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Blood glucose regulating polymer vesicle as well as preparation method and application thereof

A technology of polymers and vesicles, applied in the field of polymer materials and medicine, can solve the problems of difficulty and limited research on sugar-responsive assemblies, and achieve good stability

Active Publication Date: 2019-03-08
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been expected to make biocompatible nanobiomaterials into "sugar sponges" or blood sugar regulating vesicles, which can circulate in blood vessels and absorb sugar into nanostructures when blood sugar concentrations are high; When the blood glucose concentration is low, the stored sugar can be released, but due to the difficulty, scientists have limited research on sugar-responsive assemblies

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  • Blood glucose regulating polymer vesicle as well as preparation method and application thereof
  • Blood glucose regulating polymer vesicle as well as preparation method and application thereof
  • Blood glucose regulating polymer vesicle as well as preparation method and application thereof

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preparation example Construction

[0036]

[0037] The preparation method of the blood sugar regulating polymersome of the present invention comprises the following steps:

[0038] (1), the synthetic steps of amphiphilic sugar-containing polymer:

[0039] a. Using trithioester-modified polyoxyethylene (PEO-DDMAT) as a chain transfer agent, the coumarin monomer (CMA), phenylboronic acid monomer (AAPBA), glucose monomer (AGA), initiator and the second A class of solvents are mixed and reacted at 70-150°C for 10-60 hours under anaerobic conditions. After the reaction is completed, a polymer solution is obtained;

[0040] b. obtaining the polymer powder after rotary evaporation, dissolving, dialysis and lyophilization of the obtained polymer solution;

[0041] (2) Preparation steps of blood sugar regulating polymersomes:

[0042] Dissolve the amphiphilic sugar-based polymer PEO-b-P (CMA-stat-AAPBA-stat-AGA) obtained in step (1) in the second type of solvent at a concentration of 1.0 to 10 mg / mL, and stir vigoro...

Embodiment 1

[0057] This embodiment provides a method for preparing blood sugar regulating polymersomes, comprising the following steps:

[0058] (1), the synthesis steps of the amphiphilic sugar-containing polymer PEO-b-P (CMA-stat-AAPBA-stat-AGA):

[0059] a. Use 0.115g (0.05mmol) polyoxyethylene (PEO-DDMAT) modified by trithioester as chain transfer agent, 0.002g azobisisobutyronitrile (AIBN) as initiator, coumarin monomer (CMA ) (0.295g, 1.0mmol), phenylboronic acid monomer (AAPBA) (0.619g, 0.8mmol) and glucose monomer (AGA) (0.113g, 0.5mmol) were added together into a 25mL round bottom flask, and 5mL di Methyl sulfoxide dissolves all the above-mentioned reactants, and blows argon for 30 minutes by bubbling to remove oxygen in the reaction system (form an oxygen-free environment), and carry out chain transfer radical polymerization (RAFT), and the reaction temperature is 75 °C, the reaction time is 60h, and after the reaction is completed, a polymer solution is obtained;

[0060] b. ...

Embodiment 2

[0066] This embodiment provides a method for preparing blood sugar regulating polymersomes, comprising the following steps:

[0067] (1), the synthesis steps of the amphiphilic sugar-containing polymer PEO-b-P (CMA-stat-AAPBA-stat-AGA):

[0068] a. Use 0.115g (0.05mmol) trithioester-modified polyoxyethylene (PEO-DDMAT) as chain transfer agent, 0.004g azobisisobutyronitrile (AIBN) as initiator, coumarin monomer (CMA ) (0.443g, 1.5mmol), phenylboronic acid monomer (AAPBA) (0.923g, 1.2mmol) and glucose monomer (AGA) (0.113g, 0.5mmol) were added together into a 25mL round bottom flask, Methyl sulfoxide / dimethylformamide mixed solvent to dissolve all the above-mentioned reactants, and blow argon for 30 minutes by bubbling method to remove oxygen in the reaction system (form an oxygen-free environment), and carry out chain transfer radical polymerization reaction (RAFT), the reaction temperature is 100°C, and the reaction time is 40h. After the reaction, a polymer solution is obtai...

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Abstract

The invention relates to a blood glucose regulating polymer vesicle which can be applied to treating diabetes as well as a preparation method and application thereof. The polymer vesicle is prepared from amphipathic glycopolymer. The preparation method of the blood glucose regulating polymer vesicle comprises the following steps: firstly, preparing the amphipathic glycopolymer at least from an initiator, a chain transfer agent and a polymer monomer; then enable the amphipathic glycopolymer to conduct self-assembling to form the blood glucose regulating polymer vesicle. The blood glucose regulating polymer vesicle disclosed by the invention can respond to concentration change of glucose in the external environment to generate particle diameter change, cannot be affected by temperature, further has better stability and can be used as a blood glucose detection agent or a non-drug buffer agent for treating the diabetes.

Description

technical field [0001] The invention belongs to the field of polymer materials and medicine, and relates to a polymer vesicle capable of regulating blood sugar level, its preparation method and application. Background technique [0002] In recent years, the self-assembly technology of polymers has been a research hotspot of researchers from all over the world. Various novel structures can be obtained through self-assembly technology, such as micelles, vesicles, disc-like structures, worm-like structures, rod-like structures, etc. structure etc. Among them, polymersomes have a wider range of applications because they have a cavity inside and can efficiently entrap hydrophilic and hydrophobic drugs at the same time. [0003] Stimuli-responsive polymersomes refer to polymersomes that can respond to certain external stimuli. Common stimuli are divided into two types: physical stimuli and chemical stimuli, such as pH, temperature, light, magnetic field, and redox conditions. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/34A61P3/10A61K49/00
CPCA61K9/1273A61K47/34A61K49/0004A61P3/10
Inventor 杜建忠萧雨芬胡宇
Owner TONGJI UNIV
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