtained in an aqueous phase in the presence of a hydroxide base and a neutral surfactant, the saccharide polymer comprising a dextran, a dextrin compound, or any combination thereof. The neutral surfactant may comprise at least one compound having a structure ofin which R1 is a saturated or unsaturated hydrocarbyl group having about 8 to about 30 carbon atoms; R2 is C1-C4 optionally branched alkyl, CH2OH, CH2O(CH2CH2O)xCH2CH2OH (x is 0 or a positive integer), CH(OH)CH2OH, CO2H, or CH2SO3−, and R3 is H or C1-C4 optionally branched alkyl, and R2 and R3 are not simultaneously CH2OH and H, respectively. The reaction product of the saccharide polymer may be present in the aqueous phase at a concentration effective to lower a surface tension of the neutral surfactant.

The application discloses an anti-tumor drug / autophagy inhibitor double-loading sugar polymer modified nanogel, a preparation method and application thereof, and belongs to the technical field of biomaterials. The method is as follows: firstly, a sugar polymer is coupled on the surface of nanogel through a "click" reaction between an azido group at the end of a sugar polymer chain and an alkyne group of the nanogel, so as to prepare a sugar polymer modified nanogel; then, an anti-tumor drug, an autophagy inhibitor and the sugar polymer modified nanogel are added into distilled water, and the mixture is incubated on a shaking table to prepare the anti-tumor drug / autophagy inhibitor double-loading sugar polymer modified nanogel. In the application, the sugar polymer chain is introduced on the surface of the nanogel, and galactose has specific recognition with asialoglycoprotein receptors overexpressed on the surface of liver cells. In particular, the sugar polymer brush has stronger recognition with lectin, and the drug-loaded nanogel can be targeted to liver cells, so that the application can be used for the treatment of hepatocellular carcinoma.