Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of blood sugar regulation polymer vesicle and its preparation method and application

A technology of polymers and vesicles, applied in the field of polymer materials and medicine, can solve the problems of difficulty and limited research on sugar-responsive assemblies, and achieve good stability

Active Publication Date: 2021-08-06
TONGJI UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been expected to make biocompatible nanobiomaterials into "sugar sponges" or blood sugar regulating vesicles, which can circulate in blood vessels and absorb sugar into nanostructures when blood sugar concentrations are high; When the blood glucose concentration is low, the stored sugar can be released, but due to the difficulty, scientists have limited research on sugar-responsive assemblies

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of blood sugar regulation polymer vesicle and its preparation method and application
  • A kind of blood sugar regulation polymer vesicle and its preparation method and application
  • A kind of blood sugar regulation polymer vesicle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036]

[0037] The preparation method of the blood sugar regulating polymersome of the present invention comprises the following steps:

[0038] (1), the synthetic steps of amphiphilic sugar-containing polymer:

[0039] a. Using trithioester-modified polyoxyethylene (PEO-DDMAT) as a chain transfer agent, the coumarin monomer (CMA), phenylboronic acid monomer (AAPBA), glucose monomer (AGA), initiator and the second A class of solvents are mixed and reacted at 70-150°C for 10-60 hours under anaerobic conditions. After the reaction is completed, a polymer solution is obtained;

[0040] b. obtaining the polymer powder after rotary evaporation, dissolving, dialysis and lyophilization of the obtained polymer solution;

[0041] (2), the preparation steps of blood sugar regulating polymersomes:

[0042] Dissolve the amphiphilic glycosyl polymer PEO-b-P (CMA-stat-AAPBA-stat-AGA) obtained in step (1) in the second type of solvent at a concentration of 1.0 to 10 mg / mL, and stir vigo...

Embodiment 1

[0057] This embodiment provides a method for preparing blood sugar regulating polymersomes, comprising the following steps:

[0058] (1), the synthesis steps of the amphiphilic sugar-containing polymer PEO-b-P (CMA-stat-AAPBA-stat-AGA):

[0059] a. Use 0.115g (0.05mmol) polyoxyethylene (PEO-DDMAT) modified by trithioester as chain transfer agent, 0.002g azobisisobutyronitrile (AIBN) as initiator, coumarin monomer (CMA ) (0.295g, 1.0mmol), phenylboronic acid monomer (AAPBA) (0.619g, 0.8mmol) and glucose monomer (AGA) (0.113g, 0.5mmol) were added together in a 25mL round bottom flask, Methyl sulfoxide dissolves all the above-mentioned reactants, and blows argon for 30 minutes by bubbling to remove oxygen in the reaction system (form an oxygen-free environment), and carry out chain transfer radical polymerization (RAFT), and the reaction temperature is 75 °C, the reaction time is 60h, and after the reaction is completed, a polymer solution is obtained;

[0060] b. The obtained ...

Embodiment 2

[0066] This embodiment provides a method for preparing blood sugar regulating polymersomes, comprising the following steps:

[0067] (1), the synthesis steps of the amphiphilic sugar-containing polymer PEO-b-P (CMA-stat-AAPBA-stat-AGA):

[0068] a. Use 0.115g (0.05mmol) trithioester-modified polyoxyethylene (PEO-DDMAT) as chain transfer agent, 0.004g azobisisobutyronitrile (AIBN) as initiator, coumarin monomer (CMA ) (0.443g, 1.5mmol), phenylboronic acid monomer (AAPBA) (0.923g, 1.2mmol) and glucose monomer (AGA) (0.113g, 0.5mmol) were added together in a 25mL round bottom flask, Methyl sulfoxide / dimethylformamide mixed solvent to dissolve all the above-mentioned reactants, and blow argon for 30 minutes by bubbling method to remove oxygen in the reaction system (form an oxygen-free environment), and carry out chain transfer radical polymerization reaction (RAFT), the reaction temperature is 100° C., and the reaction time is 40 h. After the reaction is completed, a polymer sol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The present invention relates to a blood sugar regulating polymer vesicle which can be used for diabetes treatment and its preparation method and application. The polymer vesicle is assembled by amphiphilic sugar-containing polymer; transfer agent and polymerized monomers to synthesize amphiphilic sugar-containing polymers, and then self-assemble the amphiphilic sugar-containing polymers to form blood sugar-regulating polymer vesicles; the blood sugar-regulating polymer vesicles of the present invention can respond to glucose in the external environment The particle size changes with the change of concentration, it is not affected by temperature and has good stability, and can be used as a blood sugar detection reagent and a non-drug buffer for treating diabetes.

Description

technical field [0001] The invention belongs to the field of polymer materials and medicine, and relates to a polymer vesicle capable of regulating blood sugar level, its preparation method and application. Background technique [0002] In recent years, the self-assembly technology of polymers has been a research hotspot of researchers from all over the world. Various novel structures can be obtained through self-assembly technology, such as micelles, vesicles, disc-like structures, worm-like structures, rod-like structures, etc. structure etc. Among them, polymersomes have a wider range of applications because they have a cavity inside and can efficiently entrap hydrophilic and hydrophobic drugs at the same time. [0003] Stimuli-responsive polymersomes refer to polymersomes that can respond to certain external stimuli. Common stimuli are divided into two types: physical stimuli and chemical stimuli, such as pH, temperature, light, magnetic field, and redox conditions. Th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K47/34A61P3/10A61K49/00
CPCA61K9/1273A61K47/34A61K49/0004A61P3/10
Inventor 杜建忠萧雨芬胡宇
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com